Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | DNA gyrase subunit B, putative | 0.1791 | 0.4635 | 0.4635 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0811 | 0.19 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0386 | 0.0713 | 0.0713 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.0023 | 0.0123 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1791 | 0.4635 | 0.4635 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.1408 | 0.3566 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.1771 | 0.4577 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.0713 | 0.375 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.1791 | 0.4635 | 0.4635 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1408 | 0.3566 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.1791 | 0.4635 | 0.4635 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0811 | 0.19 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0681 | 0.1537 | 0.4311 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1194 | 0.2969 | 0.2969 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0811 | 0.19 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0811 | 0.19 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1408 | 0.3566 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0811 | 0.19 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.1791 | 0.4635 | 0.4635 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.0023 | 0.0123 |
Trypanosoma brucei | DNA topoisomerase ii | 0.1408 | 0.3566 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0681 | 0.1537 | 0.4311 |
Giardia lamblia | DNA topoisomerase II | 0.0754 | 0.1741 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0597 | 0.1302 | 0.2845 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0811 | 0.19 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0811 | 0.19 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0811 | 0.19 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0811 | 0.19 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0811 | 0.19 | 0.19 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0811 | 0.19 | 0.19 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.1791 | 0.4635 | 0.4635 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.0461 | 0.2426 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0811 | 0.19 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.0713 | 0.375 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0811 | 0.19 | 0.19 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.0461 | 0.2426 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.0023 | 0.0123 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0681 | 0.1537 | 0.4311 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0681 | 0.1537 | 0.4311 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.1023 | 0.249 | 0.249 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0811 | 0.19 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0681 | 0.1537 | 0.4311 |
Schistosoma mansoni | DNA topoisomerase II | 0.0811 | 0.19 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of Escherichia coli thymidylate synthase A at 120 uM | ChEMBL. | 23273520 | |
Ki (binding) | = 33 uM | Inhibition of human thymidylate synthase A | ChEMBL. | 23273520 |
Ki (binding) | > 588 uM | Inhibition of Escherichia coli thymidylate synthase A | ChEMBL. | 23273520 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.