Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tyrosine kinase, non-receptor, 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Trypanosoma brucei | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0128 | 0.3046 | 0.3046 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0186 | 0.6462 | 0.4682 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0134 | 0.3347 | 0.1672 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.02 | 0.7281 | 0.7264 |
Brugia malayi | tubulin alpha chain - mouse | 0.0186 | 0.6462 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.6462 | 0.5571 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.6462 | 0.5571 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0128 | 0.3046 | 0.3046 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.7281 | 0.7281 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Brugia malayi | Tubulin alpha chain | 0.0186 | 0.6462 | 0.4682 |
Schistosoma mansoni | tubulin subunit epsilon | 0.0134 | 0.3347 | 0.3306 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0186 | 0.6462 | 0.644 |
Plasmodium falciparum | alpha tubulin 1 | 0.0186 | 0.6462 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0186 | 0.6462 | 0.6462 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0186 | 0.6462 | 0.644 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0186 | 0.6462 | 0.4682 |
Brugia malayi | Protein kinase domain containing protein | 0.02 | 0.7281 | 0.5913 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0186 | 0.6462 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0186 | 0.6462 | 0.644 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.6462 | 0.5571 |
Echinococcus granulosus | tubulin alpha | 0.0134 | 0.3347 | 0.3306 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0186 | 0.6462 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.6462 | 0.5571 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0186 | 0.6462 | 0.644 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0186 | 0.6462 | 0.5571 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0186 | 0.6462 | 0.644 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.6462 | 0.5571 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0186 | 0.6462 | 0.644 |
Trypanosoma brucei | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0186 | 0.6462 | 0.4682 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0186 | 0.6462 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.6462 | 0.5571 |
Brugia malayi | Tubulin alpha-2 chain | 0.0186 | 0.6462 | 0.4682 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0134 | 0.3347 | 0.3347 |
Schistosoma mansoni | alpha tubulin | 0.0186 | 0.6462 | 0.644 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0186 | 0.6462 | 0.6462 |
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0186 | 0.6462 | 0.644 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.6462 | 0.6462 |
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Loa Loa (eye worm) | alpha-tubulin | 0.0186 | 0.6462 | 0.6462 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0186 | 0.6462 | 0.6462 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Echinococcus multilocularis | tubulin gamma 1 chain | 0.0134 | 0.3347 | 0.3306 |
Echinococcus granulosus | alpha tubulin | 0.0186 | 0.6462 | 0.644 |
Brugia malayi | alpha-tubulin | 0.0186 | 0.6462 | 0.4682 |
Giardia lamblia | Alpha-tubulin | 0.0186 | 0.6462 | 0.4682 |
Echinococcus multilocularis | transfer RNA-Thr | 0.02 | 0.7281 | 0.7264 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.02 | 0.7281 | 0.7264 |
Giardia lamblia | Alpha-tubulin | 0.0186 | 0.6462 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7221 | 0.7221 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0186 | 0.6462 | 0.6462 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0186 | 0.6462 | 0.644 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0111 | 0.2011 | 0.2011 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.2011 | 0.2011 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus multilocularis | tubulin epsilon chain | 0.0134 | 0.3347 | 0.3306 |
Brugia malayi | tubulin alpha-2 chain | 0.0186 | 0.6462 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0186 | 0.6462 | 0.5571 |
Plasmodium falciparum | alpha tubulin 2 | 0.0186 | 0.6462 | 0.4682 |
Echinococcus granulosus | tubulin gamma 1 chain | 0.0134 | 0.3347 | 0.3306 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0186 | 0.6462 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus granulosus | tubulin subunit TubB | 0.0186 | 0.6462 | 0.644 |
Schistosoma mansoni | tubulin subunit gamma | 0.0134 | 0.3347 | 0.3306 |
Schistosoma mansoni | tubulin subunit alpha | 0.0186 | 0.6462 | 0.644 |
Schistosoma mansoni | tubulin subunit alpha | 0.0186 | 0.6462 | 0.644 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0186 | 0.6462 | 0.644 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0128 | 0.3046 | 0.3046 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0186 | 0.6462 | 0.5571 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0186 | 0.6462 | 0.644 |
Echinococcus multilocularis | activated cdc42 kinase 1 | 0.02 | 0.7281 | 0.7264 |
Schistosoma mansoni | alpha tubulin | 0.0186 | 0.6462 | 0.644 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Trypanosoma brucei | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0186 | 0.6462 | 0.644 |
Brugia malayi | Tubulin alpha-2 chain | 0.0186 | 0.6462 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0186 | 0.6462 | 0.644 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0134 | 0.3347 | 0.1672 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.006 | 0.006 |
Echinococcus multilocularis | tubulin alpha | 0.0134 | 0.3347 | 0.3306 |
Schistosoma mansoni | tubulin subunit alpha | 0.0186 | 0.6462 | 0.644 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.3046 | 0.3046 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0134 | 0.3347 | 0.1672 |
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus granulosus | tubulin epsilon chain | 0.0134 | 0.3347 | 0.3306 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus multilocularis | hypothetical protein | 0.0186 | 0.6462 | 0.644 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0128 | 0.3046 | 0.1296 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 369.4 nM | BindingDB_Patents: AlphaScreen Assay. AlphaScreen (amplified luminescent proximity homogeneous assay) assay was used to test for ACK1 inhibitory activity. | ChEMBL. | No reference |
IC50 (binding) | = 0.37 uM | Inhibition of ACK1 (unknown origin) by biochemical assay | ChEMBL. | 23317569 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.