TDR Targets

Basic information

Technical information

TDR Targets ID: 1728205
Name: 4-[methyl-(5,5,8,8-tetramethyl-6,7-dihydronap hthalen-2-yl)amino]benzoic acid
MW: 337.455 | Formula: C22H27NO2
H donors: 1 H acceptors: 2 LogP: 6.26 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CN(c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc(cc1)C(=O)O
InChi: 1S/C22H27NO2/c1-21(2)12-13-22(3,4)19-14-17(10-11-18(19)21)23(5)16-8-6-15(7-9-16)20(24)25/h6-11,14H,12-13H2,1-5H3,(H,24,25)
InChiKey: HATHCUUYHJQEAP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[methyl-(1,1,4,4-tetramethyltetralin-6-yl)amino]benzoic acid
4-[methyl-(1,1,4,4-tetramethyl-6-tetralinyl)amino]benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO)	0.0273	0.6988	1
Schistosoma mansoni	tubulin subunit alpha	0.0238	0.5863	0.5837
Trichomonas vaginalis	tubulin alpha chain, putative	0.0103	0.1526	0.1474
Trypanosoma brucei	prostaglandin f synthase	0.0199	0.4603	0.457
Leishmania major	alpha tubulin	0.0238	0.5863	0.5837
Trichomonas vaginalis	tubulin, putative	0.0079	0.0754	0.0698
Leishmania major	prostaglandin f synthase, putative	0.0199	0.4603	0.457
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.5863	0.5837
Plasmodium falciparum	tubulin delta chain, putative	0.0079	0.0754	0.0698
Plasmodium falciparum	alpha tubulin 2	0.0238	0.5863	0.5837
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0199	0.4603	0.457
Echinococcus granulosus	Tubulin alpha 1 chain	0.0238	0.5863	0.5837
Echinococcus granulosus	tubulin epsilon chain	0.0182	0.4071	0.4035
Brugia malayi	tubulin alpha chain - mouse	0.0238	0.5863	0.5837
Brugia malayi	hypothetical protein	0.0289	0.7492	0.7477
Echinococcus multilocularis	kelch ECH associated protein 1	0.0093	0.1208	0.1154
Trypanosoma brucei	zeta tubulin	0.0079	0.0754	0.0698
Mycobacterium leprae	cell division protein FtsZ	0.0079	0.0754	0.084
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0093	0.1208	0.1154
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0199	0.4603	0.457
Schistosoma mansoni	transcription factor LCR-F1	0.0289	0.7492	0.7477
Trichomonas vaginalis	conserved hypothetical protein	0.0079	0.0754	0.0698
Trichomonas vaginalis	tubulin alpha chain, putative	0.0182	0.4071	0.4035
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0199	0.4603	0.457
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0079	0.0754	0.0698
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.5863	0.5837
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0199	0.4603	0.457
Trichomonas vaginalis	tubulin gamma chain, putative	0.0182	0.4071	0.4035
Loa Loa (eye worm)	hypothetical protein	0.0238	0.5863	0.5863
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0199	0.4603	0.457
Echinococcus granulosus	tubulin alpha chain	0.0238	0.5863	0.5837
Trichomonas vaginalis	aldo/keto reductase, putative	0.0199	0.4603	0.457
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0079	0.0754	0.0698
Trypanosoma brucei	epsilon tubulin	0.0182	0.4071	0.4035
Echinococcus granulosus	tubulin delta chain	0.0079	0.0754	0.0698
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0199	0.4603	0.457
Brugia malayi	alpha-tubulin	0.0238	0.5863	0.5837
Echinococcus multilocularis	tubulin subunit TubB	0.0238	0.5863	0.5837
Echinococcus granulosus	aldehyde reductase	0.0141	0.2751	0.2706
Trichomonas vaginalis	aldo-keto reductase, putative	0.0199	0.4603	0.457
Brugia malayi	Tubulin alpha-2 chain	0.0238	0.5863	0.5837
Toxoplasma gondii	alpha tubulin TUBA1	0.0238	0.5863	0.5837
Leishmania major	alpha tubulin	0.0238	0.5863	0.5837
Trypanosoma brucei	aldo-keto reductase, putative	0.0199	0.4603	0.457
Schistosoma mansoni	tubulin subunit alpha	0.0079	0.0754	0.0698
Trypanosoma brucei	alpha tubulin	0.0238	0.5863	0.5837
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0289	0.7492	0.7477
Schistosoma mansoni	tubulin subunit delta	0.0079	0.0754	0.0698
Onchocerca volvulus		0.0199	0.4603	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0238	0.5863	0.5837
Trichomonas vaginalis	aldo/keto reductase, putative	0.0199	0.4603	0.457
Loa Loa (eye worm)	tubulin alpha 2	0.0159	0.3317	0.3317
Brugia malayi	Cell division protein ftsZ	0.0079	0.0754	0.0698
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0238	0.5863	0.5837
Plasmodium vivax	tubulin epsilon chain, putative	0.0182	0.4071	0.4035
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0238	0.5863	0.5837
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0199	0.4603	0.457
Plasmodium vivax	tubulin alpha chain, putative	0.0238	0.5863	0.5837
Schistosoma mansoni	tubulin subunit alpha	0.0238	0.5863	0.5837
Leishmania major	alpha tubulin	0.0238	0.5863	0.5837
Schistosoma mansoni	tubulin subunit epsilon	0.0182	0.4071	0.4035
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0289	0.7492	0.7477
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0199	0.4603	0.457
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0058	0.0061	0.0061
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0238	0.5863	0.5837
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0093	0.1208	0.1154
Echinococcus multilocularis	tubulin alpha 3 chain	0.0238	0.5863	0.5837
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0199	0.4603	0.457
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0135	0.2545	0.25
Echinococcus granulosus	alpha tubulin	0.0238	0.5863	0.5837
Echinococcus granulosus	tubulin alpha	0.0182	0.4071	0.4035
Loa Loa (eye worm)	oxidoreductase	0.0199	0.4603	0.4603
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.5863	0.5837
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0199	0.4603	0.457
Trypanosoma brucei	epsilon tubulin	0.0182	0.4071	0.4035
Loa Loa (eye worm)	tubulin alpha chain	0.0238	0.5863	0.5863
Echinococcus multilocularis	geminin	0.0166	0.3554	0.3515
Echinococcus granulosus	aldo keto reductase	0.0199	0.4603	0.457
Echinococcus granulosus	tubulin alpha chain	0.0238	0.5863	0.5837
Trichomonas vaginalis	tubulin alpha chain, putative	0.0103	0.1526	0.1474
Trichomonas vaginalis	aldo-keto reductase, putative	0.0199	0.4603	0.457
Echinococcus multilocularis	peroxisome assembly protein 26	0.0238	0.5863	0.5837
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0199	0.4603	0.457
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0103	0.1526	0.1474
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0199	0.4603	0.457
Trichomonas vaginalis	tubulin gamma chain, putative	0.0079	0.0754	0.0698
Echinococcus granulosus	Tubulin alpha 1 chain	0.0238	0.5863	0.5837
Trypanosoma cruzi	epsilon tubulin, putative	0.0182	0.4071	0.4035
Leishmania major	alpha tubulin	0.0238	0.5863	0.5837
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0199	0.4603	0.457
Brugia malayi	Tubulin alpha chain	0.0079	0.0754	0.0698
Trichomonas vaginalis	aldo-keto reductase, putative	0.0199	0.4603	0.457
Loa Loa (eye worm)	hypothetical protein	0.0135	0.2545	0.2545
Entamoeba histolytica	tubulin alpha-1 chain	0.0238	0.5863	0.5837
Onchocerca volvulus		0.0199	0.4603	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0103	0.1526	0.1474
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0079	0.0754	0.0698
Echinococcus multilocularis	tubulin delta chain	0.0079	0.0754	0.0698
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0314	0.8318	0.8308
Schistosoma mansoni	hypothetical protein	0.0093	0.1216	0.1163
Trichomonas vaginalis	aldo-keto reductase, putative	0.0199	0.4603	0.457
Loa Loa (eye worm)	oxidoreductase	0.0199	0.4603	0.4603
Plasmodium falciparum	tubulin gamma chain	0.0182	0.4071	0.4035
Trichomonas vaginalis	tubulin gamma chain, putative	0.0182	0.4071	0.4035
Echinococcus granulosus	tubulin alpha 3 chain	0.0238	0.5863	0.5837
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.5863	0.5837
Schistosoma mansoni	aldo-keto reductase	0.0199	0.4603	0.457
Leishmania major	alpha tubulin	0.0238	0.5863	0.5837
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0135	0.2545	0.2545
Trypanosoma cruzi	tubulin gamma chain	0.0182	0.4071	0.4035
Entamoeba histolytica	hypothetical protein	0.0289	0.7492	0.7477
Echinococcus granulosus	tubulin alpha chain	0.0238	0.5863	0.5837
Trichomonas vaginalis	aldo-keto reductase, putative	0.0199	0.4603	0.457
Mycobacterium leprae	Conserved hypothetical protein	0.0141	0.2751	0.3257
Echinococcus multilocularis	aldo keto reductase	0.0199	0.4603	0.457
Echinococcus multilocularis	Kelch repeat type 1	0.0093	0.1216	0.1163
Trypanosoma brucei	alpha tubulin, putative	0.0103	0.1526	0.1474
Trypanosoma cruzi	tubulin delta chain	0.0079	0.0754	0.0698
Entamoeba histolytica	aldose reductase, putative	0.0199	0.4603	0.457
Trichomonas vaginalis	tubulin, putative	0.0103	0.1526	0.1474
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.5863	0.5837
Echinococcus granulosus	tubulin alpha 1C chain	0.0238	0.5863	0.5837
Trichomonas vaginalis	aldo-keto reductase, putative	0.0199	0.4603	0.457
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0199	0.4603	0.457
Trypanosoma brucei	alpha tubulin	0.0238	0.5863	0.5837
Plasmodium falciparum	alpha tubulin 1	0.0238	0.5863	0.5837
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0079	0.0754	0.0698
Trypanosoma brucei	alpha tubulin	0.0238	0.5863	0.5837
Leishmania major	alpha tubulin	0.0238	0.5863	0.5837
Loa Loa (eye worm)	oxidoreductase	0.0199	0.4603	0.4603
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0238	0.5863	0.5863
Trichomonas vaginalis	aldo-keto reductase, putative	0.0199	0.4603	0.457
Leishmania major	epsilon tubulin, putative	0.0182	0.4071	0.4035
Treponema pallidum	cell division protein FtsZ	0.0079	0.0754	0.5
Trypanosoma cruzi	tubulin delta chain	0.0079	0.0754	0.0698
Loa Loa (eye worm)	alpha-tubulin	0.0238	0.5863	0.5863
Brugia malayi	Tubulin alpha chain	0.0238	0.5863	0.5837
Leishmania major	alpha tubulin	0.0238	0.5863	0.5837
Echinococcus multilocularis	tubulin alpha 1C chain	0.0238	0.5863	0.5837
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.5863	0.5837
Trypanosoma cruzi	epsilon tubulin, putative	0.0182	0.4071	0.4035
Trichomonas vaginalis	aldo-keto reductase, putative	0.0199	0.4603	0.457
Echinococcus granulosus	hypothetical protein	0.0199	0.4603	0.457
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0199	0.4603	0.457
Mycobacterium ulcerans	cell division protein FtsZ	0.0079	0.0754	0.084
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0199	0.4603	0.457
Loa Loa (eye worm)	tubulin alpha chain	0.0238	0.5863	0.5863
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0199	0.4603	0.457
Trypanosoma brucei	alpha tubulin	0.0238	0.5863	0.5837
Leishmania major	zeta tubulin, putative	0.0079	0.0754	0.0698
Echinococcus multilocularis	tubulin alpha 1C chain	0.0238	0.5863	0.5837
Trypanosoma brucei	tubulin delta chain	0.0079	0.0754	0.0698
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0199	0.4603	0.457
Leishmania major	alpha tubulin	0.0238	0.5863	0.5837
Trypanosoma cruzi	aldo/keto reductase, putative	0.0199	0.4603	0.457
Toxoplasma gondii	alpha-tubulin I, putative	0.0238	0.5863	0.5837
Echinococcus granulosus	tubulin subunit TubB	0.0238	0.5863	0.5837
Echinococcus granulosus	tubulin alpha chain	0.0238	0.5863	0.5837
Loa Loa (eye worm)	oxidoreductase	0.0199	0.4603	0.4603
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.5863	0.5837
Loa Loa (eye worm)	tubulin alpha 2	0.0159	0.3317	0.3317
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0159	0.3317	0.3317
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0182	0.4071	0.4035
Echinococcus multilocularis	kelch ECH associated protein 1	0.0093	0.1208	0.1154
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0199	0.4603	0.55
Echinococcus granulosus	peroxisome assembly protein 26	0.0238	0.5863	0.5837
Echinococcus multilocularis	hypothetical protein	0.0238	0.5863	0.5837
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3317	0.3317
Schistosoma mansoni	hypothetical protein	0.0166	0.3554	0.3515
Onchocerca volvulus		0.0199	0.4603	1
Echinococcus multilocularis	aldo keto reductase	0.0199	0.4603	0.457
Mycobacterium tuberculosis	Probable oxidoreductase	0.0199	0.4603	0.6556
Schistosoma mansoni	alpha tubulin	0.0238	0.5863	0.5837
Echinococcus granulosus	tubulin alpha chain	0.0238	0.5863	0.5837
Trichomonas vaginalis	aldo-keto reductase, putative	0.0199	0.4603	0.457
Leishmania major	alpha tubulin	0.0238	0.5863	0.5837
Giardia lamblia	Alpha-tubulin	0.0238	0.5863	0.5525
Entamoeba histolytica	tubulin alpha chain, putative	0.0238	0.5863	0.5837
Trichomonas vaginalis	aldo-keto reductase, putative	0.0199	0.4603	0.457
Loa Loa (eye worm)	oxidoreductase	0.0199	0.4603	0.4603
Plasmodium vivax	delta tubulin, putative	0.0079	0.0754	0.0698
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0079	0.0754	0.5
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0079	0.0754	0.1001
Trypanosoma brucei	zeta tubulin, putative	0.0079	0.0754	0.0698
Trichomonas vaginalis	aldo-keto reductase, putative	0.0199	0.4603	0.457
Brugia malayi	Tubulin gamma chain	0.0182	0.4071	0.4035
Schistosoma mansoni	alpha tubulin	0.0238	0.5863	0.5837
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0199	0.4603	0.457
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0314	0.8318	0.5
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.5863	0.5837
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0199	0.4603	0.457
Trypanosoma cruzi	aldo-keto reductase	0.0199	0.4603	0.457
Brugia malayi	Tubulin beta chain	0.0103	0.1526	0.1474
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0199	0.4603	0.457
Echinococcus multilocularis	tubulin epsilon chain	0.0182	0.4071	0.4035
Echinococcus granulosus	tubulin alpha 1C chain	0.0238	0.5863	0.5837
Leishmania major	gamma-tubulin	0.0182	0.4071	0.4035
Brugia malayi	Tubulin beta chain	0.0079	0.0754	0.0698
Leishmania major	alpha tubulin	0.0238	0.5863	0.5837
Toxoplasma gondii	aldose reductase, putative	0.0199	0.4603	0.457
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0199	0.4603	0.457
Schistosoma mansoni	tubulin subunit alpha	0.0238	0.5863	0.5837
Entamoeba histolytica	hypothetical protein	0.0289	0.7492	0.7477
Schistosoma mansoni	pol-related	0.0199	0.4603	0.457
Plasmodium falciparum	tubulin epsilon chain, putative	0.0182	0.4071	0.4035
Echinococcus multilocularis	aldo keto reductase	0.0199	0.4603	0.457
Leishmania major	alpha tubulin	0.0238	0.5863	0.5837
Trypanosoma brucei	beta tubulin	0.0182	0.4071	0.4035
Entamoeba histolytica	hypothetical protein	0.0289	0.7492	0.7477
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0238	0.5863	0.5837
Entamoeba histolytica	aldose reductase, putative	0.0199	0.4603	0.457
Giardia lamblia	Gamma tubulin	0.0182	0.4071	0.3588
Schistosoma mansoni	hypothetical protein	0.0166	0.3554	0.3515
Echinococcus granulosus	tubulin gamma 1 chain	0.0182	0.4071	0.4035
Echinococcus multilocularis	tubulin alpha	0.0182	0.4071	0.4035
Loa Loa (eye worm)	hypothetical protein	0.0199	0.4603	0.4603
Echinococcus multilocularis	aldehyde reductase	0.0141	0.2751	0.2706
Entamoeba histolytica	tubulin gamma chain	0.0182	0.4071	0.4035
Echinococcus multilocularis	aldo keto reductase	0.0199	0.4603	0.457
Echinococcus multilocularis	tubulin alpha 3 chain	0.0238	0.5863	0.5837
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0314	0.8318	0.8308
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.5863	0.5837
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0199	0.4603	0.457
Schistosoma mansoni	alpha tubulin	0.0238	0.5863	0.5837
Trichomonas vaginalis	conserved hypothetical protein	0.0079	0.0754	0.0698
Trichomonas vaginalis	aldo-keto reductase, putative	0.0199	0.4603	0.457
Trichomonas vaginalis	aldo/keto reductase, putative	0.0199	0.4603	0.457
Brugia malayi	Tubulin alpha-2 chain	0.0238	0.5863	0.5837
Trypanosoma brucei	tubulin gamma chain	0.0182	0.4071	0.4035
Onchocerca volvulus		0.0199	0.4603	1
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0314	0.8318	1
Trypanosoma cruzi	alpha tubulin, putative	0.0238	0.5863	0.5837
Leishmania major	aldo-keto reductase-like protein	0.0199	0.4603	0.457
Echinococcus granulosus	Tubulin alpha 1 chain	0.0238	0.5863	0.5837
Onchocerca volvulus		0.0199	0.4603	1
Entamoeba histolytica	hypothetical protein	0.0289	0.7492	0.7477
Echinococcus granulosus	protoporphyrinogen oxidase	0.0273	0.6988	0.697
Schistosoma mansoni	tubulin subunit beta	0.0079	0.0754	0.0698
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.5863	0.5837
Giardia lamblia	Alpha-tubulin	0.0238	0.5863	0.5525
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0199	0.4603	0.457
Trichomonas vaginalis	tubulin, putative	0.0103	0.1526	0.1474
Leishmania major	alpha tubulin	0.0238	0.5863	0.5837
Trichomonas vaginalis	tubulin alpha chain, putative	0.0103	0.1526	0.1474
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0238	0.5863	0.5837
Trypanosoma cruzi	zeta tubulin, putative	0.0079	0.0754	0.0698
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0314	0.8318	1
Echinococcus granulosus	aldo keto reductase	0.0199	0.4603	0.457
Giardia lamblia	Aldose reductase	0.0199	0.4603	0.4162
Echinococcus granulosus	aldo keto reductase	0.0199	0.4603	0.457
Trypanosoma brucei	epsilon tubulin	0.0182	0.4071	0.4035
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0199	0.4603	0.457
Plasmodium vivax	tubulin alpha chain, putative	0.0238	0.5863	0.5837
Brugia malayi	tubulin alpha-2 chain	0.0238	0.5863	0.5837
Loa Loa (eye worm)	tubulin gamma chain	0.0182	0.4071	0.4071
Trypanosoma cruzi	zeta tubulin, putative	0.0079	0.0754	0.0698
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0199	0.4603	0.457
Loa Loa (eye worm)	tubulin beta chain	0.0079	0.0754	0.0754
Entamoeba histolytica	aldose reductase, putative	0.0199	0.4603	0.457
Echinococcus granulosus	kelch ECH associated protein 1	0.0093	0.1208	0.1154
Mycobacterium ulcerans	oxidoreductase	0.0199	0.4603	0.55
Giardia lamblia	Aldose reductase	0.0199	0.4603	0.4162
Echinococcus granulosus	tubulin alpha 3 chain	0.0238	0.5863	0.5837
Schistosoma mansoni	aldo-keto reductase	0.0199	0.4603	0.457
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0199	0.4603	0.457
Onchocerca volvulus		0.0103	0.1526	0.3226
Schistosoma mansoni	hypothetical protein	0.0289	0.7492	0.7477
Leishmania major	delta tubulin, putative	0.0079	0.0754	0.0698
Echinococcus granulosus	geminin	0.0166	0.3554	0.3515
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0159	0.3317	0.3276
Plasmodium vivax	tubulin gamma chain, putative	0.0182	0.4071	0.4035
Schistosoma mansoni	tubulin subunit gamma	0.0182	0.4071	0.4035
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.5863	0.5837
Loa Loa (eye worm)	alpha-tubulin	0.0238	0.5863	0.5863
Onchocerca volvulus		0.0199	0.4603	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0199	0.4603	0.457
Echinococcus multilocularis	tubulin gamma 1 chain	0.0182	0.4071	0.4035
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0199	0.4603	0.457

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2325915

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1728205