TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 380.526 | Formula: C21H20N2OS2
H donors: 0 H acceptors: 1 LogP: 5.09 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CSc1ccccc1N1C(c2ccc(s2)C)N(C)c2c(C1=O)cccc2
InChi: 1S/C21H20N2OS2/c1-14-12-13-19(26-14)20-22(2)16-9-5-4-8-15(16)21(24)23(20)17-10-6-7-11-18(17)25-3/h4-13,20H,1-3H3
InChiKey: VJQKSWUMCBFVRI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0259	0.045	0.4131
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0362	0.0692	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Mycobacterium leprae	Conserved hypothetical protein	0.052	0.1066	1
Schistosoma mansoni	voltage-gated potassium channel	0.0259	0.045	0.0435
Brugia malayi	hypothetical protein	0.0259	0.045	0.0476
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0259	0.045	0.0476
Loa Loa (eye worm)	AGC/PKG protein kinase	0.052	0.1066	0.1151
Trichomonas vaginalis	conserved hypothetical protein	0.0362	0.0692	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.078	0.1679	0.1822
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.078	0.1679	0.1666
Echinococcus multilocularis	transfer RNA-Gly	0.0259	0.045	0.0476
Loa Loa (eye worm)	hypothetical protein	0.342	0.7916	0.8654
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.052	0.1066	0.1151
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0259	0.045	0.0476
Trichomonas vaginalis	adenylate cyclase, putative	0.0362	0.0692	0.0795
Echinococcus granulosus	voltage dependent calcium channel	0.0259	0.045	0.0476
Echinococcus granulosus	hyperpolarization activated cyclic	0.078	0.1679	0.1822
Trypanosoma cruzi	protein kinase A regulatory subunit	0.052	0.1066	1
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.052	0.1066	0.1053
Echinococcus multilocularis	transient receptor potential cation channel	0.0259	0.045	0.0476
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0362	0.0692	0.0795
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.052	0.1066	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0259	0.045	0.0435
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0259	0.045	0.0476
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.3681	0.8533	1
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0259	0.045	0.0435
Trichomonas vaginalis	adenylate cyclase, putative	0.0362	0.0692	0.0795
Echinococcus multilocularis	two pore calcium channel protein 2	0.0259	0.045	0.0476
Echinococcus multilocularis	short transient receptor potential channel 6	0.0259	0.045	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Chlamydia trachomatis	DNA gyrase subunit A	0.0259	0.0449	0.3201
Echinococcus granulosus	sodium channel protein	0.0259	0.045	0.0476
Echinococcus multilocularis	potassium voltage gated channel protein	0.0259	0.045	0.0476
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.052	0.1066	1
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.052	0.1066	0.1151
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.052	0.1066	1
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Schistosoma mansoni	voltage-gated potassium channel	0.0259	0.045	0.0435
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.052	0.1066	1
Schistosoma mansoni	voltage-gated potassium channel	0.0621	0.1305	0.1291
Trichomonas vaginalis	conserved hypothetical protein	0.0362	0.0692	0.0795
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.052	0.1066	0.1053
Mycobacterium ulcerans	hypothetical protein	0.052	0.1066	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0259	0.045	0.0476
Echinococcus granulosus	hyperpolarization activated cyclic	0.078	0.1679	0.1822
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.052	0.1066	0.1151
Loa Loa (eye worm)	ion channel NompC	0.0259	0.045	0.0476
Schistosoma mansoni	serine/threonine protein kinase	0.052	0.1066	0.1053
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0259	0.045	0.0476
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0259	0.045	0.0476
Trichomonas vaginalis	adenylate cyclase, putative	0.0362	0.0692	0.0795
Echinococcus granulosus	two pore calcium channel protein 2	0.0259	0.045	0.0476
Mycobacterium tuberculosis	Conserved hypothetical protein	0.052	0.1066	1
Loa Loa (eye worm)	hypothetical protein	0.052	0.1066	0.1151
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0259	0.045	0.0476
Echinococcus multilocularis	conserved hypothetical protein	0.0259	0.045	0.0476
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.052	0.1066	0.1151
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Loa Loa (eye worm)	voltage-gated potassium channel	0.0259	0.045	0.0476
Schistosoma mansoni	voltage-gated potassium channel	0.0259	0.045	0.0435
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0362	0.0692	0.0795
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.052	0.1066	0.1053
Echinococcus multilocularis	transient receptor potential gamma protein	0.0259	0.045	0.0476
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.052	0.1066	1
Echinococcus granulosus	transient receptor potential cation channel	0.0259	0.045	0.0476
Schistosoma mansoni	voltage-gated potassium channel	0.1142	0.2534	0.2522
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0259	0.045	0.0476
Trichomonas vaginalis	guanylate cyclase beta 2 subunit, putative	0.0362	0.0692	0.0795
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0259	0.045	0.0476
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0259	0.045	0.0476
Loa Loa (eye worm)	hypothetical protein	0.1142	0.2534	0.2758
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.052	0.1066	0.1234
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.078	0.1679	0.1666
Schistosoma mansoni	voltage-gated cation channel	0.0259	0.045	0.0435
Trichomonas vaginalis	adenylate cyclase type III, putative	0.0362	0.0692	0.0795
Brugia malayi	Cyclic-nucleotide gated cation channel	0.078	0.1679	0.1822
Trichomonas vaginalis	conserved hypothetical protein	0.052	0.1066	0.1234
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0362	0.0692	0.0795
Schistosoma mansoni	voltage-dependent calcium channel	0.0259	0.045	0.0435
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.052	0.1066	0.1234
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0259	0.045	0.0435
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0259	0.045	0.0476
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.052	0.1066	1
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0259	0.045	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0259	0.045	0.0476
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.052	0.1066	0.1151
Echinococcus multilocularis	potassium voltage gated channel protein	0.0259	0.045	0.0476
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.052	0.1066	0.1151
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0259	0.045	0.4131
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0259	0.045	0.0476
Loa Loa (eye worm)	voltage-gated calcium channel	0.0259	0.045	0.0476
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0259	0.045	0.0476
Toxoplasma gondii	transporter, cation channel family protein	0.0259	0.045	0.4131
Schistosoma mansoni	ryanodine receptor related	0.0259	0.045	0.0435
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0259	0.045	0.0476
Trichomonas vaginalis	conserved hypothetical protein	0.0362	0.0692	0.0795
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Schistosoma mansoni	serine/threonine protein kinase	0.052	0.1066	0.1053
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.078	0.1679	0.1953
Schistosoma mansoni	voltage-gated potassium channel	0.0259	0.045	0.0435
Echinococcus granulosus	calcium activated potassium channel	0.0259	0.045	0.0476
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0259	0.045	0.0476
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0362	0.0692	0.0795
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.052	0.1066	0.1151
Schistosoma mansoni	two-pore calcium channel	0.0259	0.045	0.0435
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.052	0.1066	1
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0362	0.0692	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Mycobacterium ulcerans	hypothetical protein	0.052	0.1066	1
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.052	0.1066	1
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Echinococcus granulosus	potassium voltage gated channel protein	0.0259	0.045	0.0476
Schistosoma mansoni	serine/threonine protein kinase	0.052	0.1066	0.1053
Loa Loa (eye worm)	voltage-gated potassium channel	0.0259	0.045	0.0476
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0362	0.0692	0.0795
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0259	0.045	0.0476
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.078	0.1679	0.1822
Trypanosoma brucei	Flagellar Member 6	0.052	0.1066	1
Echinococcus granulosus	shaker cognate	0.0259	0.045	0.0476
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.3941	0.9145	1
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Echinococcus multilocularis	two pore calcium channel protein 1	0.0259	0.045	0.0476
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0259	0.045	0.0476
Echinococcus multilocularis	shaker cognate	0.0259	0.045	0.0476
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.052	0.1066	1
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.052	0.1066	0.1053
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0259	0.045	0.0435
Schistosoma mansoni	transient receptor potential channel	0.0259	0.045	0.0435
Echinococcus multilocularis	short transient receptor potential channel 6	0.0259	0.045	0.0476
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0259	0.045	0.0476
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.052	0.1066	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0259	0.045	0.0435
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Echinococcus multilocularis	transient receptor potential cation channel	0.0259	0.045	0.0476
Echinococcus granulosus	hypothetical protein	0.0259	0.045	0.0476
Echinococcus granulosus	cGMP dependent protein kinase 1	0.052	0.1066	0.1151
Trichomonas vaginalis	adenylate cyclase, putative	0.0362	0.0692	0.0795
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.078	0.1679	0.1822
Echinococcus multilocularis	voltage gated potassium channel	0.0259	0.045	0.0476
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0259	0.045	0.0476
Schistosoma mansoni	voltage-gated potassium channel	0.0259	0.045	0.0435
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0259	0.045	0.0435
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.078	0.1679	0.1666
Trichomonas vaginalis	intestinal guanylate cyclase, putative	0.0362	0.0692	0.0795
Toxoplasma gondii	hypothetical protein	0.0259	0.045	0.4131
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Leishmania major	protein kinase, putative	0.052	0.1066	1
Mycobacterium tuberculosis	Conserved protein	0.052	0.1066	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0259	0.045	0.0476
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0259	0.045	0.0476
Echinococcus multilocularis	transient receptor potential cation channel	0.0259	0.045	0.0476
Brugia malayi	ion channel NompC	0.0259	0.045	0.0476
Echinococcus multilocularis	transient receptor potential cation channel	0.0259	0.045	0.0476
Mycobacterium ulcerans	DNA gyrase subunit A	0.0259	0.0449	0.3201
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0259	0.045	0.0435
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0259	0.045	0.4131
Schistosoma mansoni	voltage-gated potassium channel	0.0259	0.045	0.0435
Leishmania major	protein kinase, putative	0.052	0.1066	1
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	0.0259	0.0449	1
Trypanosoma cruzi	cAMP binding protein, putative	0.052	0.1066	1
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0362	0.0692	0.644
Onchocerca volvulus		0.052	0.1066	1
Schistosoma mansoni	voltage-gated potassium channel	0.1142	0.2534	0.2522
Schistosoma mansoni	voltage-gated potassium channel	0.0259	0.045	0.0435
Trichomonas vaginalis	adenylate cyclase, putative	0.0362	0.0692	0.0795
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.052	0.1066	0.1151
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0259	0.045	0.0476
Plasmodium falciparum	cGMP-dependent protein kinase	0.052	0.1066	1
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.052	0.1066	0.1151
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.078	0.1679	0.1822
Echinococcus multilocularis	sodium channel protein	0.0259	0.045	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Echinococcus granulosus	transient receptor potential gamma protein	0.0259	0.045	0.0476
Echinococcus multilocularis	transient receptor potential cation channel	0.0259	0.045	0.0476
Toxoplasma gondii	transporter, cation channel family protein	0.0259	0.045	0.4131
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0259	0.045	0.0476
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Echinococcus granulosus	transient receptor potential cation channel	0.0259	0.045	0.0476
Echinococcus granulosus	voltage gated potassium channel	0.0259	0.045	0.0476
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0362	0.0692	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Trypanosoma cruzi	cAMP response protein 1, putative	0.052	0.1066	1
Brugia malayi	voltage-dependent calcium channel	0.0259	0.045	0.0476
Schistosoma mansoni	voltage-gated potassium channel	0.0259	0.045	0.0435
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0362	0.0692	0.0795
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.078	0.1679	0.1666
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.052	0.1066	1
Loa Loa (eye worm)	hypothetical protein	0.052	0.1066	0.1151
Plasmodium falciparum	DNA gyrase subunit B	0.0136	0.0159	0.1366
Schistosoma mansoni	transient receptor potential channel	0.0259	0.045	0.0435
Onchocerca volvulus		0.052	0.1066	1
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.052	0.1066	0.1053
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.052	0.1066	0.1151
Mycobacterium ulcerans	hypothetical protein	0.052	0.1066	1
Schistosoma mansoni	voltage-gated ion channel	0.0259	0.045	0.0435
Treponema pallidum	catabolite gene activator	0.052	0.1066	1
Echinococcus granulosus	short transient receptor potential channel 6	0.0259	0.045	0.0476
Echinococcus multilocularis	hyperpolarization activated cyclic	0.078	0.1679	0.1822
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0259	0.045	0.0476
Echinococcus granulosus	voltage dependent calcium channel	0.0259	0.045	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0259	0.045	0.4131
Mycobacterium ulcerans	transmembrane transport protein	0.052	0.1066	1
Trypanosoma cruzi	Flagellar Member 6	0.052	0.1066	1
Schistosoma mansoni	voltage-gated potassium channel	0.078	0.1679	0.1666
Leishmania major	cyclic nucleotide-binding protein-like protein	0.052	0.1066	1
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.052	0.1066	1
Echinococcus granulosus	TRP transient receptor potential channel	0.0259	0.045	0.0476
Echinococcus multilocularis	potassium voltage gated channel protein	0.0259	0.045	0.0476
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Brugia malayi	Egg laying defective protein 4	0.052	0.1066	0.1151
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0362	0.0692	0.0795
Echinococcus granulosus	transient receptor potential cation channel	0.0259	0.045	0.0476
Leishmania major	hypothetical protein, conserved	0.052	0.1066	1
Schistosoma mansoni	60S ribosomal protein L21	0.0621	0.1305	0.1291
Echinococcus granulosus	cGMP dependent protein kinase 1	0.052	0.1066	0.1151
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.078	0.1679	0.1822
Trypanosoma cruzi	cAMP response protein 1	0.052	0.1066	1
Mycobacterium ulcerans	hypothetical protein	0.052	0.1066	1
Trichomonas vaginalis	conserved hypothetical protein	0.0362	0.0692	0.0795
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0259	0.0449	0.3201
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.078	0.1679	0.1822
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0259	0.045	0.4131
Schistosoma mansoni	hypothetical protein	0.0362	0.0692	0.0678
Echinococcus granulosus	sodium leak channel non selective protein	0.0259	0.045	0.0476
Echinococcus granulosus	single minded 2	0.0362	0.0692	0.0741
Schistosoma mansoni	vesicular amine transporter	0.0259	0.045	0.0435
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.052	0.1066	0.1151
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.052	0.1066	1
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0259	0.045	0.0476
Echinococcus granulosus	short transient receptor potential channel 6	0.0259	0.045	0.0476
Brugia malayi	N-terminal motif family protein	0.052	0.1066	0.1151
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.052	0.1066	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	adenylate cyclase type III, putative	0.0362	0.0692	0.0795
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.052	0.1066	0.1151
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.052	0.1066	0.1053
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0259	0.045	0.0476
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	adenylate cyclase, putative	0.0362	0.0692	0.0795
Entamoeba histolytica	DNA topoisomerase II, putative	0.0075	0.0015	0.5
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.052	0.1066	0.1151
Trypanosoma brucei	cAMP binding protein, putative	0.052	0.1066	1
Echinococcus granulosus	potassium voltage gated channel protein	0.0259	0.045	0.0476
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.052	0.1066	0.1151
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.052	0.1066	0.1053
Mycobacterium ulcerans	transcriptional regulatory protein	0.052	0.1066	1
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.052	0.1066	1
Echinococcus granulosus	transient receptor potential cation channel	0.0259	0.045	0.0476
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.052	0.1066	0.1053
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.078	0.1679	0.1822
Brugia malayi	cation channel family protein	0.0259	0.045	0.0476
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.052	0.1066	0.1053
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0362	0.0692	0.0795
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0259	0.045	0.4131
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0259	0.045	0.0435
Echinococcus multilocularis	voltage dependent calcium channel	0.0259	0.045	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Plasmodium falciparum	DNA gyrase subunit A	0.0259	0.0449	0.413
Schistosoma mansoni	transient receptor potential channel	0.0259	0.045	0.0435
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0259	0.045	0.0476
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0259	0.045	0.0476
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0259	0.045	0.0476
Echinococcus multilocularis	voltage dependent calcium channel	0.0259	0.045	0.0476
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0259	0.045	0.0476
Trichomonas vaginalis	adenylate cyclase, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	hypothetical protein	0.0362	0.0692	0.0795
Trichomonas vaginalis	conserved hypothetical protein	0.0362	0.0692	0.0795
Trichomonas vaginalis	adenylate cyclase, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.052	0.1066	0.1234
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0259	0.045	0.0476
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.3941	0.9145	1
Leishmania major	hypothetical protein, unknown function	0.052	0.1066	1
Leishmania major	hypothetical protein, unknown function	0.0259	0.045	0.4131
Echinococcus granulosus	potassium voltage gated channel protein	0.0259	0.045	0.0476
Echinococcus multilocularis	hyperpolarization activated cyclic	0.078	0.1679	0.1822
Toxoplasma gondii	transporter, cation channel family protein	0.0259	0.045	0.4131
Schistosoma mansoni	voltage-gated potassium channel	0.0259	0.045	0.0435
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.052	0.1066	0.1053
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.0259	0.0449	0.413
Echinococcus granulosus	potassium voltage gated channel protein	0.0259	0.045	0.0476
Trichomonas vaginalis	adenylyl cyclase type V, putative	0.0362	0.0692	0.0795
Schistosoma mansoni	transient receptor potential channel 4	0.0259	0.045	0.0435
Trichomonas vaginalis	adenylate cyclase, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0362	0.0692	0.0795
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.1142	0.2534	0.2758
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.078	0.1679	0.1822
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.052	0.1066	1
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Echinococcus granulosus	patatin phospholipase domain containing protein	0.052	0.1066	0.1151
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0362	0.0692	0.0795
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.052	0.1066	0.1151
Treponema pallidum	DNA gyrase, subunit A (gyrA)	0.0259	0.0449	0.3201
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	adenylate cyclase type VI, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0362	0.0692	0.0795
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0259	0.045	0.0476
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.078	0.1679	0.1666
Echinococcus granulosus	voltage gated potassium channel	0.1142	0.2534	0.2758
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0259	0.045	0.0476
Trichomonas vaginalis	guanylate cyclase beta 1 subunit, putative	0.0362	0.0692	0.0795
Loa Loa (eye worm)	hypothetical protein	0.078	0.1679	0.1822
Loa Loa (eye worm)	ryanodine receptor	0.0259	0.045	0.0476
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.052	0.1066	0.1151
Trypanosoma brucei	protein kinase A regulatory subunit	0.052	0.1066	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.3941	0.9145	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0259	0.045	0.0435
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.052	0.1066	1
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.052	0.1066	0.1053
Mycobacterium leprae	Possible transporter protein	0.0362	0.0692	0.6008
Trichomonas vaginalis	adenylate cyclase type vIII, putative	0.0362	0.0692	0.0795
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.052	0.1066	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0362	0.0692	0.0795
Brugia malayi	cation channel family protein	0.0259	0.045	0.0476
Treponema pallidum	catabolite gene activator (Crp)	0.052	0.1066	1
Trypanosoma cruzi	hypothetical protein, conserved	0.052	0.1066	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.3941	0.9145	1
Treponema pallidum	cyclic nucleotide binding protein	0.052	0.1066	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0362	0.0692	0.0795
Leishmania major	protein kinase A regulatory subunit, putative	0.052	0.1066	1
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0259	0.045	0.0476
Leishmania major	regulatory subunit of protein kinase a-like protein	0.052	0.1066	1
Schistosoma mansoni	hypothetical protein	0.0259	0.045	0.0435
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.052	0.1066	0.1053
Echinococcus granulosus	cGMP dependent protein kinase	0.052	0.1066	0.1151
Schistosoma mansoni	voltage-gated potassium channel	0.0259	0.045	0.0435
Loa Loa (eye worm)	calcium channel	0.0259	0.045	0.0476
Echinococcus granulosus	potassium large conductance calcium activated	0.0259	0.045	0.0476
Echinococcus multilocularis	voltage gated potassium channel	0.1142	0.2534	0.2758
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.1142	0.2534	0.2758
Schistosoma mansoni	voltage-gated potassium channel	0.0259	0.045	0.0435
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.052	0.1066	1
Schistosoma mansoni	hypothetical protein	0.052	0.1066	0.1053
Leishmania major	hypothetical protein, conserved	0.0259	0.045	0.4131
Trichomonas vaginalis	adenylate cyclase type, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.052	0.1066	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.3681	0.8533	1
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Echinococcus multilocularis	expressed conserved protein	0.052	0.1066	0.1151
Echinococcus multilocularis	sodium leak channel non selective protein	0.0259	0.045	0.0476
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.052	0.1066	0.1234
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0259	0.045	0.0435
Echinococcus multilocularis	potassium large conductance calcium activated	0.0259	0.045	0.0476
Echinococcus granulosus	ryanodine receptor 44f	0.0259	0.045	0.0476
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0259	0.045	0.4131
Plasmodium vivax	DNA gyrase subunit A, putative	0.0259	0.0449	0.413
Echinococcus granulosus	potassium voltage gated channel protein	0.0259	0.045	0.0476
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0259	0.045	0.4131
Plasmodium vivax	DNA gyrase subunit B, putative	0.0136	0.0159	0.1366
Trichomonas vaginalis	conserved hypothetical protein	0.0362	0.0692	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Trichomonas vaginalis	conserved hypothetical protein	0.0362	0.0692	0.0795
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0259	0.045	0.0435
Onchocerca volvulus		0.0259	0.045	0.4131
Brugia malayi	olfactory channel protein osm-9	0.0259	0.045	0.0476
Echinococcus multilocularis	calcium activated potassium channel	0.0259	0.045	0.0476
Trichomonas vaginalis	adenylate cyclase type, putative	0.0362	0.0692	0.0795
Treponema pallidum	cyclic nucleotide binding protein	0.052	0.1066	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.078	0.1679	0.1822
Echinococcus granulosus	transient receptor potential cation channel	0.0259	0.045	0.0476
Trichomonas vaginalis	conserved hypothetical protein	0.0362	0.0692	0.0795
Brugia malayi	Transient-receptor-potential like protein	0.0259	0.045	0.0476
Echinococcus granulosus	two pore calcium channel protein 1	0.0259	0.045	0.0476
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0259	0.045	0.0476
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0259	0.045	0.0476
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0259	0.045	0.4131
Loa Loa (eye worm)	hypothetical protein	0.0259	0.045	0.0476
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Schistosoma mansoni	voltage-gated potassium channel	0.0259	0.045	0.0435
Trichomonas vaginalis	adenylate cyclase, putative	0.0362	0.0692	0.0795
Mycobacterium tuberculosis	Conserved hypothetical protein	0.052	0.1066	1
Leishmania major	hypothetical protein, conserved	0.052	0.1066	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0259	0.045	0.0435
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0259	0.045	0.0476
Trypanosoma brucei	cAMP response protein 1, putative	0.052	0.1066	1
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	conserved hypothetical protein	0.0362	0.0692	0.0795
Leishmania major	hypothetical protein, conserved	0.052	0.1066	1
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.052	0.1066	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.078	0.1679	0.1953
Schistosoma mansoni	calcium-activated potassium channel	0.0259	0.045	0.0435
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0259	0.045	0.0476
Trichomonas vaginalis	adenylate cyclase type, putative	0.0362	0.0692	0.0795
Trichomonas vaginalis	guanylate cyclase, putative	0.0362	0.0692	0.0795
Mycobacterium ulcerans	regulatory protein	0.052	0.1066	1
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0362	0.0692	0.0741
Echinococcus multilocularis	ryanodine receptor 44f	0.0259	0.045	0.0476
Trichomonas vaginalis	conserved hypothetical protein	0.0362	0.0692	0.0795
Echinococcus granulosus	transient receptor potential cation channel	0.0259	0.045	0.0476
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.1142	0.2534	0.2758
Toxoplasma gondii	hypothetical protein	0.0259	0.045	0.4131

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 150.6 %	Cytoprotective activity against shiga toxin-induced cytotoxicity in human HeLa cells at 30 uM incubated for 4 hrs prior to shiga toxin addition measured after 20 hrs by liquid scintillation counting analysis relative to Retro-2	ChEMBL.	23517565
EC50 (functional)	= 3.8 uM	Cytoprotective activity against shiga toxin-induced cytotoxicity in human HeLa cells at 30 uM incubated for 4 hrs prior to shiga toxin addition measured after 20 hrs by liquid scintillation counting analysis	ChEMBL.	23517565

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23517565

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2324641

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1726308