Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.3182 | 0.3182 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0026 | 0.3182 | 0.3182 |
Echinococcus granulosus | cathepsin l1 | 0.0026 | 0.3182 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.3182 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0026 | 0.3182 | 0.3182 |
Brugia malayi | cathepsin L-like precursor | 0.0026 | 0.3182 | 0.3182 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0026 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.3182 | 0.3182 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0026 | 0.3182 | 0.3182 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 30.71 umol/L | Inhibition of Electrophorus electricus AChE using acetylthiocholine as substrate after 10 mins by Ellman's method | ChEMBL. | 23462716 |
IC50 (binding) | = 43.95 umol/L | Inhibition of equine BChE using after 10 mins by Ellman's method | ChEMBL. | 23462716 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.