Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0037 | 0.4283 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0037 | 0.4283 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0037 | 0.4283 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0508 | 0.0508 |
Echinococcus granulosus | voltage gated potassium channel | 0.0011 | 0.0508 | 0.0748 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0037 | 0.4283 | 0.5 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0054 | 0.6791 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0054 | 0.6791 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0054 | 0.6791 | 0.6791 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.4941 | 0.7275 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0054 | 0.6791 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0037 | 0.4283 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0046 | 0.5706 | 0.8402 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0054 | 0.6791 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0011 | 0.0508 | 0.0748 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0054 | 0.6791 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0038 | 0.4433 | 0.4433 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0037 | 0.4283 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0037 | 0.4283 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0037 | 0.4283 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0037 | 0.4283 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0037 | 0.4283 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0037 | 0.4283 | 0.6306 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0054 | 0.6791 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0054 | 0.6791 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0054 | 0.6791 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0011 | 0.0508 | 0.0508 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0038 | 0.4433 | 0.6527 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0054 | 0.6791 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0054 | 0.6791 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0054 | 0.6791 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0037 | 0.4283 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0054 | 0.6791 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0508 | 0.0748 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.4283 | 0.6306 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0054 | 0.6791 | 0.6791 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0037 | 0.4283 | 0.4283 |
Echinococcus multilocularis | 0.0037 | 0.4283 | 0.6306 | |
Brugia malayi | cytochrome P450 | 0.0037 | 0.4283 | 0.4283 |
Echinococcus multilocularis | fk506 binding protein | 0.0054 | 0.6791 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.4283 | 0.4283 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0054 | 0.6791 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0054 | 0.6791 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0037 | 0.4283 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0054 | 0.6791 | 0.6791 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0054 | 0.6791 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0054 | 0.6791 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0054 | 0.6791 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3703 | 0.3703 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0046 | 0.5706 | 0.8402 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0037 | 0.4283 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.4283 | 0.4283 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0054 | 0.6791 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0037 | 0.4283 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0011 | 0.0508 | 0.0748 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0054 | 0.6791 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0038 | 0.4433 | 0.4433 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.4069 | 0.5992 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0054 | 0.6791 | 0.6791 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0054 | 0.6791 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0011 | 0.0508 | 0.0748 |
Schistosoma mansoni | immunophilin | 0.0054 | 0.6791 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0037 | 0.4283 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0037 | 0.4283 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.4941 | 0.7275 |
Loa Loa (eye worm) | cytochrome P450 | 0.0037 | 0.4283 | 0.4283 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0038 | 0.4433 | 0.6527 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.4069 | 0.5992 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.5706 | 0.5706 |
Schistosoma mansoni | immunophilin | 0.0054 | 0.6791 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0054 | 0.6791 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.4283 | 0.4283 |
Schistosoma mansoni | immunophilin | 0.0046 | 0.5706 | 0.8402 |
Mycobacterium leprae | putative cytochrome p450 | 0.0037 | 0.4283 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0508 | 0.0748 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.4283 | 0.4283 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0037 | 0.4283 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0037 | 0.4283 | 0.6306 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0037 | 0.4283 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0054 | 0.6791 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0037 | 0.4283 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0037 | 0.4283 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0037 | 0.4283 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0037 | 0.4283 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0054 | 0.6791 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.0054 | 0.6791 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.4283 | 0.4283 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 32000 nM | Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells | ChEMBL. | 23374868 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.