Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.1164 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1164 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.1128 | 0.4144 | 0.5551 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1164 | 0.4337 | 0.581 |
Mycobacterium ulcerans | polyketide synthase | 0.1236 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0952 | 0.3185 | 0.4267 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.077 | 0.2195 | 0.2941 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.1164 | 0.4337 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.077 | 0.2195 | 0.2941 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.077 | 0.2195 | 0.2941 |
Mycobacterium ulcerans | polyketide synthase | 0.1164 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.1236 | 0.473 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.1164 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1236 | 0.473 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.1236 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.1128 | 0.4144 | 0.5551 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1164 | 0.4337 | 0.581 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0755 | 0.2116 | 0.2574 |
Mycobacterium ulcerans | thioesterase | 0.097 | 0.3283 | 0.4398 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.1236 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0836 | 0.2556 | 0.3424 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.097 | 0.3283 | 0.4398 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.1087 | 0.3922 | 0.3889 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1164 | 0.4337 | 0.581 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.1236 | 0.473 | 0.6337 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.2098 | 0.9413 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1236 | 0.473 | 0.6337 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.1236 | 0.473 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1164 | 0.4337 | 0.581 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.1164 | 0.4337 | 0.0684 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1236 | 0.473 | 0.6337 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0936 | 0.3102 | 0.4155 |
Echinococcus multilocularis | neuropeptide receptor | 0.1463 | 0.5963 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0828 | 0.2515 | 0.3708 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0471 | 0.0571 | 0.0765 |
Loa Loa (eye worm) | fatty acid synthase | 0.1148 | 0.4253 | 0.4318 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0936 | 0.3102 | 0.4155 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.1463 | 0.5963 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1955 | 0.8637 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1164 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.1087 | 0.3922 | 0.5254 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.1236 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0662 | 0.1609 | 0.2155 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.097 | 0.3283 | 0.4398 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1739 | 0.7465 | 1 |
Onchocerca volvulus | 0.2026 | 0.9021 | 0.9285 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0936 | 0.3102 | 0.4155 |
Loa Loa (eye worm) | hypothetical protein | 0.0652 | 0.1557 | 0.0823 |
Mycobacterium ulcerans | thioesterase TesA | 0.097 | 0.3283 | 0.4398 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1739 | 0.7465 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1739 | 0.7465 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1739 | 0.7465 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.1463 | 0.5963 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.1463 | 0.5963 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.04 | 0.0188 | 0.0251 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 500 ug ml-1 | Antifungal activity against Candida albicans RCMB 05035 assessed as growth inhibition after 48 hrs by twofold serial dilution method | ChEMBL. | 23357308 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.