Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Canis familiaris | Transient receptor potential M8 protein | No references | |
Homo sapiens | transient receptor potential cation channel, subfamily M, member 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | transient receptor potential cation channel | Transient receptor potential M8 protein | 1104 aa | 1108 aa | 25.5 % |
Echinococcus granulosus | transient receptor potential cation channel | transient receptor potential cation channel, subfamily M, member 8 | 1104 aa | 1115 aa | 24.8 % |
Schistosoma mansoni | transient receptor potential cation channel subfamily m member | Transient receptor potential M8 protein | 1104 aa | 1075 aa | 25.3 % |
Echinococcus granulosus | transient receptor potential cation channel | Transient receptor potential M8 protein | 1104 aa | 1114 aa | 24.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.5571 | 0.5571 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0187 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha-2 chain | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1296 | 0.1296 |
Brugia malayi | Tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Brugia malayi | tubulin alpha chain - mouse | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0187 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | hypothetical protein | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0187 | 0.5571 | 0.5571 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0187 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0187 | 0.5571 | 0.5571 |
Schistosoma mansoni | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.5571 | 0.5571 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0187 | 0.5571 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin subunit TubB | 0.0187 | 0.5571 | 0.4682 |
Giardia lamblia | Alpha-tubulin | 0.0187 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0187 | 0.5571 | 0.5571 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0187 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha-2 chain | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Giardia lamblia | Alpha-tubulin | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0187 | 0.5571 | 0.4682 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0187 | 0.5571 | 0.5571 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0187 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0129 | 0.1296 | 0.1296 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.5571 | 0.5571 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0134 | 0.1672 | 0.1672 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.5571 | 0.5571 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0129 | 0.1296 | 0.1296 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0187 | 0.5571 | 0.4682 |
Brugia malayi | tubulin alpha-2 chain | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0187 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.5571 | 0.5571 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Brugia malayi | alpha-tubulin | 0.0187 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0187 | 0.5571 | 0.4682 |
Plasmodium falciparum | alpha tubulin 1 | 0.0187 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0134 | 0.1672 | 0.1672 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0187 | 0.5571 | 0.5571 |
Plasmodium falciparum | alpha tubulin 2 | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0187 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0134 | 0.1672 | 0.1672 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0129 | 0.1296 | 0.1296 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0134 | 0.1672 | 0.1672 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0187 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0129 | 0.1296 | 0.1296 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0187 | 0.5571 | 0.4682 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.8 nM | Functional Assay | BINDINGDB. | No reference |
IC50 (binding) | = 1.1 nM | Patch Clamp Assay | BINDINGDB. | No reference |
IC50 (binding) | = 2.3 nM | Patch Clamp Assay | BINDINGDB. | No reference |
IC50 (binding) | = 4 nM | Inhibition of TRPM8 (unknown origin) | ChEMBL. | 23121096 |
IC50 (binding) | = 4 nM | Functional Assay | BINDINGDB. | No reference |
IC50 (binding) | = 5 nM | Functional Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.