Detailed information for compound 1729382

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1412.35 | Formula: C51H44Br6N6O12
  • H donors: 11 H acceptors: 11 LogP: 13.03 Rotable bonds: 24
    Rule of 5 violations (Lipinski): 4
  • SMILES: O/N=C(/C(=O)NCCc1ccc(c(c1)Br)Oc1cc(C/C(=N\O)/C(=O)NCCc2ccc(c(c2)Br)O)cc(c1O)Br)\Cc1cc(Br)c(c(c1)c1cc(C/C(=N\O)/C(=O)NCCc2ccc(c(c2)Br)O)cc(c1O)Br)O
  • InChi: 1S/C51H44Br6N6O12/c52-33-15-25(1-4-42(33)64)7-10-58-49(69)39(61-72)21-28-13-31(46(66)36(55)18-28)32-14-29(19-37(56)47(32)67)22-40(62-73)50(70)60-12-9-27-3-6-44(35(54)17-27)75-45-24-30(20-38(57)48(45)68)23-41(63-74)51(71)59-11-8-26-2-5-43(65)34(53)16-26/h1-6,13-20,24,64-68,72-74H,7-12,21-23H2,(H,58,69)(H,59,71)(H,60,70)/b61-39+,62-40+,63-41+
  • InChiKey: VRWFLNVDDMVVDA-OFMCOEKFSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 4 References
Homo sapiens fms-related tyrosine kinase 4 Starlite/ChEMBL References
Homo sapiens cyclin A1 Starlite/ChEMBL References
Homo sapiens TEK tyrosine kinase, endothelial Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens mitogen-activated protein kinase kinase kinase 8 Starlite/ChEMBL References
Homo sapiens protein tyrosine kinase 2 Starlite/ChEMBL References
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens cyclin A2 References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens insulin receptor Starlite/ChEMBL References
Homo sapiens cyclin D1 Starlite/ChEMBL References
Homo sapiens platelet-derived growth factor receptor, beta polypeptide Starlite/ChEMBL References
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References
Homo sapiens aurora kinase A Starlite/ChEMBL References
Homo sapiens EPH receptor B4 Starlite/ChEMBL References
Homo sapiens polo-like kinase 1 Starlite/ChEMBL References
Homo sapiens MET proto-oncogene, receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens NUAK family, SNF1-like kinase, 1 Starlite/ChEMBL References
Homo sapiens erb-b2 receptor tyrosine kinase 2 Starlite/ChEMBL References
Homo sapiens fms-related tyrosine kinase 3 Starlite/ChEMBL References
Homo sapiens insulin-like growth factor 1 receptor Starlite/ChEMBL References
Homo sapiens polo-like kinase 4 Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Loa Loa (eye worm) CAMK/CAMKL/NUAK protein kinase Get druggable targets OG5_132133 All targets in OG5_132133
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus ephrin type A receptor 4 A Get druggable targets OG5_126715 All targets in OG5_126715
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni ephrin receptor Get druggable targets OG5_126715 All targets in OG5_126715
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/FAK protein kinase Get druggable targets OG5_130513 All targets in OG5_130513
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05109 Eph receptor A8, putative Get druggable targets OG5_126715 All targets in OG5_126715
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) TK/INSR protein kinase Get druggable targets OG5_129857 All targets in OG5_129857
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Serine/threonine-protein kinase PLK4, putative Get druggable targets OG5_134726 All targets in OG5_134726
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Protein tyrosine kinase 2 beta, putative Get druggable targets OG5_130513 All targets in OG5_130513
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_126715 All targets in OG5_126715
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi ephrin receptor 1 precursor Get druggable targets OG5_126715 All targets in OG5_126715
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK4, putative Get druggable targets OG5_134726 All targets in OG5_134726
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126715 All targets in OG5_126715
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR008957,Fibronectin, type III-like fold,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis ephrin type A receptor 4 A Get druggable targets OG5_126715 All targets in OG5_126715
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130513 All targets in OG5_130513
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K04527 insulin receptor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni kinase Get druggable targets OG5_134726 All targets in OG5_134726
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) TK/EPH protein kinase Get druggable targets OG5_126715 All targets in OG5_126715
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126715 All targets in OG5_126715
Echinococcus multilocularis insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis Serine:threonine protein kinase PLK4 Get druggable targets OG5_134726 All targets in OG5_134726
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative Get druggable targets OG5_129857 All targets in OG5_129857
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus Serine:threonine protein kinase PLK4 Get druggable targets OG5_134726 All targets in OG5_134726
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 4 303 aa 312 aa 29.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi polo-like protein kinase, putative 0.0175 0.2659 1
Trichomonas vaginalis CAMK family protein kinase 0.0175 0.2659 1
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0626 0.038
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0412 0.0476
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0111 0.153 0.4658
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0266 0.0308
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0139 0.2021 0.2338
Trichomonas vaginalis cyclin D, putative 0.0059 0.0604 0.0276
Trypanosoma cruzi aurora B kinase, putative 0.0139 0.2021 0.698
Entamoeba histolytica protein kinase domain containing protein 0.0139 0.2021 0.7106
Entamoeba histolytica protein kinase, putative 0.0139 0.2021 0.7106
Schistosoma mansoni tyrosine kinase 0.0319 0.5195 0.5981
Loa Loa (eye worm) SRC-1 0.0059 0.0612 0.0612
Loa Loa (eye worm) hypothetical protein 0.0062 0.0666 0.0666
Echinococcus multilocularis cyclin dependent kinase 0.0056 0.0546 0.0632
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0059 0.0612 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0604 0.0276
Trichomonas vaginalis cyclin B, putative 0.0059 0.0604 0.0276
Trichomonas vaginalis cyclins, putative 0.0111 0.153 0.4658
Trichomonas vaginalis cyclins, putative 0.0059 0.0604 0.0276
Trypanosoma brucei aurora B kinase 0.0139 0.2021 0.698
Entamoeba histolytica cyclin family protein 0.0059 0.0604 0.0683
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.0612 0.0708
Echinococcus granulosus epidermal growth factor receptor 0.0515 0.8645 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0059 0.0604 0.0699
Schistosoma mansoni tyrosine kinase 0.0333 0.5436 0.6263
Schistosoma mansoni cyclin B3 0.0059 0.0604 0.0635
Loa Loa (eye worm) hypothetical protein 0.0041 0.0291 0.0291
Echinococcus granulosus tyrosine protein kinase Src64B 0.0059 0.0612 0.0708
Brugia malayi Protein kinase domain containing protein 0.0056 0.0546 0.0632
Schistosoma mansoni protein kinase 0.0139 0.2021 0.2284
Echinococcus granulosus protein tyrosine kinase 0.0319 0.5195 0.6009
Schistosoma mansoni tyrosine kinase 0.0442 0.7363 0.8506
Loa Loa (eye worm) TK/INSR protein kinase 0.0442 0.7363 0.7363
Echinococcus granulosus cyclin dependent kinase 0.0056 0.0546 0.0632
Echinococcus multilocularis aurora kinase A 0.0139 0.2021 0.2338
Brugia malayi ephrin receptor 1 precursor 0.0046 0.0381 0.044
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0449 0.7483 0.8656
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0056 0.0546 0.0546
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0059 0.0612 0.0708
Brugia malayi serine/threonine-protein kinase plk-2 0.0175 0.2659 0.3076
Echinococcus granulosus tyrosine protein kinase Blk 0.0055 0.0534 0.0618
Trichomonas vaginalis cyclin B, putative 0.0111 0.153 0.4658
Trypanosoma cruzi cyclin, putative 0.0111 0.153 0.4658
Trichomonas vaginalis cyclin B, putative 0.0111 0.153 0.4658
Echinococcus granulosus cyclins 0.0059 0.0604 0.0699
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.0612 0.0708
Loa Loa (eye worm) hypothetical protein 0.0066 0.0727 0.0727
Leishmania major cyclin 0.0111 0.153 0.4658
Schistosoma mansoni kinase 0.0254 0.4039 0.4636
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0059 0.0612 0.0708
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0546 0.0567
Schistosoma mansoni tyrosine kinase 0.0348 0.5704 0.6575
Schistosoma mansoni tyrosine kinase 0.0036 0.0207 0.0172
Echinococcus multilocularis neuroglian 0.0051 0.0456 0.0527
Schistosoma mansoni cyclin B 0.0111 0.153 0.1713
Echinococcus granulosus cyclin dependent kinase 5 0.0056 0.0546 0.0632
Echinococcus multilocularis cyclins 0.0059 0.0604 0.0699
Echinococcus multilocularis cyclins 0.0059 0.0604 0.0699
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0028 0.0059 0.0069
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0059 0.0059
Echinococcus granulosus roundabout 2 0.0069 0.0786 0.091
Brugia malayi Furin-like cysteine rich region family protein 0.0515 0.8645 1
Echinococcus multilocularis neuroglian 0.0028 0.0059 0.0069
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0055 0.0534 0.0618
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0348 0.5704 0.6599
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0059 0.0069
Loa Loa (eye worm) hypothetical protein 0.0048 0.0412 0.0412
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.0612 0.0708
Echinococcus multilocularis roundabout 2 0.0028 0.0059 0.0069
Brugia malayi Protein kinase domain containing protein 0.0323 0.5258 0.6083
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0056 0.0546 0.0546
Echinococcus granulosus ephrin type A receptor 4 A 0.0097 0.1272 0.1472
Giardia lamblia Kinase, PLK 0.0175 0.2659 1
Entamoeba histolytica cyclin, putative 0.0059 0.0604 0.0683
Onchocerca volvulus 0.0111 0.153 0.1364
Echinococcus granulosus contactin 0.0028 0.0059 0.0069
Giardia lamblia Cyclin A 0.0059 0.0604 0.0276
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0059 0.0612 0.0708
Echinococcus granulosus aurora kinase A 0.0139 0.2021 0.2338
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0139 0.2021 0.7106
Echinococcus granulosus cyclins 0.0059 0.0604 0.0699
Loa Loa (eye worm) TK/FAK protein kinase 0.0323 0.5258 0.5258
Loa Loa (eye worm) hypothetical protein 0.0048 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0172 0.2606 0.2606
Trichomonas vaginalis CAMK family protein kinase 0.0175 0.2659 1
Echinococcus multilocularis roundabout 2 0.0069 0.0786 0.091
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0534 0.0618
Trichomonas vaginalis AGC family protein kinase 0.0139 0.2021 0.698
Echinococcus granulosus roundabout 2 0.0028 0.0059 0.0069
Schistosoma mansoni tyrosine kinase 0.0059 0.0612 0.0644
Trichomonas vaginalis AGC family protein kinase 0.0139 0.2021 0.698
Loa Loa (eye worm) hypothetical protein 0.0052 0.049 0.049
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0056 0.0546 0.0546
Loa Loa (eye worm) AUR protein kinase 0.0139 0.2021 0.2021
Brugia malayi Immunoglobulin I-set domain containing protein 0.0443 0.7386 0.8543
Brugia malayi serine/threonine kinase 12 0.0139 0.2021 0.2338
Echinococcus granulosus epidermal growth factor receptor 0.0348 0.5704 0.6599
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0449 0.7483 0.8656
Echinococcus multilocularis tyrosine protein kinase Srms 0.0055 0.0534 0.0618
Trypanosoma brucei polo-like protein kinase 0.0175 0.2659 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0059 0.0604 0.0604
Echinococcus granulosus cyclin B3 1 0.0059 0.0604 0.0699
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0612 0.0708
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0032 0.0132 0.0132
Echinococcus multilocularis cyclin dependent kinase 1 0.0056 0.0546 0.0632
Brugia malayi Protein kinase domain containing protein 0.0442 0.7363 0.8517
Loa Loa (eye worm) hypothetical protein 0.0111 0.153 0.153
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0612 0.0708
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0053 0.0501 0.058
Echinococcus granulosus cyclins 0.0059 0.0604 0.0699
Trichomonas vaginalis cyclins, putative 0.0111 0.153 0.4658
Entamoeba histolytica cyclin family protein 0.0059 0.0604 0.0683
Echinococcus multilocularis cyclins 0.0059 0.0604 0.0699
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.2021 0.2284
Echinococcus granulosus cyclin b3 0.0059 0.0604 0.0699
Echinococcus multilocularis roundabout 2 0.0028 0.0059 0.0069
Brugia malayi serine/threonine protein kinase 6 0.0139 0.2021 0.2338
Plasmodium falciparum cyclin 0.0059 0.0604 0.0396
Echinococcus multilocularis cyclin b3 0.0059 0.0604 0.0699
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0059 0.0069
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0175 0.2659 0.3076
Giardia lamblia G2/mitotic-specific cyclin B 0.0111 0.153 0.4658
Trypanosoma cruzi polo-like protein kinase, putative 0.0175 0.2659 1
Brugia malayi Fibronectin type III domain containing protein 0.0048 0.0412 0.0476
Echinococcus granulosus cyclins 0.0059 0.0604 0.0699
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0138 0.2007 0.2321
Brugia malayi Cyclin, N-terminal domain containing protein 0.0111 0.153 0.177
Entamoeba histolytica cell division protein kinase 2, putative 0.0056 0.0546 0.0418
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0028 0.0059 0.0069
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0138 0.2007 0.2321
Entamoeba histolytica cyclin, putative 0.0111 0.153 0.4881
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0175 0.2659 0.3076
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0139 0.2021 0.2338
Loa Loa (eye worm) TK protein kinase 0.005 0.0454 0.0454
Schistosoma mansoni tyrosine kinase 0.0515 0.8645 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0041 0.0291 0.0337
Echinococcus granulosus cyclin B 0.0111 0.153 0.177
Schistosoma mansoni cell adhesion molecule 0.006 0.0622 0.0655
Echinococcus multilocularis protein tyrosine kinase 0.0319 0.5195 0.6009
Onchocerca volvulus Serine\/threonine kinase homolog 0.0175 0.2659 0.3282
Schistosoma mansoni tyrosine kinase 0.0348 0.5704 0.6575
Echinococcus multilocularis epidermal growth factor receptor 0.0515 0.8645 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0175 0.2659 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0056 0.0546 0.1155
Echinococcus granulosus cyclins 0.0059 0.0604 0.0699
Schistosoma mansoni tyrosine kinase 0.0442 0.7363 0.8506
Brugia malayi protein-tyrosine kinase 0.0055 0.0534 0.0618
Echinococcus granulosus tyrosine protein kinase HCK 0.005 0.0454 0.0525
Trichomonas vaginalis AGC family protein kinase 0.0139 0.2021 0.698
Echinococcus multilocularis cyclins 0.0059 0.0604 0.0699
Echinococcus multilocularis cyclins 0.0059 0.0604 0.0699
Trichomonas vaginalis CAMK family protein kinase 0.0175 0.2659 1
Onchocerca volvulus Tyrosine kinase homolog 0.04 0.6613 1
Giardia lamblia Hypothetical protein 0.0059 0.0604 0.0276
Trypanosoma cruzi CYC2-like cyclin, putative 0.0111 0.153 0.4658
Entamoeba histolytica protein kinase , putative 0.0139 0.2021 0.7106
Brugia malayi SRC-1 0.0059 0.0612 0.0708
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0028 0.0059 0.0069
Toxoplasma gondii aurora kinase 0.0139 0.2021 1
Schistosoma mansoni tyrosine kinase 0.0333 0.5436 0.6263
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0546 0.0567
Echinococcus multilocularis cyclin B 0.0111 0.153 0.177
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0266 0.0308
Schistosoma mansoni cyclins 0.0059 0.0604 0.0635
Trichomonas vaginalis cyclin B, putative 0.0111 0.153 0.4658
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0028 0.0059 0.0069
Echinococcus multilocularis tyrosine protein kinase HCK 0.005 0.0454 0.0525
Loa Loa (eye worm) AUR protein kinase 0.0139 0.2021 0.2021
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0028 0.0059 0.0069
Brugia malayi Cyclin, N-terminal domain containing protein 0.0059 0.0604 0.0699
Brugia malayi cell division control protein 2 homolog 0.0056 0.0546 0.0632
Echinococcus multilocularis cyclin dependent kinase 1 0.0056 0.0546 0.0632
Brugia malayi Protein kinase domain containing protein 0.0188 0.2875 0.3325
Echinococcus granulosus Immunoglobulin 0.0041 0.0291 0.0337
Schistosoma mansoni tyrosine kinase 0.0059 0.0612 0.0644
Trichomonas vaginalis CAMK family protein kinase 0.0175 0.2659 1
Schistosoma mansoni nephrin 0.0057 0.0576 0.0602
Trichomonas vaginalis CAMK family protein kinase 0.0175 0.2659 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0291 0.0291
Trichomonas vaginalis cyclins, putative 0.0067 0.0741 0.0924
Loa Loa (eye worm) TK/EPH protein kinase 0.0099 0.1314 0.1314
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0626 0.038
Echinococcus multilocularis Immunoglobulin 0.0041 0.0291 0.0337
Trichomonas vaginalis CAMK family protein kinase 0.0175 0.2659 1
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0139 0.2021 0.7106
Loa Loa (eye worm) hypothetical protein 0.0111 0.153 0.153
Trichomonas vaginalis cyclin B, putative 0.0111 0.153 0.4658
Echinococcus granulosus defective proboscis extension response 0.0041 0.0291 0.0337
Loa Loa (eye worm) hypothetical protein 0.0041 0.0291 0.0291
Entamoeba histolytica cell division protein kinase 2, putative 0.0056 0.0546 0.0418
Schistosoma mansoni ephrin receptor 0.0081 0.0995 0.109
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0612 0.0708
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0059 0.0612 0.0708
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0059 0.0069
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0059 0.0612 0.0708
Loa Loa (eye worm) hypothetical protein 0.0053 0.0501 0.0501
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0139 0.2021 0.7106
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0041 0.0291 0.027
Schistosoma mansoni tyrosine kinase 0.0333 0.5436 0.6263
Echinococcus granulosus tyrosine protein kinase Src42A 0.0059 0.0612 0.0708
Echinococcus granulosus neuroglian 0.0028 0.0059 0.0069
Schistosoma mansoni vesicular amine transporter 0.0041 0.0291 0.027
Loa Loa (eye worm) hypothetical protein 0.0052 0.0474 0.0474
Echinococcus multilocularis epidermal growth factor receptor 0.0348 0.5704 0.6599
Echinococcus granulosus tyrosine protein kinase Lyn 0.0063 0.0684 0.0792
Trypanosoma cruzi cyclin, putative 0.0111 0.153 0.4658
Echinococcus granulosus insulin receptor 0.0442 0.7363 0.8517
Echinococcus multilocularis tyrosine protein kinase Blk 0.0055 0.0534 0.0618
Echinococcus multilocularis cyclins 0.0059 0.0604 0.0699
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0175 0.2659 0.2659
Plasmodium falciparum serine/threonine protein kinase, putative 0.0139 0.2021 1
Leishmania major protein kinase, putative 0.0139 0.2021 0.698
Loa Loa (eye worm) TK/EGFR protein kinase 0.0515 0.8645 0.8645
Brugia malayi hypothetical protein 0.0048 0.0412 0.0476
Echinococcus granulosus tyrosine kinase 0.0055 0.0534 0.0618
Trypanosoma brucei mitotic cyclin 6 0.0111 0.153 0.4658
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.2659 0.3028
Loa Loa (eye worm) AUR protein kinase 0.0139 0.2021 0.2021
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0056 0.0546 0.0632
Loa Loa (eye worm) TK protein kinase 0.0055 0.0534 0.0534
Echinococcus multilocularis cyclin B3 1 0.0059 0.0604 0.0699
Loa Loa (eye worm) hypothetical protein 0.0038 0.0233 0.0233
Onchocerca volvulus 0.0375 0.6181 0.9265
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0139 0.2021 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0666 0.0666
Echinococcus granulosus neuroglian 0.0051 0.0456 0.0527
Trypanosoma cruzi cyclin 6, putative 0.0111 0.153 0.4658
Echinococcus multilocularis cyclins 0.0059 0.0604 0.0699
Brugia malayi Cyclin, N-terminal domain containing protein 0.0111 0.153 0.177
Loa Loa (eye worm) hypothetical protein 0.0048 0.0412 0.0412
Echinococcus multilocularis ephrin type A receptor 4 A 0.0097 0.1272 0.1472
Loa Loa (eye worm) hypothetical protein 0.0028 0.0059 0.0059
Trichomonas vaginalis cyclin A, putative 0.0111 0.153 0.4658
Trichomonas vaginalis cyclin D, putative 0.0059 0.0604 0.0276
Giardia lamblia Aurora kinase 0.0139 0.2021 0.698
Echinococcus multilocularis 0.0153 0.2261 0.2615
Trichomonas vaginalis AGC family protein kinase 0.0139 0.2021 0.698
Trichomonas vaginalis cyclin B3, putative 0.0059 0.0604 0.0276
Trichomonas vaginalis cyclins, putative 0.0111 0.153 0.4658
Entamoeba histolytica protein kinase, putative 0.0139 0.2021 0.7106
Trichomonas vaginalis CAMK family protein kinase 0.0175 0.2659 1
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0041 0.0291 0.027
Brugia malayi serine/threonine-protein kinase 6 0.0139 0.2021 0.2338
Echinococcus granulosus roundabout 2 0.0028 0.0059 0.0069
Echinococcus multilocularis Immunoglobulin 0.0041 0.0291 0.0337
Echinococcus multilocularis insulin receptor 0.0442 0.7363 0.8517
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0175 0.2659 1
Trichomonas vaginalis cyclins, putative 0.0111 0.153 0.4658
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0443 0.7386 0.7386
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0059 0.0604 0.0699
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0059 0.0612 0.0708
Echinococcus granulosus twitchin 0.0055 0.0528 0.0611
Echinococcus multilocularis cyclin dependent kinase 5 0.0056 0.0546 0.0632
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0059 0.0612 0.0708
Echinococcus granulosus cyclin dependent kinase 1 0.0056 0.0546 0.0632

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.6 uM Inhibition of EGFR (unknown origin) ChEMBL. 23249297
IC50 (binding) = 0.6 uM Inhibition of TIE2 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 0.6 uM Inhibition of VEGFR2 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 0.7 uM Inhibition of SAK (unknown origin) ChEMBL. 23249297
IC50 (binding) = 0.7 uM Inhibition of SRC (unknown origin) ChEMBL. 23249297
IC50 (binding) = 0.8 uM Inhibition of MET (unknown origin) ChEMBL. 23249297
IC50 (binding) = 1 uM Inhibition of IGF1R (unknown origin) ChEMBL. 23249297
IC50 (binding) = 1.3 uM Inhibition of COT (unknown origin) ChEMBL. 23249297
IC50 (binding) = 1.4 uM Inhibition of CDK4/cyclin-D1 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 1.4 uM Inhibition of FLT3 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 1.4 uM Inhibition of INSR (unknown origin) ChEMBL. 23249297
IC50 (binding) = 1.6 uM Inhibition of VEGFR3 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 1.7 uM Inhibition of ARK5 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 2.1 uM Inhibition of ERBB2 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 2.3 uM Inhibition of aurora-B (unknown origin) ChEMBL. 23249297
IC50 (binding) = 2.6 uM Inhibition of aurora-A (unknown origin) ChEMBL. 23249297
IC50 (binding) = 3.4 uM Inhibition of EPHB4 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 3.5 uM Inhibition of FAK (unknown origin) ChEMBL. 23249297
IC50 (binding) = 4 uM Inhibition of PDGFR-beta (unknown origin) ChEMBL. 23249297
IC50 (binding) = 6.4 uM Inhibition of PLK1 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 6.5 uM Inhibition of CDK2/cyclin-A (unknown origin) ChEMBL. 23249297

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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