Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.5004 | 0.4844 |
Echinococcus multilocularis | 0.0018 | 0.5004 | 0.4883 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.9924 | 0.9922 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0018 | 0.5004 | 0.4844 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0018 | 0.5004 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.9924 | 1 |
Brugia malayi | cytochrome P450 | 0.0018 | 0.5004 | 0.4844 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1686 | 0.1421 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0018 | 0.5004 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0018 | 0.5004 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.2784 | 0.2554 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0018 | 0.5004 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.1968 | 0.1725 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0018 | 0.5004 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.9924 | 0.9922 |
Schistosoma mansoni | lamin | 0.0027 | 0.9924 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.9924 | 0.9922 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.5004 | 0.4844 |
Echinococcus multilocularis | musashi | 0.0027 | 0.9924 | 1 |
Onchocerca volvulus | 0.0027 | 0.9924 | 1 | |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.001 | 0.0026 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.2784 | 0.2554 |
Echinococcus multilocularis | lamin | 0.0027 | 0.9924 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0018 | 0.5004 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0018 | 0.5004 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.9924 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0018 | 0.5004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.9643 | 0.9631 |
Loa Loa (eye worm) | cytochrome P450 | 0.0018 | 0.5004 | 0.4844 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0018 | 0.5004 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0018 | 0.5004 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0018 | 0.5004 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0018 | 0.5004 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.9924 | 0.9922 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0018 | 0.5004 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0018 | 0.5004 | 0.4883 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0018 | 0.5004 | 0.5 |
Echinococcus granulosus | lamin | 0.0027 | 0.9924 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0018 | 0.5004 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0018 | 0.5004 | 0.4883 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0018 | 0.5004 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.1968 | 0.1725 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.001 | 0.0026 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.9924 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0018 | 0.5004 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.9924 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0018 | 0.5004 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0018 | 0.5004 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0018 | 0.5004 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.5004 | 0.4883 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0018 | 0.5004 | 0.5 |
Giardia lamblia | Myb 1-like protein | 0.001 | 0.0025 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.9924 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.9924 | 0.9922 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1968 | 0.1711 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0018 | 0.5004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1686 | 0.1421 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0018 | 0.5004 | 0.5 |
Trichomonas vaginalis | MYB, putative | 0.001 | 0.0026 | 1 |
Onchocerca volvulus | 0.0027 | 0.9924 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug uptake (ADMET) | = 3.16 % ID/g | Biodistribution in ddY mouse brain at 0.1 to 0.4 uCi, iv after 10 mins by gamma counting | ChEMBL. | 23344363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.