Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sodium channel, voltage-gated, type IX, alpha subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1824 | 0.1145 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0042 | 0.0897 | 0.043 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0897 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.1824 | 0.1414 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0046 | 0.1824 | 0.1145 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0897 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0079 | 0.992 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0046 | 0.1824 | 0.1019 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0075 | 0.8993 | 0.8894 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.0897 | 0.043 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0046 | 0.1824 | 0.1019 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0042 | 0.0897 | 0.043 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0075 | 0.8993 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0042 | 0.0897 | 0.043 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0046 | 0.1824 | 0.1019 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0042 | 0.0897 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.766 | 0.8354 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0042 | 0.0897 | 0.043 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0079 | 0.992 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.1824 | 0.1414 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0075 | 0.8993 | 0.8894 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0075 | 0.8993 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0046 | 0.1824 | 0.1019 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.4318 | Inhibition of NaV1.7 ion channel (unknown origin) | ChEMBL. | 23177785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.