Detailed information for compound 1726441

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 364.785 | Formula: C19H13ClN4O2
  • H donors: 1 H acceptors: 5 LogP: 3.18 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)c1cc(C(=O)O)c2c(n1)n(nc2)Cc1ccncc1
  • InChi: 1S/C19H13ClN4O2/c20-14-3-1-2-13(8-14)17-9-15(19(25)26)16-10-22-24(18(16)23-17)11-12-4-6-21-7-5-12/h1-10H,11H2,(H,25,26)
  • InChiKey: OBQYJVWFTVRFHF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi PAN domain containing protein 0.0039 0.0249 0.0886
Toxoplasma gondii hypothetical protein 0.0122 0.1319 0.1628
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0103 0.0121
Echinococcus granulosus transmembrane protease serine 3 0.0028 0.0103 0.0121
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0048 0.0057
Brugia malayi MH2 domain containing protein 0.0232 0.2747 0.9767
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0103 0.0121
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0103 0.0121
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.559 0.559
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0033 0.0161 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0185 0.0659
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0407 0.1335
Brugia malayi PAS domain containing protein 0.0125 0.1364 0.4849
Brugia malayi Endoplasmin precursor 0.0071 0.0666 0.2368
Trypanosoma brucei Heat shock protein 83, putative 0.0071 0.0666 0.2485
Toxoplasma gondii microneme protein MIC4 0.0039 0.0249 0.022
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0185 0.0219
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0103 0.0121
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0185 0.0219
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0042 0.0281 0.0869
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0072 0.0669 0.0773
Loa Loa (eye worm) hypothetical protein 0.0028 0.0103 0.0317
Onchocerca volvulus 0.0269 0.3235 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0064 0.0565 0.4285
Trypanosoma brucei heat shock protein, putative 0.0071 0.0666 0.2485
Trichomonas vaginalis adenylate cyclase, putative 0.0033 0.0161 0.0418
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Echinococcus granulosus endoplasmin 0.0051 0.0407 0.0481
Onchocerca volvulus Putative endochitinase 0.0077 0.0734 0.2269
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0033 0.0161 0.0472
Onchocerca volvulus 0.0028 0.0103 0.0317
Toxoplasma gondii microneme protein MIC17B 0.0039 0.0249 0.022
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0038 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0185 0.0659
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Loa Loa (eye worm) PAN domain-containing protein 0.0039 0.0249 0.0771
Leishmania major hypothetical protein, conserved 0.0207 0.243 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0185 0.0219
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0051 0.0407 0.6715
Schistosoma mansoni hypothetical protein 0.0122 0.1319 0.1557
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0185 0.0659
Entamoeba histolytica hypothetical protein 0.0039 0.0245 0.2182
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0185 0.0219
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0135 0.1489 0.1489
Echinococcus granulosus heat shock protein 90 0.0071 0.0666 0.0786
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0407 0.1335
Echinococcus multilocularis transmembrane protease serine 3 0.0028 0.0103 0.0103
Onchocerca volvulus Putative endochitinase 0.0086 0.0854 0.2641
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0185 0.0185
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0273 0.0273
Brugia malayi hypothetical protein 0.0033 0.0161 0.0572
Trypanosoma cruzi heat shock protein, putative 0.0026 0.0082 0.0143
Trypanosoma cruzi heat shock protein 85, putative 0.0071 0.0666 0.2593
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0033 0.0161 0.0418
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0122 0.1319 0.1319
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0116 0.0137
Treponema pallidum heat shock protein 90 0.0051 0.0407 0.5
Toxoplasma gondii kringle domain-containing protein 0.0064 0.0565 0.0636
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0984 0.0984
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.559 0.559
Brugia malayi PAN domain containing protein 0.0039 0.0249 0.0886
Mycobacterium ulcerans hypothetical protein 0.0024 0.0048 0.0111
Brugia malayi Endochitinase 0.0086 0.0854 0.3037
Loa Loa (eye worm) microfilarial chitinase 0.0075 0.0708 0.2187
Entamoeba histolytica hypothetical protein 0.0039 0.0245 0.2182
Brugia malayi nuclear hormone receptor 0.0034 0.0185 0.0659
Schistosoma mansoni pyruvate dehydrogenase 0.0135 0.1489 0.1757
Loa Loa (eye worm) hypothetical protein 0.0119 0.1289 0.3983
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0116 0.0137
Loa Loa (eye worm) hypothetical protein 0.003 0.0126 0.0389
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0051 0.0407 0.0481
Toxoplasma gondii PAN domain-containing protein 0.0611 0.7678 1
Echinococcus granulosus potassium large conductance calcium activated 0.0045 0.0322 0.038
Loa Loa (eye worm) cuticular endochitinase 0.0077 0.0734 0.2269
Brugia malayi PAN domain containing protein 0.0039 0.0249 0.0886
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0185 0.0219
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0185 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0185 0.0573
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0033 0.0161 0.0418
Echinococcus multilocularis heat shock protein 90 0.0071 0.0666 0.0666
Brugia malayi Pre-SET motif family protein 0.0203 0.2372 0.8433
Toxoplasma gondii PAN domain-containing protein 0.0039 0.0249 0.022
Leishmania major protein kinase, putative 0.0033 0.0161 0.0512
Loa Loa (eye worm) hypothetical protein 0.0028 0.0103 0.0317
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0185 0.0573
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0123 0.1337 0.1337
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0119
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0103 0.0121
Toxoplasma gondii microneme protein MIC17A 0.0039 0.0249 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0565 0.217
Brugia malayi heat shock protein 90 0.0071 0.0666 0.2368
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0185 0.0659
Mycobacterium ulcerans putative regulatory protein 0.0093 0.0941 1
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0026 0.0082 0.0466
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0028 0.0103 0.0121
Loa Loa (eye worm) PAN domain-containing protein 0.0039 0.0249 0.0771
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0185 0.0659
Schistosoma mansoni hypothetical protein 0.004 0.0254 0.03
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0185 0.0573
Brugia malayi hypothetical protein 0.0119 0.1289 0.4582
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.0103 0.0317
Brugia malayi Trypsin family protein 0.0028 0.0103 0.0364
Mycobacterium ulcerans chitinase/cellulase 0.0065 0.0587 0.6081
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0273 0.0322
Brugia malayi kinase, mitochondrial precursor 0.0135 0.1489 0.5293
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0185 0.0573
Onchocerca volvulus 0.0039 0.0249 0.0771
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0026 0.0082 0.0082
Brugia malayi endochitinase 0.0077 0.0734 0.261
Schistosoma mansoni retinoic acid receptor RXR 0.0141 0.1573 0.1857
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0048 0.0111
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0033 0.0161 0.0472
Loa Loa (eye worm) hypothetical protein 0.0049 0.0369 0.1141
Trypanosoma brucei heat shock protein 90, putative 0.0071 0.0666 0.2485
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.003 0.0126 0.0389
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0185 0.0659
Onchocerca volvulus Putative endochitinase 0.0086 0.0854 0.2641
Echinococcus multilocularis inositol monophosphatase 1 0.0072 0.0669 0.0669
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0082 0.0127
Brugia malayi Trypsin-like protease protein 5 0.0028 0.0103 0.0364
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0471 0.0471
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0273 0.0844
Loa Loa (eye worm) hypothetical protein 0.0028 0.0103 0.0317
Echinococcus multilocularis protein dispatched 1 0.0047 0.0349 0.0349
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Plasmodium vivax heat shock protein, putative 0.0026 0.0082 0.0625
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2736 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0116 0.0044
Mycobacterium leprae Possible regulatory protein 0.0033 0.0161 0.2295
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0103 0.0121
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.05 0.0591
Onchocerca volvulus 0.0094 0.0955 0.2953
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.243 1
Echinococcus granulosus tumor protein p63 0.0366 0.4495 0.5306
Brugia malayi Trypsin family protein 0.0028 0.0103 0.0364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0185 0.0573
Echinococcus granulosus aryl hydrocarbon receptor 0.027 0.3249 0.3836
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.05 0.1931
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0033 0.0161 0.0418
Toxoplasma gondii PAN domain-containing protein 0.0039 0.0249 0.022
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0369 0.1313
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.559 0.6599
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0984 0.1162
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.05 0.05
Toxoplasma gondii heat shock protein HSP90 0.0071 0.0666 0.0768
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0122 0.1319 0.469
Schistosoma mansoni lipoxygenase 0.0056 0.0471 0.0556
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0669 0.2606
Trichomonas vaginalis inositol monophosphatase, putative 0.0072 0.0669 0.231
Leishmania major chitinase 0.0077 0.0734 0.2909
Loa Loa (eye worm) hypothetical protein 0.0034 0.0185 0.0573
Echinococcus multilocularis enteropeptidase 0.0028 0.0103 0.0103
Echinococcus multilocularis glycoprotein Antigen 5 0.0028 0.0103 0.0103
Onchocerca volvulus 0.0028 0.0103 0.0317
Toxoplasma gondii microneme protein MIC17C 0.0039 0.0249 0.022
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Onchocerca volvulus 0.0028 0.0103 0.0317
Onchocerca volvulus 0.0039 0.0249 0.0771
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0141 0.1573 0.1857
Loa Loa (eye worm) endoplasmin 0.0071 0.0666 0.2058
Echinococcus granulosus geminin 0.0165 0.1883 0.2222
Echinococcus multilocularis heat shock protein 90 0.0051 0.0407 0.0407
Schistosoma mansoni inositol monophosphatase 0.0072 0.0669 0.079
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0043 0.029 0.0274
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.003 0.0126 0.0447
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0185 0.0659
Echinococcus multilocularis expressed conserved protein 0.009 0.0909 0.0909
Brugia malayi PAN domain containing protein 0.0039 0.0249 0.0886
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0185 0.0185
Entamoeba histolytica heat shock protein 90, putative 0.0071 0.0666 0.6635
Toxoplasma gondii microneme protein, putative 0.0039 0.0249 0.022
Echinococcus granulosus expressed conserved protein 0.009 0.0909 0.1073
Brugia malayi PAN domain containing protein 0.0039 0.0249 0.0886
Onchocerca volvulus Huntingtin homolog 0.0119 0.1289 0.3983
Brugia malayi endochitinase 0.0086 0.0854 0.3037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0185 0.0659
Loa Loa (eye worm) hypothetical protein 0.0039 0.0249 0.0771
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2372 0.7332
Entamoeba histolytica heat shock protein 90, putative 0.0071 0.0666 0.6635
Trypanosoma brucei heat shock protein, putative 0.0071 0.0666 0.2485
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0062 0.0549 0.0615
Onchocerca volvulus 0.0039 0.0249 0.0771
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Loa Loa (eye worm) hypothetical protein 0.0064 0.0565 0.1747
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0033 0.0161 0.0418
Brugia malayi Protein kinase domain containing protein 0.0064 0.0565 0.201
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0103 0.0121
Trichomonas vaginalis guanylate cyclase, putative 0.0033 0.0161 0.0418
Onchocerca volvulus Putative endochitinase 0.0077 0.0734 0.2269
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0103 0.0121
Schistosoma mansoni pyruvate dehydrogenase 0.0115 0.123 0.1452
Schistosoma mansoni hypothetical protein 0.0064 0.0565 0.0667
Schistosoma mansoni hypothetical protein 0.0028 0.0103 0.0121
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0185 0.0219
Mycobacterium tuberculosis Possible chitinase 0.0065 0.0587 1
Leishmania major heat shock protein, putative 0.0026 0.0082 0.0184
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0034 0.0175 0.054
Loa Loa (eye worm) heat shock protein 75 0.0026 0.0082 0.0255
Brugia malayi Kringle domain containing protein 0.0064 0.0565 0.201
Schistosoma mansoni heat shock protein 0.0071 0.0666 0.0786
Echinococcus multilocularis microtubule associated protein 2 0.0672 0.8471 0.8471
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0048 0.0111
Onchocerca volvulus 0.0039 0.0249 0.0771
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0369 0.1313
Brugia malayi PAN domain containing protein 0.0039 0.0249 0.0886
Schistosoma mansoni hypothetical protein 0.0028 0.0103 0.0121
Echinococcus granulosus tissue type plasminogen activator 0.0064 0.0565 0.0667
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0103 0.0121
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0103 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.243 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0185 0.0573
Toxoplasma gondii hypothetical protein 0.0039 0.0249 0.022
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0064 0.0565 0.4285
Trypanosoma brucei heat shock protein, putative 0.0071 0.0666 0.2485
Echinococcus granulosus enteropeptidase 0.0028 0.0103 0.0121
Echinococcus multilocularis geminin 0.0165 0.1883 0.1883
Echinococcus multilocularis tissue type plasminogen activator 0.0064 0.0565 0.0565
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0072 0.0669 0.6669
Schistosoma mansoni hypothetical protein 0.004 0.0254 0.03
Brugia malayi Trypsin family protein 0.0028 0.0103 0.0364
Brugia malayi hypothetical protein 0.0028 0.0103 0.0364
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0103 0.0121
Mycobacterium ulcerans chitinase/cellulase 0.0065 0.0587 0.6081
Onchocerca volvulus 0.0023 0.0038 0.0119
Brugia malayi PAN domain containing protein 0.0039 0.0249 0.0886
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0048 0.0182
Trypanosoma brucei heat shock protein, putative 0.0071 0.0666 0.2485
Brugia malayi PAN domain containing protein 0.0039 0.0249 0.0886
Onchocerca volvulus Huntingtin homolog 0.0119 0.1289 0.3983
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0185 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0161 0.0418
Loa Loa (eye worm) hypothetical protein 0.0096 0.0984 0.3042
Plasmodium vivax endoplasmin, putative 0.0071 0.0666 0.5048
Plasmodium vivax heat shock protein 90, putative 0.0026 0.0082 0.0625
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0669 0.231
Trypanosoma brucei heat shock protein 90, putative 0.0071 0.0666 0.2485
Schistosoma mansoni hypothetical protein 0.0165 0.1883 0.2222
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0103 0.0121
Mycobacterium ulcerans hypothetical protein 0.0028 0.0103 0.071
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0033 0.0161 0.0472
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0033 0.0161 0.0472
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0103 0.0121
Onchocerca volvulus 0.0028 0.0103 0.0317
Onchocerca volvulus 0.0039 0.0249 0.0771
Loa Loa (eye worm) MH2 domain-containing protein 0.0232 0.2747 0.8491
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.05 0.5115
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0043 0.029 0.1054
Echinococcus multilocularis endoplasmin 0.0051 0.0407 0.0407
Toxoplasma gondii subtilisin SUB12 0.0039 0.0249 0.022
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0185 0.0185
Brugia malayi Inositol-1 0.0072 0.0669 0.2379
Loa Loa (eye worm) PAN domain-containing protein 0.0039 0.0249 0.0771
Loa Loa (eye worm) TK/ROR protein kinase 0.0064 0.0565 0.1747
Loa Loa (eye worm) hypothetical protein 0.0028 0.0103 0.0317
Toxoplasma gondii PAN domain-containing protein 0.0039 0.0249 0.022
Schistosoma mansoni heat shock protein 0.0071 0.0666 0.0786
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0082 0.0625
Trypanosoma brucei heat shock protein, putative 0.0071 0.0666 0.2485
Loa Loa (eye worm) PAN domain-containing protein 0.0039 0.0249 0.0771
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0103 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0273 0.0836
Echinococcus granulosus calcium activated potassium channel variant 0.0042 0.0281 0.0332
Loa Loa (eye worm) hypothetical protein 0.0034 0.0185 0.0573
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0434 0.0513
Echinococcus multilocularis heat shock protein 0.0071 0.0666 0.0666
Echinococcus granulosus microtubule associated protein 2 0.0672 0.8471 1
Echinococcus multilocularis protein patched 0.0041 0.0273 0.0273
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0185 0.0219
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0497
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0237 0.2813 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0185 0.0573
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0273 0.0322
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0028 0.0103 0.0121
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0185 0.0219
Loa Loa (eye worm) hypothetical protein 0.0028 0.0103 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0185 0.0659
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0161 0.0418
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0116 0.0116
Onchocerca volvulus 0.0029 0.0116 0.0359
Loa Loa (eye worm) hypothetical protein 0.005 0.0393 0.1216
Schistosoma mansoni microtubule-associated protein tau 0.0672 0.8471 1
Plasmodium vivax hypothetical protein, conserved 0.0122 0.1319 1
Entamoeba histolytica chitinase, putative 0.0077 0.0734 0.7356
Mycobacterium ulcerans heat shock protein 90 0.0051 0.0407 0.4083
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0103 0.0121
Leishmania major protein kinase, putative 0.0033 0.0161 0.0512
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0135 0.1489 0.6046
Loa Loa (eye worm) hypothetical protein 0.0119 0.1289 0.3983
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0185 0.0219
Leishmania major hypothetical protein, conserved 0.0064 0.0565 0.2203
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0082 0.0625
Onchocerca volvulus 0.0054 0.0434 0.1343
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0043 0.029 0.0886
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0185 0.0573
Loa Loa (eye worm) hypothetical protein 0.0238 0.2827 0.8738
Schistosoma mansoni hypothetical protein 0.0039 0.0245 0.0289
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0185 0.0185
Echinococcus multilocularis transfer RNA-Lys 0.0093 0.0941 0.0941
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0034 0.0175 0.0175
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0185 0.0659
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0185 0.0185
Echinococcus multilocularis calcium activated potassium channel 0.0045 0.0322 0.0322
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.017 0.0603
Onchocerca volvulus 0.0231 0.2738 0.8462
Schistosoma mansoni heat shock protein 0.0026 0.0082 0.0097
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0033 0.0161 0.0512
Schistosoma mansoni hypothetical protein 0.004 0.0254 0.03
Loa Loa (eye worm) hypothetical protein 0.0039 0.0249 0.0771
Trypanosoma cruzi heat shock protein 85, putative 0.0071 0.0666 0.2593
Trichomonas vaginalis endoplasmin, putative 0.0046 0.0341 0.109
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0185 0.0219
Schistosoma mansoni hypothetical protein 0.0033 0.017 0.02
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0051 0.0407 0.1541
Brugia malayi hypothetical protein 0.0039 0.0245 0.087
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0028 0.0103 0.0364
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0103 0.0121
Loa Loa (eye worm) transcription factor SMAD2 0.0232 0.2747 0.8491
Toxoplasma gondii hypothetical protein 0.0039 0.0249 0.022
Schistosoma mansoni endoplasmin 0.0071 0.0666 0.0786
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0072 0.0669 0.6986
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0471 0.0556
Echinococcus multilocularis aryl hydrocarbon receptor 0.027 0.3249 0.3249
Echinococcus granulosus heat shock protein 0.0071 0.0666 0.0786
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0116 0.0137
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1519 0.1519
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0102 0.0121
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0984 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0185 0.0573
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0033 0.0161 0.0472
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0245 0.0289
Loa Loa (eye worm) hypothetical protein 0.0039 0.0249 0.0771
Schistosoma mansoni inositol monophosphatase 0.0072 0.0669 0.079
Brugia malayi bHLH-PAS transcription factor 0.0093 0.0941 0.3347
Leishmania major developmentally regulated phosphoprotein-like protein 0.0135 0.1489 0.6063
Schistosoma mansoni pyruvate dehydrogenase 0.0115 0.123 0.1452
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0369 0.1141
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0185 0.0185
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0034 0.0175 0.0206
Loa Loa (eye worm) hypothetical protein 0.0041 0.0273 0.0844
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0341 0.109
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0185 0.0573
Loa Loa (eye worm) hypothetical protein 0.0033 0.017 0.0524
Brugia malayi PAN domain containing protein 0.0039 0.0249 0.0886
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0039 0.0249 0.022
Echinococcus multilocularis tumor protein p63 0.0366 0.4495 0.4495
Trypanosoma brucei developmentally regulated phosphoprotein 0.0135 0.1489 0.5989
Loa Loa (eye worm) chitinase I 0.0077 0.0734 0.2269
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0185 0.0219
Echinococcus granulosus neuropeptide s receptor 0.0451 0.559 0.6599
Trypanosoma cruzi Heat shock protein 83, putative 0.0071 0.0666 0.2593
Trypanosoma cruzi heat shock protein 90, putative 0.0071 0.0666 0.2593
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0185 0.0573
Loa Loa (eye worm) hypothetical protein 0.0054 0.0434 0.1343
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0119
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0185 0.0573
Brugia malayi Trypsin family protein 0.0028 0.0103 0.0364
Loa Loa (eye worm) trypsin family protein 0.0028 0.0103 0.0317
Onchocerca volvulus 0.0039 0.0249 0.0771
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0064 0.0572 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0103 0.0121
Brugia malayi Pre-SET motif family protein 0.0029 0.0116 0.0413
Onchocerca volvulus 0.0039 0.0249 0.0771
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.05 0.5115
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0245 0.0245
Toxoplasma gondii heat shock protein 90, putative 0.0071 0.0666 0.0768
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.0407 0.1506
Onchocerca volvulus 0.0034 0.0185 0.0573
Echinococcus granulosus inositol monophosphatase 1 0.0072 0.0669 0.079
Trypanosoma brucei heat shock protein, putative 0.0071 0.0666 0.2485
Loa Loa (eye worm) hypothetical protein 0.0034 0.0185 0.0573
Loa Loa (eye worm) inositol-1 0.0072 0.0669 0.2068
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0051 0.0407 0.6914
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0669 0.231
Schistosoma mansoni patched 1 0.0041 0.0273 0.0322
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0359
Loa Loa (eye worm) PAN domain-containing protein 0.0039 0.0249 0.0771
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.0775 0.0775
Brugia malayi nuclear receptor NHR-88 0.0034 0.0185 0.0659
Loa Loa (eye worm) heat shock protein 90 0.0071 0.0666 0.2058
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0038 0.0136
Plasmodium vivax SET domain protein, putative 0.0029 0.0116 0.088
Onchocerca volvulus 0.0039 0.0249 0.0771
Mycobacterium tuberculosis Conserved protein 0.0024 0.0048 0.0182
Echinococcus granulosus single minded 2 0.0093 0.0941 0.1111
Echinococcus multilocularis Mastin 0.0028 0.0103 0.0103
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0038 0.0136
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0028 0.0103 0.0103
Onchocerca volvulus 0.0122 0.1319 0.4078
Loa Loa (eye worm) hypothetical protein 0.0122 0.1319 0.4078
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0064 0.0572 0.9712
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0116 0.0137
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.05 0.0591
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.243 1
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0103 0.0103
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0072 0.0669 1
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0043 0.029 0.1016
Loa Loa (eye worm) hypothetical protein 0.0034 0.0185 0.0573
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0185 0.0185
Plasmodium falciparum heat shock protein 90 0.0071 0.0666 0.5048
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0185 0.0219
Loa Loa (eye worm) hypothetical protein 0.0039 0.0249 0.0771
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0185 0.0219
Onchocerca volvulus Putative endochitinase 0.0086 0.0854 0.2641
Trichomonas vaginalis guanylate cyclase, putative 0.0033 0.0161 0.0418
Brugia malayi CHE-14 protein 0.0041 0.0273 0.0971
Echinococcus granulosus heat shock protein 90 0.0051 0.0407 0.0481
Plasmodium falciparum conserved protein, unknown function 0.0122 0.1319 1
Schistosoma mansoni hypothetical protein 0.004 0.0254 0.03
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0185 0.0219
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0028 0.0103 0.0121
Entamoeba histolytica hypothetical protein 0.0039 0.0245 0.2182
Onchocerca volvulus 0.0039 0.0249 0.0771
Brugia malayi steroid hormone receptor 0.0034 0.0185 0.0659
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.05 0.055
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.05 0.5115
Schistosoma mansoni hypothetical protein 0.0165 0.1883 0.2222
Toxoplasma gondii PAN domain-containing protein 0.0611 0.7678 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.2813 0.8694
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.05 0.8411
Schistosoma mansoni aryl hydrocarbon receptor 0.0363 0.4452 0.5256
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0135 0.1489 0.1757
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0048 0.0048
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0052 0.042 0.5
Brugia malayi PAN domain containing protein 0.0039 0.0249 0.0886
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0185 0.0659
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0185 0.0219
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0407 0.1335
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0103 0.0121
Entamoeba histolytica hypothetical protein 0.0039 0.0245 0.2182
Onchocerca volvulus 0.0122 0.1319 0.4078
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0026 0.0082 0.0255
Onchocerca volvulus 0.0028 0.0103 0.0317
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Trichomonas vaginalis heat shock protein, putative 0.0071 0.0666 0.2298
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0033 0.0161 0.0472
Loa Loa (eye worm) hypothetical protein 0.0135 0.1489 0.4601
Toxoplasma gondii PAN/Apple domain-containing protein 0.0039 0.0249 0.022
Loa Loa (eye worm) hypothetical protein 0.0269 0.3235 1
Toxoplasma gondii PAN domain-containing protein 0.0039 0.0249 0.022
Loa Loa (eye worm) hypothetical protein 0.0065 0.0587 0.1816
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0048 0.0111
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0669 0.2499
Brugia malayi ecdysteroid receptor 0.0034 0.0185 0.0659
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0116 0.0137
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0122 0.1319 0.1557
Trypanosoma cruzi heat shock protein 85, putative 0.0071 0.0666 0.2593
Loa Loa (eye worm) hypothetical protein 0.0039 0.0249 0.0771
Schistosoma mansoni calcium-activated potassium channel 0.0042 0.0281 0.0332
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1003 0.1185
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0185 0.0659
Loa Loa (eye worm) hypothetical protein 0.0039 0.0249 0.0771
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0984 0.3499
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.0775 0.0915
Mycobacterium ulcerans hypothetical protein 0.0024 0.0048 0.0111
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0669 0.2606
Echinococcus granulosus calcium activated potassium channel 0.0045 0.0322 0.038
Onchocerca volvulus 0.0039 0.0249 0.0771
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0245 0.0289
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0185 0.0185
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0185 0.0659
Echinococcus granulosus glycoprotein Antigen 5 0.0028 0.0103 0.0121
Loa Loa (eye worm) hypothetical protein 0.0034 0.0185 0.0573
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0119
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0185 0.0219
Echinococcus multilocularis potassium large conductance calcium activated 0.0045 0.0322 0.0322
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0185 0.0659
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.05 0.0591
Plasmodium vivax heat shock protein 86, putative 0.0071 0.0666 0.5048
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Trypanosoma brucei heat shock protein, putative 0.0071 0.0666 0.2485
Onchocerca volvulus 0.0028 0.0103 0.0317
Trypanosoma brucei heat shock protein, putative 0.0071 0.0666 0.2485
Echinococcus multilocularis calcium activated potassium channel variant 0.0042 0.0281 0.0281
Schistosoma mansoni coup transcription factor 0.0034 0.0185 0.0219
Echinococcus granulosus Mastin 0.0028 0.0103 0.0121
Trypanosoma cruzi heat shock protein 90, putative 0.0051 0.0407 0.1506
Loa Loa (eye worm) hypothetical protein 0.0122 0.1319 0.4078
Plasmodium falciparum endoplasmin, putative 0.0046 0.0341 0.2587
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0185 0.0573
Leishmania major heat shock protein 83-1 0.0071 0.0666 0.2624
Onchocerca volvulus 0.0064 0.0565 0.1747
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0135 0.1489 0.1489
Loa Loa (eye worm) hypothetical protein 0.0034 0.0185 0.0573
Loa Loa (eye worm) hypothetical protein 0.0039 0.0249 0.0771
Loa Loa (eye worm) hypothetical protein 0.0028 0.0103 0.0317
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0026 0.0082 0.0097
Schistosoma mansoni single-minded 0.0125 0.1364 0.161
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0322 0.1148
Schistosoma mansoni endoplasmin 0.0071 0.0666 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0161 0.0418
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0185 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0185 0.0659
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0669 0.2637
Giardia lamblia Heat shock protein HSP 90-alpha 0.0071 0.0666 1
Onchocerca volvulus 0.0039 0.0249 0.0771
Schistosoma mansoni calcium-activated potassium channel 0.0045 0.0322 0.038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0185 0.0659
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0185 0.0185
Brugia malayi Hsp90 protein 0.0026 0.0082 0.0293
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1519 0.1793

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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