Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0291 | 0.5 |
Echinococcus multilocularis | geminin | 0.0169 | 0.136 | 0.1101 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.136 | 0.2333 |
Mycobacterium ulcerans | thymidylate synthase | 0.0272 | 0.2557 | 0.3432 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0151 | 0.115 | 0.205 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0472 | 0.4873 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0272 | 0.2557 | 0.2334 |
Echinococcus granulosus | geminin | 0.0169 | 0.136 | 0.2333 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0272 | 0.2557 | 0.4163 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0318 | 0.309 | 0.5627 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0318 | 0.309 | 0.4499 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0129 | 0.0905 | 0.1599 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0318 | 0.309 | 0.4499 |
Loa Loa (eye worm) | thymidylate synthase | 0.0272 | 0.2557 | 0.519 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0472 | 0.4873 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0523 | 0.5463 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.0782 | 0.1506 |
Brugia malayi | thymidylate synthase | 0.0272 | 0.2557 | 0.519 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0272 | 0.2557 | 0.4945 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.0782 | 0.1506 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0129 | 0.0905 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0472 | 0.4873 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.136 | 0.2333 |
Echinococcus granulosus | dihydrofolate reductase | 0.0472 | 0.4873 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0472 | 0.4873 | 0.472 |
Onchocerca volvulus | 0.0272 | 0.2557 | 0.5 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.0472 | 0.4873 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0523 | 0.5463 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0272 | 0.2557 | 0.4945 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0291 | 0.0485 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0472 | 0.4873 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0168 | 0.1347 | 0.1113 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0291 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0523 | 0.5463 | 1 |
Brugia malayi | hypothetical protein | 0.0129 | 0.0905 | 0.176 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0318 | 0.309 | 0.5627 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0291 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0523 | 0.5463 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.0782 | 0.1506 |
Brugia malayi | dihydrofolate reductase family protein | 0.0472 | 0.4873 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0472 | 0.4873 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0523 | 0.5463 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0472 | 0.4873 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0523 | 0.5463 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0291 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 163000 nM | Viral Plaque Reduction Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.