TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 542.722 | Formula: C18H19ClF3IN4O2
H donors: 0 H acceptors: 2 LogP: 4.02 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1nc(c(c1C)I)C(F)(F)F
InChi: 1S/C18H19ClF3IN4O2/c1-11-16(23)17(18(20,21)22)24-27(11)10-15(28)26-7-5-25(6-8-26)12-3-4-13(19)14(9-12)29-2/h3-4,9H,5-8,10H2,1-2H3
InChiKey: WXVCARJCVBSLBW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chemokine (C-C motif) receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	hypothetical protein	chemokine (C-C motif) receptor 1	355 aa	289 aa	21.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	CMGC family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Giardia lamblia	Kinase, CMGC CDK	0.0611	0.5757	0.8686
Trichomonas vaginalis	CMGC family protein kinase	0.0293	0.2639	0.3982
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.024	0.2115	0.3192
Trichomonas vaginalis	CMGC family protein kinase	0.024	0.2115	0.3192
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trypanosoma brucei	protein kinase, putative	0.0317	0.2877	0.2877
Loa Loa (eye worm)	haspin protein kinase	0.0024	0.0003	0.0003
Echinococcus granulosus	dual specificity	0.024	0.2115	0.2115
Echinococcus granulosus	cyclin dependent kinase 9	0.0161	0.1341	0.1341
Schistosoma mansoni	hypothetical protein	0.0024	0.0003	0.0003
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0032	0.0078	0.0078
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.07	0.6627	0.6627
Trichomonas vaginalis	CMGC family protein kinase	0.07	0.6627	1
Entamoeba histolytica	cell division protein kinase 2, putative	0.0611	0.5757	0.5757
Plasmodium vivax	serine/threonine kinase-1, putative	0.07	0.6627	1
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0611	0.5757	0.5757
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0033	0.0086	0.0086
Echinococcus granulosus	cyclin dependent kinase 5	0.0611	0.5757	0.5757
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CMGC family protein kinase	0.0293	0.2639	0.3982
Leishmania major	protein kinase, putative	0.07	0.6627	0.6627
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0046	0.0221	0.0221
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.0046	0.0221	0.0221
Giardia lamblia	Kinase, CMGC MAPK	0.0293	0.2639	0.3982
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Echinococcus granulosus	serine:threonine protein kinase NLK	0.0046	0.0221	0.0221
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.0161	0.1341	0.1341
Trichomonas vaginalis	CMGC family protein kinase	0.024	0.2115	0.3192
Trypanosoma cruzi	cdc2-related kinase 3	0.0611	0.5757	0.5757
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.07	0.6627	0.6627
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Plasmodium vivax	cyclin dependent kinase 7 (cdk7), putative	0.0046	0.0221	0.0333
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0046	0.0221	0.0221
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0046	0.0221	0.0221
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0611	0.5757	0.5757
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trypanosoma cruzi	cdc2-related kinase 1	0.0611	0.5757	0.5757
Loa Loa (eye worm)	haspin protein kinase	0.0024	0.0003	0.0003
Plasmodium falciparum	protein kinase 5	0.0611	0.5757	0.8686
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0086	0.013
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.07	0.6627	1
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.024	0.2115	0.2115
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0024	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0293	0.2639	0.2639
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	G protein-coupled receptor kinase, putative	0.0046	0.0221	0.0333
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Schistosoma mansoni	serine/threonine protein kinase	0.07	0.6627	0.6627
Plasmodium falciparum	MO15-related protein kinase	0.0046	0.0221	0.0333
Brugia malayi	Protein kinase domain containing protein	0.0611	0.5757	0.5757
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.07	0.6627	0.6627
Brugia malayi	cyclin-dependent kinase 9	0.0161	0.1341	0.1341
Trichomonas vaginalis	CMGC family protein kinase	0.0046	0.0221	0.0333
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0293	0.2639	0.3982
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Entamoeba histolytica	cell division protein kinase 2, putative	0.0635	0.5995	0.5995
Schistosoma mansoni	rotamase	0.0033	0.0086	0.0086
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0677	0.641	0.641
Echinococcus granulosus	cyclin dependent kinase	0.0611	0.5757	0.5757
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Plasmodium vivax	serine/threonine protein kinase KIN, putative	0.0046	0.0221	0.0333
Trichomonas vaginalis	CMGC family protein kinase	0.024	0.2115	0.3192
Trichomonas vaginalis	CMGC family protein kinase	0.024	0.2115	0.3192
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0024	0.0003	0.0003
Echinococcus multilocularis	dual specificity protein kinase clk2	0.07	0.6627	0.6627
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Echinococcus granulosus	cyclin dependent kinase 1	0.0611	0.5757	0.5757
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0046	0.0221	0.0221
Trypanosoma cruzi	cdc2-related kinase 1	0.0611	0.5757	0.5757
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Echinococcus multilocularis	cyclin dependent kinase 9	0.0161	0.1341	0.1341
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0611	0.5757	0.8686
Echinococcus granulosus	dual specificity protein kinase clk2	0.07	0.6627	0.6627
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0221	0.0333
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.0046	0.0221	0.0221
Echinococcus multilocularis	expressed protein	0.0033	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.1021	0.9782	0.9782
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Loa Loa (eye worm)	haspin protein kinase	0.0046	0.0221	0.0221
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Entamoeba histolytica	protein kinase domain containing protein	0.0161	0.1341	0.1341
Trypanosoma brucei	cdc2-related kinase 1	0.0611	0.5757	0.5757
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Plasmodium vivax	protein kinase Crk2	0.0611	0.5757	0.8686
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0046	0.0221	0.0221
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Giardia lamblia	Kinase, CMGC CDK	0.0611	0.5757	0.8686
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Echinococcus multilocularis	dual specificity	0.024	0.2115	0.2115
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0024	0.0003	0.0003
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0293	0.2639	0.2639
Entamoeba histolytica	protein kinase, putative	0.024	0.2115	0.2115
Echinococcus multilocularis	mitogen activated protein kinase	0.0293	0.2639	0.2639
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0293	0.2639	0.2639
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0032	0.0078	0.0078
Echinococcus granulosus	mitogen activated protein kinase	0.0293	0.2639	0.2639
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.0046	0.0221	0.0221
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0046	0.0221	0.0221
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0221	0.0333
Echinococcus granulosus	mitogen activated protein kinase 15	0.0046	0.0221	0.0221
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Schistosoma mansoni	serine/threonine protein kinase	0.0161	0.1341	0.1341
Toxoplasma gondii	peptidylprolyl isomerase	0.0032	0.0078	0.0118
Schistosoma mansoni	hypothetical protein	0.0024	0.0003	0.0003
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Echinococcus multilocularis	cyclin dependent kinase 5	0.0611	0.5757	0.5757
Giardia lamblia	Kinase, CAMK CAMKL	0.0046	0.0221	0.0333
Trypanosoma cruzi	cdc2-related kinase 3	0.0611	0.5757	0.5757
Entamoeba histolytica	hypothetical protein	0.0024	0.0003	0.0003
Echinococcus multilocularis		0.0677	0.641	0.641
Trichomonas vaginalis	CMGC family protein kinase	0.0611	0.5757	0.8686
Schistosoma mansoni	protein kinase	0.0046	0.0221	0.0221
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0293	0.2639	0.2639
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.07	0.6627	0.6627
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0293	0.2639	0.2639
Echinococcus multilocularis	hypothetical protein	0.0024	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0611	0.5757	0.5757
Echinococcus granulosus	mitogen activated protein kinase 3	0.0293	0.2639	0.2639
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0033	0.0086	0.0086
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.07	0.6627	0.6627
Leishmania major	mitogen-activated protein kinase, putative,map kinase-like protein	0.0046	0.0221	0.0221
Schistosoma mansoni	kinase	0.0161	0.1341	0.1341
Echinococcus granulosus	hypothetical protein	0.0677	0.641	0.641
Echinococcus granulosus	dual specificity	0.024	0.2115	0.2115
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Giardia lamblia	Kinase, CAMK CAMKL	0.0046	0.0221	0.0333
Trypanosoma brucei	cdc2-related kinase 3	0.0611	0.5757	0.5757
Trichomonas vaginalis	rotamase, putative	0.0032	0.0078	0.0118
Trichomonas vaginalis	CMGC family protein kinase	0.024	0.2115	0.3192
Trichomonas vaginalis	serine/threonine kinase, putative	0.0046	0.0221	0.0333
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.1021	0.9782	0.9782
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0024	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0589	0.5539	0.5539
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.07	0.6627	0.6627
Brugia malayi	Protein kinase domain containing protein	0.07	0.6627	0.6627
Brugia malayi	cell division control protein 2 homolog	0.0611	0.5757	0.5757
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0293	0.2639	0.2639
Schistosoma mansoni	serine/threonine protein kinase	0.024	0.2115	0.2115
Schistosoma mansoni	serine/threonine protein kinase	0.07	0.6627	0.6627
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0221	0.0221
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0078	0.0078
Leishmania major	serine/threonine kinase-like protein, putative	0.0046	0.0221	0.0221
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Echinococcus multilocularis	dual specificity	0.024	0.2115	0.2115
Plasmodium falciparum	protein serine/threonine kinase-1	0.07	0.6627	1
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0032	0.0078	0.0078
Echinococcus multilocularis	cyclin dependent kinase 1	0.0611	0.5757	0.5757
Trichomonas vaginalis	CMGC family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CMGC family protein kinase	0.0293	0.2639	0.3982
Entamoeba histolytica	protein kinase domain containing protein	0.024	0.2115	0.2115
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CMGC family protein kinase	0.0293	0.2639	0.3982
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0221	0.0221
Brugia malayi	MAP kinase sur-1	0.0293	0.2639	0.2639
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.024	0.2115	0.2115
Brugia malayi	hypothetical protein	0.0024	0.0003	0.0003
Trichomonas vaginalis	CMGC family protein kinase	0.0046	0.0221	0.0333
Trypanosoma brucei	Mitogen-activated protein kinase 10, putative	0.0046	0.0221	0.0221
Echinococcus granulosus	Pfam-B_8186 domain containing protein	0.0024	0.0003	0.0003
Echinococcus multilocularis	cyclin dependent kinase 9	0.0185	0.158	0.158
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0221	0.0333
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0611	0.5757	0.5757
Entamoeba histolytica	protein kinase domain containing protein	0.0046	0.0221	0.0221
Trichomonas vaginalis	rotamase, putative	0.0033	0.0086	0.013
Trichomonas vaginalis	CMGC family protein kinase	0.0611	0.5757	0.8686
Echinococcus granulosus	cyclin dependent kinase 9	0.0185	0.158	0.158
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.024	0.2115	0.2115
Schistosoma mansoni	serine/threonine kinase	0.0046	0.0221	0.0221
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0611	0.5757	0.5757
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0024	0.0003	0.0003
Echinococcus multilocularis	dual specificity	0.024	0.2115	0.2115
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0293	0.2639	0.2639
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CMGC family protein kinase	0.0611	0.5757	0.8686
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0221	0.0333
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.024	0.2115	0.2115
Brugia malayi	GSG2	0.0024	0.0003	0.0003
Giardia lamblia	Kinase, CMGC CLK	0.07	0.6627	1
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0611	0.5757	0.5757
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.07	0.6627	0.6627
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0611	0.5757	0.5757
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0293	0.2639	0.2639
Echinococcus granulosus	dual specificity	0.024	0.2115	0.2115
Echinococcus multilocularis	cyclin dependent kinase	0.0611	0.5757	0.5757
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0293	0.2639	0.2639
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.024	0.2115	0.2115
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0293	0.2639	0.2639
Giardia lamblia	Kinase, CMGC DYRK	0.024	0.2115	0.3192
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	protein kinase atmrk1, putative	0.0046	0.0221	0.0333
Giardia lamblia	Kinase, CAMK CAMKL	0.0046	0.0221	0.0333
Echinococcus multilocularis	cyclin dependent kinase 1	0.0611	0.5757	0.5757
Echinococcus granulosus	expressed protein	0.0033	0.0086	0.0086
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0221	0.0333
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0221	0.0333
Brugia malayi	Cell division protein kinase 2	0.0046	0.0221	0.0221
Schistosoma mansoni	serine/threonine protein kinase	0.0611	0.5757	0.5757
Trichomonas vaginalis	CMGC family protein kinase	0.024	0.2115	0.3192
Leishmania major	protein kinase, putative	0.07	0.6627	0.6627

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 7 nM	Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells	ChEMBL.	23374868

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2322860

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1727199