Detailed information for compound 1730356

Basic information

Technical information
  • TDR Targets ID: 1730356
  • Name: 2-hydroxy-6-[(E)-2-phenylethenyl]benzoic acid
  • MW: 240.254 | Formula: C15H12O3
  • H donors: 2 H acceptors: 3 LogP: 3.91 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1c(cccc1O)/C=C/c1ccccc1
  • InChi: 1S/C15H12O3/c16-13-8-4-7-12(14(13)15(17)18)10-9-11-5-2-1-3-6-11/h1-10,16H,(H,17,18)/b10-9+
  • InChiKey: YZDMGNJPLDORQM-MDZDMXLPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-hydroxy-6-[(E)-2-phenylvinyl]benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0028 0.0073 0.0244
Schistosoma mansoni transient receptor potential channel 4 0.0279 0.1718 0.3728
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0235 0.0462
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0317 0.0691
Loa Loa (eye worm) RNA binding protein 0.0062 0.0299 0.0994
Echinococcus granulosus short transient receptor potential channel 6 0.0184 0.1099 0.2406
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0057 0.0267 0.0582
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0054 0.0174
Echinococcus granulosus smad 0.0032 0.0103 0.0223
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0235 0.0462
Plasmodium falciparum ataxin-2 like protein, putative 0.0046 0.0191 0.1009
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0057 0.0267 0.0582
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0176 0.0425
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0073 0.0157
Loa Loa (eye worm) hypothetical protein 0.0052 0.0235 0.078
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0317 0.5741
Brugia malayi ecdysone receptor 0.0025 0.0054 0.0179
Schistosoma mansoni cpg binding protein 0.0057 0.0267 0.0532
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0239
Schistosoma mansoni transient receptor potential channel 0.0279 0.1718 0.3728
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0176 0.0425
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0054 0.0157
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0299 0.0603
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1449 0.9386 0.9384
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0235 0.0784
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0138 0.0298
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0054 0.0174
Loa Loa (eye worm) hypothetical protein 0.0046 0.0191 0.0631
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0235 0.0512
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0235 0.0462
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1555 1
Schistosoma mansoni alpha glucosidase 0.0034 0.0115 0.0197
Brugia malayi conserved hypotetical protein 0.0025 0.0054 0.0179
Echinococcus multilocularis Smad4 0.0032 0.0103 0.0223
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0199 0.0433
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0235 0.0784
Echinococcus multilocularis short transient receptor potential channel 6 0.0184 0.1099 0.2406
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0317 0.5741
Brugia malayi nuclear hormone receptor 0.0025 0.0054 0.0179
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0235 0.0462
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0317 0.1051
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0034 0.0115 0.1754
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0777 0.17
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0024
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0073 0.0239
Schistosoma mansoni alpha-glucosidase 0.0132 0.0759 0.1615
Echinococcus multilocularis cpg binding protein 0.0057 0.0267 0.0582
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0025 0.0054 0.0114
Loa Loa (eye worm) hypothetical protein 0.0101 0.0556 0.185
Loa Loa (eye worm) DR-78 0.0025 0.0054 0.0174
Schistosoma mansoni smad1 5 8 and 0.0032 0.0103 0.0171
Echinococcus multilocularis short transient receptor potential channel 6 0.0184 0.1099 0.2406
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0299 0.0603
Echinococcus granulosus short transient receptor potential channel 6 0.0184 0.1099 0.2406
Leishmania major hypothetical protein, conserved 0.0046 0.0191 0.3253
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0317 0.523
Echinococcus multilocularis GPCR, family 2 0.0047 0.0199 0.0433
Brugia malayi hypothetical protein 0.0028 0.0073 0.0244
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1555 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0299 0.0603
Toxoplasma gondii aldehyde dehydrogenase 0.0057 0.0267 0.3209
Echinococcus granulosus tar DNA binding protein 0.0062 0.0299 0.0653
Schistosoma mansoni smad 0.0032 0.0103 0.0171
Schistosoma mansoni transcription factor btf3 0.0098 0.0532 0.1115
Brugia malayi MH2 domain containing protein 0.0032 0.0103 0.0344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0777 0.1656
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0556 0.1853
Loa Loa (eye worm) hypothetical protein 0.0052 0.0235 0.078
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0073 0.0104
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0235 0.0512
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0235 0.0512
Loa Loa (eye worm) hypothetical protein 0.0052 0.0235 0.078
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0235 0.078
Loa Loa (eye worm) nuclear factor I 0.0018 0.0009 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0777 0.1656
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0235 0.0784
Schistosoma mansoni hypothetical protein 0.0713 0.4564 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0267 0.5019
Brugia malayi nuclear hormone receptor 0.0052 0.0235 0.0784
Schistosoma mansoni nuclear receptor 0.0025 0.0054 0.0061
Echinococcus multilocularis transcription factor btf3 0.0098 0.0532 0.1163
Brugia malayi Transient-receptor-potential like protein 0.0104 0.0571 0.1902
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0235 0.0784
Loa Loa (eye worm) hypothetical protein 0.0052 0.0235 0.078
Loa Loa (eye worm) transcription factor SMAD2 0.0474 0.3001 1
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1555 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.1555 0.5181
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0235 0.0784
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0199 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0235 0.0784
Schistosoma mansoni cpg binding protein 0.0057 0.0267 0.0532
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0115 0.0645 0.1365
Echinococcus granulosus microtubule associated protein 2 0.0599 0.3819 0.8368
Schistosoma mansoni hypothetical protein 0.0047 0.0199 0.0382
Schistosoma mansoni coup transcription factor 0.0052 0.0235 0.0462
Echinococcus multilocularis lysosomal alpha glucosidase 0.0154 0.0899 0.1967
Onchocerca volvulus 0.0285 0.1761 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0054 0.0179
Brugia malayi nuclear receptor RXR 0.0025 0.0054 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0235 0.0784
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0103 0.0223
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0317 0.523
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0532 0.2895
Plasmodium falciparum basic transcription factor 3b, putative 0.0098 0.0532 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0054 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0115 0.0764
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0235 0.0512
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0235 0.1204
Loa Loa (eye worm) CXXC zinc finger family protein 0.0054 0.0247 0.0818
Echinococcus granulosus TRP transient receptor potential channel 0.0104 0.0571 0.1248
Brugia malayi steroid hormone receptor 0.0052 0.0235 0.0784
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0777 0.17
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0054 0.0061
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.0235 0.0512
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0103 0.0223
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0235 0.0512
Trypanosoma brucei glucosidase, putative 0.0034 0.0115 0.0764
Trypanosoma brucei transcription factor BTF3, putative 0.0098 0.0532 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0239
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0199 0.0433
Schistosoma mansoni transient receptor potential channel 0.0184 0.1099 0.2366
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0153 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0267 0.5019
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0983 0.6027
Brugia malayi MH1 domain containing protein 0.0018 0.0009 0.0029
Echinococcus granulosus neutral alpha glucosidase AB 0.0034 0.0115 0.0249
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0235 0.078
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0235 0.1204
Toxoplasma gondii NAC domain-containing protein 0.0098 0.0532 0.8804
Loa Loa (eye worm) hypothetical protein 0.0094 0.051 0.1695
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0174
Brugia malayi MH1 domain containing protein 0.0032 0.0103 0.0344
Leishmania major basic transcription factor 3a, putative 0.0098 0.0532 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0777 0.17
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0983 0.6027
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0532 0.2895
Brugia malayi Glycosyl hydrolases family 31 protein 0.0034 0.0115 0.0383
Echinococcus multilocularis geminin 0.0713 0.4564 1
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0235 0.0462
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0054 0.0114
Entamoeba histolytica transcription factor BTF3, putative 0.0098 0.0532 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0046 0.0191 0.2443
Echinococcus granulosus Smad4 0.0032 0.0103 0.0223
Brugia malayi Glycosyl hydrolases family 31 protein 0.0154 0.0899 0.2996
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0054 0.0179
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0026 0.0088
Schistosoma mansoni nuclear receptor 0.0025 0.0054 0.0061
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1555 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0299 0.0994
Leishmania major alpha glucosidase II subunit, putative 0.0034 0.0115 0.1754
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0025 0.0054 0.0114
Schistosoma mansoni smad1 5 8 and 0.0032 0.0103 0.0171
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1555 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0174
Onchocerca volvulus 0.0052 0.0235 0.1204
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0983 0.6027
Brugia malayi TAR-binding protein 0.0062 0.0299 0.0998
Echinococcus multilocularis neutral alpha glucosidase AB 0.0034 0.0115 0.0249
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0054 0.0061
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0235 0.0462
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0235 0.0512
Echinococcus multilocularis lysosomal alpha glucosidase 0.0154 0.0899 0.1967
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0174
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0235 0.0512
Brugia malayi beta-NAC-like protein 0.0098 0.0532 0.1772
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0176 0.1294
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0054 0.0114
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0235 0.0512
Mycobacterium leprae Conserved hypothetical protein 0.055 0.3494 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.0588 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.086 0.1882
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0235 0.078
Echinococcus multilocularis microtubule associated protein 2 0.0599 0.3819 0.8368
Echinococcus multilocularis transient receptor potential ion channel A 0.0269 0.1657 0.3628
Echinococcus multilocularis smad 0.0032 0.0103 0.0223
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0864 0.2879
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0235 0.0512
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0154 0.0899 0.2993
Brugia malayi hypothetical protein 0.0029 0.0085 0.0282
Brugia malayi ecdysteroid receptor 0.0052 0.0235 0.0784
Echinococcus granulosus thyroid hormone receptor alpha 0.0025 0.0054 0.0114
Loa Loa (eye worm) hypothetical protein 0.0052 0.0235 0.078
Loa Loa (eye worm) hypothetical protein 0.0285 0.1761 0.5867
Chlamydia trachomatis recombinase RecA 0.0094 0.0506 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0235 0.0462
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0057 0.0267 0.0241
Onchocerca volvulus 0.0054 0.0247 0.1271
Brugia malayi hypothetical protein 0.0046 0.0191 0.0636
Brugia malayi Smad1 0.0032 0.0103 0.0344
Echinococcus granulosus transcription factor btf3 0.0098 0.0532 0.1163
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0235 0.0784
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0235 0.0462
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0054 0.0179
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0199 0.0433
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0235 0.0462
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1041 0.6435
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0235 0.0784
Brugia malayi nuclear receptor NHR-67 0.0025 0.0054 0.0179
Schistosoma mansoni Smad4 0.0032 0.0103 0.0171
Schistosoma mansoni zinc finger protein 0.0025 0.0054 0.0061
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0317 0.523
Schistosoma mansoni hypothetical protein 0.0047 0.0199 0.0382
Echinococcus granulosus lysosomal alpha glucosidase 0.0154 0.0899 0.1967
Brugia malayi RNA binding protein 0.0062 0.0299 0.0998
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0026 0.0088
Brugia malayi tailless protein 0.0025 0.0054 0.0179
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0199 0.0433
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1041 0.6435
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0299 0.0994
Echinococcus multilocularis nuclear receptor nhr 48 0.0025 0.0054 0.0114
Toxoplasma gondii LsmAD domain-containing protein 0.0046 0.0191 0.1601
Treponema pallidum recombinase A 0.0094 0.0506 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0073 0.0244
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0174
Entamoeba histolytica hypothetical protein 0.0098 0.0532 1
Schistosoma mansoni alpha-glucosidase 0.0132 0.0759 0.1615
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0054 0.0179
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0073 0.0244
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0174
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0174
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0235 0.0512
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0235 0.078
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0317 0.0641
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0025 0.0054 0.0114
Plasmodium vivax ataxin-2 like protein, putative 0.0046 0.0191 0.0409
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0054 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0235 0.078
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.0833 0.1822
Plasmodium falciparum ataxin-2 like protein, putative 0.0046 0.0191 0.1009
Echinococcus granulosus cpg binding protein 0.0057 0.0267 0.0582
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0267 0.0532
Echinococcus granulosus nuclear receptor nhr 48 0.0025 0.0054 0.0114
Brugia malayi nuclear receptor NHR-88 0.0025 0.0054 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0235 0.0784
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0235 0.0784
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0983 0.5512
Brugia malayi MH2 domain containing protein 0.0474 0.3001 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0235 0.0784
Schistosoma mansoni hypothetical protein 0.0713 0.4564 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0279 0.1718 0.3761
Brugia malayi nuclear receptor NHR-88 0.0052 0.0235 0.0784
Schistosoma mansoni cpg binding protein 0.0054 0.0247 0.0487
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0299 0.0603
Schistosoma mansoni smad1 5 8 and 0.0032 0.0103 0.0171
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.086 0.2866
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0103 0.0223
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0103 0.0171
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0235 0.0512
Loa Loa (eye worm) hypothetical protein 0.0279 0.1718 0.5722
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0983 0.6027
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0239
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0176 0.0383
Loa Loa (eye worm) hypothetical protein 0.0052 0.0235 0.078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0777 0.17
Loa Loa (eye worm) acetyltransferase 0.0148 0.086 0.2863
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0083
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0094 0.0506 0.1382
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0054 0.0061
Onchocerca volvulus 0.0089 0.0474 0.2581
Trypanosoma cruzi PAB1-binding protein , putative 0.0046 0.0191 0.2443
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0054 0.0174
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0235 0.0784
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.1555 0.5178
Loa Loa (eye worm) ICD-1 protein 0.0098 0.0532 0.1768
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0153 0.2496
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0174
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0864 0.2879
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0235 0.078
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0235 0.1204
Brugia malayi hypothetical protein 0.0025 0.0054 0.0179
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0054 0.0157
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0235 0.0512
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0115 0.0764
Brugia malayi MH2 domain containing protein 0.0032 0.0103 0.0344
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0174
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0034 0.0115 0.1754
Schistosoma mansoni transient receptor potential channel 0.0184 0.1099 0.2366
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0235 0.078
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0235 0.0784
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0267 0.0532
Mycobacterium ulcerans recombinase A 0.0094 0.0506 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0199 0.0659
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0299 0.0603
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0094 0.0506 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0235 0.0462
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0103 0.034
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0083
Plasmodium vivax basic transcription factor 3b, putative 0.0098 0.0532 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0317 0.0691
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0138 0.0298
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0299 0.0653
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0239
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0104 0.0571 0.1248
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.086 0.1838
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0235 0.0512
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0864 0.2875
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0176 0.1294
Schistosoma mansoni hypothetical protein 0.0047 0.0199 0.0382
Loa Loa (eye worm) hypothetical protein 0.0104 0.0571 0.1898
Trypanosoma cruzi transcription factor btf3, putative 0.0098 0.0532 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0083
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0026 0.0088
Echinococcus granulosus GPCR family 2 0.0047 0.0199 0.0433
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.0777 0.259
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0983 0.6027
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0983 0.6027
Loa Loa (eye worm) MH2 domain-containing protein 0.0474 0.3001 1
Brugia malayi MH1 domain containing protein 0.0032 0.0103 0.0344
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0103 0.034
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0235 0.0512
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0054 0.0114
Schistosoma mansoni microtubule-associated protein tau 0.0599 0.3819 0.8359
Brugia malayi hypothetical protein 0.0025 0.0054 0.0179
Trypanosoma cruzi transcription factor btf3, putative 0.0098 0.0532 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0235 0.0512
Loa Loa (eye worm) hypothetical protein 0.0052 0.0235 0.078
Loa Loa (eye worm) Smad1 0.0032 0.0103 0.034
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0235 0.0462
Brugia malayi CXXC zinc finger family protein 0.0054 0.0247 0.0823
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0054 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0235 0.078
Brugia malayi nuclear receptor RXR 0.0028 0.0073 0.0244
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0199 0.0664
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0054 0.0179
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1555 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0054 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0235 0.0784
Onchocerca volvulus 0.0025 0.0054 0.0157
Schistosoma mansoni hypothetical protein 0.0047 0.0199 0.0382
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0054 0.0061
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0034 0.0115 0.0379
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0235 0.0784
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0103 0.0223
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0057 0.0267 0.4759
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0235 0.0462
Brugia malayi hypothetical protein 0.0285 0.1761 0.5869
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0073 0.0157
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0299 0.0998
Echinococcus granulosus transient receptor potential ion channel A 0.0269 0.1657 0.3628
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0317 0.1055
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0073 0.0104
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0239
Loa Loa (eye worm) hypothetical protein 0.0175 0.1038 0.3457
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0777 0.1656
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.002 0.0026 0.0053
Brugia malayi MH1 domain containing protein 0.0018 0.0009 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0532 0.2895
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0235 0.0512
Echinococcus granulosus geminin 0.0713 0.4564 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0659
Loa Loa (eye worm) hypothetical protein 0.0148 0.0864 0.2875
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.0777 0.2586
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0983 0.6027
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0235 0.0512
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0267 0.5019
Loa Loa (eye worm) hypothetical protein 0.0052 0.0235 0.078
Onchocerca volvulus 0.0025 0.0054 0.0157
Schistosoma mansoni hypothetical protein 0.0101 0.0556 0.1169
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0054 0.0179
Trypanosoma brucei PAB1-binding protein , putative 0.0046 0.0191 0.2443
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.002 0.0026 0.0053
Echinococcus granulosus transient receptor potential gamma protein 0.0279 0.1718 0.3761

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) > 100 uM Cytotoxicity against human HepG2 cells after 24 hrs by resazurin assay ChEMBL. 23416004

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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