Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0054 | 0.7404 | 0.7098 |
Plasmodium vivax | vivapain-2 | 0.0018 | 0.1053 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.1053 | 0.3513 |
Echinococcus multilocularis | cysteine protease | 0.0018 | 0.1053 | 0.2673 |
Onchocerca volvulus | Cathepsin L homolog | 0.0018 | 0.1053 | 0.3513 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0018 | 0.1053 | 0.3513 |
Plasmodium vivax | vivapain-2 | 0.0018 | 0.1053 | 0.5 |
Onchocerca volvulus | 0.0018 | 0.1053 | 0.3513 | |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.1053 | 0.3513 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.2997 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0018 | 0.1053 | 0.2673 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0018 | 0.1053 | 0.2673 |
Toxoplasma gondii | cathepsin CPL | 0.0018 | 0.1053 | 0.5 |
Loa Loa (eye worm) | ctsf protein | 0.0018 | 0.1053 | 0.3513 |
Echinococcus multilocularis | lamin | 0.0029 | 0.2997 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2997 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.2997 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Echinococcus granulosus | lamin | 0.0029 | 0.2997 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.1053 | 0.3513 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Onchocerca volvulus | 0.0029 | 0.2997 | 1 | |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0616 | 0.2055 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0018 | 0.1053 | 1 |
Onchocerca volvulus | 0.0018 | 0.1053 | 0.3513 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.2997 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.1053 | 0.3513 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0018 | 0.1053 | 0.2673 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0018 | 0.1053 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0018 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0018 | 0.1053 | 0.3513 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0018 | 0.1053 | 0.3513 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0018 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.2903 | 0.9687 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0018 | 0.1053 | 0.3513 |
Onchocerca volvulus | 0.0018 | 0.1053 | 0.3513 | |
Loa Loa (eye worm) | fibroinase | 0.0018 | 0.1053 | 0.3513 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.2997 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0018 | 0.1053 | 0.2673 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.025 | 0.0833 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Onchocerca volvulus | 0.0018 | 0.1053 | 0.3513 | |
Echinococcus granulosus | cathepsin l1 | 0.0018 | 0.1053 | 0.3513 |
Schistosoma mansoni | lamin | 0.0029 | 0.2997 | 1 |
Echinococcus multilocularis | musashi | 0.0029 | 0.2997 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.2997 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.2997 | 1 |
Schistosoma mansoni | lamin | 0.0029 | 0.2997 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0018 | 0.1053 | 0.3513 |
Onchocerca volvulus | Cathepsin L homolog | 0.0018 | 0.1053 | 0.3513 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0018 | 0.1053 | 0.2673 |
Onchocerca volvulus | 0.0029 | 0.2997 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0018 | 0.1053 | 0.3513 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0018 | 0.1053 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0343 | 0.1146 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.0343 | 0.1146 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Onchocerca volvulus | 0.0018 | 0.1053 | 0.3513 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0018 | 0.1053 | 0.3513 |
Onchocerca volvulus | 0.0018 | 0.1053 | 0.3513 | |
Onchocerca volvulus | 0.0018 | 0.1053 | 0.3513 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0063 | 0.8947 | 0.8824 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0018 | 0.1053 | 0.3513 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.2997 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0018 | 0.1053 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.1053 | 0.3513 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.2997 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1053 | 0.3513 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.0616 | 0.2055 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.025 | 0.0833 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.1053 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0018 | 0.1053 | 0.3513 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.1053 | 0.3513 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 250 uM | Inhibition of [3H]GABA uptake at GAT2 in mouse neurons after 3 mins by scintillation counting analysis | ChEMBL. | 23398473 |
IC50 (binding) | > 250 uM | Inhibition of [3H]GABA uptake at GAT2 in mouse astrocytes after 3 mins by scintillation counting analysis | ChEMBL. | 23398473 |
IC50 (binding) | > 500 uM | Inhibition of [3H]GABA uptake at mouse GAT4 expressed in HEK293 cells after 3 mins by scintillation counting analysis | ChEMBL. | 23398473 |
IC50 (binding) | > 500 uM | Inhibition of [3H]GABA uptake at mouse GAT3 expressed in HEK293 cells after 3 mins by scintillation counting analysis | ChEMBL. | 23398473 |
IC50 (binding) | > 500 uM | Inhibition of [3H]GABA uptake at mouse GAT2 expressed in HEK293 cells after 3 mins by scintillation counting analysis | ChEMBL. | 23398473 |
IC50 (binding) | > 500 uM | Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 3 mins by scintillation counting analysis | ChEMBL. | 23398473 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.