Detailed information for compound 1727120

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 401.246 | Formula: C19H14Cl2N4O2
  • H donors: 1 H acceptors: 4 LogP: 4.38 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1nn2c(c1Cc1cccc(c1Cl)Cl)nc(cc2O)c1ccncc1
  • InChi: 1S/C19H14Cl2N4O2/c1-27-19-13(9-12-3-2-4-14(20)17(12)21)18-23-15(10-16(26)25(18)24-19)11-5-7-22-8-6-11/h2-8,10,26H,9H2,1H3
  • InChiKey: YSMSSJBFBPYZSK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica phosphatidylinositol 3-kinase, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1068 aa 927 aa 29.0 %
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 582 aa 491 aa 25.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0193 0.0361 0.0361
Loa Loa (eye worm) calcium channel 0.0193 0.0361 0.0396
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.058 0.1602 0.1753
Schistosoma mansoni transient receptor potential channel 0.0193 0.0361 0.0361
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0387 0.0984 0.0984
Trypanosoma brucei cAMP response protein 1, putative 0.0387 0.0984 1
Schistosoma mansoni two-pore calcium channel 0.0193 0.0361 0.0361
Schistosoma mansoni voltage-gated potassium channel 0.0849 0.2465 0.2465
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0269 0.0606 0.0712
Brugia malayi N-terminal motif family protein 0.0387 0.0984 0.1077
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.058 0.1602 0.1602
Trypanosoma cruzi protein kinase A regulatory subunit 0.0387 0.0984 0.7444
Trichomonas vaginalis adenylate cyclase, putative 0.0269 0.0606 0.0712
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Schistosoma mansoni hypothetical protein 0.0193 0.0361 0.0361
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Echinococcus multilocularis transient receptor potential cation channel 0.0193 0.0361 0.0396
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0208 0.0411 0.045
Echinococcus granulosus voltage gated hydrogen channel 1 0.0193 0.0361 0.0396
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0387 0.0984 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0193 0.0361 0.0396
Trichomonas vaginalis adenylate cyclase type, putative 0.0269 0.0606 0.0712
Toxoplasma gondii hypothetical protein 0.0193 0.0361 0.3673
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.058 0.1602 0.1602
Echinococcus granulosus transient receptor potential cation channel 0.0193 0.0361 0.0396
Schistosoma mansoni transient receptor potential channel 4 0.0193 0.0361 0.0361
Schistosoma mansoni ryanodine receptor related 0.0193 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Treponema pallidum cyclic nucleotide binding protein 0.0387 0.0984 1
Schistosoma mansoni voltage-gated potassium channel 0.0193 0.0361 0.0361
Trichomonas vaginalis adenylate cyclase type, putative 0.0269 0.0606 0.0712
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0193 0.0361 0.0396
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0701 0.1989 0.1989
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0387 0.0984 0.0984
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0193 0.0361 0.0396
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0193 0.0361 0.0396
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0493 0.1322 0.1551
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Leishmania major protein kinase, putative 0.0387 0.0984 1
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Trichomonas vaginalis adenylate cyclase, putative 0.0269 0.0606 0.0712
Mycobacterium ulcerans transmembrane transport protein 0.0387 0.0984 1
Trichomonas vaginalis adenylate cyclase, putative 0.0269 0.0606 0.0712
Mycobacterium ulcerans hypothetical protein 0.0387 0.0984 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.2932 0.9137 1
Echinococcus granulosus potassium voltage gated channel protein 0.0193 0.0361 0.0396
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0193 0.0361 0.0396
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0193 0.0361 0.3673
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0193 0.0361 0.0396
Echinococcus granulosus short transient receptor potential channel 6 0.0193 0.0361 0.0396
Entamoeba histolytica hypothetical protein 0.0415 0.1074 0.8126
Echinococcus granulosus calcium activated potassium channel 0.0193 0.0361 0.0396
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Schistosoma mansoni serine/threonine protein kinase 0.0387 0.0984 0.0984
Echinococcus granulosus potassium voltage gated channel protein 0.0193 0.0361 0.0396
Mycobacterium tuberculosis Conserved hypothetical protein 0.0387 0.0984 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0157 0.0248 0.1874
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0193 0.0361 0.0396
Treponema pallidum catabolite gene activator 0.0387 0.0984 1
Echinococcus granulosus two pore calcium channel protein 1 0.0193 0.0361 0.0396
Echinococcus multilocularis voltage dependent calcium channel 0.0193 0.0361 0.0396
Brugia malayi ion channel NompC 0.0193 0.0361 0.0396
Echinococcus granulosus cGMP dependent protein kinase 1 0.0387 0.0984 0.1077
Trypanosoma cruzi cAMP response protein 1, putative 0.0387 0.0984 0.7444
Echinococcus granulosus sodium leak channel non selective protein 0.0193 0.0361 0.0396
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0238 0.0506 0.514
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0387 0.0984 1
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Echinococcus granulosus patatin phospholipase domain containing protein 0.0387 0.0984 0.1077
Loa Loa (eye worm) voltage-gated potassium channel 0.0193 0.0361 0.0396
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0387 0.0984 0.7444
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0387 0.0984 0.1077
Brugia malayi Transient-receptor-potential like protein 0.0193 0.0361 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.0606 0.0712
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0193 0.0361 0.0396
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0387 0.0984 1
Schistosoma mansoni voltage-gated potassium channel 0.0193 0.0361 0.0361
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0157 0.0248 0.1874
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0269 0.0606 0.0712
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.0606 0.0712
Echinococcus multilocularis voltage dependent calcium channel 0.0193 0.0361 0.0396
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0193 0.0361 0.0361
Echinococcus granulosus voltage gated potassium channel 0.0849 0.2465 0.2698
Loa Loa (eye worm) AGC/PKG protein kinase 0.0387 0.0984 0.1077
Schistosoma mansoni voltage-gated ion channel 0.0193 0.0361 0.0361
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0387 0.0984 1
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0387 0.0984 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0493 0.1322 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0849 0.2465 0.2698
Echinococcus multilocularis transient receptor potential cation channel 0.0193 0.0361 0.0396
Echinococcus granulosus potassium voltage gated channel protein 0.0193 0.0361 0.0396
Echinococcus multilocularis voltage gated potassium channel 0.0193 0.0361 0.0396
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0269 0.0606 0.0712
Echinococcus granulosus transient receptor potential gamma protein 0.0193 0.0361 0.0396
Trichomonas vaginalis adenylate cyclase type, putative 0.0269 0.0606 0.0712
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0387 0.0984 0.1077
Echinococcus granulosus cGMP dependent protein kinase 1 0.0387 0.0984 0.1077
Leishmania major hypothetical protein, unknown function 0.0193 0.0361 0.3673
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0193 0.0361 0.3673
Schistosoma mansoni serine/threonine protein kinase 0.0387 0.0984 0.0984
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0493 0.1322 1
Trichomonas vaginalis adenylate cyclase, putative 0.0269 0.0606 0.0712
Loa Loa (eye worm) voltage-gated calcium channel 0.0193 0.0361 0.0396
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0387 0.0984 1
Mycobacterium ulcerans regulatory protein 0.0387 0.0984 1
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0193 0.0361 0.2734
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0387 0.0984 0.0984
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0193 0.0361 0.0361
Trypanosoma cruzi cAMP response protein 1 0.0387 0.0984 0.7444
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0193 0.0361 0.0396
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0193 0.0361 0.0396
Trichomonas vaginalis adenylate cyclase type III, putative 0.0269 0.0606 0.0712
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0701 0.1989 0.2177
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0193 0.0361 0.0396
Echinococcus multilocularis hyperpolarization activated cyclic 0.058 0.1602 0.1753
Loa Loa (eye worm) phosphatidylinositol 3 0.0139 0.0189 0.0207
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0387 0.0984 0.1077
Trypanosoma brucei cAMP binding protein, putative 0.0387 0.0984 1
Mycobacterium ulcerans hypothetical protein 0.0387 0.0984 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0193 0.0361 0.0396
Schistosoma mansoni voltage-gated potassium channel 0.0193 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0269 0.0606 0.0712
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0157 0.0248 0.2517
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0193 0.0361 0.0396
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.058 0.1602 0.1753
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0387 0.0984 0.0984
Echinococcus multilocularis voltage gated potassium channel 0.0849 0.2465 0.2698
Trichomonas vaginalis adenylate cyclase, putative 0.0269 0.0606 0.0712
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.2739 0.8519 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0701 0.1989 0.2177
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Echinococcus granulosus hyperpolarization activated cyclic 0.058 0.1602 0.1753
Trichomonas vaginalis adenylate cyclase, putative 0.0269 0.0606 0.0712
Brugia malayi cation channel family protein 0.0193 0.0361 0.0396
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0269 0.0606 0.0712
Trichomonas vaginalis hypothetical protein 0.0269 0.0606 0.0712
Loa Loa (eye worm) ryanodine receptor 0.0193 0.0361 0.0396
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0193 0.0361 0.0396
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0193 0.0361 0.0361
Plasmodium vivax DNA gyrase subunit A, putative 0.0238 0.0506 0.514
Echinococcus granulosus cGMP dependent protein kinase 0.0387 0.0984 0.1077
Echinococcus granulosus TRP transient receptor potential channel 0.0193 0.0361 0.0396
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0238 0.0506 1
Brugia malayi voltage-dependent calcium channel 0.0193 0.0361 0.0396
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0415 0.1074 0.8126
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Schistosoma mansoni voltage-gated potassium channel 0.0193 0.0361 0.0361
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0387 0.0984 0.1077
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0193 0.0361 0.0361
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0387 0.0984 0.7444
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0269 0.0606 0.0712
Brugia malayi olfactory channel protein osm-9 0.0193 0.0361 0.0396
Echinococcus granulosus shaker cognate 0.0193 0.0361 0.0396
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0269 0.0606 0.0712
Brugia malayi Cyclic-nucleotide gated cation channel 0.058 0.1602 0.1753
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0193 0.0361 0.0361
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0193 0.0361 0.2734
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0269 0.0606 0.0712
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.058 0.1602 0.188
Leishmania major hypothetical protein, unknown function 0.0387 0.0984 1
Echinococcus multilocularis transient receptor potential cation channel 0.0193 0.0361 0.0396
Schistosoma mansoni voltage-gated potassium channel 0.0193 0.0361 0.0361
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0193 0.0361 0.0361
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0387 0.0984 1
Echinococcus granulosus sodium channel protein 0.0193 0.0361 0.0396
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0269 0.0606 0.0712
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0493 0.1322 0.1446
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0387 0.0984 0.1077
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0193 0.0361 0.0396
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Trichomonas vaginalis adenylate cyclase type III, putative 0.0269 0.0606 0.0712
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0269 0.0606 0.0712
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.058 0.1602 0.1602
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0387 0.0984 0.0984
Trichomonas vaginalis adenylate cyclase, putative 0.0269 0.0606 0.0712
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0387 0.0984 0.1077
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0157 0.0248 0.0291
Leishmania major cyclic nucleotide-binding protein-like protein 0.0387 0.0984 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0193 0.0361 0.0396
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0269 0.0606 0.0664
Leishmania major protein kinase A regulatory subunit, putative 0.0387 0.0984 1
Trichomonas vaginalis adenylate cyclase, putative 0.0269 0.0606 0.0712
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0387 0.0984 1
Trypanosoma cruzi hypothetical protein, conserved 0.0387 0.0984 0.7444
Loa Loa (eye worm) voltage-gated potassium channel 0.0193 0.0361 0.0396
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0269 0.0606 0.0712
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0193 0.0361 0.0396
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0193 0.0361 0.0396
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Toxoplasma gondii transporter, cation channel family protein 0.0193 0.0361 0.3673
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0193 0.0361 0.0361
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Loa Loa (eye worm) hypothetical protein 0.0387 0.0984 0.1077
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Schistosoma mansoni vesicular amine transporter 0.0193 0.0361 0.0361
Mycobacterium ulcerans hypothetical protein 0.0387 0.0984 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0193 0.0361 0.0396
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0387 0.0984 0.1077
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0269 0.0606 0.0712
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0849 0.2465 0.2698
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0387 0.0984 0.1077
Schistosoma mansoni hypothetical protein 0.0387 0.0984 0.0984
Echinococcus granulosus two pore calcium channel protein 2 0.0193 0.0361 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.0606 0.0712
Schistosoma mansoni voltage-gated potassium channel 0.0193 0.0361 0.0361
Echinococcus granulosus voltage gated potassium channel 0.0193 0.0361 0.0396
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0387 0.0984 0.1077
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0387 0.0984 1
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0238 0.0506 0.4306
Toxoplasma gondii hypothetical protein 0.0193 0.0361 0.3673
Brugia malayi Egg laying defective protein 4 0.0387 0.0984 0.1077
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0493 0.1322 0.1551
Echinococcus multilocularis sodium leak channel non selective protein 0.0193 0.0361 0.0396
Schistosoma mansoni voltage-gated potassium channel 0.0193 0.0361 0.0361
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.0606 0.0712
Schistosoma mansoni 60S ribosomal protein L21 0.0462 0.1224 0.1224
Brugia malayi hypothetical protein 0.0193 0.0361 0.0396
Toxoplasma gondii transporter, cation channel family protein 0.0193 0.0361 0.3673
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0193 0.0361 0.0396
Echinococcus multilocularis hyperpolarization activated cyclic 0.058 0.1602 0.1753
Schistosoma mansoni transient receptor potential channel 0.0193 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0276 0.0627 0.0687
Echinococcus multilocularis calcium activated potassium channel 0.0193 0.0361 0.0396
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0157 0.0248 0.0248
Echinococcus granulosus voltage dependent calcium channel 0.0193 0.0361 0.0396
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0387 0.0984 0.0984
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0276 0.0627 0.0687
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.0606 0.0712
Echinococcus granulosus potassium voltage gated channel protein 0.0193 0.0361 0.0396
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0387 0.0984 0.1077
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Schistosoma mansoni voltage-gated potassium channel 0.0849 0.2465 0.2465
Mycobacterium leprae Conserved hypothetical protein 0.0387 0.0984 1
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0387 0.0984 1
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0193 0.0361 0.0396
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0193 0.0361 0.0396
Mycobacterium leprae Possible transporter protein 0.0269 0.0606 0.5695
Leishmania major protein kinase, putative 0.0387 0.0984 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0493 0.1322 1
Echinococcus multilocularis potassium large conductance calcium activated 0.0193 0.0361 0.0396
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0297 0.0694 0.6901
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0193 0.0361 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.0606 0.0712
Loa Loa (eye worm) hypothetical protein 0.2545 0.7897 0.8642
Echinococcus granulosus voltage dependent calcium channel 0.0193 0.0361 0.0396
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.058 0.1602 0.1753
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0193 0.0361 0.0396
Echinococcus multilocularis potassium voltage gated channel protein 0.0193 0.0361 0.0396
Mycobacterium ulcerans transcriptional regulatory protein 0.0387 0.0984 1
Chlamydia trachomatis DNA gyrase subunit A 0.0238 0.0506 0.4306
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0269 0.0606 0.0712
Echinococcus granulosus transient receptor potential cation channel 0.0193 0.0361 0.0396
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0387 0.0984 1
Schistosoma mansoni voltage-gated potassium channel 0.0193 0.0361 0.0361
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0387 0.0984 0.1155
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0387 0.0984 0.1077
Schistosoma mansoni voltage-gated potassium channel 0.0193 0.0361 0.0361
Loa Loa (eye worm) voltage-dependent calcium channel 0.0193 0.0361 0.0396
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0387 0.0984 0.0984
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Toxoplasma gondii transporter, cation channel family protein 0.0193 0.0361 0.3673
Echinococcus granulosus cyclic nucleotide gated cation channel 0.058 0.1602 0.1753
Leishmania major hypothetical protein, conserved 0.0387 0.0984 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.058 0.1602 0.1753
Plasmodium falciparum DNA gyrase subunit A 0.0238 0.0506 0.514
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0193 0.0361 0.0396
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0387 0.0984 0.0984
Schistosoma mansoni voltage-gated potassium channel 0.0193 0.0361 0.0361
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0193 0.0361 0.0396
Echinococcus multilocularis sodium channel protein 0.0193 0.0361 0.0396
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0276 0.0627 0.0687
Loa Loa (eye worm) hypothetical protein 0.0217 0.0438 0.0479
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0193 0.0361 0.3673
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0387 0.0984 0.1077
Treponema pallidum cyclic nucleotide binding protein 0.0387 0.0984 1
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0269 0.0606 0.0712
Echinococcus multilocularis transient receptor potential cation channel 0.0193 0.0361 0.0396
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0157 0.0248 0.1874
Echinococcus granulosus transient receptor potential cation channel 0.0193 0.0361 0.0396
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0193 0.0361 0.0396
Echinococcus multilocularis transient receptor potential gamma protein 0.0193 0.0361 0.0396
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0474 0.1263 0.9559
Schistosoma mansoni calcium-activated potassium channel 0.0193 0.0361 0.0361
Leishmania major hypothetical protein, conserved 0.0193 0.0361 0.3673
Echinococcus granulosus cyclic nucleotide gated cation channel 0.058 0.1602 0.1753
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0193 0.0361 0.0396
Leishmania major hypothetical protein, conserved 0.0387 0.0984 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.2932 0.9137 1
Trichomonas vaginalis adenylate cyclase, putative 0.0269 0.0606 0.0712
Loa Loa (eye worm) ion channel NompC 0.0193 0.0361 0.0396
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0387 0.0984 0.0984
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0193 0.0361 0.0396
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0269 0.0606 0.0712
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0193 0.0361 0.0361
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0193 0.0361 0.0361
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0193 0.0361 0.0396
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0387 0.0984 1
Schistosoma mansoni serine/threonine protein kinase 0.0387 0.0984 0.0984
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0193 0.0361 0.0396
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0493 0.1322 0.1551
Trichomonas vaginalis conserved hypothetical protein 0.0387 0.0984 0.1155
Echinococcus multilocularis transient receptor potential cation channel 0.0193 0.0361 0.0396
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0193 0.0361 0.3673
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0269 0.0606 0.0712
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0387 0.0984 0.1077
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0269 0.0606 0.0712
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0387 0.0984 1
Trichomonas vaginalis adenylate cyclase, putative 0.0269 0.0606 0.0712
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.2932 0.9137 1
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0193 0.0361 0.0361
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0193 0.0361 0.0396
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0387 0.0984 0.0984
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0157 0.0248 0.0291
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0276 0.0627 0.0687
Trichomonas vaginalis adenylate cyclase, putative 0.0269 0.0606 0.0712
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0193 0.0361 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.0606 0.0712
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0193 0.0361 0.0396
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Schistosoma mansoni voltage-gated potassium channel 0.058 0.1602 0.1602
Schistosoma mansoni voltage-gated potassium channel 0.0193 0.0361 0.0361
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0387 0.0984 1
Trypanosoma brucei protein kinase A regulatory subunit 0.0387 0.0984 1
Trypanosoma brucei Flagellar Member 6 0.0387 0.0984 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0193 0.0361 0.0396
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0387 0.0984 0.1155
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0387 0.0984 0.0984
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0387 0.0984 0.1155
Echinococcus multilocularis shaker cognate 0.0193 0.0361 0.0396
Schistosoma mansoni voltage-gated potassium channel 0.0193 0.0361 0.0361
Treponema pallidum catabolite gene activator (Crp) 0.0387 0.0984 1
Schistosoma mansoni voltage-gated cation channel 0.0193 0.0361 0.0361
Echinococcus multilocularis short transient receptor potential channel 6 0.0193 0.0361 0.0396
Mycobacterium tuberculosis Conserved hypothetical protein 0.0387 0.0984 1
Loa Loa (eye worm) hypothetical protein 0.058 0.1602 0.1753
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.058 0.1602 0.188
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0269 0.0606 0.0712
Schistosoma mansoni transient receptor potential channel 0.0193 0.0361 0.0361
Trichomonas vaginalis adenylate cyclase, putative 0.0269 0.0606 0.0712
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0387 0.0984 0.7444
Echinococcus multilocularis potassium voltage gated channel protein 0.0193 0.0361 0.0396
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0387 0.0984 1
Plasmodium falciparum DNA gyrase subunit B 0.0125 0.0144 0.1464
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0374 0.0942 0.1106
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0193 0.0361 0.0396
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0193 0.0361 0.0396
Echinococcus granulosus transient receptor potential cation channel 0.0193 0.0361 0.0396
Mycobacterium ulcerans hypothetical protein 0.0387 0.0984 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0387 0.0984 0.1077
Loa Loa (eye worm) hypothetical protein 0.0387 0.0984 0.1077
Echinococcus multilocularis ryanodine receptor 44f 0.0193 0.0361 0.0396
Leishmania major regulatory subunit of protein kinase a-like protein 0.0387 0.0984 1
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.0606 0.0712
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0387 0.0984 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.2739 0.8519 1
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0269 0.0606 0.0712
Schistosoma mansoni voltage-gated potassium channel 0.0462 0.1224 0.1224
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0849 0.2465 0.2698
Echinococcus multilocularis conserved hypothetical protein 0.0193 0.0361 0.0396
Echinococcus granulosus transient receptor potential cation channel 0.0193 0.0361 0.0396
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0387 0.0984 0.1155
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0374 0.0942 0.1106
Loa Loa (eye worm) hypothetical protein 0.0849 0.2465 0.2698
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.058 0.1602 0.1602
Echinococcus granulosus ryanodine receptor 44f 0.0193 0.0361 0.0396
Plasmodium falciparum cGMP-dependent protein kinase 0.0387 0.0984 1
Echinococcus granulosus hyperpolarization activated cyclic 0.058 0.1602 0.1753
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0269 0.0606 0.0712
Echinococcus granulosus short transient receptor potential channel 6 0.0193 0.0361 0.0396
Loa Loa (eye worm) phosphatidylinositol 3 0.0624 0.1742 0.1906
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0269 0.0606 0.6162
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0387 0.0984 0.1077
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0238 0.0506 0.4306
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Echinococcus granulosus potassium voltage gated channel subfamily H 0.2932 0.9137 1
Echinococcus granulosus single minded 2 0.0269 0.0606 0.0664
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0193 0.0361 0.0396
Brugia malayi cation channel family protein 0.0193 0.0361 0.0396
Echinococcus granulosus hypothetical protein 0.0193 0.0361 0.0396
Mycobacterium tuberculosis Conserved protein 0.0387 0.0984 1
Trichomonas vaginalis adenylate cyclase, putative 0.0269 0.0606 0.0712
Echinococcus multilocularis two pore calcium channel protein 2 0.0193 0.0361 0.0396
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0269 0.0606 0.0712
Trypanosoma cruzi Flagellar Member 6 0.0387 0.0984 0.7444
Echinococcus multilocularis transient receptor potential cation channel 0.0193 0.0361 0.0396
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0387 0.0984 1
Schistosoma mansoni voltage-dependent calcium channel 0.0193 0.0361 0.0361
Echinococcus multilocularis transfer RNA-Gly 0.0193 0.0361 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.0606 0.0712
Schistosoma mansoni hypothetical protein 0.0269 0.0606 0.0606
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0193 0.0361 0.0396
Echinococcus granulosus potassium large conductance calcium activated 0.0193 0.0361 0.0396
Trichomonas vaginalis guanylate cyclase, putative 0.0269 0.0606 0.0712
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.058 0.1602 0.1753
Trypanosoma cruzi cAMP binding protein, putative 0.0387 0.0984 0.7444
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0387 0.0984 0.0984
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0157 0.0248 0.0271
Onchocerca volvulus 0.0387 0.0984 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.058 0.1602 0.1753
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0193 0.0361 0.3673
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0387 0.0984 0.1077
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Onchocerca volvulus 0.0387 0.0984 1
Echinococcus granulosus transient receptor potential cation channel 0.0193 0.0361 0.0396
Leishmania major hypothetical protein, conserved 0.0387 0.0984 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0157 0.0248 0.0291
Plasmodium vivax DNA gyrase subunit B, putative 0.0125 0.0144 0.1464
Loa Loa (eye worm) hypothetical protein 0.0193 0.0361 0.0396
Trichomonas vaginalis adenylate cyclase, putative 0.0269 0.0606 0.0712
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0387 0.0984 1
Mycobacterium ulcerans DNA gyrase subunit A 0.0238 0.0506 0.4306
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0139 0.0189 0.1432
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0269 0.0606 0.0712
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.058 0.1602 0.1602
Echinococcus multilocularis expressed conserved protein 0.0387 0.0984 0.1077
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0269 0.0606 0.0712
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0199 0.038 0.2873
Echinococcus granulosus potassium voltage gated channel protein 0.0193 0.0361 0.0396
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0269 0.0606 0.0712
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.058 0.1602 0.1753
Echinococcus multilocularis two pore calcium channel protein 1 0.0193 0.0361 0.0396
Echinococcus multilocularis potassium voltage gated channel protein 0.0193 0.0361 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.0606 0.0712

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) > 4.5 Inhibition of PI3Kbeta human in PTEN wild type HCC1954 cells assessed as reduction of AKT phosphorylation at Ser 473 ChEMBL. 24900655
EC50 (binding) > 4.5 Inhibition of PI3Kbeta human in PTEN wild type HCC1954 cells assessed as cell growth inhibition ChEMBL. 24900655
EC50 (binding) = 4.6 Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as cell growth inhibition ChEMBL. 24900655
EC50 (binding) = 4.9 Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serum ChEMBL. 24900655
EC50 (binding) = 6.8 Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in absence of serum ChEMBL. 24900655
IC50 (binding) = 6.3 Inhibition of PI3Kgamma (unknown origin) ChEMBL. 24900655
IC50 (binding) = 6.8 Inhibition of PI3Kalpha (unknown origin) ChEMBL. 24900655
IC50 (binding) = 7.6 Inhibition of PI3Kdelta (unknown origin) ChEMBL. 24900655
IC50 (binding) = 8.9 Inhibition of PI3Kbeta (unknown origin) ChEMBL. 24900655

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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