Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | porcupine homolog (Drosophila) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | protein cysteine N palmitoyltransferase | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Loa Loa (eye worm) | MBOAT family protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Echinococcus granulosus | zinc finger protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Brugia malayi | MBOAT family protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Schistosoma japonicum | ko:K00181 porcupine, putative | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Schistosoma mansoni | zinc finger protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Echinococcus multilocularis | zinc finger protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0949 | 0.5899 | 1 | |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0019 | 0.0032 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0949 | 0.5899 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0104 | 0.0176 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.0104 | 0.0176 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0019 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.0865 | 0.1466 |
Brugia malayi | hypothetical protein | 0.0452 | 0.2676 | 0.4536 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0054 | 0.0104 | 0.0176 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0019 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0019 | 0.0032 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0949 | 0.5899 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0019 | 0.0032 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0019 | 0.0032 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.0104 | 0.0176 |
Schistosoma mansoni | zinc finger protein | 0.0299 | 0.1688 | 0.2861 |
Loa Loa (eye worm) | thymidylate synthase | 0.0949 | 0.5899 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0019 | 0.0032 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.0513 | 0.0869 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0019 | 0.0032 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0104 | 0.0176 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0264 | 0.146 | 0.1444 |
Brugia malayi | Pre-SET motif family protein | 0.0244 | 0.1331 | 0.2256 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0949 | 0.5899 | 0.5891 |
Echinococcus granulosus | tumor protein p63 | 0.0388 | 0.2261 | 0.3833 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.0299 | 0.1688 | 0.2861 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0949 | 0.5899 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0452 | 0.2676 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0054 | 0.0104 | 0.0176 |
Onchocerca volvulus | 0.0041 | 0.0019 | 0.0032 | |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.0104 | 0.0176 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0549 | 0.3303 | 0.56 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.0104 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0513 | 0.0869 |
Echinococcus granulosus | thymidylate synthase | 0.0949 | 0.5899 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0119 | 0.0201 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0019 | 0.0032 |
Echinococcus multilocularis | tumor protein p63 | 0.0388 | 0.2261 | 0.3833 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0054 | 0.0104 | 0.0176 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0452 | 0.2676 | 0.2662 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0452 | 0.2676 | 0.4519 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0019 | 0.0032 |
Echinococcus granulosus | zinc finger protein | 0.0273 | 0.1521 | 0.2578 |
Mycobacterium ulcerans | thymidylate synthase | 0.0949 | 0.5899 | 0.5891 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0019 | 0.0032 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0172 | 0.0865 | 0.1466 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0019 | 0.0032 |
Echinococcus granulosus | GPCR family 2 | 0.0054 | 0.0104 | 0.0176 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0949 | 0.5899 | 0.5 |
Onchocerca volvulus | 0.0278 | 0.1549 | 0.2626 | |
Brugia malayi | MH2 domain containing protein | 0.0549 | 0.3303 | 0.56 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0054 | 0.0104 | 0.0176 |
Trichomonas vaginalis | set domain proteins, putative | 0.0278 | 0.1549 | 0.5761 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0949 | 0.5899 | 0.5891 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0019 | 0.0032 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0118 | 0.0513 | 0.0869 |
Onchocerca volvulus | 0.0041 | 0.0019 | 0.0032 | |
Loa Loa (eye worm) | MBOAT family protein | 0.0299 | 0.1688 | 0.2861 |
Echinococcus multilocularis | thymidylate synthase | 0.0949 | 0.5899 | 1 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0019 | 0.0032 |
Onchocerca volvulus | 0.0041 | 0.0019 | 0.0032 | |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0019 | 0.0032 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.0299 | 0.1688 | 0.2861 |
Brugia malayi | thymidylate synthase | 0.0949 | 0.5899 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0949 | 0.5899 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0949 | 0.5899 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0104 | 0.0176 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0172 | 0.0865 | 0.1466 |
Echinococcus multilocularis | zinc finger protein | 0.0273 | 0.1521 | 0.2578 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0057 | 0.0119 | 0.0201 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0244 | 0.1331 | 0.2256 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0549 | 0.3303 | 0.56 |
Onchocerca volvulus | 0.0057 | 0.0119 | 0.0201 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0104 | 0.0176 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0104 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0019 | 0.0032 |
Brugia malayi | MBOAT family protein | 0.0299 | 0.1688 | 0.2861 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0172 | 0.0865 | 0.1466 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0949 | 0.5899 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 350 nM | Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay | ChEMBL. | 23477365 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.