Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sodium channel, voltage-gated, type IX, alpha subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0041 | 0.043 | 0.0464 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0196 | 0.9017 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0059 | 0.1414 | 0.1556 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0041 | 0.043 | 0.0301 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0041 | 0.043 | 0.043 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0041 | 0.043 | 0.043 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0059 | 0.1414 | 0.1556 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0041 | 0.043 | 0.0464 |
Echinococcus granulosus | sodium channel protein | 0.0058 | 0.1372 | 0.151 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0041 | 0.043 | 0.0464 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0059 | 0.1414 | 0.1414 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0059 | 0.1414 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1414 | 0.1204 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.018 | 0.8149 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0059 | 0.1414 | 0.1414 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.7603 | 0.8365 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0196 | 0.9017 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0041 | 0.043 | 0.0464 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.004 | 0.0373 | 0.0236 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0196 | 0.9017 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.018 | 0.8149 | 1 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0041 | 0.043 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0887 | 0.0595 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0041 | 0.043 | 0.043 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0045 | 0.0678 | 0.0678 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0041 | 0.043 | 0.0464 |
Echinococcus granulosus | voltage gated potassium channel | 0.0059 | 0.1414 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.043 | 0.0066 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.043 | 0.043 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0041 | 0.043 | 0.0464 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0041 | 0.043 | 0.0464 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0196 | 0.9017 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0059 | 0.1414 | 0.1411 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0041 | 0.043 | 0.0464 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0041 | 0.043 | 0.043 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0041 | 0.043 | 0.0464 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0041 | 0.043 | 0.0464 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0049 | 0.0887 | 0.0972 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0034 | 0.0012 | 0.0012 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0049 | 0.0887 | 0.0972 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0058 | 0.1372 | 0.5 |
Echinococcus multilocularis | sodium channel protein | 0.0058 | 0.1372 | 0.151 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0041 | 0.043 | 0.043 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0041 | 0.043 | 0.0066 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0041 | 0.043 | 0.0066 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0058 | 0.1372 | 0.151 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.6383 | Inhibition of NaV1.7 ion channel (unknown origin) | ChEMBL. | 23177785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.