Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Janus kinase 3 | Starlite/ChEMBL | References |
Homo sapiens | Janus kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | Janus kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tubulin alpha chain | 0.018 | 0.6814 | 0.6814 |
Loa Loa (eye worm) | tubulin alpha chain | 0.018 | 0.6814 | 0.6814 |
Plasmodium falciparum | tubulin epsilon chain, putative | 0.0129 | 0.4008 | 0.4008 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.018 | 0.6814 | 0.6814 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.018 | 0.6814 | 0.6814 |
Echinococcus granulosus | tubulin alpha chain | 0.018 | 0.6814 | 0.6814 |
Schistosoma mansoni | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Echinococcus multilocularis | tubulin alpha | 0.0129 | 0.4008 | 0.4008 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.018 | 0.6814 | 0.6814 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.018 | 0.6814 | 0.6814 |
Leishmania major | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Leishmania major | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Brugia malayi | Tubulin gamma chain | 0.0129 | 0.4008 | 0.4008 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0129 | 0.4008 | 0.4008 |
Toxoplasma gondii | tubulin/FtsZ family, GTPase domain-containing protein | 0.0129 | 0.4008 | 0.4008 |
Loa Loa (eye worm) | alpha-tubulin | 0.018 | 0.6814 | 0.6814 |
Schistosoma mansoni | tubulin subunit alpha | 0.018 | 0.6814 | 0.6814 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.018 | 0.6814 | 0.6814 |
Loa Loa (eye worm) | alpha-tubulin | 0.018 | 0.6814 | 0.6814 |
Echinococcus granulosus | tubulin subunit TubB | 0.018 | 0.6814 | 0.6814 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.018 | 0.6814 | 0.6814 |
Giardia lamblia | Alpha-tubulin | 0.018 | 0.6814 | 0.6814 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0073 | 0.0932 | 0.0932 |
Trypanosoma brucei | tubulin gamma chain | 0.0129 | 0.4008 | 0.4008 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.018 | 0.6814 | 0.6814 |
Trypanosoma brucei | alpha tubulin, putative | 0.0073 | 0.0932 | 0.0932 |
Trypanosoma brucei | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Trypanosoma cruzi | alpha tubulin, putative | 0.018 | 0.6814 | 0.6814 |
Brugia malayi | alpha-tubulin | 0.018 | 0.6814 | 0.6814 |
Echinococcus multilocularis | tubulin alpha chain | 0.018 | 0.6814 | 0.6814 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.018 | 0.6814 | 0.6814 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0073 | 0.0932 | 0.0932 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0107 | 0.2805 | 0.2805 |
Trichomonas vaginalis | tubulin, putative | 0.0073 | 0.0932 | 0.0932 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.018 | 0.6814 | 0.6814 |
Schistosoma mansoni | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0129 | 0.4008 | 0.4008 |
Echinococcus granulosus | tubulin gamma 1 chain | 0.0129 | 0.4008 | 0.4008 |
Plasmodium falciparum | alpha tubulin 1 | 0.018 | 0.6814 | 0.6814 |
Plasmodium vivax | tubulin alpha chain, putative | 0.018 | 0.6814 | 0.6814 |
Brugia malayi | Tubulin alpha-2 chain | 0.018 | 0.6814 | 0.6814 |
Trichomonas vaginalis | tubulin, putative | 0.0073 | 0.0932 | 0.0932 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.018 | 0.6814 | 0.6814 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.018 | 0.6814 | 0.6814 |
Echinococcus multilocularis | tubulin epsilon chain | 0.0129 | 0.4008 | 0.4008 |
Schistosoma mansoni | tubulin subunit epsilon | 0.0129 | 0.4008 | 0.4008 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.018 | 0.6814 | 0.6814 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0124 | 0.3738 | 0.3738 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.018 | 0.6814 | 0.6814 |
Leishmania major | epsilon tubulin, putative | 0.0129 | 0.4008 | 0.4008 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.3738 | 0.3738 |
Leishmania major | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Trypanosoma brucei | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Echinococcus multilocularis | tubulin alpha chain | 0.018 | 0.6814 | 0.6814 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0107 | 0.2805 | 0.2805 |
Echinococcus granulosus | tubulin epsilon chain | 0.0129 | 0.4008 | 0.4008 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.018 | 0.6814 | 0.6814 |
Onchocerca volvulus | 0.0073 | 0.0932 | 0.5 | |
Entamoeba histolytica | tubulin alpha chain, putative | 0.018 | 0.6814 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.018 | 0.6814 | 0.6814 |
Leishmania major | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Trypanosoma brucei | epsilon tubulin | 0.0129 | 0.4008 | 0.4008 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0124 | 0.3738 | 0.3738 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0129 | 0.4008 | 0.4008 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0073 | 0.0932 | 0.0932 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0124 | 0.3738 | 0.3738 |
Echinococcus multilocularis | tubulin subunit TubB | 0.018 | 0.6814 | 0.6814 |
Schistosoma mansoni | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Echinococcus granulosus | tubulin alpha chain | 0.018 | 0.6814 | 0.6814 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.018 | 0.6814 | 0.6814 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.6814 | 0.6814 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.018 | 0.6814 | 0.6814 |
Echinococcus granulosus | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.018 | 0.6814 | 0.6814 |
Leishmania major | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0129 | 0.4008 | 0.4008 |
Leishmania major | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Echinococcus multilocularis | hypothetical protein | 0.018 | 0.6814 | 0.6814 |
Trypanosoma brucei | epsilon tubulin | 0.0129 | 0.4008 | 0.4008 |
Schistosoma mansoni | tubulin subunit alpha | 0.018 | 0.6814 | 0.6814 |
Echinococcus granulosus | tubulin alpha chain | 0.018 | 0.6814 | 0.6814 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0129 | 0.4008 | 0.4008 |
Echinococcus multilocularis | tubulin alpha chain | 0.018 | 0.6814 | 0.6814 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.018 | 0.6814 | 0.6814 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.018 | 0.6814 | 0.6814 |
Leishmania major | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0124 | 0.3738 | 0.3738 |
Leishmania major | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.018 | 0.6814 | 0.6814 |
Brugia malayi | tubulin alpha-2 chain | 0.018 | 0.6814 | 0.6814 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2805 | 0.2805 |
Trypanosoma brucei | epsilon tubulin | 0.0129 | 0.4008 | 0.4008 |
Schistosoma mansoni | tubulin subunit alpha | 0.018 | 0.6814 | 0.6814 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.018 | 0.6814 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.018 | 0.6814 | 0.6814 |
Brugia malayi | Tubulin alpha chain | 0.018 | 0.6814 | 0.6814 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.018 | 0.6814 | 0.6814 |
Loa Loa (eye worm) | tubulin alpha chain | 0.018 | 0.6814 | 0.6814 |
Echinococcus granulosus | tubulin alpha | 0.0129 | 0.4008 | 0.4008 |
Plasmodium vivax | tubulin alpha chain, putative | 0.018 | 0.6814 | 0.6814 |
Brugia malayi | tubulin alpha chain - mouse | 0.018 | 0.6814 | 0.6814 |
Brugia malayi | Tubulin alpha-2 chain | 0.018 | 0.6814 | 0.6814 |
Plasmodium falciparum | alpha tubulin 2 | 0.018 | 0.6814 | 0.6814 |
Schistosoma mansoni | tubulin subunit gamma | 0.0129 | 0.4008 | 0.4008 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.018 | 0.6814 | 0.6814 |
Leishmania major | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Echinococcus granulosus | tubulin alpha chain | 0.018 | 0.6814 | 0.6814 |
Leishmania major | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.018 | 0.6814 | 0.6814 |
Echinococcus multilocularis | tubulin gamma 1 chain | 0.0129 | 0.4008 | 0.4008 |
Plasmodium vivax | tubulin epsilon chain, putative | 0.0129 | 0.4008 | 0.4008 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.018 | 0.6814 | 0.6814 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0073 | 0.0932 | 0.0932 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.018 | 0.6814 | 0.6814 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.018 | 0.6814 | 0.6814 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0073 | 0.0932 | 0.0932 |
Giardia lamblia | Gamma tubulin | 0.0129 | 0.4008 | 0.4008 |
Leishmania major | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Plasmodium vivax | tubulin gamma chain, putative | 0.0129 | 0.4008 | 0.4008 |
Trypanosoma cruzi | tubulin gamma chain | 0.0129 | 0.4008 | 0.4008 |
Trypanosoma brucei | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Trypanosoma brucei | beta tubulin | 0.0129 | 0.4008 | 0.4008 |
Brugia malayi | Tubulin beta chain | 0.0073 | 0.0932 | 0.0932 |
Giardia lamblia | Alpha-tubulin | 0.018 | 0.6814 | 0.6814 |
Echinococcus multilocularis | tubulin alpha chain | 0.018 | 0.6814 | 0.6814 |
Plasmodium falciparum | tubulin gamma chain | 0.0129 | 0.4008 | 0.4008 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.018 | 0.6814 | 0.6814 |
Leishmania major | gamma-tubulin | 0.0129 | 0.4008 | 0.4008 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0129 | 0.4008 | 0.4008 |
Leishmania major | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Trypanosoma brucei | alpha tubulin | 0.018 | 0.6814 | 0.6814 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 44.5 nM | Inhibition of JAK3 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP | ChEMBL. | 23214979 |
IC50 (binding) | = 106.2 nM | Inhibition of JAK2 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP | ChEMBL. | 23214979 |
IC50 (binding) | = 224.3 nM | Inhibition of JAK1 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured after 1 hr by scintillation counting analysis in presence of [gamma-33P]ATP | ChEMBL. | 23214979 |
Inhibition (binding) | = -28 % | Inhibition of PIM2 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = -22 % | Inhibition of PKCbeta (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = -8 % | Inhibition of IGF1R (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = -4 % | Inhibition of SYK (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 1 % | Inhibition of INSR (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 7 % | Inhibition of p38alpha (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 7 % | Inhibition of BTK (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 9 % | Inhibition of AKT2 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 10 % | Inhibition of p70S6K (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 16 % | Inhibition of PKCzeta (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 16 % | Inhibition of AKT1 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 23 % | Inhibition of IRAK4 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 24 % | Inhibition of PRAK (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 24 % | Inhibition of MET (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 28 % | Inhibition of MSK1 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 42 % | Inhibition of c-Raf (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 46 % | Inhibition of FLT3 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 48 % | Inhibition of CHK1 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 52 % | Inhibition of CAMK4 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 59 % | Inhibition of SRC (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 62 % | Inhibition of PAK2 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 62 % | Inhibition of ERK2 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 62 % | Inhibition of CK1D (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 63 % | Inhibition of LYN (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 64 % | Inhibition of LCK (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 65 % | Inhibition of ABL (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 67 % | Inhibition of DYRK1A (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 68 % | Inhibition of SGK1 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 71 % | Inhibition of FYN (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 73 % | Inhibition of CTAK1 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 80 % | Inhibition of ROCK2 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 81 % | Inhibition of ERK1 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 82 % | Inhibition of PKD2 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 83 % | Inhibition of HGK (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 84 % | Inhibition of KDR (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 89 % | Inhibition of Aurora kinase A (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 90 % | Inhibition of CHK2 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 91 % | Inhibition of AMPK (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 92 % | Inhibition of CDK2 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 93 % | Inhibition of MARK1 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 95 % | Inhibition of RSK1 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 95 % | Inhibition of FGFR1 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 97 % | Inhibition of GSK3B (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Inhibition (binding) | = 98 % | Inhibition of MST2 (unknown origin) at 10 uM | ChEMBL. | 23214979 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.