TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 372.441 | Formula: C18H20N4O3S
H donors: 1 H acceptors: 4 LogP: 1.28 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CS(=O)(=O)Cc1cc(nc(n1)c1ccc2c(c1)[nH]cc2)N1CCOCC1
InChi: 1S/C18H20N4O3S/c1-26(23,24)12-15-11-17(22-6-8-25-9-7-22)21-18(20-15)14-3-2-13-4-5-19-16(13)10-14/h2-5,10-11,19H,6-9,12H2,1H3
InChiKey: NRKVQDOIIAADQP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATR serine/threonine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	phosphatidylinositol 3-related kinase, putative	Get druggable targets OG5_128386	All targets in OG5_128386
Leishmania donovani	phosphatidylinositol 3-related kinase, putative	Get druggable targets OG5_128386	All targets in OG5_128386
Leishmania mexicana	phosphatidylinositol 3-related kinase, putative	Get druggable targets OG5_128386	All targets in OG5_128386
Cryptosporidium parvum	FRP1 like protein involved in DNA repair with a FAT domain and a phosphatidylinositol kinase domain at the C-terminus	Get druggable targets OG5_128386	All targets in OG5_128386
Schistosoma japonicum	Serine/threonine-protein kinase atr, putative	Get druggable targets OG5_128386	All targets in OG5_128386
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	Get druggable targets OG5_128386	All targets in OG5_128386
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_128386	All targets in OG5_128386
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	Get druggable targets OG5_128386	All targets in OG5_128386
Candida albicans	potential phosphatidylinositol kinase similar to S. cerevisiae MEC1 (YBR136W) involved in DNA repair and recombination	Get druggable targets OG5_128386	All targets in OG5_128386
Babesia bovis	phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_128386	All targets in OG5_128386
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128386	All targets in OG5_128386
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128386	All targets in OG5_128386
Schistosoma japonicum	Serine/threonine-protein kinase ATR, putative	Get druggable targets OG5_128386	All targets in OG5_128386
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_128386	All targets in OG5_128386
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_128386	All targets in OG5_128386
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	Get druggable targets OG5_128386	All targets in OG5_128386
Neospora caninum	phosphatidylinositol 3- and 4-kinase domain- containing protein, putative	Get druggable targets OG5_128386	All targets in OG5_128386
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	Get druggable targets OG5_128386	All targets in OG5_128386
Schistosoma japonicum	ko:K06640 ataxia telangiectasia and Rad3 related, putative	Get druggable targets OG5_128386	All targets in OG5_128386
Leishmania braziliensis	phosphatidylinositol 3-related kinase, putative	Get druggable targets OG5_128386	All targets in OG5_128386
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128386	All targets in OG5_128386
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128386	All targets in OG5_128386
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128386	All targets in OG5_128386
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	Get druggable targets OG5_128386	All targets in OG5_128386
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	Get druggable targets OG5_128386	All targets in OG5_128386
Trypanosoma brucei gambiense	phosphatidylinositol 3-related kinase, putative	Get druggable targets OG5_128386	All targets in OG5_128386
Candida albicans	potential phosphatidylinositol kinase similar to S. cerevisiae MEC1 (YBR136W) involved in DNA repair and recombination	Get druggable targets OG5_128386	All targets in OG5_128386
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	Get druggable targets OG5_128386	All targets in OG5_128386
Cryptosporidium hominis	ataxia telangiectasia and Rad3-related protein	Get druggable targets OG5_128386	All targets in OG5_128386
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_128386	All targets in OG5_128386
Leishmania infantum	phosphatidylinositol 3-related kinase, putative	Get druggable targets OG5_128386	All targets in OG5_128386

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0253	0.0542	0.0473
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0353	0.0783	0.0895
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0761	0.176	0.1663
Echinococcus multilocularis	calcium activated potassium channel	0.0253	0.0542	0.0473
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0508	0.1153	0.126
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0253	0.0542	0.0473
Schistosoma mansoni	60S ribosomal protein L21	0.0606	0.1389	0.1289
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0253	0.0542	0.0473
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0508	0.1153	1
Echinococcus multilocularis	ryanodine receptor 44f	0.0253	0.0542	0.0473
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0075	0.0115	0.0329
Treponema pallidum	cyclic nucleotide binding protein	0.0508	0.1153	1
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0508	0.1153	0.1148
Echinococcus granulosus	ryanodine receptor 44f	0.0253	0.0542	0.0473
Chlamydia trachomatis	DNA gyrase subunit B	0.0135	0.026	0.2253
Trichomonas vaginalis	conserved hypothetical protein	0.0353	0.0783	0.0895
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0508	0.1153	0.1148
Trypanosoma cruzi	hypothetical protein, conserved	0.0508	0.1153	1
Echinococcus granulosus	two pore calcium channel protein 2	0.0253	0.0542	0.0473
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0353	0.0783	0.0895
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0353	0.0783	0.0895
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0508	0.1153	0.1148
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0253	0.0542	0.0432
Echinococcus multilocularis	conserved hypothetical protein	0.0253	0.0542	0.0473
Echinococcus granulosus	TRP transient receptor potential channel	0.0253	0.0542	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0353	0.0783	0.0895
Schistosoma mansoni	hypothetical protein	0.0508	0.1153	0.105
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0253	0.0542	0.4457
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0253	0.0542	0.0473
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0761	0.176	0.1663
Echinococcus granulosus	voltage gated potassium channel	0.0253	0.0542	0.0473
Leishmania major	protein kinase, putative	0.0508	0.1153	1
Echinococcus granulosus	transient receptor potential cation channel	0.0253	0.0542	0.0473
Schistosoma mansoni	voltage-gated cation channel	0.0253	0.0542	0.0432
Echinococcus multilocularis	two pore calcium channel protein 1	0.0253	0.0542	0.0473
Mycobacterium ulcerans	hypothetical protein	0.0508	0.1153	1
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0508	0.1153	0.105
Echinococcus granulosus	transient receptor potential gamma protein	0.0253	0.0542	0.0473
Echinococcus multilocularis	transient receptor potential cation channel	0.0253	0.0542	0.0473
Onchocerca volvulus		0.0508	0.1153	1
Treponema pallidum	catabolite gene activator (Crp)	0.0508	0.1153	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0253	0.0542	0.0473
Echinococcus granulosus	transient receptor potential cation channel	0.0253	0.0542	0.0473
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0508	0.1153	0.1148
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0253	0.0542	0.0473
Echinococcus multilocularis	transient receptor potential cation channel	0.0253	0.0542	0.0473
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.3847	0.9153	1
Trichomonas vaginalis	conserved hypothetical protein	0.0353	0.0783	0.0895
Chlamydia trachomatis	DNA gyrase subunit B	0.0135	0.026	0.2253
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0083	0.0134	0.002
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Echinococcus granulosus	potassium voltage gated channel protein	0.0253	0.0542	0.0473
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0253	0.0542	0.0473
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0253	0.0542	0.0473
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0508	0.1153	1
Schistosoma mansoni	voltage-gated potassium channel	0.1114	0.2606	0.252
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0508	0.1153	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0353	0.0783	0.0895
Trichomonas vaginalis	conserved hypothetical protein	0.0353	0.0783	0.0895
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0083	0.0134	0.002
Echinococcus granulosus	short transient receptor potential channel 6	0.0253	0.0542	0.0473
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0508	0.1153	0.105
Schistosoma mansoni	voltage-gated potassium channel	0.0253	0.0542	0.0432
Echinococcus granulosus	hyperpolarization activated cyclic	0.0761	0.176	0.1819
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0253	0.0542	0.0432
Trichomonas vaginalis	adenylate cyclase, putative	0.0353	0.0783	0.0895
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0508	0.1153	0.1148
Trypanosoma brucei	protein kinase A regulatory subunit	0.0508	0.1153	1
Schistosoma mansoni	calcium-activated potassium channel	0.0253	0.0542	0.0432
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0253	0.0542	0.0473
Schistosoma mansoni	transient receptor potential channel	0.0253	0.0542	0.0432
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0353	0.0783	0.6732
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0508	0.1153	0.105
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0508	0.1153	1
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0353	0.0783	0.0895
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0508	0.1153	0.133
Echinococcus multilocularis	voltage gated potassium channel	0.1114	0.2606	0.2756
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0253	0.0542	0.4309
Echinococcus granulosus	transient receptor potential cation channel	0.0253	0.0542	0.0473
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0253	0.0542	0.0473
Loa Loa (eye worm)	ryanodine receptor	0.0253	0.0542	0.0593
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0508	0.1153	0.133
Echinococcus granulosus	potassium voltage gated channel protein	0.0253	0.0542	0.0473
Trichomonas vaginalis	adenylate cyclase, putative	0.0353	0.0783	0.0895
Trichomonas vaginalis	conserved hypothetical protein	0.0353	0.0783	0.0895
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0253	0.0542	0.0473
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0253	0.0542	0.0473
Leishmania major	DNA topoisomerase ii	0.006	0.008	0.0535
Loa Loa (eye worm)	hypothetical protein	0.3339	0.7936	0.867
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0761	0.176	0.2041
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0508	0.1153	0.105
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Trichomonas vaginalis	guanylate cyclase beta 1 subunit, putative	0.0353	0.0783	0.0895
Trichomonas vaginalis	adenylate cyclase, putative	0.0353	0.0783	0.0895
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0508	0.1153	0.105
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0353	0.0783	0.0895
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0253	0.0542	0.0473
Echinococcus multilocularis	sodium leak channel non selective protein	0.0253	0.0542	0.0473
Echinococcus multilocularis	potassium voltage gated channel protein	0.0253	0.0542	0.0473
Brugia malayi	N-terminal motif family protein	0.0508	0.1153	0.1148
Loa Loa (eye worm)	voltage-gated potassium channel	0.0253	0.0542	0.0593
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0508	0.1153	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0353	0.0783	0.0895
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0508	0.1153	1
Brugia malayi	cation channel family protein	0.0253	0.0542	0.0473
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0253	0.0542	0.0432
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0253	0.0542	0.0473
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0761	0.176	0.1663
Echinococcus granulosus	calcium activated potassium channel	0.0253	0.0542	0.0473
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0253	0.0542	0.0473
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.3847	0.9153	1
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0508	0.1153	1
Trichomonas vaginalis	intestinal guanylate cyclase, putative	0.0353	0.0783	0.0895
Echinococcus multilocularis	two pore calcium channel protein 2	0.0253	0.0542	0.0473
Loa Loa (eye worm)	calcium channel	0.0253	0.0542	0.0593
Echinococcus granulosus	voltage dependent calcium channel	0.0253	0.0542	0.0473
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0761	0.176	0.1819
Trichomonas vaginalis	conserved hypothetical protein	0.0353	0.0783	0.0895
Echinococcus multilocularis	short transient receptor potential channel 6	0.0253	0.0542	0.0473
Brugia malayi	olfactory channel protein osm-9	0.0253	0.0542	0.0473
Brugia malayi	cation channel family protein	0.0253	0.0542	0.0473
Loa Loa (eye worm)	phosphatidylinositol 3	0.0035	0.0019	0.0021
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0761	0.176	0.1819
Trypanosoma cruzi	cAMP binding protein, putative	0.0508	0.1153	1
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0508	0.1153	1
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0508	0.1153	0.1148
Schistosoma mansoni	vesicular amine transporter	0.0253	0.0542	0.0432
Loa Loa (eye worm)	voltage-gated potassium channel	0.0253	0.0542	0.0593
Trichomonas vaginalis	adenylate cyclase, putative	0.0353	0.0783	0.0895
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0253	0.0542	0.0473
Leishmania major	hypothetical protein, conserved	0.0253	0.0542	0.4613
Trichomonas vaginalis	conserved hypothetical protein	0.0353	0.0783	0.0895
Echinococcus multilocularis	transient receptor potential gamma protein	0.0253	0.0542	0.0473
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0508	0.1153	1
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0508	0.1153	0.1148
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0253	0.0542	0.0473
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0508	0.1153	0.1148
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0253	0.0542	0.0432
Leishmania major	hypothetical protein, unknown function	0.0253	0.0542	0.4613
Trypanosoma brucei	cAMP binding protein, putative	0.0508	0.1153	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0253	0.0542	0.0473
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0761	0.176	0.1819
Trichomonas vaginalis	adenylate cyclase, putative	0.0353	0.0783	0.0895
Brugia malayi	ion channel NompC	0.0253	0.0542	0.0473
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0353	0.0783	0.0895
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0253	0.0542	0.0473
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Schistosoma mansoni	transient receptor potential channel	0.0253	0.0542	0.0432
Trichomonas vaginalis	adenylate cyclase type III, putative	0.0353	0.0783	0.0895
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0761	0.176	0.1819
Trypanosoma brucei	cAMP response protein 1, putative	0.0508	0.1153	1
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0353	0.0783	0.0895
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0253	0.0542	0.0473
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0353	0.0783	0.0895
Trichomonas vaginalis	hypothetical protein	0.0353	0.0783	0.0895
Trypanosoma cruzi	Flagellar Member 6	0.0508	0.1153	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.3847	0.9153	1
Echinococcus granulosus	voltage dependent calcium channel	0.0253	0.0542	0.0473
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0253	0.0542	0.0473
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Mycobacterium ulcerans	regulatory protein	0.0508	0.1153	1
Loa Loa (eye worm)	hypothetical protein	0.0508	0.1153	0.126
Echinococcus granulosus	sodium leak channel non selective protein	0.0253	0.0542	0.0473
Brugia malayi	hypothetical protein	0.0253	0.0542	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Echinococcus granulosus	short transient receptor potential channel 6	0.0253	0.0542	0.0473
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0508	0.1153	0.1148
Echinococcus multilocularis	shaker cognate	0.0253	0.0542	0.0473
Plasmodium falciparum	DNA gyrase subunit B	0.0135	0.026	0.1392
Trichomonas vaginalis	adenylate cyclase, putative	0.0353	0.0783	0.0895
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0508	0.1153	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0761	0.176	0.1819
Leishmania major	hypothetical protein, conserved	0.0508	0.1153	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0761	0.176	0.1819
Trypanosoma cruzi	cAMP response protein 1, putative	0.0508	0.1153	1
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0508	0.1153	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0761	0.176	0.1922
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0253	0.0542	0.0432
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0508	0.1153	0.126
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0508	0.1153	0.1148
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Mycobacterium ulcerans	hypothetical protein	0.0508	0.1153	1
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0508	0.1153	1
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.006	0.008	0.0535
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0253	0.0542	0.0593
Trypanosoma brucei	DNA topoisomerase ii	0.0075	0.0115	0.0847
Toxoplasma gondii	transporter, cation channel family protein	0.0253	0.0542	0.4457
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0508	0.1153	0.133
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0508	0.1153	1
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0508	0.1153	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0253	0.0542	0.0473
Trichomonas vaginalis	adenylate cyclase, putative	0.0353	0.0783	0.0895
Trichomonas vaginalis	adenylate cyclase, putative	0.0353	0.0783	0.0895
Echinococcus granulosus	voltage gated potassium channel	0.1114	0.2606	0.2756
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0761	0.176	0.1819
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0353	0.0783	0.0895
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0508	0.1153	1
Trichomonas vaginalis	adenylate cyclase type vIII, putative	0.0353	0.0783	0.0895
Echinococcus granulosus	potassium large conductance calcium activated	0.0253	0.0542	0.0473
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0083	0.0134	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0353	0.0783	0.0895
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0761	0.176	0.1819
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.0257	0.0552	0.4544
Trichomonas vaginalis	adenylate cyclase type, putative	0.0353	0.0783	0.0895
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0508	0.1153	0.105
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0508	0.1153	1
Trichomonas vaginalis	conserved hypothetical protein	0.0353	0.0783	0.0895
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0508	0.1153	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.3594	0.8547	1
Schistosoma mansoni	hypothetical protein	0.0353	0.0783	0.0675
Schistosoma mansoni	voltage-gated potassium channel	0.0253	0.0542	0.0432
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0253	0.0542	0.0473
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Loa Loa (eye worm)	hypothetical protein	0.1114	0.2606	0.2848
Schistosoma mansoni	two-pore calcium channel	0.0253	0.0542	0.0432
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0508	0.1153	0.1148
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0253	0.0542	0.4613
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0508	0.1153	1
Entamoeba histolytica	DNA topoisomerase II, putative	0.0075	0.0115	0.5
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0075	0.0115	0.0329
Schistosoma mansoni	serine/threonine protein kinase	0.0508	0.1153	0.105
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0508	0.1153	0.105
Mycobacterium leprae	Possible transporter protein	0.0353	0.0783	0.5988
Onchocerca volvulus		0.0508	0.1153	1
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0253	0.0542	0.0473
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0508	0.1153	1
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0253	0.0542	0.0473
Plasmodium falciparum	cGMP-dependent protein kinase	0.0508	0.1153	1
Trichomonas vaginalis	conserved hypothetical protein	0.0353	0.0783	0.0895
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0508	0.1153	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0253	0.0542	0.0432
Treponema pallidum	cyclic nucleotide binding protein	0.0508	0.1153	1
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0075	0.0115	0.0581
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Loa Loa (eye worm)	TOPoisomerase family member	0.0075	0.0115	0.0126
Onchocerca volvulus		0.0253	0.0542	0.4115
Leishmania major	hypothetical protein, unknown function	0.0508	0.1153	1
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0253	0.0542	0.0473
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0353	0.0783	0.0895
Echinococcus granulosus	potassium voltage gated channel protein	0.0253	0.0542	0.0473
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0353	0.0783	0.0895
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.1114	0.2606	0.2756
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0253	0.0542	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0508	0.1153	0.126
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0508	0.1153	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0253	0.0542	0.0473
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0083	0.0134	0.002
Echinococcus multilocularis	transient receptor potential cation channel	0.0253	0.0542	0.0473
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Schistosoma mansoni	transient receptor potential channel 4	0.0253	0.0542	0.0432
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0257	0.0552	0.3272
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0253	0.0542	0.4613
Schistosoma mansoni	voltage-gated potassium channel	0.0253	0.0542	0.0432
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0253	0.0542	0.0432
Mycobacterium ulcerans	transcriptional regulatory protein	0.0508	0.1153	1
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0353	0.0783	0.0738
Echinococcus granulosus	cGMP dependent protein kinase	0.0508	0.1153	0.1148
Mycobacterium leprae	Conserved hypothetical protein	0.0508	0.1153	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0508	0.1153	0.133
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0508	0.1153	0.105
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.1114	0.2606	0.2756
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Echinococcus granulosus	potassium voltage gated channel protein	0.0253	0.0542	0.0473
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0083	0.0134	0.0501
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0508	0.1153	1
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.1114	0.2606	0.2756
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0508	0.1153	1
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0253	0.0542	0.0473
Trypanosoma cruzi	cAMP response protein 1	0.0508	0.1153	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0761	0.176	0.1819
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0253	0.0542	0.0473
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0253	0.0542	0.0473
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0253	0.0542	0.0473
Mycobacterium ulcerans	transmembrane transport protein	0.0508	0.1153	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0761	0.176	0.1663
Echinococcus granulosus	hyperpolarization activated cyclic	0.0761	0.176	0.1819
Echinococcus granulosus	transient receptor potential cation channel	0.0253	0.0542	0.0473
Mycobacterium ulcerans	DNA gyrase subunit A	0.0257	0.0552	0.3272
Schistosoma mansoni	voltage-gated potassium channel	0.0253	0.0542	0.0432
Echinococcus granulosus	hypothetical protein	0.0253	0.0542	0.0473
Schistosoma mansoni	voltage-gated potassium channel	0.0253	0.0542	0.0432
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0253	0.0542	0.0473
Trichomonas vaginalis	adenylate cyclase, putative	0.0353	0.0783	0.0895
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0253	0.0542	0.0473
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0253	0.0542	0.0473
Treponema pallidum	DNA gyrase, subunit A (gyrA)	0.0257	0.0552	0.3272
Echinococcus multilocularis	transient receptor potential cation channel	0.0253	0.0542	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Echinococcus granulosus	two pore calcium channel protein 1	0.0253	0.0542	0.0473
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0353	0.0783	0.0895
Trichomonas vaginalis	adenylate cyclase type, putative	0.0353	0.0783	0.0895
Mycobacterium tuberculosis	Conserved protein	0.0508	0.1153	1
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Echinococcus granulosus	sodium channel protein	0.0253	0.0542	0.0473
Mycobacterium ulcerans	hypothetical protein	0.0508	0.1153	1
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0508	0.1153	0.105
Echinococcus granulosus	transient receptor potential cation channel	0.0253	0.0542	0.0473
Echinococcus multilocularis	expressed conserved protein	0.0508	0.1153	0.1148
Schistosoma mansoni	hypothetical protein	0.0253	0.0542	0.0432
Loa Loa (eye worm)	ion channel NompC	0.0253	0.0542	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0761	0.176	0.1922
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0253	0.0542	0.0432
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0253	0.0542	0.0473
Leishmania major	mitochondrial DNA topoisomerase II	0.0075	0.0115	0.0847
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0075	0.0115	0.0113
Echinococcus granulosus	transient receptor potential cation channel	0.0253	0.0542	0.0473
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0253	0.0542	0.0432
Toxoplasma gondii	hypothetical protein	0.0253	0.0542	0.4457
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0508	0.1153	0.1148
Trichomonas vaginalis	adenylate cyclase, putative	0.0353	0.0783	0.0895
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.3847	0.9153	1
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0508	0.1153	1
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Leishmania major	hypothetical protein, conserved	0.0508	0.1153	1
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0253	0.0542	0.4309
Plasmodium vivax	DNA gyrase subunit B, putative	0.0135	0.026	0.1392
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0253	0.0542	0.0473
Trypanosoma brucei	Flagellar Member 6	0.0508	0.1153	1
Plasmodium vivax	DNA gyrase subunit A, putative	0.0257	0.0552	0.4208
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0508	0.1153	0.1148
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0761	0.176	0.1663
Schistosoma mansoni	voltage-gated ion channel	0.0253	0.0542	0.0432
Schistosoma mansoni	voltage-gated potassium channel	0.0253	0.0542	0.0432
Plasmodium falciparum	DNA gyrase subunit A	0.0257	0.0552	0.4208
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0253	0.0542	0.0473
Leishmania major	hypothetical protein, conserved	0.0508	0.1153	1
Schistosoma mansoni	voltage-gated potassium channel	0.0606	0.1389	0.1289
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0353	0.0783	0.0895
Trichomonas vaginalis	adenylate cyclase type III, putative	0.0353	0.0783	0.0895
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0253	0.0542	0.0432
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	0.0257	0.0552	1
Schistosoma mansoni	voltage-gated potassium channel	0.0253	0.0542	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Leishmania major	protein kinase, putative	0.0508	0.1153	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0353	0.0783	0.0895
Chlamydia trachomatis	DNA gyrase subunit A	0.0257	0.0552	0.4788
Brugia malayi	voltage-dependent calcium channel	0.0253	0.0542	0.0473
Schistosoma mansoni	voltage-dependent calcium channel	0.0253	0.0542	0.0432
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0253	0.0542	0.4457
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0508	0.1153	0.105
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0016	0.0018
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0508	0.1153	1
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0253	0.0542	0.4613
Echinococcus granulosus	potassium voltage gated channel protein	0.0253	0.0542	0.0473
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0508	0.1153	0.1148
Echinococcus multilocularis	voltage dependent calcium channel	0.0253	0.0542	0.0473
Echinococcus multilocularis	transient receptor potential cation channel	0.0253	0.0542	0.0473
Trichomonas vaginalis	conserved hypothetical protein	0.0508	0.1153	0.133
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0508	0.1153	0.1148
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0508	0.1153	0.1148
Schistosoma mansoni	voltage-gated potassium channel	0.0253	0.0542	0.0432
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0253	0.0542	0.0432
Schistosoma mansoni	voltage-gated potassium channel	0.0253	0.0542	0.0432
Toxoplasma gondii	transporter, cation channel family protein	0.0253	0.0542	0.4457
Echinococcus multilocularis	sodium channel protein	0.0253	0.0542	0.0473
Loa Loa (eye worm)	voltage-gated calcium channel	0.0253	0.0542	0.0593
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0353	0.0783	0.0895
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0761	0.176	0.1922
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Schistosoma mansoni	serine/threonine protein kinase	0.0508	0.1153	0.105
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0253	0.0542	0.0473
Mycobacterium ulcerans	hypothetical protein	0.0508	0.1153	1
Echinococcus multilocularis	voltage gated potassium channel	0.0253	0.0542	0.0473
Echinococcus multilocularis	transfer RNA-Gly	0.0253	0.0542	0.0473
Trichomonas vaginalis	conserved hypothetical protein	0.0353	0.0783	0.0895
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0083	0.0134	0.0501
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0508	0.1153	0.105
Schistosoma mansoni	voltage-gated potassium channel	0.0253	0.0542	0.0432
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0508	0.1153	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0016	0.0018
Echinococcus granulosus	single minded 2	0.0353	0.0783	0.0738
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0253	0.0542	0.0473
Schistosoma mansoni	voltage-gated potassium channel	0.0253	0.0542	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0542	0.0593
Trichomonas vaginalis	adenylate cyclase, putative	0.0353	0.0783	0.0895
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0508	0.1153	0.1148
Trichomonas vaginalis	adenylate cyclase type, putative	0.0353	0.0783	0.0895
Schistosoma mansoni	voltage-gated potassium channel	0.1114	0.2606	0.252
Trichomonas vaginalis	adenylate cyclase, putative	0.0353	0.0783	0.0895
Schistosoma mansoni	voltage-gated potassium channel	0.0761	0.176	0.1663
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.3594	0.8547	1
Brugia malayi	Egg laying defective protein 4	0.0508	0.1153	0.1148
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0508	0.1153	0.105
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0508	0.1153	0.1148
Echinococcus multilocularis	short transient receptor potential channel 6	0.0253	0.0542	0.0473
Echinococcus multilocularis	potassium voltage gated channel protein	0.0253	0.0542	0.0473
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0253	0.0542	0.4115
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0353	0.0783	0.0895
Schistosoma mansoni	transient receptor potential channel	0.0253	0.0542	0.0432
Echinococcus multilocularis	voltage dependent calcium channel	0.0253	0.0542	0.0473
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0761	0.176	0.1819
Trichomonas vaginalis	adenylate cyclase type VI, putative	0.0353	0.0783	0.0895
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0353	0.0783	0.0895
Schistosoma mansoni	ryanodine receptor related	0.0253	0.0542	0.0432
Toxoplasma gondii	hypothetical protein	0.0253	0.0542	0.4457
Echinococcus granulosus	shaker cognate	0.0253	0.0542	0.0473
Echinococcus multilocularis	potassium large conductance calcium activated	0.0253	0.0542	0.0473
Leishmania major	protein kinase A regulatory subunit, putative	0.0508	0.1153	1
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.006	0.008	0.0535
Trichomonas vaginalis	guanylate cyclase, putative	0.0353	0.0783	0.0895
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0761	0.176	0.2041
Schistosoma mansoni	serine/threonine protein kinase	0.0508	0.1153	0.105
Trichomonas vaginalis	guanylate cyclase beta 2 subunit, putative	0.0353	0.0783	0.0895
Treponema pallidum	catabolite gene activator	0.0508	0.1153	1
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0253	0.0542	0.4115
Brugia malayi	Transient-receptor-potential like protein	0.0253	0.0542	0.0473
Toxoplasma gondii	transporter, cation channel family protein	0.0253	0.0542	0.4457
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0253	0.0542	0.0473
Trichomonas vaginalis	adenylyl cyclase type V, putative	0.0353	0.0783	0.0895
Schistosoma mansoni	voltage-gated potassium channel	0.0253	0.0542	0.0432

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.5 uM	Inhibition of ATR in human HeLa cell nuclear extracts using glutathione S-transferase-p53N66 and ATP as substrate incubated for 10 mins prior to ATP addition measured after 1 hr by ELISA	ChEMBL.	23394205
IC50 (binding)	> 30 uM	Inhibition of ATR-mediated CHK1 phosphorylation at serine 345 in human HT29 cells after 1 hr in presence of 4-nitroquinoline 1-oxide	ChEMBL.	23394205

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2325700

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1727836