Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | tubulin alpha 2 | 0.0132 | 0.1296 | 0.1296 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0192 | 0.5571 | 0.5571 |
Echinococcus multilocularis | tubulin alpha chain | 0.0192 | 0.5571 | 0.4682 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0192 | 0.5571 | 0.4682 |
Brugia malayi | alpha-tubulin | 0.0192 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Echinococcus granulosus | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha chain | 0.0192 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0192 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0192 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0138 | 0.1672 | 0.1672 |
Plasmodium falciparum | alpha tubulin 2 | 0.0192 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0192 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha-2 chain | 0.0192 | 0.5571 | 0.4682 |
Giardia lamblia | Alpha-tubulin | 0.0192 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0192 | 0.5571 | 0.5571 |
Leishmania major | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0192 | 0.5571 | 0.5571 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0132 | 0.1296 | 0.1296 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0192 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0192 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0192 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0192 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0138 | 0.1672 | 0.1672 |
Echinococcus granulosus | tubulin alpha chain | 0.0192 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.5571 | 0.5571 |
Trypanosoma brucei | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Echinococcus multilocularis | hypothetical protein | 0.0192 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0192 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0192 | 0.5571 | 0.4682 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0192 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0138 | 0.1672 | 0.1672 |
Leishmania major | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0192 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0132 | 0.1296 | 0.1296 |
Echinococcus granulosus | tubulin alpha chain | 0.0192 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0192 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0132 | 0.1296 | 0.1296 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0192 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0192 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0192 | 0.5571 | 0.4682 |
Plasmodium falciparum | alpha tubulin 1 | 0.0192 | 0.5571 | 0.4682 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0192 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0192 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha chain | 0.0192 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0192 | 0.5571 | 0.5571 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0192 | 0.5571 | 0.4682 |
Giardia lamblia | Alpha-tubulin | 0.0192 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0192 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0192 | 0.5571 | 0.5571 |
Trypanosoma brucei | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0138 | 0.1672 | 0.1672 |
Leishmania major | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0192 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin subunit TubB | 0.0192 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1296 | 0.1296 |
Brugia malayi | tubulin alpha-2 chain | 0.0192 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0192 | 0.5571 | 0.5571 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0192 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0192 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0192 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0192 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0192 | 0.5571 | 0.5571 |
Leishmania major | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0192 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0192 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0192 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0192 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0192 | 0.5571 | 0.5571 |
Loa Loa (eye worm) | alpha-tubulin | 0.0192 | 0.5571 | 0.5571 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0192 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0192 | 0.5571 | 0.4682 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0192 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0192 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0192 | 0.5571 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0192 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0192 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Brugia malayi | tubulin alpha chain - mouse | 0.0192 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha-2 chain | 0.0192 | 0.5571 | 0.4682 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0192 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0192 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0192 | 0.5571 | 0.4682 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 15.8 nM | Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calcium immobilization treated 10 mins prior to TRPV4 agonist, GSK1016790A by FLIPR assay | ChEMBL. | 24900661 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.