Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0036 | 0.0724 | 0.5 | |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0178 | 0.6959 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.9122 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0178 | 0.6959 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0178 | 0.6959 | 1 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0178 | 0.6959 | 1 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.007 | 0.2206 | 0.1946 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0105 | 0.3765 | 0.3557 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0036 | 0.0724 | 0.1166 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0036 | 0.0724 | 0.0415 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0036 | 0.0724 | 0.0456 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0178 | 0.6959 | 0.5 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0036 | 0.0724 | 0.0456 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0036 | 0.0724 | 0.044 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0036 | 0.0724 | 0.1166 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0036 | 0.0724 | 0.0415 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0036 | 0.0724 | 0.0415 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0036 | 0.0724 | 0.044 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.007 | 0.2206 | 0.1946 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0724 | 0.5 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.007 | 0.2206 | 0.2065 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0322 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0724 | 0.0456 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0105 | 0.3765 | 0.3557 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.007 | 0.2206 | 0.5472 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0235 | 0.9444 | 0.9425 |
Schistosoma mansoni | tyrosine kinase | 0.0036 | 0.0724 | 0.1166 |
Echinococcus granulosus | tyrosine kinase | 0.0036 | 0.0724 | 0.0415 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0724 | 0.0456 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0105 | 0.3765 | 0.3557 |
Loa Loa (eye worm) | glutamate receptor | 0.0036 | 0.0724 | 0.0456 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0105 | 0.3765 | 0.3557 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0105 | 0.3765 | 0.3557 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0724 | 0.0456 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.0036 | 0.0724 | 0.044 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0036 | 0.0724 | 0.0415 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0036 | 0.0724 | 0.0415 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0026 | 0.0322 | 0.5 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.007 | 0.2206 | 0.1946 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.007 | 0.2206 | 0.1946 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0724 | 0.0456 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Schistosoma mansoni | glutamate receptor AMPA | 0.007 | 0.2206 | 0.5472 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0036 | 0.0724 | 0.0415 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Loa Loa (eye worm) | metabotropic glutamate receptor 8 | 0.0036 | 0.0724 | 0.0456 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0026 | 0.0322 | 0.5 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0235 | 0.9444 | 1 |
Onchocerca volvulus | 0.0036 | 0.0724 | 0.5 | |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.007 | 0.2206 | 0.1946 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.007 | 0.2206 | 0.5472 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.0036 | 0.0724 | 0.5 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0036 | 0.0724 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.8287 | 0.9051 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0724 | 0.0456 |
Schistosoma mansoni | glutamate receptor kainate | 0.007 | 0.2206 | 0.5472 |
Trichomonas vaginalis | cAMP/cGMP cyclic nucleotide phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0036 | 0.0724 | 0.0415 |
Schistosoma mansoni | glutamate receptor AMPA | 0.007 | 0.2206 | 0.5472 |
Echinococcus multilocularis | glutamate receptor 2 | 0.007 | 0.2206 | 0.1946 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0036 | 0.0724 | 1 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0235 | 0.9444 | 0.9425 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0036 | 0.0724 | 0.044 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.007 | 0.2206 | 0.1946 |
Chlamydia trachomatis | glutamine binding protein | 0.0178 | 0.6959 | 0.5 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.007 | 0.2206 | 0.214 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0105 | 0.3765 | 0.3557 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0036 | 0.0724 | 0.1166 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0105 | 0.3765 | 0.3557 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0105 | 0.3765 | 0.3557 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0036 | 0.0724 | 0.0415 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Echinococcus multilocularis | tyrosine kinase | 0.0036 | 0.0724 | 0.0415 |
Schistosoma mansoni | glutamate receptor kainate | 0.007 | 0.2206 | 0.5472 |
Echinococcus multilocularis | NMDA receptor | 0.007 | 0.2206 | 0.1946 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0036 | 0.0724 | 0.0415 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0036 | 0.0724 | 0.044 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0036 | 0.0724 | 0.0415 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0105 | 0.3765 | 1 |
Leishmania major | extracellular receptor, putative | 0.0036 | 0.0724 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.007 | 0.2206 | 0.214 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0036 | 0.0724 | 0.0456 |
Schistosoma mansoni | protein kinase | 0.0036 | 0.0724 | 0.1166 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0036 | 0.0724 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0724 | 0.0456 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0036 | 0.0724 | 0.0456 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0105 | 0.3765 | 0.3557 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0036 | 0.0724 | 0.0415 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.007 | 0.2206 | 0.5472 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.007 | 0.2206 | 0.1946 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0724 | 0.0456 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.007 | 0.2206 | 0.1946 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0724 | 0.0456 |
Trichomonas vaginalis | cGMP-inhibited 3,5-cyclic phosphodiesterase, putative | 0.0026 | 0.0322 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.007 | 0.2206 | 0.2065 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0105 | 0.3765 | 0.3557 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.007 | 0.2206 | 0.1946 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.2206 | 0.5472 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0724 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0724 | 0.0456 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0036 | 0.0724 | 0.0415 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.