Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0573 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0042 | 0.0573 | 0.5 |
Onchocerca volvulus | 0.0042 | 0.0573 | 1 | |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0573 | 0.124 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0573 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0573 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0573 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0042 | 0.0573 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0042 | 0.0573 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0573 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0573 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0042 | 0.0573 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0573 | 0.124 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0573 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.4624 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0042 | 0.0573 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0573 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0573 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0573 | 0.5 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0573 | 0.124 |
Mycobacterium ulcerans | hypothetical protein | 0.0042 | 0.0573 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0.0573 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0573 | 0.124 |
Onchocerca volvulus | 0.0042 | 0.0573 | 1 | |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0573 | 0.124 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0573 | 0.124 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0573 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.4624 | 1 |
Onchocerca volvulus | 0.0042 | 0.0573 | 1 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0573 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0573 | 0.124 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0042 | 0.0573 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0573 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0.0573 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0573 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0573 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0573 | 0.124 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0573 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0573 | 0.124 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.4624 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 438 % | Cytoprotective activity against shiga toxin-induced cytotoxicity in human HeLa cells at 30 uM incubated for 4 hrs prior to shiga toxin addition measured after 20 hrs by liquid scintillation counting analysis relative to Retro-2 | ChEMBL. | 23517565 |
EC50 (functional) | = 4 uM | Cytoprotective activity against shiga toxin-induced cytotoxicity in human HeLa cells at 30 uM incubated for 4 hrs prior to shiga toxin addition measured after 20 hrs by liquid scintillation counting analysis | ChEMBL. | 23517565 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23517565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.