Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | chemokine (C-C motif) receptor 1 | 355 aa | 289 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0034 | 0.17 | 0.1326 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1548 | 0.1713 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.005 | 0.3205 | 0.3107 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0046 | 0.2846 | 0.2732 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.002 | 0.036 | 0.0207 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0022 | 0.058 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.3205 | 0.3549 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0034 | 0.17 | 0.1569 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0111 | 0.9032 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0032 | 0.1548 | 0.137 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0022 | 0.058 | 0.043 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0111 | 0.9032 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.005 | 0.3205 | 0.3107 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0104 | 0.8339 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0111 | 0.9032 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0032 | 0.1548 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0032 | 0.1548 | 0.1414 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0037 | 0.1961 | 0.1847 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0022 | 0.058 | 0.043 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0022 | 0.058 | 0.0642 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.764 | 0.8459 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0022 | 0.058 | 0.043 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0032 | 0.1548 | 0.1414 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0022 | 0.058 | 0.043 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0111 | 0.9032 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.058 | 0.0642 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0032 | 0.1548 | 0.1145 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0022 | 0.058 | 0.0253 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0022 | 0.058 | 0.043 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0034 | 0.17 | 0.1326 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.004 | 0.2321 | 0.2262 |
Echinococcus granulosus | voltage gated potassium channel | 0.0032 | 0.1548 | 0.1145 |
Loa Loa (eye worm) | glutamate receptor | 0.004 | 0.2321 | 0.257 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0022 | 0.058 | 0.0642 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0104 | 0.8339 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0032 | 0.1548 | 0.1145 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14 nM | Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells | ChEMBL. | 23374868 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.