Detailed information for compound 1728974

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 495.546 | Formula: C24H18FN3O4S2
  • H donors: 1 H acceptors: 4 LogP: 4.43 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1ccc(cc1)c1cc(F)ccc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1nccs1
  • InChi: 1S/C24H18FN3O4S2/c1-31-15-16-2-4-17(5-3-16)21-13-19(25)6-8-23(21)32-22-9-7-20(12-18(22)14-26)34(29,30)28-24-27-10-11-33-24/h2-13H,15H2,1H3,(H,27,28)
  • InChiKey: STIRUPVTMRVNHV-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sodium channel, voltage-gated, type IX, alpha subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania mexicana calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania braziliensis calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania donovani calcium channel protein, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania infantum calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus multilocularis sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.7842 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0034 0.5898 0.5898
Schistosoma mansoni biogenic amine receptor 0.0034 0.5898 0.6659
Brugia malayi G protein-coupled receptor F59B2.13 0.0034 0.5898 0.752
Echinococcus granulosus allatostatin A receptor 0.0034 0.5898 0.5898
Brugia malayi hypothetical protein 0.0034 0.5898 0.752
Schistosoma mansoni biogenic amine receptor 0.0034 0.5898 0.6659
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.5898 0.752
Echinococcus multilocularis neuropeptide s receptor 0.0034 0.5898 0.5898
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Brugia malayi hypothetical protein 0.0034 0.5898 0.752
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Brugia malayi larval opioid receptor 0.0034 0.5898 0.752
Brugia malayi Serotonin receptor 0.0034 0.5898 0.752
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0034 0.5898 0.752
Brugia malayi hypothetical protein 0.0034 0.5898 0.752
Schistosoma mansoni hypothetical protein 0.0034 0.5898 0.6659
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.5898 0.752
Echinococcus multilocularis g-protein coupled receptor 0.0034 0.5898 0.5898
Echinococcus multilocularis G-protein coupled receptor, putative 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0034 0.5898 0.5898
Echinococcus multilocularis dro:myosuppressin receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Schistosoma mansoni growth hormone secretagogue receptor 0.0034 0.5898 0.6659
Brugia malayi sulfakinin receptor protein 0.0034 0.5898 0.752
Schistosoma mansoni amine GPCR 0.0034 0.5898 0.6659
Schistosoma mansoni biogenic amine (5HT) receptor 0.0034 0.5898 0.6659
Echinococcus granulosus hypothetical protein 0.0034 0.5898 0.5898
Echinococcus granulosus g protein coupled receptor 0.0034 0.5898 0.5898
Onchocerca volvulus 0.0034 0.5898 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.5898 0.5898
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0034 0.5898 0.5898
Echinococcus multilocularis fmrfamide receptor 0.0034 0.5898 0.5898
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0034 0.5898 0.752
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.5898 0.6659
Brugia malayi Melatonin receptor type 1A 0.0034 0.5898 0.752
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Onchocerca volvulus 0.0034 0.5898 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0034 0.5898 0.5898
Echinococcus granulosus dro:myosuppressin receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.5898 0.6659
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0034 0.5898 0.5898
Brugia malayi Dopamine receptor protein 2 0.0034 0.5898 0.752
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.5898 0.5898
Schistosoma mansoni amine GPCR 0.0034 0.5898 0.6659
Schistosoma mansoni amine GPCR 0.0034 0.5898 0.6659
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.5898 0.6659
Brugia malayi follicle stimulating hormone receptor 0.0034 0.5898 0.752
Onchocerca volvulus 0.0034 0.5898 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0034 0.5898 0.752
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Loa Loa (eye worm) melatonin receptor type 1A 0.0034 0.5898 0.752
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Echinococcus granulosus g protein coupled receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus granulosus 7tm_1 domain containing protein 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Schistosoma mansoni myosin xvIII 0.0034 0.5898 0.6659
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0034 0.5898 0.6659
Schistosoma mansoni opsin-like receptor 0.0034 0.5898 0.6659
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.5898 0.5898
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.5898 0.5898
Echinococcus multilocularis serotonin receptor 0.0034 0.5898 0.5898
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Brugia malayi Tachykinin-like peptides receptor 99D 0.0034 0.5898 0.752
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.5898 0.6659
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.5898 0.5898
Echinococcus granulosus sex peptide receptor 0.0034 0.5898 0.5898
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Onchocerca volvulus 0.0034 0.5898 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.5898 0.5898
Brugia malayi GnHR receptor homolog 0.0034 0.5898 0.752
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.7842 0.7842
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0034 0.5898 0.752
Echinococcus multilocularis allatostatin A receptor 0.0034 0.5898 0.5898
Brugia malayi RE15519p 0.0034 0.5898 0.752
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0034 0.5898 0.5898
Echinococcus granulosus biogenic amine 5HT receptor 0.0034 0.5898 0.5898
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Onchocerca volvulus 0.0034 0.5898 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Schistosoma mansoni hypothetical protein 0.0034 0.5898 0.6659
Brugia malayi G-protein coupled receptor 0.0034 0.5898 0.752
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.5898 0.6659
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.5898 0.6659
Onchocerca volvulus 0.0034 0.5898 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.5898 0.5898
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0034 0.5898 0.6659
Onchocerca volvulus 0.0034 0.5898 0.5
Brugia malayi hypothetical protein 0.0034 0.5898 0.752
Echinococcus multilocularis G protein coupled receptor 139 0.0034 0.5898 0.5898
Onchocerca volvulus 0.0034 0.5898 0.5
Schistosoma mansoni neuropeptide receptor 0.0034 0.5898 0.6659
Echinococcus multilocularis serotonin receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.7842 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.6384 0.8141
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.5898 0.752
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.5898 0.6659
Onchocerca volvulus 0.0034 0.5898 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus multilocularis g protein coupled receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.5898 0.5898
Brugia malayi putative neuropeptide receptor NPR1 0.0034 0.5898 0.752
Echinococcus granulosus serotonin receptor 0.0034 0.5898 0.5898
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.5898 0.5898
Echinococcus granulosus biogenic amine 5HT receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.8857 1
Echinococcus multilocularis somatostatin receptor 0.0034 0.5898 0.5898
Onchocerca volvulus 0.0034 0.5898 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Brugia malayi hypothetical protein 0.0034 0.5898 0.752
Schistosoma mansoni opsin-like receptor 0.0034 0.5898 0.6659
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.5898 0.5898
Echinococcus granulosus fmrfamide receptor 0.0034 0.5898 0.5898
Schistosoma mansoni neuropeptide receptor 0.0034 0.5898 0.6659
Echinococcus granulosus tachykinin peptides receptor 99D 0.0034 0.5898 0.5898
Onchocerca volvulus 0.0034 0.5898 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Brugia malayi Dopamine receptor 0.0034 0.5898 0.752
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.6253 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0034 0.5898 0.6659
Echinococcus multilocularis neuropeptide receptor 0.0034 0.5898 0.5898
Brugia malayi G protein-coupled receptor 0.0034 0.5898 0.752
Echinococcus multilocularis neuropeptide receptor A26 0.0034 0.5898 0.5898
Brugia malayi neuropeptide F receptor 0.0034 0.5898 0.752
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0034 0.5898 0.752
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0034 0.5898 0.5898
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0034 0.5898 0.6659
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus granulosus neuropeptide receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0034 0.5898 0.752
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.5898 0.6659
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0034 0.5898 0.5898
Echinococcus multilocularis fmrfamide receptor 0.0034 0.5898 0.5898
Onchocerca volvulus 0.0034 0.5898 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0034 0.5898 0.6659
Schistosoma mansoni biogenic amine receptor 0.0034 0.5898 0.6659
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.5898 0.5898
Schistosoma mansoni histamine h1 receptor 0.0034 0.5898 0.6659
Brugia malayi hypothetical protein 0.0034 0.5898 0.752
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0034 0.5898 0.752
Onchocerca volvulus 0.0034 0.5898 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Schistosoma mansoni opsin-like receptor 0.0034 0.5898 0.6659
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Brugia malayi Serotonin receptor 0.0034 0.5898 0.752
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.7842 0.7842
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.5898 0.5898
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.5898 0.6659
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0034 0.5898 0.5898
Schistosoma mansoni hypothetical protein 0.0034 0.5898 0.6659
Echinococcus granulosus neuropeptide s receptor 0.0034 0.5898 0.5898
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0034 0.5898 0.6659
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.5898 0.6659
Onchocerca volvulus 0.0034 0.5898 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.5898 0.6659
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus multilocularis g protein coupled receptor 0.0034 0.5898 0.5898
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Schistosoma mansoni amine GPCR 0.0034 0.5898 0.6659
Brugia malayi putative neuropeptide receptor 0.0034 0.5898 0.752
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Brugia malayi hypothetical protein 0.0034 0.5898 0.752
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Schistosoma mansoni adenoreceptor 0.0034 0.5898 0.6659
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus granulosus g protein coupled receptor 0.0034 0.5898 0.5898
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.6253 0.5
Onchocerca volvulus 0.0034 0.5898 0.5
Schistosoma mansoni neuropeptide receptor 0.0034 0.5898 0.6659
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.5898 0.5898
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0034 0.5898 0.752
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Brugia malayi hypothetical protein 0.0034 0.5898 0.752
Echinococcus multilocularis orexin receptor type 2 0.0034 0.5898 0.5898
Echinococcus multilocularis sex peptide receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0034 0.5898 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0034 0.5898 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus granulosus 7TM GPCR rhodopsin 0.0034 0.5898 0.5898
Schistosoma mansoni hypothetical protein 0.0034 0.5898 0.6659
Schistosoma mansoni biogenic amine (5HT) receptor 0.0034 0.5898 0.6659
Echinococcus granulosus g-protein coupled receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.5898 0.5898
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.5898 0.5898
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Loa Loa (eye worm) TYRA-2 protein 0.0034 0.5898 0.752
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.5898 0.6659
Brugia malayi AKH receptor 0.0034 0.5898 0.752
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0034 0.5898 0.5898
Brugia malayi ORL1-like opioid receptor 0.0034 0.5898 0.752
Echinococcus granulosus neuropeptide receptor 0.0034 0.5898 0.5898
Echinococcus multilocularis g protein coupled receptor 0.0034 0.5898 0.5898
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.5898 0.6659
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.5898 0.5898
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.8857 1
Schistosoma mansoni neuropeptide receptor 0.0034 0.5898 0.6659
Echinococcus granulosus somatostatin receptor 0.0034 0.5898 0.5898
Echinococcus granulosus alpha 1A adrenergic receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0034 0.5898 0.752
Schistosoma mansoni neuropeptide f receptor 76f 0.0034 0.5898 0.6659
Onchocerca volvulus 0.0034 0.5898 0.5
Brugia malayi neuropeptide F receptor 0.0034 0.5898 0.752
Echinococcus granulosus neuropeptide FF receptor 2 0.0034 0.5898 0.5898
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.5898 0.6659
Schistosoma mansoni amine GPCR 0.0034 0.5898 0.6659
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0034 0.5898 0.752
Echinococcus granulosus peptide allatostatin:somatostatin 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Brugia malayi hypothetical protein 0.0034 0.5898 0.752
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.5898 0.5898
Echinococcus granulosus orexin receptor type 2 0.0034 0.5898 0.5898
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0034 0.5898 0.6659
Brugia malayi Dopamine receptor protein 1 0.0034 0.5898 0.752
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.5898 0.752
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0034 0.5898 0.6659
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Brugia malayi hypothetical protein 0.0034 0.5898 0.752
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.5898 0.6659
Onchocerca volvulus 0.0034 0.5898 0.5
Echinococcus multilocularis neuropeptide receptor 0.0034 0.5898 0.5898
Loa Loa (eye worm) hypothetical protein 0.0034 0.5898 0.752
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.5898 0.6659
Schistosoma mansoni alpha-1 adrenergic receptor 0.0034 0.5898 0.6659
Brugia malayi G-protein coupled receptor 0.0034 0.5898 0.752

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.3872 Inhibition of NaV1.7 ion channel (unknown origin) ChEMBL. 23177785

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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