Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATR serine/threonine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0063 | 0.1526 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0035 | 0.0482 | 0.1453 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0111 | 0.3316 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.0128 | 0.0838 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0083 | 0.2259 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0053 | 0.1154 | 0.348 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0053 | 0.1154 | 0.348 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0035 | 0.0482 | 0.3159 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0063 | 0.1526 | 0.6754 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0063 | 0.1526 | 0.6754 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0063 | 0.1526 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.0063 | 0.1526 | 0.6754 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0063 | 0.1526 | 0.6754 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.031 | 0.2035 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.031 | 0.2035 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0083 | 0.2259 | 0.6812 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0053 | 0.1154 | 0.348 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0081 | 0.2193 | 0.2193 |
Leishmania major | phosphatidylinositol 3-related kinase, putative | 0.0035 | 0.0482 | 0.1453 |
Plasmodium falciparum | DNA gyrase subunit B | 0.014 | 0.4388 | 0.3378 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0063 | 0.1526 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0482 | 0.3159 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.014 | 0.4388 | 0.4208 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0092 | 0.2598 | 0.236 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0063 | 0.1526 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0063 | 0.1526 | 0.1526 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0031 | 0.0205 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0063 | 0.1526 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0111 | 0.3316 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0063 | 0.1526 | 0.6754 |
Entamoeba histolytica | Phosphatidylinositol 3- and 4-kinase family | 0.0025 | 0.0128 | 0.0838 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0063 | 0.1526 | 0.6754 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0083 | 0.2259 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0083 | 0.2259 | 0.6812 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.014 | 0.4388 | 0.3378 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0111 | 0.3316 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0083 | 0.2259 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0031 | 0.0205 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0139 | 0.4342 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0053 | 0.1154 | 0.348 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0111 | 0.3316 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0058 | 0.1363 | 1 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0083 | 0.2259 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0063 | 0.1526 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0053 | 0.1154 | 0.348 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.016 uM | Inhibition of ATR in human HeLa cell nuclear extracts using glutathione S-transferase-p53N66 and ATP as substrate incubated for 10 mins prior to ATP addition measured after 1 hr by ELISA | ChEMBL. | 23394205 |
IC50 (binding) | = 0.72 uM | Inhibition of ATR-mediated CHK1 phosphorylation at serine 345 in human HT29 cells after 1 hr in presence of 4-nitroquinoline 1-oxide | ChEMBL. | 23394205 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.