Detailed information for compound 1728017

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 490.599 | Formula: C30H30N6O
  • H donors: 1 H acceptors: 4 LogP: 4.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)C1CCN(CC1)C(=O)c1ccc(c(c1)c1nc2c([nH]1)cnc(c2)N1CCCC1)C
  • InChi: 1S/C30H30N6O/c1-20-4-7-24(30(37)36-14-10-23(11-15-36)22-8-5-21(18-31)6-9-22)16-25(20)29-33-26-17-28(32-19-27(26)34-29)35-12-2-3-13-35/h4-9,16-17,19,23H,2-3,10-15H2,1H3,(H,33,34)
  • InChiKey: RUUONBUDIHHUFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Fatty acid synthase Starlite/ChEMBL References
Homo sapiens fatty acid synthase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Fatty acid synthase homolog Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Soraphen polyketide synthase A, related Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks12 Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) acyl carrier protein Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks5 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks7 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks2 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum KR domain domain-containing protein, putative Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii AMP-binding enzyme domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks8 Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks15 Get druggable targets OG5_126633 All targets in OG5_126633
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Fatty acid synthase   2505 aa 2611 aa 43.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0051 0.1667 0.435
Mycobacterium ulcerans thioesterase TesA 0.0053 0.177 0.4619
Loa Loa (eye worm) fatty acid synthase 0.0062 0.2286 0.4497
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0051 0.1667 0.435
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0051 0.1667 0.435
Brugia malayi Cytochrome P450 family protein 0.0051 0.1667 0.3217
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0117 0.5182 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0687 0.0443
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0059 0.211 0.405
Mycobacterium ulcerans polyketide synthase Pks9 0.0039 0.1027 0.2681
Mycobacterium leprae Conserved hypothetical protein 0.0051 0.1667 0.4317
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0051 0.1667 0.435
Mycobacterium ulcerans fatty acid synthase Fas 0.002 0.0022 0.0059
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0051 0.1667 0.435
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0051 0.1667 0.435
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0048 0.151 0.394
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0051 0.1667 0.435
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0051 0.1667 0.435
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0039 0.1027 0.2681
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0051 0.1667 0.435
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0061 0.2228 0.5814
Brugia malayi Cytochrome P450 family protein 0.0051 0.1667 0.3217
Mycobacterium ulcerans Type I modular polyketide synthase 0.006 0.2168 0.5656
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0053 0.177 0.4587
Brugia malayi Cytochrome P450 family protein 0.0051 0.1667 0.3217
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.002 0.0022 0.0059
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0048 0.151 0.394
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0051 0.1667 0.435
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0051 0.1667 0.5
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0051 0.1667 0.435
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0036 0.0879 0.2293
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0051 0.1667 0.435
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.006 0.2168 0.5656
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.1667 0.2927
Mycobacterium leprae Polyketide synthase Pks13 0.0091 0.3832 1
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0045 0.1383 0.3609
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0059 0.211 0.5506
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.1667 0.5
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0064 0.2377 0.6202
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0051 0.1667 0.435
Loa Loa (eye worm) hypothetical protein 0.0103 0.4456 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0039 0.1027 0.2638
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0051 0.1667 0.435
Mycobacterium ulcerans Type I modular polyketide synthase 0.006 0.2168 0.5656
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0051 0.1667 0.435
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0051 0.1667 0.5
Loa Loa (eye worm) CYP4Cod1 0.0051 0.1667 0.2927
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0051 0.1667 0.435
Leishmania major cytochrome p450-like protein 0.0051 0.1667 0.5
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0051 0.1667 0.435
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0051 0.1667 0.435
Mycobacterium leprae putative cytochrome p450 0.0051 0.1667 0.4317
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0051 0.1667 0.5
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0051 0.1667 0.435
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0051 0.1667 0.5
Trypanosoma brucei cytochrome P450, putative 0.0051 0.1667 0.5
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0064 0.2377 0.6202
Onchocerca volvulus 0.011 0.4824 0.9285
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0051 0.1667 0.5
Brugia malayi Cytochrome P450 family protein 0.0051 0.1667 0.3217
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.1667 0.2927
Leishmania major cytochrome p450-like protein 0.0051 0.1667 0.5
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0051 0.1667 0.435
Mycobacterium ulcerans thioesterase 0.0053 0.177 0.4619
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0051 0.1667 0.435
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0064 0.2377 0.6202
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0064 0.2377 0.6202
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0051 0.1667 0.435
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0048 0.151 0.3904
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.006 0.2168 0.563
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0051 0.1667 0.435
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0026 0.0326 0.0851
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.006 0.2168 0.5656
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0051 0.1667 0.435
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0051 0.1667 0.435
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0051 0.1667 0.435
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0051 0.1667 0.435
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0051 0.1667 0.435
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0051 0.1667 0.435
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.006 0.2168 0.4183
Mycobacterium ulcerans polyketide synthase 0.006 0.2168 0.5656
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0051 0.1667 0.435
Toxoplasma gondii type I fatty acid synthase, putative 0.0045 0.1361 0.4063
Mycobacterium ulcerans polyketide synthase Pks13 0.0091 0.3832 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0053 0.177 0.4619
Toxoplasma gondii type I fatty acid synthase, putative 0.0064 0.2377 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0064 0.2377 0.6179
Brugia malayi AMP-binding enzyme family protein 0.0059 0.211 0.4072
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0051 0.1667 0.435
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.006 0.2168 0.5656
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0051 0.1667 0.435
Loa Loa (eye worm) cytochrome P450 0.0051 0.1667 0.2927
Mycobacterium leprae Probable polyketide synthase Pks1 0.0064 0.2377 0.6179
Brugia malayi cytochrome P450 0.0051 0.1667 0.3217
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0064 0.2377 0.6179
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0051 0.1667 0.435
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.1667 0.2927
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0051 0.1667 0.435
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0051 0.1667 0.435
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0041 0.1149 0.2821
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0051 0.1667 0.435
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0051 0.1667 0.435
Leishmania major cytochrome p450-like protein 0.0051 0.1667 0.5
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0091 0.3832 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0051 0.1667 0.5851
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0051 0.1667 0.435
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0051 0.1667 0.435
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0064 0.2377 0.6202
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0051 0.1667 0.435
Onchocerca volvulus Fatty acid synthase homolog 0.0114 0.5033 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.006 0.2168 0.5656
Mycobacterium ulcerans polyketide synthase 0.0064 0.2377 0.6202
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0049 0.1554 0.4056
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0061 0.2228 0.5814
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.1667 0.5
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0091 0.3832 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0051 0.1667 0.435
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.006 0.2168 0.563
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.006 0.2168 0.5656

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) > 20 uM Cytotoxicity against human HuH7 cells after 72 hrs by celltiter glo assay ChEMBL. 24900571
IC50 (binding) = 107 nM BindingDB_Patents: Biochemical Assay. The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FASN comprises about 25% of the cytosolic proteins in this cell line. SKBr3 cells were homogenized in a dounce homogenizer then centrifuged for 15 minutes at 4C. to remove particulate matter. The supernatant was then analyzed for protein content, diluted to the appropriate concentration, and used to measure FASN activity. The presence of FASN was confirmed by western blot analysis. A similar method for isolation of FASN from SKBr3 cells is described in Teresa, P. et al. (Clin. Cancer Res. 2009; 15(24), 7608-7615).FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) released during the fatty acid synthase reaction. The dye CPM (7-diethylamino-3-(4â-maleimidyl-phenyl)-4-methylcoumarin) contains a thiol reactive group that increases its fluorescence emission. ChEMBL. No reference
IC50 (binding) = 0.107 uM Inhibition of human FASN assessed as release of co-enzyme A ChEMBL. 24900571
IC50 (binding) = 1.72 uM Inhibition of rat FASN assessed as release of co-enzyme A ChEMBL. 24900571

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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