Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.008 | 0.2945 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.4841 | 0.378 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.008 | 0.2945 | 0.2945 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2945 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.008 | 0.2945 | 0.2945 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.008 | 0.2945 | 1 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2945 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2945 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.1706 | 0.5793 |
Brugia malayi | hypothetical protein | 0.008 | 0.2945 | 0.1494 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2945 | 0.5 |
Onchocerca volvulus | 0.005 | 0.1706 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.1706 | 0.5793 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.