Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | thymidylate synthetase | Starlite/ChEMBL | References |
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0029 | 0.5 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0029 | 0.0044 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0117 | 0.1125 | 0.1937 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.025 | 0.3007 | 0.4568 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0029 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.013 | 0.1308 | 0.2322 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0029 | 0.0029 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0029 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.0201 | 0.0173 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.6582 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.4969 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.4969 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0406 | 0.0406 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.4969 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.0406 | 0.0378 |
Loa Loa (eye worm) | thymidylate synthase | 0.0389 | 0.4969 | 0.7549 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0178 | 0.027 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0178 | 0.0149 |
Mycobacterium tuberculosis | Probable reductase | 0.0117 | 0.1125 | 0.1937 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.4969 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0178 | 0.0149 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0117 | 0.1125 | 0.1937 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.0201 | 0.0306 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0178 | 0.027 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0178 | 0.0149 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.0406 | 0.043 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 0.4969 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.025 | 0.3007 | 0.4568 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.024 | 0.0365 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0178 | 0.0178 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.0406 | 0.043 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.024 | 0.0365 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 0.4969 | 0.4954 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.0929 | 0.0929 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0406 | 0.0406 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0185 | 0.2091 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0178 | 0.0149 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.013 | 0.1308 | 0.0477 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 0.4969 | 0.4954 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.024 | 0.0365 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0117 | 0.1125 | 0.1937 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.0201 | 0.0306 |
Brugia malayi | hypothetical protein | 0.0504 | 0.6582 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0053 | 0.0234 | 0.0234 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.4969 | 0.4969 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0504 | 0.6582 | 0.6572 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0103 | 0.0929 | 0.1411 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.0406 | 0.043 |
Brugia malayi | glutathione reductase | 0.0051 | 0.0201 | 0.0306 |
Echinococcus multilocularis | tumor protein p63 | 0.0365 | 0.4631 | 0.4616 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0117 | 0.1125 | 0.1937 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.0406 | 0.0378 |
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 0.4969 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 0.4969 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0178 | 0.0178 |
Onchocerca volvulus | 0.0103 | 0.0929 | 0.1467 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.4969 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0117 | 0.1125 | 0.1937 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0185 | 0.2091 | 0.3965 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.013 | 0.1308 | 0.2322 |
Onchocerca volvulus | 0.0389 | 0.4969 | 1 | |
Brugia malayi | thymidylate synthase | 0.0389 | 0.4969 | 0.7549 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.0201 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0234 | 0.0356 |
Echinococcus granulosus | tumor protein p63 | 0.0365 | 0.4631 | 0.4616 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0185 | 0.2091 | 0.3965 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0178 | 0.0178 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.0201 | 0.0173 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0029 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0504 | 0.6582 | 0.6572 |
Brugia malayi | hypothetical protein | 0.0185 | 0.2091 | 0.3177 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.013 | 0.1308 | 0.2322 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.024 | 0.0365 |
Brugia malayi | MH2 domain containing protein | 0.025 | 0.3007 | 0.4568 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0389 | 0.4969 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0103 | 0.0929 | 0.0929 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.