TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 225.243 | Formula: C14H11NO2
H donors: 1 H acceptors: 2 LogP: 3.06 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)c1cc(O)ccc1nc2
InChi: 1S/C14H11NO2/c1-17-11-4-2-9-8-15-14-5-3-10(16)6-13(14)12(9)7-11/h2-8,16H,1H3
InChiKey: LNXZOIZCCROTGY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0218	0.0426	0.0448
Schistosoma mansoni	hypothetical protein	0.0218	0.0426	0.0409
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.025	0.0518	0.4869
Schistosoma mansoni	voltage-dependent calcium channel	0.0218	0.0426	0.0409
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0218	0.0426	0.0448
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0655	0.1658	0.1798
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0218	0.0426	0.3979
Mycobacterium ulcerans	DNA gyrase subunit A	0.025	0.0518	0.3885
Trichomonas vaginalis	adenylate cyclase, putative	0.0304	0.0669	0.0766
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Echinococcus multilocularis	two pore calcium channel protein 2	0.0218	0.0426	0.0448
Echinococcus granulosus	transient receptor potential cation channel	0.0218	0.0426	0.0448
Echinococcus granulosus	sodium channel protein	0.0218	0.0426	0.0448
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0304	0.0669	0.0766
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Echinococcus multilocularis	potassium large conductance calcium activated	0.0218	0.0426	0.0448
Leishmania major	protein kinase, putative	0.0437	0.1045	1
Loa Loa (eye worm)	hypothetical protein	0.0655	0.1658	0.1798
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0437	0.1045	1
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0437	0.1045	1
Schistosoma mansoni	voltage-gated potassium channel	0.0959	0.2516	0.2502
Trichomonas vaginalis	adenylate cyclase, putative	0.0304	0.0669	0.0766
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0655	0.1658	0.1798
Echinococcus granulosus	voltage dependent calcium channel	0.0218	0.0426	0.0448
Mycobacterium ulcerans	regulatory protein	0.0437	0.1045	1
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0218	0.0426	0.0448
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0218	0.0426	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0218	0.0426	0.0448
Echinococcus granulosus	two pore calcium channel protein 1	0.0218	0.0426	0.0448
Echinococcus granulosus	TRP transient receptor potential channel	0.0218	0.0426	0.0448
Schistosoma mansoni	hypothetical protein	0.0437	0.1045	0.1029
Trichomonas vaginalis	adenylate cyclase, putative	0.0304	0.0669	0.0766
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.3309	0.9143	1
Trichomonas vaginalis	conserved hypothetical protein	0.0304	0.0669	0.0766
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0437	0.1045	0.1125
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0218	0.0426	0.3979
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0437	0.1045	0.1029
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0218	0.0426	0.0448
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0437	0.1045	0.1029
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0437	0.1045	0.1029
Trichomonas vaginalis	conserved hypothetical protein	0.0304	0.0669	0.0766
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0218	0.0426	0.0448
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0218	0.0426	0.0448
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0655	0.1658	0.1928
Echinococcus multilocularis	voltage dependent calcium channel	0.0218	0.0426	0.0448
Mycobacterium ulcerans	transmembrane transport protein	0.0437	0.1045	1
Schistosoma mansoni	voltage-gated potassium channel	0.0218	0.0426	0.0409
Leishmania major	hypothetical protein, conserved	0.0437	0.1045	1
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0218	0.0426	0.0409
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0437	0.1045	1
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0304	0.0669	0.0766
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0437	0.1045	1
Leishmania major	hypothetical protein, conserved	0.0437	0.1045	1
Echinococcus granulosus	single minded 2	0.0304	0.0669	0.0714
Echinococcus granulosus	transient receptor potential cation channel	0.0218	0.0426	0.0448
Trypanosoma cruzi	cAMP response protein 1	0.0437	0.1045	1
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0218	0.0426	0.3979
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0218	0.0426	0.0409
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0437	0.1045	0.1125
Leishmania major	protein kinase A regulatory subunit, putative	0.0437	0.1045	1
Leishmania major	hypothetical protein, conserved	0.0218	0.0426	0.3979
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0437	0.1045	0.1125
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0437	0.1045	0.1029
Trichomonas vaginalis	adenylate cyclase type vIII, putative	0.0304	0.0669	0.0766
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0437	0.1045	1
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0437	0.1045	1
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0437	0.1045	1
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0218	0.0426	0.0448
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0218	0.0426	0.0448
Trichomonas vaginalis	conserved hypothetical protein	0.0304	0.0669	0.0766
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0437	0.1045	0.1029
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0437	0.1045	0.1125
Echinococcus multilocularis	short transient receptor potential channel 6	0.0218	0.0426	0.0448
Brugia malayi	voltage-dependent calcium channel	0.0218	0.0426	0.0448
Chlamydia trachomatis	DNA gyrase subunit A	0.025	0.0518	0.3885
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Echinococcus granulosus	two pore calcium channel protein 2	0.0218	0.0426	0.0448
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0218	0.0426	0.0448
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0437	0.1045	0.1125
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0959	0.2516	0.2737
Schistosoma mansoni	voltage-gated ion channel	0.0218	0.0426	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0959	0.2516	0.2737
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0437	0.1045	0.1125
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0218	0.0426	0.3979
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Schistosoma mansoni	two-pore calcium channel	0.0218	0.0426	0.0409
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0218	0.0426	0.0409
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Echinococcus multilocularis	transient receptor potential cation channel	0.0218	0.0426	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Trichomonas vaginalis	adenylate cyclase, putative	0.0304	0.0669	0.0766
Trypanosoma cruzi	cAMP binding protein, putative	0.0437	0.1045	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0304	0.0669	0.0766
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0437	0.1045	0.1125
Trichomonas vaginalis	adenylyl cyclase type V, putative	0.0304	0.0669	0.0766
Echinococcus granulosus	voltage gated potassium channel	0.0959	0.2516	0.2737
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0655	0.1658	0.1644
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.3092	0.8529	1
Trichomonas vaginalis	adenylate cyclase type, putative	0.0304	0.0669	0.0766
Schistosoma mansoni	voltage-gated potassium channel	0.0218	0.0426	0.0409
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0218	0.0426	0.0448
Trichomonas vaginalis	intestinal guanylate cyclase, putative	0.0304	0.0669	0.0766
Echinococcus granulosus	transient receptor potential cation channel	0.0218	0.0426	0.0448
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0437	0.1045	1
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0218	0.0426	0.0448
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0437	0.1045	1
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0437	0.1045	0.1029
Echinococcus granulosus	potassium voltage gated channel protein	0.0218	0.0426	0.0448
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0437	0.1045	0.1029
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Trichomonas vaginalis	adenylate cyclase, putative	0.0304	0.0669	0.0766
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0655	0.1658	0.1644
Schistosoma mansoni	serine/threonine protein kinase	0.0437	0.1045	0.1029
Brugia malayi	cation channel family protein	0.0218	0.0426	0.0448
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0437	0.1045	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0218	0.0426	0.0448
Echinococcus multilocularis	transfer RNA-Gly	0.0218	0.0426	0.0448
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0304	0.0669	0.0766
Mycobacterium ulcerans	hypothetical protein	0.0437	0.1045	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0304	0.0669	0.0766
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0655	0.1658	0.1644
Echinococcus granulosus	potassium voltage gated channel protein	0.0218	0.0426	0.0448
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0437	0.1045	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0218	0.0426	0.0448
Schistosoma mansoni	voltage-gated potassium channel	0.0218	0.0426	0.0409
Schistosoma mansoni	ryanodine receptor related	0.0218	0.0426	0.0409
Trichomonas vaginalis	guanylate cyclase beta 2 subunit, putative	0.0304	0.0669	0.0766
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0218	0.0426	0.0448
Loa Loa (eye worm)	calcium channel	0.0218	0.0426	0.0448
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0437	0.1045	0.1125
Schistosoma mansoni	voltage-gated potassium channel	0.0218	0.0426	0.0409
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0218	0.0426	0.0448
Mycobacterium leprae	Conserved hypothetical protein	0.0437	0.1045	1
Trichomonas vaginalis	conserved hypothetical protein	0.0304	0.0669	0.0766
Schistosoma mansoni	transient receptor potential channel	0.0218	0.0426	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Trichomonas vaginalis	conserved hypothetical protein	0.0304	0.0669	0.0766
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0218	0.0426	0.3979
Echinococcus multilocularis	two pore calcium channel protein 1	0.0218	0.0426	0.0448
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0218	0.0426	0.0409
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0304	0.0669	0.0766
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0655	0.1658	0.1798
Toxoplasma gondii	hypothetical protein	0.0218	0.0426	0.3979
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	0.025	0.0518	1
Schistosoma mansoni	voltage-gated potassium channel	0.0522	0.1283	0.1268
Trichomonas vaginalis	adenylate cyclase type III, putative	0.0304	0.0669	0.0766
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0218	0.0426	0.0409
Loa Loa (eye worm)	voltage-gated potassium channel	0.0218	0.0426	0.0448
Plasmodium vivax	DNA gyrase subunit A, putative	0.025	0.0518	0.4869
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0437	0.1045	0.1125
Brugia malayi	N-terminal motif family protein	0.0437	0.1045	0.1125
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0218	0.0426	0.0409
Plasmodium vivax	DNA gyrase subunit B, putative	0.0132	0.0183	0.1611
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0437	0.1045	1
Brugia malayi	olfactory channel protein osm-9	0.0218	0.0426	0.0448
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0437	0.1045	1
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0218	0.0426	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Schistosoma mansoni	voltage-gated potassium channel	0.0218	0.0426	0.0409
Treponema pallidum	DNA gyrase, subunit A (gyrA)	0.025	0.0518	0.3885
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0655	0.1658	0.1798
Schistosoma mansoni	vesicular amine transporter	0.0218	0.0426	0.0409
Echinococcus granulosus	cGMP dependent protein kinase	0.0437	0.1045	0.1125
Mycobacterium ulcerans	hypothetical protein	0.0437	0.1045	1
Schistosoma mansoni	transient receptor potential channel	0.0218	0.0426	0.0409
Loa Loa (eye worm)	ryanodine receptor	0.0218	0.0426	0.0448
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0437	0.1045	0.1125
Echinococcus multilocularis	voltage gated potassium channel	0.0218	0.0426	0.0448
Leishmania major	hypothetical protein, unknown function	0.0218	0.0426	0.3979
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0218	0.0426	0.0409
Schistosoma mansoni	voltage-gated potassium channel	0.0218	0.0426	0.0409
Toxoplasma gondii	hypothetical protein	0.0218	0.0426	0.3979
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0218	0.0426	0.0448
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.025	0.0518	0.3885
Schistosoma mansoni	voltage-gated cation channel	0.0218	0.0426	0.0409
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0304	0.0669	0.0766
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0437	0.1045	1
Brugia malayi	hypothetical protein	0.0218	0.0426	0.0448
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0218	0.0426	0.0448
Trypanosoma cruzi	hypothetical protein, conserved	0.0437	0.1045	1
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0437	0.1045	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0304	0.0669	0.0766
Schistosoma mansoni	serine/threonine protein kinase	0.0437	0.1045	0.1029
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0218	0.0426	0.0409
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Schistosoma mansoni	transient receptor potential channel	0.0218	0.0426	0.0409
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0655	0.1658	0.1798
Loa Loa (eye worm)	ion channel NompC	0.0218	0.0426	0.0448
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Onchocerca volvulus		0.0437	0.1045	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0218	0.0426	0.0409
Trypanosoma brucei	cAMP binding protein, putative	0.0437	0.1045	1
Echinococcus multilocularis	expressed conserved protein	0.0437	0.1045	0.1125
Echinococcus multilocularis	transient receptor potential cation channel	0.0218	0.0426	0.0448
Schistosoma mansoni	calcium-activated potassium channel	0.0218	0.0426	0.0409
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0304	0.0669	0.0766
Mycobacterium ulcerans	transcriptional regulatory protein	0.0437	0.1045	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0218	0.0426	0.0448
Schistosoma mansoni	voltage-gated potassium channel	0.0218	0.0426	0.0409
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0218	0.0426	0.0448
Trichomonas vaginalis	adenylate cyclase, putative	0.0304	0.0669	0.0766
Echinococcus granulosus	potassium large conductance calcium activated	0.0218	0.0426	0.0448
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0437	0.1045	0.1125
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Echinococcus multilocularis	voltage gated potassium channel	0.0959	0.2516	0.2737
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0437	0.1045	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0437	0.1045	0.1029
Loa Loa (eye worm)	hypothetical protein	0.2872	0.7911	0.865
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0655	0.1658	0.1798
Brugia malayi	Transient-receptor-potential like protein	0.0218	0.0426	0.0448
Schistosoma mansoni	transient receptor potential channel 4	0.0218	0.0426	0.0409
Trichomonas vaginalis	adenylate cyclase, putative	0.0304	0.0669	0.0766
Trichomonas vaginalis	adenylate cyclase type, putative	0.0304	0.0669	0.0766
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0437	0.1045	0.1125
Loa Loa (eye worm)	voltage-gated calcium channel	0.0218	0.0426	0.0448
Trichomonas vaginalis	guanylate cyclase beta 1 subunit, putative	0.0304	0.0669	0.0766
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Echinococcus granulosus	short transient receptor potential channel 6	0.0218	0.0426	0.0448
Echinococcus multilocularis	transient receptor potential cation channel	0.0218	0.0426	0.0448
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0218	0.0426	0.0448
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0959	0.2516	0.2737
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0304	0.0669	0.0766
Loa Loa (eye worm)	hypothetical protein	0.0437	0.1045	0.1125
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0437	0.1045	0.1125
Trichomonas vaginalis	adenylate cyclase, putative	0.0304	0.0669	0.0766
Trichomonas vaginalis	conserved hypothetical protein	0.0304	0.0669	0.0766
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0218	0.0426	0.0448
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0218	0.0426	0.3979
Echinococcus granulosus	transient receptor potential cation channel	0.0218	0.0426	0.0448
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0437	0.1045	0.1125
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0304	0.0669	0.0766
Trypanosoma cruzi	cAMP response protein 1, putative	0.0437	0.1045	1
Brugia malayi	cation channel family protein	0.0218	0.0426	0.0448
Onchocerca volvulus		0.0437	0.1045	1
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0218	0.0426	0.0448
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0218	0.0426	0.3979
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0437	0.1045	1
Echinococcus granulosus	voltage dependent calcium channel	0.0218	0.0426	0.0448
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0304	0.0669	0.0766
Schistosoma mansoni	serine/threonine protein kinase	0.0437	0.1045	0.1029
Schistosoma mansoni	60S ribosomal protein L21	0.0522	0.1283	0.1268
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0218	0.0426	0.0448
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0218	0.0426	0.0448
Treponema pallidum	catabolite gene activator	0.0437	0.1045	1
Echinococcus multilocularis	short transient receptor potential channel 6	0.0218	0.0426	0.0448
Mycobacterium leprae	Possible transporter protein	0.0304	0.0669	0.5814
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0218	0.0426	0.0448
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0655	0.1658	0.1798
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Brugia malayi	Egg laying defective protein 4	0.0437	0.1045	0.1125
Mycobacterium ulcerans	hypothetical protein	0.0437	0.1045	1
Echinococcus granulosus	short transient receptor potential channel 6	0.0218	0.0426	0.0448
Onchocerca volvulus		0.0218	0.0426	0.3979
Trichomonas vaginalis	conserved hypothetical protein	0.0304	0.0669	0.0766
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0437	0.1045	0.1206
Echinococcus multilocularis	conserved hypothetical protein	0.0218	0.0426	0.0448
Echinococcus multilocularis	transient receptor potential cation channel	0.0218	0.0426	0.0448
Treponema pallidum	cyclic nucleotide binding protein	0.0437	0.1045	1
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0437	0.1045	0.1029
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0437	0.1045	1
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0218	0.0426	0.0448
Plasmodium falciparum	DNA gyrase subunit B	0.0132	0.0183	0.1611
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.3309	0.9143	1
Trichomonas vaginalis	conserved hypothetical protein	0.0304	0.0669	0.0766
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0437	0.1045	0.1125
Brugia malayi	ion channel NompC	0.0218	0.0426	0.0448
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0218	0.0426	0.0409
Echinococcus multilocularis	potassium voltage gated channel protein	0.0218	0.0426	0.0448
Echinococcus granulosus	voltage gated potassium channel	0.0218	0.0426	0.0448
Echinococcus granulosus	ryanodine receptor 44f	0.0218	0.0426	0.0448
Echinococcus granulosus	hyperpolarization activated cyclic	0.0655	0.1658	0.1798
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0437	0.1045	1
Echinococcus granulosus	potassium voltage gated channel protein	0.0218	0.0426	0.0448
Echinococcus granulosus	potassium voltage gated channel protein	0.0218	0.0426	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0437	0.1045	0.1029
Toxoplasma gondii	transporter, cation channel family protein	0.0218	0.0426	0.3979
Echinococcus multilocularis	voltage dependent calcium channel	0.0218	0.0426	0.0448
Leishmania major	protein kinase, putative	0.0437	0.1045	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0655	0.1658	0.1798
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0655	0.1658	0.1798
Entamoeba histolytica	DNA topoisomerase II, putative	0.0073	0.0018	0.5
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0218	0.0426	0.0448
Schistosoma mansoni	hypothetical protein	0.0304	0.0669	0.0653
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0437	0.1045	1
Loa Loa (eye worm)	hypothetical protein	0.0437	0.1045	0.1125
Schistosoma mansoni	voltage-gated potassium channel	0.0218	0.0426	0.0409
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0218	0.0426	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0437	0.1045	1
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0218	0.0426	0.3979
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0437	0.1045	0.1125
Mycobacterium ulcerans	hypothetical protein	0.0437	0.1045	1
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0437	0.1045	0.1029
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0218	0.0426	0.0448
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0655	0.1658	0.1928
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0218	0.0426	0.0409
Trypanosoma brucei	protein kinase A regulatory subunit	0.0437	0.1045	1
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0437	0.1045	0.1125
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0304	0.0669	0.0766
Trichomonas vaginalis	hypothetical protein	0.0304	0.0669	0.0766
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Echinococcus multilocularis	calcium activated potassium channel	0.0218	0.0426	0.0448
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0304	0.0669	0.0766
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0218	0.0426	0.0448
Echinococcus granulosus	potassium voltage gated channel protein	0.0218	0.0426	0.0448
Treponema pallidum	cyclic nucleotide binding protein	0.0437	0.1045	1
Echinococcus granulosus	hypothetical protein	0.0218	0.0426	0.0448
Trichomonas vaginalis	conserved hypothetical protein	0.0304	0.0669	0.0766
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0437	0.1045	0.1125
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0304	0.0669	0.0766
Plasmodium falciparum	cGMP-dependent protein kinase	0.0437	0.1045	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.3309	0.9143	1
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0218	0.0426	0.0448
Plasmodium falciparum	DNA gyrase subunit A	0.025	0.0518	0.4869
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0304	0.0669	0.0766
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0655	0.1658	0.1644
Echinococcus granulosus	sodium leak channel non selective protein	0.0218	0.0426	0.0448
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0437	0.1045	0.1206
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0304	0.0669	0.0766
Trichomonas vaginalis	adenylate cyclase type III, putative	0.0304	0.0669	0.0766
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0959	0.2516	0.2737
Echinococcus granulosus	hyperpolarization activated cyclic	0.0655	0.1658	0.1798
Schistosoma mansoni	voltage-gated potassium channel	0.0218	0.0426	0.0409
Schistosoma mansoni	voltage-gated potassium channel	0.0959	0.2516	0.2502
Schistosoma mansoni	voltage-gated potassium channel	0.0218	0.0426	0.0409
Echinococcus granulosus	calcium activated potassium channel	0.0218	0.0426	0.0448
Trichomonas vaginalis	adenylate cyclase, putative	0.0304	0.0669	0.0766
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0304	0.0669	0.0766
Trypanosoma brucei	cAMP response protein 1, putative	0.0437	0.1045	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.3092	0.8529	1
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0304	0.0669	0.0714
Trichomonas vaginalis	conserved hypothetical protein	0.0437	0.1045	0.1206
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0304	0.0669	0.0766
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0437	0.1045	0.1125
Mycobacterium tuberculosis	Conserved protein	0.0437	0.1045	1
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0437	0.1045	0.1125
Treponema pallidum	catabolite gene activator (Crp)	0.0437	0.1045	1
Echinococcus granulosus	shaker cognate	0.0218	0.0426	0.0448
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0218	0.0426	0.0448
Echinococcus multilocularis	potassium voltage gated channel protein	0.0218	0.0426	0.0448
Trichomonas vaginalis	conserved hypothetical protein	0.0304	0.0669	0.0766
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0304	0.0669	0.0766
Leishmania major	hypothetical protein, unknown function	0.0437	0.1045	1
Leishmania major	hypothetical protein, conserved	0.0437	0.1045	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0655	0.1658	0.1798
Trypanosoma cruzi	Flagellar Member 6	0.0437	0.1045	1
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0218	0.0426	0.0448
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0218	0.0426	0.0448
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0218	0.0426	0.0448
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0655	0.1658	0.1644
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Trichomonas vaginalis	adenylate cyclase, putative	0.0304	0.0669	0.0766
Echinococcus multilocularis	sodium leak channel non selective protein	0.0218	0.0426	0.0448
Schistosoma mansoni	voltage-gated potassium channel	0.0218	0.0426	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Trichomonas vaginalis	adenylate cyclase, putative	0.0304	0.0669	0.0766
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0437	0.1045	1
Schistosoma mansoni	voltage-gated potassium channel	0.0218	0.0426	0.0409
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0437	0.1045	1
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0437	0.1045	1
Echinococcus multilocularis	transient receptor potential gamma protein	0.0218	0.0426	0.0448
Echinococcus multilocularis	shaker cognate	0.0218	0.0426	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.3309	0.9143	1
Trichomonas vaginalis	adenylate cyclase type, putative	0.0304	0.0669	0.0766
Trypanosoma brucei	Flagellar Member 6	0.0437	0.1045	1
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0218	0.0426	0.0448
Echinococcus multilocularis	transient receptor potential cation channel	0.0218	0.0426	0.0448
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0218	0.0426	0.0448
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0218	0.0426	0.0448
Schistosoma mansoni	voltage-gated potassium channel	0.0655	0.1658	0.1644
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0218	0.0426	0.3979
Toxoplasma gondii	transporter, cation channel family protein	0.0218	0.0426	0.3979
Toxoplasma gondii	transporter, cation channel family protein	0.0218	0.0426	0.3979
Loa Loa (eye worm)	voltage-gated potassium channel	0.0218	0.0426	0.0448
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0304	0.0669	0.6348
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0655	0.1658	0.1798
Trichomonas vaginalis	guanylate cyclase, putative	0.0304	0.0669	0.0766
Echinococcus multilocularis	ryanodine receptor 44f	0.0218	0.0426	0.0448
Echinococcus granulosus	transient receptor potential gamma protein	0.0218	0.0426	0.0448
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0437	0.1045	1
Trichomonas vaginalis	adenylate cyclase type VI, putative	0.0304	0.0669	0.0766
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0655	0.1658	0.1798
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0437	0.1045	1
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0426	0.0448
Echinococcus multilocularis	sodium channel protein	0.0218	0.0426	0.0448
Trichomonas vaginalis	adenylate cyclase, putative	0.0304	0.0669	0.0766
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0437	0.1045	1
Echinococcus granulosus	transient receptor potential cation channel	0.0218	0.0426	0.0448
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0437	0.1045	0.1029
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0218	0.0426	0.0448
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0437	0.1045	0.1206
Echinococcus granulosus	transient receptor potential cation channel	0.0218	0.0426	0.0448

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)		Inhibition of human recombinant topoisomerase 1-mediated relaxation of supercoiled pUC18 plasmid DNA in human MCF7 cells nuclear extracts at 100 uM after 30 mins by ethidium bromide staining based gel electrophoresis analysis	ChEMBL.	23266176

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2323157

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1726028