Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0104 | 0.3102 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0135 | 0.4392 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0059 | 0.1254 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0131 | 0.4208 | 0.4208 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0059 | 0.1254 | 0.5 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0131 | 0.4208 | 0.3378 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0131 | 0.4208 | 0.3378 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0059 | 0.1254 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.0055 | 0.1086 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0135 | 0.4392 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0086 | 0.236 | 0.236 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0075 | 0.1943 | 0.0788 |
Schistosoma mansoni | DNA topoisomerase II | 0.0059 | 0.1254 | 0.5 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0129 | 0.4161 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0059 | 0.1254 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0104 | 0.3102 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0135 | 0.4392 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0104 | 0.3102 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0059 | 0.1254 | 0.5 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0059 | 0.1254 | 0.2855 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0104 | 0.3102 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0059 | 0.1254 | 0.5 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0059 | 0.1254 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 37000 nM | Viral Plaque Reduction Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.