Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA topoisomerase II | 0.0719 | 0.1499 | 0.5 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0719 | 0.1499 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.028 | 0.1868 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.127 | 0.3295 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0719 | 0.1499 | 0.5 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0719 | 0.1499 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0719 | 0.1499 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.16 | 0.437 | 0.4208 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0719 | 0.1499 | 0.5 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.1586 | 0.4324 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.127 | 0.3295 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.127 | 0.3295 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.127 | 0.3295 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0719 | 0.1499 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1049 | 0.2574 | 0.236 |
Plasmodium falciparum | DNA gyrase subunit B | 0.16 | 0.437 | 0.3378 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0719 | 0.1499 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0719 | 0.1499 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.028 | 0.1868 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0719 | 0.1499 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0719 | 0.1499 | 0.5 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0719 | 0.1499 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.0669 | 0.1335 | 0.5 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0925 | 0.2169 | 0.0788 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.16 | 0.437 | 0.3378 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.4816 | Inhibition of NaV1.7 ion channel (unknown origin) | ChEMBL. | 23177785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.