TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 272.346 | Formula: C15H20N4O
H donors: 2 H acceptors: 3 LogP: 1.95 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: C[C@@H](C(C)C)NC(=O)c1c[nH]c2c1nc(cn2)C1CC1
InChi: 1S/C15H20N4O/c1-8(2)9(3)18-15(20)11-6-16-14-13(11)19-12(7-17-14)10-4-5-10/h6-10H,4-5H2,1-3H3,(H,16,17)(H,18,20)/t9-/m0/s1
InChiKey: NFTVSOUVOHMGDQ-VIFPVBQESA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Janus kinase 2	Starlite/ChEMBL	References
Homo sapiens	Janus kinase 3	Starlite/ChEMBL	References
Homo sapiens	Janus kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0061	0.0074	0.0157
Mycobacterium tuberculosis	Two component sensor histidine kinase TrcS	0.0061	0.0074	0.0033
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0048	0.0041	0.0196
Brugia malayi	Carboxylesterase family protein	0.0048	0.0041	0.0196
Schistosoma mansoni	survival motor neuron protein	0.0051	0.005	0.0235
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0864	0.212	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0043	0.0203
Onchocerca volvulus		0.0252	0.0561	0.2644
Leishmania major	DNA topoisomerase ii	0.0725	0.1767	0.4704
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0061	0.0074	0.0074
Chlamydia trachomatis	DNA gyrase subunit B	0.1271	0.3158	0.3107
Trichomonas vaginalis	endoplasmin, putative	0.0061	0.0074	0.0157
Trypanosoma cruzi	DNA topoisomerase III, putative	0.0139	0.0272	0.0666
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0864	0.212	0.212
Toxoplasma gondii	DNA topoisomerase family protein	0.0139	0.0272	0.0272
Schistosoma mansoni	heat shock protein	0.0061	0.0074	0.035
Entamoeba histolytica	DNA topoisomerase III, putative	0.0139	0.0272	0.0968
Echinococcus multilocularis	carboxylesterase 5A	0.0284	0.0643	0.3032
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.1908	0.478	0.4741
Trichomonas vaginalis	receptor histidine kinase, putative	0.0061	0.0074	0.0157
Echinococcus granulosus	geminin	0.0165	0.034	0.1604
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0864	0.212	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0043	0.0203
Schistosoma mansoni	endoplasmin	0.0061	0.0074	0.035
Schistosoma mansoni	heat shock protein	0.0061	0.0074	0.035
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0294	0.0669	0.1734
Loa Loa (eye worm)	carboxylesterase	0.0284	0.0643	0.3032
Onchocerca volvulus		0.0139	0.0272	0.1284
Onchocerca volvulus		0.0048	0.0041	0.0196
Trypanosoma cruzi	DNA topoisomerase III, putative	0.0139	0.0272	0.0666
Mycobacterium ulcerans	DNA topoisomerase I	0.0139	0.0272	0.0232
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0061	0.0074	0.0133
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Trichomonas vaginalis	receptor histidine kinase, putative	0.0061	0.0074	0.0157
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0139	0.0272	0.0272
Mycobacterium leprae	Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (	0.0139	0.0272	0.0426
Echinococcus granulosus	carboxylesterase 5A	0.0284	0.0643	0.3032
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Loa Loa (eye worm)	glutaminase	0.029	0.0659	0.311
Schistosoma mansoni	hypothetical protein	0.0165	0.034	0.1604
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.1501	0.3743	1
Loa Loa (eye worm)	hypothetical protein	0.0314	0.072	0.3397
Toxoplasma gondii	hypothetical protein	0.0047	0.004	0.004
Loa Loa (eye worm)	carboxylesterase	0.0048	0.0041	0.0196
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0048	0.0062
Echinococcus multilocularis	neuroligin	0.0048	0.0041	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0284	0.0643	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0314	0.072	0.3397
Onchocerca volvulus		0.0051	0.005	0.0235
Echinococcus granulosus	DNA topoisomerase 3 beta 1	0.0139	0.0272	0.1284
Brugia malayi	Pre-SET motif family protein	0.0221	0.0483	0.2277
Loa Loa (eye worm)	endoplasmin	0.0061	0.0074	0.035
Trypanosoma brucei	heat shock protein, putative	0.0061	0.0074	0.0133
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0061	0.0074	0.0074
Mycobacterium tuberculosis	Probable two component sensor kinase	0.0061	0.0074	0.0033
Trypanosoma brucei	heat shock protein 90, putative	0.0061	0.0074	0.0133
Giardia lamblia	DNA topoisomerase III	0.0139	0.0272	0.1048
Mycobacterium leprae	Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.1886	0.4725	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0074	0.035
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Echinococcus granulosus	acetylcholinesterase	0.0284	0.0643	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0041	0.0196
Echinococcus granulosus	heat shock protein	0.0061	0.0074	0.035
Plasmodium vivax	heat shock protein 86, putative	0.0061	0.0074	0.0074
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.1908	0.478	0.4759
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0864	0.212	1
Leishmania major	mitochondrial DNA topoisomerase II	0.1501	0.3743	1
Loa Loa (eye worm)	hypothetical protein	0.0411	0.0966	0.4556
Mycobacterium tuberculosis	Possible two component sensor kinase TcrY	0.0061	0.0074	0.0033
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0061	0.0074	0.0033
Trichomonas vaginalis	set domain proteins, putative	0.0252	0.0561	0.2497
Mycobacterium tuberculosis	Two component sensor kinase [second part]	0.0061	0.0074	0.0033
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0048	0.0041	0.0196
Trypanosoma cruzi	DNA topoisomerase IA, putative	0.0139	0.0272	0.0666
Echinococcus multilocularis	acetylcholinesterase	0.0284	0.0643	0.3032
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0864	0.212	1
Mycobacterium ulcerans	putative regultory protein	0.0061	0.0074	0.0033
Chlamydia trachomatis	DNA gyrase subunit A	0.0411	0.0966	0.0898
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0061	0.0074	0.035
Mycobacterium ulcerans	glutaminase	0.029	0.0659	0.062
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0041	0.0196
Plasmodium vivax	DNA topoisomerase 3, putative	0.0139	0.0272	0.0272
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0061	0.0074	0.0133
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0043	0.0203
Trypanosoma cruzi	DNA topoisomerase III, putative	0.0139	0.0272	0.0666
Schistosoma mansoni	DNA topoisomerase II	0.0864	0.212	1
Brugia malayi	kinase, mitochondrial precursor	0.0061	0.0074	0.035
Schistosoma mansoni	microtubule-associated protein tau	0.0733	0.1788	0.8432
Trypanosoma brucei	heat shock protein, putative	0.0061	0.0074	0.0133
Trypanosoma brucei	heat shock protein, putative	0.0061	0.0074	0.0133
Echinococcus granulosus	para nitrobenzyl esterase	0.0048	0.0041	0.0196
Brugia malayi	Carboxylesterase family protein	0.0048	0.0041	0.0196
Echinococcus multilocularis	heat shock protein	0.0061	0.0074	0.035
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0041	0.0196
Brugia malayi	Carboxylesterase family protein	0.0048	0.0041	0.0196
Mycobacterium tuberculosis	Possible two component sensor kinase	0.0061	0.0074	0.0033
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0725	0.1767	0.4687
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Schistosoma mansoni	hypothetical protein	0.0051	0.005	0.0235
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0725	0.1767	0.4687
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0043	0.0203
Plasmodium falciparum	DNA topoisomerase 3, putative	0.0139	0.0272	0.02
Trypanosoma brucei	DNA topoisomerase III, putative	0.0139	0.0272	0.0666
Brugia malayi	GRF zinc finger family protein	0.0139	0.0272	0.1284
Leishmania major	mitochondrial DNA polymerase beta	0.0294	0.0669	0.176
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0043	0.0203
Loa Loa (eye worm)	DNA topoisomerase III	0.0139	0.0272	0.1284
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0043	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0251	0.0559	0.2639
Chlamydia trachomatis	DNA topoisomerase I	0.0139	0.0272	0.02
Echinococcus multilocularis	acetylcholinesterase	0.0284	0.0643	0.3032
Brugia malayi	heat shock protein 90	0.0061	0.0074	0.035
Trypanosoma cruzi	heat shock protein 85, putative	0.0061	0.0074	0.0133
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Schistosoma mansoni	gliotactin	0.0048	0.0041	0.0196
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0139	0.0274	0.0671
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0061	0.0074	0.0157
Echinococcus granulosus	heat shock protein 90	0.0061	0.0074	0.035
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0043	0.0203
Schistosoma mansoni	endoplasmin	0.0061	0.0074	0.035
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0041	0.0196
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0294	0.0669	0.1734
Trypanosoma cruzi	DNA topoisomerase IA, putative	0.0139	0.0272	0.0666
Trypanosoma cruzi	heat shock protein 85, putative	0.0061	0.0074	0.0133
Loa Loa (eye worm)	glutaminase 2	0.029	0.0659	0.311
Brugia malayi	Probable DNA topoisomerase II	0.0864	0.212	1
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0048	0.0041	0.0196
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0061	0.0074	0.035
Echinococcus multilocularis	survival motor neuron protein 1	0.0251	0.0559	0.2639
Trypanosoma brucei	DNA topoisomerase ii	0.1501	0.3743	1
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0061	0.0074	0.0033
Trypanosoma cruzi	heat shock protein 85, putative	0.0061	0.0074	0.0133
Loa Loa (eye worm)	acetylcholinesterase 1	0.0284	0.0643	0.3032
Mycobacterium tuberculosis	Conserved protein	0.0061	0.0074	0.0033
Loa Loa (eye worm)	carboxylesterase	0.0048	0.0041	0.0196
Loa Loa (eye worm)	DNA topoisomerase III beta-1	0.0139	0.0272	0.1284
Mycobacterium tuberculosis	Possible two component system response sensor kinase membrane associated PhoR	0.0061	0.0074	0.0033
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0294	0.0669	0.1734
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0061	0.0074	0.0165
Schistosoma mansoni	pyruvate dehydrogenase	0.0061	0.0074	0.035
Plasmodium vivax	DNA topoisomerase II, putative	0.0864	0.212	0.212
Plasmodium falciparum	DNA gyrase subunit B	0.1908	0.478	0.4741
Schistosoma mansoni	glutaminase	0.029	0.0659	0.311
Brugia malayi	hypothetical protein	0.0048	0.0041	0.0196
Entamoeba histolytica	DNA topoisomerase III, putative	0.0139	0.0272	0.0968
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0037	0.0013	0.006
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0061	0.0074	0.0133
Trypanosoma brucei	Heat shock protein 83, putative	0.0061	0.0074	0.0133
Trypanosoma cruzi	Heat shock protein 83, putative	0.0061	0.0074	0.0133
Trichomonas vaginalis	prokaryotic DNA topoisomerase, putative	0.0139	0.0272	0.111
Entamoeba histolytica	DNA topoisomerase II, putative	0.0864	0.212	1
Trypanosoma brucei	heat shock protein, putative	0.0061	0.0074	0.0133
Echinococcus granulosus	neuroligin	0.0048	0.0041	0.0196
Loa Loa (eye worm)	heat shock protein 90	0.0061	0.0074	0.035
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0061	0.0074	0.0033
Echinococcus granulosus	acetylcholinesterase	0.0284	0.0643	0.3032
Onchocerca volvulus		0.0048	0.0041	0.0196
Mycobacterium tuberculosis	Two component sensory transduction histidine kinase MtrB	0.0061	0.0074	0.0033
Schistosoma mansoni	hypothetical protein	0.0165	0.034	0.1604
Trypanosoma cruzi	heat shock protein 90, putative	0.0061	0.0074	0.0133
Mycobacterium ulcerans	two component sensor kinase MprB	0.0061	0.0074	0.0033
Toxoplasma gondii	heat shock protein HSP90	0.0061	0.0074	0.0074
Onchocerca volvulus		0.0048	0.0041	0.0196
Echinococcus multilocularis	rho GTPase activating protein 20	0.0139	0.0272	0.1284
Schistosoma mansoni	prokaryotic DNA topoisomerase	0.0139	0.0272	0.1284
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0061	0.0074	0.0133
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0725	0.1767	0.4687
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0061	0.0074	0.0157
Giardia lamblia	DNA topoisomerase III	0.0139	0.0272	0.1048
Mycobacterium leprae	Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0637	0.1542	0.3155
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Onchocerca volvulus		0.0048	0.0041	0.0196
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0043	0.0203
Leishmania major	DNA topoisomerase III, putative	0.0139	0.0272	0.0696
Brugia malayi	Endoplasmin precursor	0.0061	0.0074	0.035
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.1908	0.478	0.4741
Loa Loa (eye worm)	hypothetical protein	0.0411	0.0966	0.4556
Brugia malayi	Carboxylesterase family protein	0.0284	0.0643	0.3032
Trichomonas vaginalis	prokaryotic DNA topoisomerase, putative	0.0139	0.0272	0.111
Schistosoma mansoni	acetylcholinesterase	0.0048	0.0041	0.0196
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0048	0.0041	0.0196
Schistosoma mansoni	prokaryotic DNA topoisomerase	0.0139	0.0272	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0041	0.0196
Trichomonas vaginalis	glutaminase, putative	0.029	0.0659	0.2973
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0862	0.2115	0.9975
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.0274	0.0701
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0864	0.212	1
Brugia malayi	Carboxylesterase family protein	0.0284	0.0643	0.3032
Schistosoma mansoni	BC026374 protein (S09 family)	0.0048	0.0041	0.0196
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0155	0.0314	0.0274
Mycobacterium ulcerans	hypothetical protein	0.0155	0.0314	0.0274
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Echinococcus granulosus	sodium channel protein	0.0037	0.0013	0.006
Echinococcus multilocularis	sodium channel protein	0.0037	0.0013	0.006
Echinococcus multilocularis	geminin	0.0165	0.034	0.1604
Trichomonas vaginalis	sensor histidine kinase, putative	0.0061	0.0074	0.0157
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.0274	0.0671
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0043	0.0203
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0725	0.1767	0.4687
Echinococcus granulosus	microtubule associated protein 2	0.0733	0.1788	0.8432
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0061	0.0074	0.0033
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0061	0.0074	0.0033
Mycobacterium ulcerans	DNA gyrase subunit B	0.1908	0.478	0.4759
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0061	0.0074	0.0033
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0061	0.0074	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0284	0.0643	0.3032
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0061	0.0074	0.0033
Echinococcus granulosus	DNA topoisomerase 3 alpha	0.0139	0.0272	0.1284
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0061	0.0074	0.035
Mycobacterium tuberculosis	Two component sensor kinase MprB	0.0061	0.0074	0.0033
Trypanosoma brucei	heat shock protein, putative	0.0061	0.0074	0.0133
Brugia malayi	glutaminase DH11.1	0.029	0.0659	0.311
Plasmodium vivax	hypothetical protein, conserved	0.0061	0.0074	0.0074
Brugia malayi	hypothetical protein	0.0251	0.0559	0.2639
Trichomonas vaginalis	heat shock protein, putative	0.0061	0.0074	0.0157
Chlamydia trachomatis	DNA gyrase subunit B	0.1908	0.478	0.4741
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0061	0.0074	0.0157
Trypanosoma brucei	heat shock protein, putative	0.0061	0.0074	0.0133
Trypanosoma brucei	heat shock protein 90, putative	0.0061	0.0074	0.0133
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.109	0.2696	0.2696
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0864	0.212	1
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.1501	0.3743	1
Mycobacterium tuberculosis	Probable sensor protein KdpD	0.0061	0.0074	0.0033
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0221	0.0483	0.2277
Trypanosoma brucei	heat shock protein, putative	0.0061	0.0074	0.0133
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0864	0.212	1
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0061	0.0074	0.0033
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.005	0.0235
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0061	0.0074	0.0033
Mycobacterium tuberculosis	Two component sensor histidine kinase PrrB	0.0061	0.0074	0.0033
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0048	0.0041	0.0196
Echinococcus multilocularis	DNA topoisomerase 3 beta 1	0.0139	0.0272	0.1284
Treponema pallidum	DNA topoisomerase I (topA)	0.0139	0.0272	0.02
Trypanosoma brucei	DNA topoisomerase IA, putative	0.0139	0.0272	0.0666
Brugia malayi	Carboxylesterase family protein	0.0048	0.0041	0.0196
Trichomonas vaginalis	heat shock protein, putative	0.0061	0.0074	0.0157
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0864	0.212	1
Trypanosoma brucei	heat shock protein, putative	0.0061	0.0074	0.0133
Giardia lamblia	DNA topoisomerase II	0.0803	0.1965	1
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Brugia malayi	DNA topoisomerase III beta-1	0.0139	0.0272	0.1284
Trypanosoma brucei	DNA topoisomerase III, putative	0.0139	0.0272	0.0666
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0048	0.0041	0.0196
Loa Loa (eye worm)	TOPoisomerase family member	0.0864	0.212	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0041	0.0196
Onchocerca volvulus		0.0048	0.0041	0.0196
Leishmania major	DNA topoisomerase 1A	0.0139	0.0272	0.0696
Plasmodium vivax	DNA gyrase subunit B, putative	0.1908	0.478	0.478
Plasmodium vivax	endoplasmin, putative	0.0061	0.0074	0.0074
Echinococcus granulosus	BC026374 protein S09 family	0.0048	0.0041	0.0196
Leishmania major	hypothetical protein, conserved	0.0061	0.0074	0.0165
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Wolbachia endosymbiont of Brugia malayi	topoisomerase IA, TopA	0.0139	0.0272	0.02
Toxoplasma gondii	heat shock protein 90, putative	0.0061	0.0074	0.0074
Echinococcus multilocularis	microtubule associated protein 2	0.0733	0.1788	0.8432
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Leishmania major	DNA topoisomerase III, putative	0.0139	0.0272	0.0696
Trypanosoma cruzi	heat shock protein 90, putative	0.0061	0.0074	0.0133
Plasmodium falciparum	DNA topoisomerase 2	0.0864	0.212	0.2061
Echinococcus multilocularis	para nitrobenzyl esterase	0.0048	0.0041	0.0196
Echinococcus multilocularis	heat shock protein 90	0.0061	0.0074	0.035
Trichomonas vaginalis	mismatch repair protein Mlh1C (mutL homolog)	0.0061	0.0074	0.0157
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0048	0.0041	0.0196
Echinococcus granulosus	survival motor neuron protein 1	0.0251	0.0559	0.2639
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0284	0.0643	0.3032
Leishmania major	heat shock protein 83-1	0.0061	0.0074	0.0165
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0061	0.0074	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0041	0.0196
Brugia malayi	DNA topoisomerase III	0.0139	0.0272	0.1284

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 7.8 nM	Inhibition of JAK3 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP	ChEMBL.	23214979
IC50 (binding)	= 32.6 nM	Inhibition of JAK2 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP	ChEMBL.	23214979
IC50 (binding)	= 44.8 nM	Inhibition of JAK1 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured after 1 hr by scintillation counting analysis in presence of [gamma-33P]ATP	ChEMBL.	23214979

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2325899

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1726532