TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 382.659 | Formula: C15H9BrClNO2S
H donors: 2 H acceptors: 2 LogP: 5.3 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)Sc1c([nH]c2c1ccc(c2)Br)C(=O)O
InChi: 1S/C15H9BrClNO2S/c16-8-1-6-11-12(7-8)18-13(15(19)20)14(11)21-10-4-2-9(17)3-5-10/h1-7,18H,(H,19,20)
InChiKey: RVJFDZCSUMJRIP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0476	0.1054	1
Schistosoma mansoni	hypothetical protein	0.0331	0.0679	0.0664
Entamoeba histolytica	DNA topoisomerase II, putative	0.0075	0.0017	0.5
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0237	0.0436	0.046
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0714	0.1667	0.1808
Leishmania major	protein kinase, putative	0.0476	0.1054	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0714	0.1667	0.1808
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0237	0.0436	0.042
Loa Loa (eye worm)	hypothetical protein	0.0476	0.1054	0.1136
Schistosoma mansoni	voltage-gated potassium channel	0.0237	0.0436	0.042
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0476	0.1054	0.1039
Mycobacterium ulcerans	hypothetical protein	0.0476	0.1054	1
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0476	0.1054	0.1136
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0476	0.1054	1
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0237	0.0436	0.4046
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0476	0.1054	0.1136
Trypanosoma brucei	protein kinase A regulatory subunit	0.0476	0.1054	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0237	0.0436	0.042
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0237	0.0436	0.046
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0714	0.1667	0.1939
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0331	0.0679	0.0778
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0331	0.0679	0.0778
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0237	0.0436	0.046
Echinococcus multilocularis	calcium activated potassium channel	0.0237	0.0436	0.046
Trichomonas vaginalis	hypothetical protein	0.0331	0.0679	0.0778
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Treponema pallidum	cyclic nucleotide binding protein	0.0476	0.1054	1
Echinococcus granulosus	potassium voltage gated channel protein	0.0237	0.0436	0.046
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0237	0.0436	0.046
Plasmodium falciparum	cGMP-dependent protein kinase	0.0476	0.1054	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.3607	0.9144	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0331	0.0679	0.0778
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0476	0.1054	0.1136
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Echinococcus granulosus	hypothetical protein	0.0237	0.0436	0.046
Trichomonas vaginalis	conserved hypothetical protein	0.0331	0.0679	0.0778
Echinococcus granulosus	sodium leak channel non selective protein	0.0237	0.0436	0.046
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0331	0.0679	0.0778
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0714	0.1667	0.1653
Plasmodium falciparum	DNA gyrase subunit A	0.0257	0.0488	0.4545
Echinococcus granulosus	hyperpolarization activated cyclic	0.0714	0.1667	0.1808
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.1045	0.2523	0.2746
Trichomonas vaginalis	adenylate cyclase type III, putative	0.0331	0.0679	0.0778
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0331	0.0679	0.0778
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0476	0.1054	0.1218
Trichomonas vaginalis	adenylate cyclase, putative	0.0331	0.0679	0.0778
Echinococcus granulosus	calcium activated potassium channel	0.0237	0.0436	0.046
Schistosoma mansoni	voltage-gated potassium channel	0.0237	0.0436	0.042
Schistosoma mansoni	voltage-gated potassium channel	0.0237	0.0436	0.042
Schistosoma mansoni	voltage-gated potassium channel	0.1045	0.2523	0.2511
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0476	0.1054	0.1136
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0331	0.0679	0.0778
Trichomonas vaginalis	conserved hypothetical protein	0.0476	0.1054	0.1218
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.337	0.8531	1
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0331	0.0679	0.0726
Trypanosoma brucei	cAMP response protein 1, putative	0.0476	0.1054	1
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0331	0.0679	0.0778
Echinococcus granulosus	shaker cognate	0.0237	0.0436	0.046
Treponema pallidum	catabolite gene activator (Crp)	0.0476	0.1054	1
Mycobacterium tuberculosis	Conserved protein	0.0476	0.1054	1
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0476	0.1054	0.1136
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0237	0.0436	0.046
Trichomonas vaginalis	conserved hypothetical protein	0.0331	0.0679	0.0778
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0331	0.0679	0.0778
Echinococcus multilocularis	potassium voltage gated channel protein	0.0237	0.0436	0.046
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0714	0.1667	0.1808
Trypanosoma cruzi	Flagellar Member 6	0.0476	0.1054	1
Leishmania major	hypothetical protein, conserved	0.0476	0.1054	1
Leishmania major	hypothetical protein, unknown function	0.0476	0.1054	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0714	0.1667	0.1653
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0237	0.0436	0.046
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0237	0.0436	0.046
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0237	0.0436	0.046
Echinococcus multilocularis	sodium leak channel non selective protein	0.0237	0.0436	0.046
Trichomonas vaginalis	adenylate cyclase, putative	0.0331	0.0679	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Schistosoma mansoni	voltage-gated potassium channel	0.0237	0.0436	0.042
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0476	0.1054	1
Schistosoma mansoni	voltage-gated potassium channel	0.0237	0.0436	0.042
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0476	0.1054	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0331	0.0679	0.0778
Echinococcus multilocularis	shaker cognate	0.0237	0.0436	0.046
Echinococcus multilocularis	transient receptor potential gamma protein	0.0237	0.0436	0.046
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0476	0.1054	1
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0237	0.0436	0.046
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0237	0.0436	0.046
Echinococcus multilocularis	transient receptor potential cation channel	0.0237	0.0436	0.046
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0237	0.0436	0.046
Trichomonas vaginalis	adenylate cyclase type, putative	0.0331	0.0679	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.3607	0.9144	1
Trypanosoma brucei	Flagellar Member 6	0.0476	0.1054	1
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0237	0.0436	0.4046
Toxoplasma gondii	transporter, cation channel family protein	0.0237	0.0436	0.4046
Schistosoma mansoni	voltage-gated potassium channel	0.0714	0.1667	0.1653
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0331	0.0679	0.6388
Loa Loa (eye worm)	voltage-gated potassium channel	0.0237	0.0436	0.046
Toxoplasma gondii	transporter, cation channel family protein	0.0237	0.0436	0.4046
Echinococcus multilocularis	ryanodine receptor 44f	0.0237	0.0436	0.046
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0714	0.1667	0.1808
Echinococcus granulosus	transient receptor potential gamma protein	0.0237	0.0436	0.046
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0476	0.1054	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0714	0.1667	0.1808
Trichomonas vaginalis	adenylate cyclase type VI, putative	0.0331	0.0679	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0476	0.1054	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0331	0.0679	0.0778
Echinococcus multilocularis	sodium channel protein	0.0237	0.0436	0.046
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0476	0.1054	1
Echinococcus granulosus	transient receptor potential cation channel	0.0237	0.0436	0.046
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0476	0.1054	0.1218
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0237	0.0436	0.046
Echinococcus granulosus	transient receptor potential cation channel	0.0237	0.0436	0.046
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0476	0.1054	0.1039
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0237	0.0436	0.042
Loa Loa (eye worm)	ion channel NompC	0.0237	0.0436	0.046
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0714	0.1667	0.1808
Schistosoma mansoni	transient receptor potential channel	0.0237	0.0436	0.042
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0237	0.0436	0.042
Onchocerca volvulus		0.0476	0.1054	1
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0331	0.0679	0.0778
Echinococcus multilocularis	transient receptor potential cation channel	0.0237	0.0436	0.046
Schistosoma mansoni	calcium-activated potassium channel	0.0237	0.0436	0.042
Trypanosoma brucei	cAMP binding protein, putative	0.0476	0.1054	1
Echinococcus multilocularis	expressed conserved protein	0.0476	0.1054	0.1136
Schistosoma mansoni	voltage-gated potassium channel	0.0237	0.0436	0.042
Echinococcus multilocularis	potassium voltage gated channel protein	0.0237	0.0436	0.046
Mycobacterium ulcerans	transcriptional regulatory protein	0.0476	0.1054	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0331	0.0679	0.0778
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0237	0.0436	0.046
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0476	0.1054	0.1136
Echinococcus granulosus	potassium large conductance calcium activated	0.0237	0.0436	0.046
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0476	0.1054	0.1218
Echinococcus multilocularis	voltage gated potassium channel	0.1045	0.2523	0.2746
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0476	0.1054	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Brugia malayi	Transient-receptor-potential like protein	0.0237	0.0436	0.046
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0714	0.1667	0.1808
Loa Loa (eye worm)	hypothetical protein	0.3131	0.7913	0.8651
Trichomonas vaginalis	adenylate cyclase, putative	0.0331	0.0679	0.0778
Schistosoma mansoni	transient receptor potential channel 4	0.0237	0.0436	0.042
Trichomonas vaginalis	guanylate cyclase beta 1 subunit, putative	0.0331	0.0679	0.0778
Loa Loa (eye worm)	voltage-gated calcium channel	0.0237	0.0436	0.046
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0476	0.1054	0.1136
Trichomonas vaginalis	adenylate cyclase type, putative	0.0331	0.0679	0.0778
Echinococcus multilocularis	transient receptor potential cation channel	0.0237	0.0436	0.046
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0237	0.0436	0.046
Echinococcus granulosus	short transient receptor potential channel 6	0.0237	0.0436	0.046
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0476	0.1054	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0476	0.1054	0.1136
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.1045	0.2523	0.2746
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0331	0.0679	0.0778
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0237	0.0436	0.046
Trichomonas vaginalis	adenylate cyclase, putative	0.0331	0.0679	0.0778
Trichomonas vaginalis	conserved hypothetical protein	0.0331	0.0679	0.0778
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0476	0.1054	0.1136
Echinococcus granulosus	transient receptor potential cation channel	0.0237	0.0436	0.046
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0237	0.0436	0.4046
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0331	0.0679	0.0778
Onchocerca volvulus		0.0476	0.1054	1
Brugia malayi	cation channel family protein	0.0237	0.0436	0.046
Trypanosoma cruzi	cAMP response protein 1, putative	0.0476	0.1054	1
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0237	0.0436	0.4046
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0237	0.0436	0.046
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0331	0.0679	0.0778
Echinococcus granulosus	voltage dependent calcium channel	0.0237	0.0436	0.046
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0476	0.1054	1
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0237	0.0436	0.046
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0237	0.0436	0.046
Schistosoma mansoni	serine/threonine protein kinase	0.0476	0.1054	0.1039
Schistosoma mansoni	60S ribosomal protein L21	0.0569	0.1293	0.1278
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0714	0.1667	0.1808
Mycobacterium leprae	Possible transporter protein	0.0331	0.0679	0.59
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0237	0.0436	0.046
Echinococcus multilocularis	short transient receptor potential channel 6	0.0237	0.0436	0.046
Treponema pallidum	catabolite gene activator	0.0476	0.1054	1
Echinococcus granulosus	short transient receptor potential channel 6	0.0237	0.0436	0.046
Mycobacterium ulcerans	hypothetical protein	0.0476	0.1054	1
Brugia malayi	Egg laying defective protein 4	0.0476	0.1054	0.1136
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Trichomonas vaginalis	conserved hypothetical protein	0.0331	0.0679	0.0778
Onchocerca volvulus		0.0237	0.0436	0.4046
Echinococcus multilocularis	conserved hypothetical protein	0.0237	0.0436	0.046
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0476	0.1054	0.1218
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0476	0.1054	1
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0237	0.0436	0.046
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0476	0.1054	0.1039
Treponema pallidum	cyclic nucleotide binding protein	0.0476	0.1054	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0237	0.0436	0.046
Plasmodium falciparum	DNA gyrase subunit B	0.0135	0.0173	0.1503
Echinococcus multilocularis	potassium voltage gated channel protein	0.0237	0.0436	0.046
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0237	0.0436	0.042
Brugia malayi	ion channel NompC	0.0237	0.0436	0.046
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0476	0.1054	0.1136
Trichomonas vaginalis	conserved hypothetical protein	0.0331	0.0679	0.0778
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.3607	0.9144	1
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0476	0.1054	1
Echinococcus granulosus	potassium voltage gated channel protein	0.0237	0.0436	0.046
Echinococcus granulosus	hyperpolarization activated cyclic	0.0714	0.1667	0.1808
Echinococcus granulosus	ryanodine receptor 44f	0.0237	0.0436	0.046
Echinococcus granulosus	voltage gated potassium channel	0.0237	0.0436	0.046
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0476	0.1054	0.1039
Toxoplasma gondii	transporter, cation channel family protein	0.0237	0.0436	0.4046
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Echinococcus granulosus	potassium voltage gated channel protein	0.0237	0.0436	0.046
Echinococcus multilocularis	voltage dependent calcium channel	0.0237	0.0436	0.046
Trichomonas vaginalis	adenylate cyclase type, putative	0.0331	0.0679	0.0778
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.337	0.8531	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0714	0.1667	0.1653
Trichomonas vaginalis	adenylate cyclase, putative	0.0331	0.0679	0.0778
Echinococcus granulosus	voltage gated potassium channel	0.1045	0.2523	0.2746
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0476	0.1054	0.1136
Trichomonas vaginalis	adenylyl cyclase type V, putative	0.0331	0.0679	0.0778
Echinococcus granulosus	transient receptor potential cation channel	0.0237	0.0436	0.046
Trichomonas vaginalis	intestinal guanylate cyclase, putative	0.0331	0.0679	0.0778
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0237	0.0436	0.046
Schistosoma mansoni	voltage-gated potassium channel	0.0237	0.0436	0.042
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0476	0.1054	1
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0237	0.0436	0.046
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0476	0.1054	0.1039
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0476	0.1054	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0476	0.1054	0.1039
Echinococcus granulosus	potassium voltage gated channel protein	0.0237	0.0436	0.046
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0714	0.1667	0.1653
Trichomonas vaginalis	adenylate cyclase, putative	0.0331	0.0679	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0476	0.1054	1
Schistosoma mansoni	serine/threonine protein kinase	0.0476	0.1054	0.1039
Brugia malayi	cation channel family protein	0.0237	0.0436	0.046
Mycobacterium ulcerans	hypothetical protein	0.0476	0.1054	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0331	0.0679	0.0778
Echinococcus multilocularis	potassium voltage gated channel protein	0.0237	0.0436	0.046
Echinococcus multilocularis	transfer RNA-Gly	0.0237	0.0436	0.046
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0714	0.1667	0.1653
Trichomonas vaginalis	adenylate cyclase, putative	0.0331	0.0679	0.0778
Schistosoma mansoni	voltage-gated potassium channel	0.0237	0.0436	0.042
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0476	0.1054	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0237	0.0436	0.046
Echinococcus granulosus	potassium voltage gated channel protein	0.0237	0.0436	0.046
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0237	0.0436	0.046
Trichomonas vaginalis	guanylate cyclase beta 2 subunit, putative	0.0331	0.0679	0.0778
Schistosoma mansoni	ryanodine receptor related	0.0237	0.0436	0.042
Trichomonas vaginalis	conserved hypothetical protein	0.0331	0.0679	0.0778
Mycobacterium leprae	Conserved hypothetical protein	0.0476	0.1054	1
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0237	0.0436	0.046
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0476	0.1054	0.1136
Loa Loa (eye worm)	calcium channel	0.0237	0.0436	0.046
Schistosoma mansoni	voltage-gated potassium channel	0.0237	0.0436	0.042
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Schistosoma mansoni	transient receptor potential channel	0.0237	0.0436	0.042
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0237	0.0436	0.4046
Echinococcus multilocularis	two pore calcium channel protein 1	0.0237	0.0436	0.046
Trichomonas vaginalis	conserved hypothetical protein	0.0331	0.0679	0.0778
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0331	0.0679	0.0778
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0237	0.0436	0.042
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0714	0.1667	0.1808
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Schistosoma mansoni	voltage-gated potassium channel	0.0569	0.1293	0.1278
Trichomonas vaginalis	adenylate cyclase type III, putative	0.0331	0.0679	0.0778
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	0.0257	0.0488	1
Toxoplasma gondii	hypothetical protein	0.0237	0.0436	0.4046
Loa Loa (eye worm)	voltage-gated potassium channel	0.0237	0.0436	0.046
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0237	0.0436	0.042
Brugia malayi	N-terminal motif family protein	0.0476	0.1054	0.1136
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0476	0.1054	0.1136
Plasmodium vivax	DNA gyrase subunit A, putative	0.0257	0.0488	0.4545
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0476	0.1054	1
Brugia malayi	olfactory channel protein osm-9	0.0237	0.0436	0.046
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0237	0.0436	0.042
Plasmodium vivax	DNA gyrase subunit B, putative	0.0135	0.0173	0.1503
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0237	0.0436	0.046
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0476	0.1054	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0714	0.1667	0.1808
Treponema pallidum	DNA gyrase, subunit A (gyrA)	0.0257	0.0488	0.358
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Schistosoma mansoni	voltage-gated potassium channel	0.0237	0.0436	0.042
Schistosoma mansoni	transient receptor potential channel	0.0237	0.0436	0.042
Mycobacterium ulcerans	hypothetical protein	0.0476	0.1054	1
Echinococcus granulosus	cGMP dependent protein kinase	0.0476	0.1054	0.1136
Schistosoma mansoni	vesicular amine transporter	0.0237	0.0436	0.042
Echinococcus multilocularis	voltage gated potassium channel	0.0237	0.0436	0.046
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0476	0.1054	0.1136
Loa Loa (eye worm)	ryanodine receptor	0.0237	0.0436	0.046
Schistosoma mansoni	voltage-gated potassium channel	0.0237	0.0436	0.042
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0237	0.0436	0.042
Leishmania major	hypothetical protein, unknown function	0.0237	0.0436	0.4046
Schistosoma mansoni	voltage-gated cation channel	0.0237	0.0436	0.042
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0237	0.0436	0.046
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0257	0.0488	0.358
Toxoplasma gondii	hypothetical protein	0.0237	0.0436	0.4046
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0476	0.1054	1
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0331	0.0679	0.0778
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0476	0.1054	1
Brugia malayi	hypothetical protein	0.0237	0.0436	0.046
Trypanosoma cruzi	hypothetical protein, conserved	0.0476	0.1054	1
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0237	0.0436	0.046
Schistosoma mansoni	serine/threonine protein kinase	0.0476	0.1054	0.1039
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0331	0.0679	0.0778
Schistosoma mansoni	hypothetical protein	0.0237	0.0436	0.042
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0237	0.0436	0.046
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0237	0.0436	0.046
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0714	0.1667	0.1808
Schistosoma mansoni	voltage-dependent calcium channel	0.0237	0.0436	0.042
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.0257	0.0488	0.4545
Echinococcus granulosus	sodium channel protein	0.0237	0.0436	0.046
Echinococcus multilocularis	two pore calcium channel protein 2	0.0237	0.0436	0.046
Echinococcus granulosus	transient receptor potential cation channel	0.0237	0.0436	0.046
Trichomonas vaginalis	adenylate cyclase, putative	0.0331	0.0679	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Mycobacterium ulcerans	DNA gyrase subunit A	0.0257	0.0488	0.358
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0237	0.0436	0.4046
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0331	0.0679	0.0778
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0476	0.1054	1
Loa Loa (eye worm)	hypothetical protein	0.0714	0.1667	0.1808
Leishmania major	protein kinase, putative	0.0476	0.1054	1
Echinococcus multilocularis	potassium large conductance calcium activated	0.0237	0.0436	0.046
Schistosoma mansoni	voltage-gated potassium channel	0.1045	0.2523	0.2511
Trichomonas vaginalis	adenylate cyclase, putative	0.0331	0.0679	0.0778
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0476	0.1054	1
Mycobacterium ulcerans	regulatory protein	0.0476	0.1054	1
Echinococcus granulosus	voltage dependent calcium channel	0.0237	0.0436	0.046
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0714	0.1667	0.1808
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0237	0.0436	0.046
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0237	0.0436	0.046
Echinococcus granulosus	two pore calcium channel protein 1	0.0237	0.0436	0.046
Echinococcus granulosus	TRP transient receptor potential channel	0.0237	0.0436	0.046
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0237	0.0436	0.046
Trichomonas vaginalis	adenylate cyclase, putative	0.0331	0.0679	0.0778
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.3607	0.9144	1
Schistosoma mansoni	hypothetical protein	0.0476	0.1054	0.1039
Trichomonas vaginalis	conserved hypothetical protein	0.0331	0.0679	0.0778
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0476	0.1054	0.1136
Trichomonas vaginalis	conserved hypothetical protein	0.0331	0.0679	0.0778
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0476	0.1054	0.1039
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0476	0.1054	0.1039
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0237	0.0436	0.046
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0476	0.1054	0.1039
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0237	0.0436	0.4046
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0237	0.0436	0.046
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0714	0.1667	0.1939
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0237	0.0436	0.046
Schistosoma mansoni	voltage-gated potassium channel	0.0237	0.0436	0.042
Mycobacterium ulcerans	transmembrane transport protein	0.0476	0.1054	1
Echinococcus multilocularis	voltage dependent calcium channel	0.0237	0.0436	0.046
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0331	0.0679	0.0778
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0476	0.1054	1
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0237	0.0436	0.042
Leishmania major	hypothetical protein, conserved	0.0476	0.1054	1
Echinococcus granulosus	transient receptor potential cation channel	0.0237	0.0436	0.046
Echinococcus granulosus	single minded 2	0.0331	0.0679	0.0726
Leishmania major	hypothetical protein, conserved	0.0476	0.1054	1
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0476	0.1054	1
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0237	0.0436	0.4046
Trypanosoma cruzi	cAMP response protein 1	0.0476	0.1054	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0476	0.1054	0.1136
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0237	0.0436	0.042
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0476	0.1054	0.1136
Leishmania major	hypothetical protein, conserved	0.0237	0.0436	0.4046
Leishmania major	protein kinase A regulatory subunit, putative	0.0476	0.1054	1
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0476	0.1054	1
Trichomonas vaginalis	adenylate cyclase type vIII, putative	0.0331	0.0679	0.0778
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0476	0.1054	0.1039
Trichomonas vaginalis	conserved hypothetical protein	0.0331	0.0679	0.0778
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0476	0.1054	0.1039
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0476	0.1054	0.1136
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0237	0.0436	0.046
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0237	0.0436	0.046
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0476	0.1054	1
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0476	0.1054	1
Chlamydia trachomatis	DNA gyrase subunit A	0.0257	0.0488	0.358
Brugia malayi	voltage-dependent calcium channel	0.0237	0.0436	0.046
Echinococcus multilocularis	short transient receptor potential channel 6	0.0237	0.0436	0.046
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0237	0.0436	0.046
Echinococcus granulosus	two pore calcium channel protein 2	0.0237	0.0436	0.046
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.1045	0.2523	0.2746
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0476	0.1054	0.1136
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0237	0.0436	0.4046
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0476	0.1054	0.1136
Loa Loa (eye worm)	hypothetical protein	0.1045	0.2523	0.2746
Schistosoma mansoni	voltage-gated ion channel	0.0237	0.0436	0.042
Schistosoma mansoni	two-pore calcium channel	0.0237	0.0436	0.042
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Echinococcus multilocularis	transient receptor potential cation channel	0.0237	0.0436	0.046
Trichomonas vaginalis	guanylate cyclase, putative	0.0331	0.0679	0.0778
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0237	0.0436	0.042
Trypanosoma cruzi	cAMP binding protein, putative	0.0476	0.1054	1
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0436	0.046
Trichomonas vaginalis	adenylate cyclase, putative	0.0331	0.0679	0.0778

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 51000 nM	Viral Plaque Reduction Assay	BINDINGDB.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2327018

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1727108