TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 352.235 | Formula: C16H11Cl2NO2S
H donors: 2 H acceptors: 2 LogP: 5.6 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc2c(c1)[nH]c(c2Sc1ccc(c(c1)Cl)Cl)C(=O)O
InChi: 1S/C16H11Cl2NO2S/c1-8-2-4-10-13(6-8)19-14(16(20)21)15(10)22-9-3-5-11(17)12(18)7-9/h2-7,19H,1H3,(H,20,21)
InChiKey: UGIXPZNFYAQTAH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0499	0.1062	1
Schistosoma mansoni	serine/threonine protein kinase	0.0499	0.1062	0.1048
Brugia malayi	cation channel family protein	0.0249	0.0445	0.047
Mycobacterium ulcerans	hypothetical protein	0.0499	0.1062	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0347	0.0688	0.0789
Echinococcus multilocularis	transfer RNA-Gly	0.0249	0.0445	0.047
Echinococcus multilocularis	potassium voltage gated channel protein	0.0249	0.0445	0.047
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0499	0.1062	0.1048
Echinococcus granulosus	potassium voltage gated channel protein	0.0249	0.0445	0.047
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0748	0.1675	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Trichomonas vaginalis	adenylate cyclase, putative	0.0347	0.0688	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0499	0.1062	1
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0249	0.0445	0.047
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0499	0.1062	1
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0499	0.1062	0.1048
Trichomonas vaginalis	adenylate cyclase type, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.3533	0.8532	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0748	0.1675	0.1661
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0499	0.1062	0.1146
Echinococcus granulosus	voltage gated potassium channel	0.1096	0.253	0.2754
Trichomonas vaginalis	adenylate cyclase, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	adenylyl cyclase type V, putative	0.0347	0.0688	0.0789
Echinococcus granulosus	transient receptor potential cation channel	0.0249	0.0445	0.047
Trichomonas vaginalis	intestinal guanylate cyclase, putative	0.0347	0.0688	0.0789
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0249	0.0445	0.047
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.0445	0.043
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0249	0.0445	0.043
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0748	0.1675	0.1817
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Schistosoma mansoni	transient receptor potential channel	0.0249	0.0445	0.043
Echinococcus multilocularis	two pore calcium channel protein 1	0.0249	0.0445	0.047
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0249	0.0445	0.4102
Trichomonas vaginalis	conserved hypothetical protein	0.0347	0.0688	0.0789
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0249	0.0445	0.047
Schistosoma mansoni	ryanodine receptor related	0.0249	0.0445	0.043
Trichomonas vaginalis	guanylate cyclase beta 2 subunit, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	conserved hypothetical protein	0.0347	0.0688	0.0789
Mycobacterium leprae	Conserved hypothetical protein	0.0499	0.1062	1
Loa Loa (eye worm)	calcium channel	0.0249	0.0445	0.047
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0499	0.1062	0.1146
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0249	0.0445	0.047
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.0445	0.043
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0748	0.1675	0.1661
Trichomonas vaginalis	adenylate cyclase, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.0445	0.043
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0499	0.1062	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0249	0.0445	0.047
Echinococcus granulosus	potassium voltage gated channel protein	0.0249	0.0445	0.047
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0249	0.0445	0.047
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0499	0.1062	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0748	0.1675	0.1817
Treponema pallidum	DNA gyrase, subunit A (gyrA)	0.0256	0.0463	0.3331
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.0445	0.043
Brugia malayi	N-terminal motif family protein	0.0499	0.1062	0.1146
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0499	0.1062	0.1146
Plasmodium vivax	DNA gyrase subunit A, putative	0.0256	0.0463	0.4274
Brugia malayi	olfactory channel protein osm-9	0.0249	0.0445	0.047
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0499	0.1062	1
Plasmodium vivax	DNA gyrase subunit B, putative	0.0135	0.0164	0.1414
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0249	0.0445	0.043
Loa Loa (eye worm)	voltage-gated potassium channel	0.0249	0.0445	0.047
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0249	0.0445	0.043
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	voltage-gated potassium channel	0.0596	0.13	0.1287
Trichomonas vaginalis	adenylate cyclase type III, putative	0.0347	0.0688	0.0789
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	0.0256	0.0463	1
Toxoplasma gondii	hypothetical protein	0.0249	0.0445	0.4102
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0499	0.1062	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0499	0.1062	1
Brugia malayi	hypothetical protein	0.0249	0.0445	0.047
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0249	0.0445	0.047
Schistosoma mansoni	serine/threonine protein kinase	0.0499	0.1062	0.1048
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	voltage-gated cation channel	0.0249	0.0445	0.043
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0256	0.0463	0.3331
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0249	0.0445	0.047
Toxoplasma gondii	hypothetical protein	0.0249	0.0445	0.4102
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0499	0.1062	1
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.0445	0.043
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0249	0.0445	0.043
Leishmania major	hypothetical protein, unknown function	0.0249	0.0445	0.4102
Schistosoma mansoni	transient receptor potential channel	0.0249	0.0445	0.043
Mycobacterium ulcerans	hypothetical protein	0.0499	0.1062	1
Echinococcus granulosus	cGMP dependent protein kinase	0.0499	0.1062	0.1146
Schistosoma mansoni	vesicular amine transporter	0.0249	0.0445	0.043
Echinococcus multilocularis	voltage gated potassium channel	0.0249	0.0445	0.047
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0499	0.1062	0.1146
Loa Loa (eye worm)	ryanodine receptor	0.0249	0.0445	0.047
Mycobacterium ulcerans	regulatory protein	0.0499	0.1062	1
Echinococcus granulosus	voltage dependent calcium channel	0.0249	0.0445	0.047
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0748	0.1675	0.1817
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0249	0.0445	0.047
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0249	0.0445	0.047
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0499	0.1062	1
Loa Loa (eye worm)	hypothetical protein	0.0748	0.1675	0.1817
Echinococcus multilocularis	potassium large conductance calcium activated	0.0249	0.0445	0.047
Leishmania major	protein kinase, putative	0.0499	0.1062	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	voltage-gated potassium channel	0.1096	0.253	0.2518
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0499	0.1062	1
Echinococcus granulosus	sodium channel protein	0.0249	0.0445	0.047
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Echinococcus granulosus	transient receptor potential cation channel	0.0249	0.0445	0.047
Echinococcus multilocularis	two pore calcium channel protein 2	0.0249	0.0445	0.047
Trichomonas vaginalis	adenylate cyclase, putative	0.0347	0.0688	0.0789
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0249	0.0445	0.4102
Mycobacterium ulcerans	DNA gyrase subunit A	0.0256	0.0463	0.3331
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	hypothetical protein	0.0249	0.0445	0.043
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0249	0.0445	0.047
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0748	0.1675	0.1817
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0249	0.0445	0.047
Schistosoma mansoni	voltage-dependent calcium channel	0.0249	0.0445	0.043
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.0256	0.0463	0.4274
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0249	0.0445	0.047
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0748	0.1675	0.1948
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0249	0.0445	0.047
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.0445	0.043
Mycobacterium ulcerans	transmembrane transport protein	0.0499	0.1062	1
Echinococcus multilocularis	voltage dependent calcium channel	0.0249	0.0445	0.047
Trichomonas vaginalis	conserved hypothetical protein	0.0347	0.0688	0.0789
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0499	0.1062	0.1048
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0499	0.1062	0.1048
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0249	0.0445	0.047
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0249	0.0445	0.4102
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0499	0.1062	0.1048
Trichomonas vaginalis	adenylate cyclase, putative	0.0347	0.0688	0.0789
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.3781	0.9145	1
Schistosoma mansoni	hypothetical protein	0.0499	0.1062	0.1048
Trichomonas vaginalis	conserved hypothetical protein	0.0347	0.0688	0.0789
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0499	0.1062	0.1146
Echinococcus granulosus	two pore calcium channel protein 1	0.0249	0.0445	0.047
Echinococcus granulosus	TRP transient receptor potential channel	0.0249	0.0445	0.047
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0249	0.0445	0.047
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0499	0.1062	1
Trichomonas vaginalis	adenylate cyclase type vIII, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0499	0.1062	0.1048
Leishmania major	hypothetical protein, conserved	0.0249	0.0445	0.4102
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0499	0.1062	0.1146
Leishmania major	protein kinase A regulatory subunit, putative	0.0499	0.1062	1
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0249	0.0445	0.4102
Trypanosoma cruzi	cAMP response protein 1	0.0499	0.1062	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0499	0.1062	0.1146
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0249	0.0445	0.043
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0249	0.0445	0.043
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0499	0.1062	1
Leishmania major	hypothetical protein, conserved	0.0499	0.1062	1
Echinococcus granulosus	transient receptor potential cation channel	0.0249	0.0445	0.047
Leishmania major	hypothetical protein, conserved	0.0499	0.1062	1
Echinococcus granulosus	single minded 2	0.0347	0.0688	0.0736
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0499	0.1062	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0249	0.0445	0.047
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0249	0.0445	0.043
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Trypanosoma cruzi	cAMP binding protein, putative	0.0499	0.1062	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0347	0.0688	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0249	0.0445	0.4102
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0499	0.1062	0.1146
Loa Loa (eye worm)	hypothetical protein	0.1096	0.253	0.2754
Schistosoma mansoni	voltage-gated ion channel	0.0249	0.0445	0.043
Schistosoma mansoni	two-pore calcium channel	0.0249	0.0445	0.043
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0249	0.0445	0.047
Echinococcus granulosus	two pore calcium channel protein 2	0.0249	0.0445	0.047
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.1096	0.253	0.2754
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0499	0.1062	0.1146
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0499	0.1062	0.1146
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0499	0.1062	0.1048
Trichomonas vaginalis	conserved hypothetical protein	0.0347	0.0688	0.0789
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0249	0.0445	0.047
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0249	0.0445	0.047
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0499	0.1062	1
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0499	0.1062	1
Chlamydia trachomatis	DNA gyrase subunit A	0.0256	0.0463	0.3331
Brugia malayi	voltage-dependent calcium channel	0.0249	0.0445	0.047
Echinococcus multilocularis	short transient receptor potential channel 6	0.0249	0.0445	0.047
Treponema pallidum	cyclic nucleotide binding protein	0.0499	0.1062	1
Echinococcus granulosus	potassium voltage gated channel protein	0.0249	0.0445	0.047
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0249	0.0445	0.047
Plasmodium falciparum	cGMP-dependent protein kinase	0.0499	0.1062	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0347	0.0688	0.0789
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.3781	0.9145	1
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0499	0.1062	0.1146
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Echinococcus granulosus	hypothetical protein	0.0249	0.0445	0.047
Trichomonas vaginalis	conserved hypothetical protein	0.0347	0.0688	0.0789
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0347	0.0688	0.0789
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0249	0.0445	0.047
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	hypothetical protein	0.0347	0.0688	0.0789
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Echinococcus multilocularis	calcium activated potassium channel	0.0249	0.0445	0.047
Mycobacterium ulcerans	hypothetical protein	0.0499	0.1062	1
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0499	0.1062	0.1048
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0499	0.1062	0.1146
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0249	0.0445	0.4102
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0499	0.1062	1
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0499	0.1062	0.1146
Trypanosoma brucei	protein kinase A regulatory subunit	0.0499	0.1062	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0249	0.0445	0.043
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0249	0.0445	0.047
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0748	0.1675	0.1948
Schistosoma mansoni	hypothetical protein	0.0347	0.0688	0.0673
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0499	0.1062	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0249	0.0445	0.047
Entamoeba histolytica	DNA topoisomerase II, putative	0.0075	0.0016	0.5
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0748	0.1675	0.1817
Leishmania major	protein kinase, putative	0.0499	0.1062	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0748	0.1675	0.1817
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0249	0.0445	0.043
Loa Loa (eye worm)	hypothetical protein	0.0499	0.1062	0.1146
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.0445	0.043
Trichomonas vaginalis	conserved hypothetical protein	0.0347	0.0688	0.0789
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0347	0.0688	0.0789
Echinococcus multilocularis	potassium voltage gated channel protein	0.0249	0.0445	0.047
Echinococcus granulosus	shaker cognate	0.0249	0.0445	0.047
Treponema pallidum	catabolite gene activator (Crp)	0.0499	0.1062	1
Mycobacterium tuberculosis	Conserved protein	0.0499	0.1062	1
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0499	0.1062	0.1146
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0249	0.0445	0.047
Trichomonas vaginalis	adenylate cyclase, putative	0.0347	0.0688	0.0789
Echinococcus granulosus	calcium activated potassium channel	0.0249	0.0445	0.047
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.0445	0.043
Schistosoma mansoni	voltage-gated potassium channel	0.1096	0.253	0.2518
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.0445	0.043
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0499	0.1062	0.1146
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0347	0.0688	0.0789
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0347	0.0688	0.0736
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.3533	0.8532	1
Trichomonas vaginalis	conserved hypothetical protein	0.0499	0.1062	0.1228
Trypanosoma brucei	cAMP response protein 1, putative	0.0499	0.1062	1
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0347	0.0688	0.0789
Echinococcus granulosus	sodium leak channel non selective protein	0.0249	0.0445	0.047
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0748	0.1675	0.1661
Plasmodium falciparum	DNA gyrase subunit A	0.0256	0.0463	0.4274
Echinococcus granulosus	hyperpolarization activated cyclic	0.0748	0.1675	0.1817
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.1096	0.253	0.2754
Trichomonas vaginalis	adenylate cyclase type III, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0499	0.1062	0.1228
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0249	0.0445	0.047
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0249	0.0445	0.047
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0249	0.0445	0.047
Echinococcus multilocularis	transient receptor potential cation channel	0.0249	0.0445	0.047
Trypanosoma brucei	Flagellar Member 6	0.0499	0.1062	1
Trichomonas vaginalis	adenylate cyclase type, putative	0.0347	0.0688	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.3781	0.9145	1
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0249	0.0445	0.4102
Toxoplasma gondii	transporter, cation channel family protein	0.0249	0.0445	0.4102
Schistosoma mansoni	voltage-gated potassium channel	0.0748	0.1675	0.1661
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0499	0.1062	1
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0499	0.1062	1
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.0445	0.043
Trichomonas vaginalis	adenylate cyclase, putative	0.0347	0.0688	0.0789
Echinococcus multilocularis	shaker cognate	0.0249	0.0445	0.047
Echinococcus multilocularis	transient receptor potential gamma protein	0.0249	0.0445	0.047
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0499	0.1062	1
Echinococcus multilocularis	sodium leak channel non selective protein	0.0249	0.0445	0.047
Trichomonas vaginalis	adenylate cyclase, putative	0.0347	0.0688	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.0445	0.043
Trypanosoma cruzi	Flagellar Member 6	0.0499	0.1062	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0748	0.1675	0.1817
Leishmania major	hypothetical protein, conserved	0.0499	0.1062	1
Leishmania major	hypothetical protein, unknown function	0.0499	0.1062	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0748	0.1675	0.1661
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0249	0.0445	0.047
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0249	0.0445	0.047
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0249	0.0445	0.047
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0499	0.1062	1
Echinococcus granulosus	transient receptor potential cation channel	0.0249	0.0445	0.047
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0499	0.1062	0.1228
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0249	0.0445	0.047
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0499	0.1062	0.1048
Echinococcus granulosus	transient receptor potential cation channel	0.0249	0.0445	0.047
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0499	0.1062	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0347	0.0688	0.0789
Echinococcus multilocularis	sodium channel protein	0.0249	0.0445	0.047
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0499	0.1062	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0748	0.1675	0.1817
Trichomonas vaginalis	adenylate cyclase type VI, putative	0.0347	0.0688	0.0789
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0347	0.0688	0.6422
Loa Loa (eye worm)	voltage-gated potassium channel	0.0249	0.0445	0.047
Toxoplasma gondii	transporter, cation channel family protein	0.0249	0.0445	0.4102
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Echinococcus granulosus	transient receptor potential gamma protein	0.0249	0.0445	0.047
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0748	0.1675	0.1817
Echinococcus multilocularis	ryanodine receptor 44f	0.0249	0.0445	0.047
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Echinococcus granulosus	potassium large conductance calcium activated	0.0249	0.0445	0.047
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0499	0.1062	0.1146
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0499	0.1062	0.1228
Echinococcus multilocularis	voltage gated potassium channel	0.1096	0.253	0.2754
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.0445	0.043
Echinococcus multilocularis	potassium voltage gated channel protein	0.0249	0.0445	0.047
Mycobacterium ulcerans	transcriptional regulatory protein	0.0499	0.1062	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0347	0.0688	0.0789
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0249	0.0445	0.047
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0249	0.0445	0.043
Onchocerca volvulus		0.0499	0.1062	1
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	calcium-activated potassium channel	0.0249	0.0445	0.043
Echinococcus multilocularis	transient receptor potential cation channel	0.0249	0.0445	0.047
Echinococcus multilocularis	expressed conserved protein	0.0499	0.1062	0.1146
Trypanosoma brucei	cAMP binding protein, putative	0.0499	0.1062	1
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0249	0.0445	0.043
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0748	0.1675	0.1817
Loa Loa (eye worm)	ion channel NompC	0.0249	0.0445	0.047
Schistosoma mansoni	transient receptor potential channel	0.0249	0.0445	0.043
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0249	0.0445	0.047
Trichomonas vaginalis	adenylate cyclase, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	conserved hypothetical protein	0.0347	0.0688	0.0789
Echinococcus granulosus	transient receptor potential cation channel	0.0249	0.0445	0.047
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0499	0.1062	0.1146
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0249	0.0445	0.4102
Echinococcus multilocularis	transient receptor potential cation channel	0.0249	0.0445	0.047
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0249	0.0445	0.047
Echinococcus granulosus	short transient receptor potential channel 6	0.0249	0.0445	0.047
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0499	0.1062	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0499	0.1062	0.1146
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.1096	0.253	0.2754
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	adenylate cyclase, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	transient receptor potential channel 4	0.0249	0.0445	0.043
Trichomonas vaginalis	guanylate cyclase beta 1 subunit, putative	0.0347	0.0688	0.0789
Loa Loa (eye worm)	voltage-gated calcium channel	0.0249	0.0445	0.047
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0499	0.1062	0.1146
Trichomonas vaginalis	adenylate cyclase type, putative	0.0347	0.0688	0.0789
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0499	0.1062	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Brugia malayi	Transient-receptor-potential like protein	0.0249	0.0445	0.047
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0748	0.1675	0.1817
Loa Loa (eye worm)	hypothetical protein	0.3282	0.7915	0.8653
Echinococcus granulosus	short transient receptor potential channel 6	0.0249	0.0445	0.047
Brugia malayi	Egg laying defective protein 4	0.0499	0.1062	0.1146
Mycobacterium ulcerans	hypothetical protein	0.0499	0.1062	1
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	conserved hypothetical protein	0.0347	0.0688	0.0789
Onchocerca volvulus		0.0249	0.0445	0.4102
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0249	0.0445	0.047
Schistosoma mansoni	60S ribosomal protein L21	0.0596	0.13	0.1287
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0249	0.0445	0.047
Schistosoma mansoni	serine/threonine protein kinase	0.0499	0.1062	0.1048
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0748	0.1675	0.1817
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0249	0.0445	0.047
Mycobacterium leprae	Possible transporter protein	0.0347	0.0688	0.5971
Echinococcus multilocularis	short transient receptor potential channel 6	0.0249	0.0445	0.047
Treponema pallidum	catabolite gene activator	0.0499	0.1062	1
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0249	0.0445	0.4102
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0249	0.0445	0.047
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Trichomonas vaginalis	guanylate cyclase, putative	0.0347	0.0688	0.0789
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0347	0.0688	0.0789
Echinococcus granulosus	voltage dependent calcium channel	0.0249	0.0445	0.047
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0499	0.1062	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0347	0.0688	0.0789
Onchocerca volvulus		0.0499	0.1062	1
Trypanosoma cruzi	cAMP response protein 1, putative	0.0499	0.1062	1
Brugia malayi	cation channel family protein	0.0249	0.0445	0.047
Echinococcus multilocularis	voltage dependent calcium channel	0.0249	0.0445	0.047
Echinococcus granulosus	potassium voltage gated channel protein	0.0249	0.0445	0.047
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0499	0.1062	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0748	0.1675	0.1817
Echinococcus granulosus	ryanodine receptor 44f	0.0249	0.0445	0.047
Echinococcus granulosus	voltage gated potassium channel	0.0249	0.0445	0.047
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0499	0.1062	0.1048
Toxoplasma gondii	transporter, cation channel family protein	0.0249	0.0445	0.4102
Echinococcus granulosus	potassium voltage gated channel protein	0.0249	0.0445	0.047
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0445	0.047
Plasmodium falciparum	DNA gyrase subunit B	0.0135	0.0164	0.1414
Echinococcus multilocularis	potassium voltage gated channel protein	0.0249	0.0445	0.047
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0249	0.0445	0.043
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0499	0.1062	0.1146
Brugia malayi	ion channel NompC	0.0249	0.0445	0.047
Trichomonas vaginalis	conserved hypothetical protein	0.0347	0.0688	0.0789
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.3781	0.9145	1
Echinococcus multilocularis	conserved hypothetical protein	0.0249	0.0445	0.047
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0499	0.1062	0.1228
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0249	0.0445	0.047
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0499	0.1062	1
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0499	0.1062	0.1048
Treponema pallidum	cyclic nucleotide binding protein	0.0499	0.1062	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0249	0.0445	0.047

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 34000 nM	Viral Plaque Reduction Assay	BINDINGDB.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2323889

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1727827