Detailed information for compound 1730476

Basic information

Technical information
  • TDR Targets ID: 1730476
  • Name: 2-bromo-5-(2-bromo-2-nitroethenyl)furan
  • MW: 296.901 | Formula: C6H3Br2NO3
  • H donors: 0 H acceptors: 2 LogP: 3.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)/C(=C/c1ccc(o1)Br)/Br
  • InChi: 1S/C6H3Br2NO3/c7-5(9(10)11)3-4-1-2-6(8)12-4/h1-3H/b5-3+
  • InChiKey: MJPPGVVIDGQOQT-HWKANZROSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-bromo-5-[(Z)-2-bromo-2-nitroethenyl]furan
  • 2-bromo-5-(2-bromo-2-nitro-vinyl)furan
  • 2-bromo-5-[(Z)-2-bromo-2-nitro-vinyl]furan
  • 2-bromo-5-(2-bromo-2-nitrovinyl)furan
  • 2-bromo-5-[(Z)-2-bromo-2-nitrovinyl]furan
  • 2-bromo-5-[(Z)-2-bromo-2-nitro-ethenyl]furan
  • 2-bromo-5-(2-bromo-2-nitro-ethenyl)furan

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli UDP-N-acetylglucosamine 1-carboxyvinyltransferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase Get druggable targets OG5_131267 All targets in OG5_131267
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA Get druggable targets OG5_131267 All targets in OG5_131267
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase Get druggable targets OG5_131267 All targets in OG5_131267
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA Get druggable targets OG5_131267 All targets in OG5_131267
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase Get druggable targets OG5_131267 All targets in OG5_131267
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase Get druggable targets OG5_131267 All targets in OG5_131267
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0303 0.0333
Brugia malayi glutathione reductase 0.005 0.0423 0.0988
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0307 0.0338
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0112 0.1233 0.2882
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0112 0.1233 0.2454
Brugia malayi acetyltransferase, GNAT family protein 0.0323 0.4037 0.9437
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0084 0.007
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0052 0.0128
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0303 0.0412
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0423 0.0605
Onchocerca volvulus 0.0041 0.0303 0.0823
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0026 0.0061
Toxoplasma gondii thioredoxin reductase 0.005 0.0423 0.0558
Entamoeba histolytica phosphomannose isomerase, putative 0.0112 0.1233 0.1455
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0647 0.8323 1
Schistosoma mansoni phd/f-box containing protein 0.0056 0.0491 0.1216
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0116 0.0091
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0089 0.0929 0.2171
Brugia malayi chromobox protein homolog 3 0.0042 0.0307 0.0717
Leishmania major trypanothione reductase 0.005 0.0423 0.0571
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0303 0.0412
Schistosoma mansoni protein phosphatase 2C 0.0056 0.0491 0.1216
Schistosoma mansoni rab6-interacting 0.0044 0.0333 0.0826
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0316 0.394 0.3926
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0052 0.0128
Echinococcus granulosus PHD finger protein rhinoceros 0.0065 0.061 0.1214
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0112 0.1233 0.1765
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0026 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0529 0.1235
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0052 0.0121
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0052 0.0103
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0401 0.0574
Brugia malayi jmjC domain containing protein 0.0342 0.4278 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0177 0.0204
Mycobacterium ulcerans hypothetical protein 0.0054 0.0473 0.045
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0349 0.0974
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0226 0.0202
Echinococcus granulosus zinc finger protein 0.0029 0.0136 0.027
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0209 0.2524 0.4129
Echinococcus multilocularis jumonji domain containing protein 0.009 0.0945 0.188
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0052 0.0128
Trypanosoma brucei phosphomannose isomerase 0.0112 0.1233 0.2012
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1126 0.1326
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Schistosoma mansoni rab6-interacting 0.0044 0.0333 0.0826
Loa Loa (eye worm) hypothetical protein 0.0145 0.168 0.2405
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0134 0.1535 0.2148
Echinococcus granulosus axis inhibition protein axin 0.002 0.0026 0.0052
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0054 0.0473 0.045
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0116 0.027
Brugia malayi nuclear hormone receptor 0.0022 0.0052 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0052 0.0121
Loa Loa (eye worm) hypothetical protein 0.0065 0.061 0.0873
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0052 0.0074
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0303 0.0279
Echinococcus multilocularis PHD finger protein rhinoceros 0.0065 0.061 0.1214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0116 0.0091
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.1448 0.2025
Loa Loa (eye worm) hypothetical protein 0.0058 0.0529 0.0757
Loa Loa (eye worm) doublecortin family protein 0.0044 0.0333 0.0477
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0116 0.027
Giardia lamblia Kinase, PLK 0.0209 0.2524 0.2838
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Echinococcus granulosus jumonji domain containing 1A 0.0056 0.0491 0.0977
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0218 0.2643 0.2625
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0556 0.7112 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0491 0.0703
Echinococcus granulosus chromobox protein 1 0.0074 0.0739 0.1471
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Treponema pallidum fructose-bisphosphate aldolase 0.0647 0.8323 0.8308
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0052 0.0103
Trypanosoma brucei hypothetical protein, conserved 0.0471 0.5991 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0052 0.0074
Echinococcus multilocularis chromobox protein 1 0.0074 0.0739 0.1471
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0052 0.0074
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0052 0.0128
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0702 0.1398
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0085 0.0085
Brugia malayi MH2 domain containing protein 0.0127 0.1441 0.3367
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Schistosoma mansoni serine/threonine protein kinase 0.0209 0.2524 0.6252
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0047 0.0067
Echinococcus granulosus RUN 0.0044 0.0333 0.0663
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0026 0.0052
Brugia malayi PHD-finger family protein 0.0034 0.0211 0.0493
Echinococcus multilocularis lysine specific demethylase 5A 0.0208 0.2514 0.5003
Plasmodium vivax JmjC domain containing protein 0.0056 0.0491 0.3859
Echinococcus granulosus chromobox protein 1 0.0074 0.0739 0.1471
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0134 0.1535 0.3056
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0307 0.0837
Brugia malayi nuclear receptor NHR-88 0.0022 0.0052 0.0121
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.1448 0.2025
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0052 0.0121
Mycobacterium ulcerans hypothetical protein 0.0054 0.0473 0.045
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0116 0.0108
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0054 0.0473 0.0539
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0423 0.0341
Schistosoma mansoni aldehyde dehydrogenase 0.0134 0.1535 0.3803
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0303 0.0412
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0116 0.0108
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0116 0.0108
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.1448 0.2025
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0349 0.0389
Chlamydia trachomatis pyruvate kinase 0.0036 0.0226 0.0202
Schistosoma mansoni jumonji domain containing protein 0.0298 0.3703 0.9172
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0401 0.0798
Schistosoma mansoni aldehyde dehydrogenase 0.0134 0.1535 0.3803
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0035 0.0087
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0074 0.0182
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0401 0.0937
Loa Loa (eye worm) hypothetical protein 0.0027 0.0116 0.0166
Mycobacterium ulcerans beta-lactamase 0.0041 0.0303 0.0279
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0226 0.0324
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0303 0.0433
Echinococcus granulosus mannose 6 phosphate isomerase 0.0112 0.1233 0.2454
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0401 0.0798
Onchocerca volvulus 0.0253 0.3099 1
Leishmania major phosphomannose isomerase 0.0112 0.1233 0.1943
Brugia malayi jmjC domain containing protein 0.0056 0.0491 0.1147
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0052 0.0103
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0054 0.0473 0.045
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0342 0.4278 0.8515
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0303 0.0749
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0058 0.0518 0.1031
Echinococcus granulosus axis inhibition protein axin 0.002 0.0026 0.0052
Trypanosoma cruzi polo-like protein kinase, putative 0.0209 0.2524 0.3986
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0026 0.0061
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0161 0.0321
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0056 0.0491 0.0656
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0739 0.1058
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0134 0.1535 0.2455
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0303 0.0707
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0218 0.2643 0.2625
Schistosoma mansoni bromodomain containing protein 0.0075 0.0753 0.1864
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0702 0.1398
Schistosoma mansoni polycystin 1-related 0.0044 0.0333 0.0826
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0056 0.0491 0.0459
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0085 0.0073
Giardia lamblia Fructose-bisphosphate aldolase 0.0647 0.8323 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0333 0.0477
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0116 0.0091
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.1535 0.1514
Brugia malayi PHD-finger family protein 0.0023 0.0062 0.0144
Brugia malayi hypothetical protein 0.0044 0.0333 0.0779
Brugia malayi jmjC domain containing protein 0.0056 0.0491 0.1147
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0052 0.0128
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0546 0.6986 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1441 0.2062
Echinococcus granulosus L aminoadipate semialdehyde 0.0089 0.0929 0.1849
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0052 0.0121
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0226 0.0322
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0052 0.0121
Mycobacterium tuberculosis Conserved protein 0.0041 0.0303 0.0412
Mycobacterium tuberculosis Conserved protein 0.0054 0.0473 0.0653
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0058 0.0518 0.1031
Loa Loa (eye worm) glutaminase 0.0314 0.391 0.5596
Loa Loa (eye worm) hypothetical protein 0.0036 0.0226 0.0324
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0052 0.0074
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0284 0.0664
Brugia malayi glutaminase DH11.1 0.0314 0.391 0.9138
Trichomonas vaginalis esterase, putative 0.0041 0.0303 0.0333
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0303 0.0412
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0177 0.0438
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0026 0.0061
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0112 0.1233 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0052 0.0103
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0226 0.0305
Brugia malayi ecdysteroid receptor 0.0022 0.0052 0.0121
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0303 0.0333
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0035 0.0087
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0209 0.2524 0.5024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.1535 0.1514
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0026 0.0052
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0056 0.0491 0.0766
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Plasmodium vivax glutathione reductase, putative 0.005 0.0423 0.3296
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0226 0.0324
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0052 0.0103
Echinococcus granulosus phd:f box containing protein 0.0056 0.0491 0.0977
Trypanosoma cruzi phosphomannose isomerase, putative 0.0112 0.1233 0.1746
Loa Loa (eye worm) hypothetical protein 0.0075 0.0754 0.1079
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0035 0.005
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0052 0.0128
Giardia lamblia Histone acetyltransferase GCN5 0.0086 0.0901 0.0833
Schistosoma mansoni hypothetical protein 0.004 0.0284 0.0703
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0074 0.0146
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Toxoplasma gondii hypothetical protein 0.0546 0.6986 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0056 0.0491 0.1216
Brugia malayi Heterochromatin protein 1 0.0074 0.0739 0.1727
Loa Loa (eye worm) hypothetical protein 0.005 0.0417 0.0598
Entamoeba histolytica serine/threonine protein kinase, putative 0.0209 0.2524 0.3011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0052 0.0121
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.1278 0.1785
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0116 0.0149
Loa Loa (eye worm) hypothetical protein 0.0546 0.6986 1
Plasmodium falciparum phd finger protein, putative 0.0065 0.061 0.4844
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0116 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Mycobacterium ulcerans glutaminase 0.0314 0.391 0.3895
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0423 0.0842
Mycobacterium ulcerans hypothetical protein 0.0027 0.0116 0.0091
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0134 0.1535 0.3056
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.0406
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0303 0.0412
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0417 0.0831
Loa Loa (eye worm) hypothetical protein 0.0041 0.0297 0.0425
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0026 0.0052
Schistosoma mansoni pyruvate kinase 0.0036 0.0226 0.056
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0035 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0401 0.0993
Brugia malayi PXA domain containing protein 0.002 0.0026 0.0061
Brugia malayi Bromodomain containing protein 0.0049 0.04 0.0935
Onchocerca volvulus 0.0044 0.0338 0.0939
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0085 0.0106
Toxoplasma gondii aldehyde dehydrogenase 0.0134 0.1535 0.2159
Trypanosoma cruzi phosphomannose isomerase, putative 0.0112 0.1233 0.1746
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0054 0.0473 0.045
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0112 0.1233 0.1455
Brugia malayi jmjC domain containing protein 0.0056 0.0491 0.1147
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.1278 0.1785
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0026 0.0037
Echinococcus granulosus lysine specific demethylase 5A 0.021 0.2541 0.5057
Toxoplasma gondii PHD-finger domain-containing protein 0.0065 0.061 0.0828
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0035 0.007
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1126 0.1326
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0194 0.2327 0.4631
Brugia malayi steroid hormone receptor 0.0022 0.0052 0.0121
Echinococcus multilocularis Polycystic kidney disease protein 0.0044 0.0333 0.0663
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0088
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0026 0.0052
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0647 0.8323 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0116 0.0091
Brugia malayi Pre-SET motif family protein 0.0032 0.0177 0.0413
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Onchocerca volvulus Serine\/threonine kinase homolog 0.0209 0.2524 0.8114
Echinococcus multilocularis pyruvate kinase 0.0036 0.0226 0.045
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0333 0.0663
Echinococcus multilocularis jumonji domain containing 1A 0.0056 0.0491 0.0977
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0077 0.018
Echinococcus multilocularis RUN 0.0044 0.0333 0.0663
Leishmania major hypothetical protein, conserved 0.0056 0.0491 0.0687
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.005 0.0124
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0303 0.0333
Loa Loa (eye worm) hypothetical protein 0.0027 0.0116 0.0166
Loa Loa (eye worm) hypothetical protein 0.0053 0.0461 0.0661
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0026 0.0061
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0116 0.0051
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0263 0.0523
Echinococcus multilocularis pyruvate kinase 0.0028 0.0127 0.0253
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0035 0.0084
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0116 0.0149
Trypanosoma brucei polo-like protein kinase 0.0209 0.2524 0.418
Schistosoma mansoni jumonji domain containing protein 0.0056 0.0491 0.1216
Trypanosoma cruzi hypothetical protein, conserved 0.0471 0.5991 1
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0112 0.1233 0.1765
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0035 0.007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.1535 0.1514
Schistosoma mansoni phosphatidylserine receptor 0.0056 0.0491 0.1216
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0052 0.0121
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.012
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0085 0.0504
Echinococcus multilocularis pyruvate kinase 0.0036 0.0226 0.045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0052 0.0103
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0026 0.0052
Brugia malayi PXA domain containing protein 0.002 0.0026 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0116 0.0091
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0263 0.0523
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0194 0.2327 0.4631
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0226 0.0573
Loa Loa (eye worm) hypothetical protein 0.0546 0.6986 1
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0026 0.0052
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.2693 0.3855
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0226 0.0324
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Schistosoma mansoni hypothetical protein 0.0044 0.0333 0.0826
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0056 0.0491 0.0459
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0052 0.0103
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0116 0.0091
Schistosoma mansoni hypothetical protein 0.0022 0.0047 0.0115
Echinococcus multilocularis zinc finger protein 0.0029 0.0136 0.027
Echinococcus multilocularis JmjC domain containing protein 4 0.0056 0.0491 0.0977
Leishmania major hypothetical protein, conserved 0.0471 0.5991 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0026 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0097 0.1038 0.122
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0026 0.0052
Loa Loa (eye worm) hypothetical protein 0.0546 0.6986 1
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0026 0.0052
Brugia malayi Thioredoxin reductase 0.005 0.0423 0.0988
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0226 0.0241
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0052 0.0074
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0052 0.0103
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.1278 0.1785
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0052 0.0103
Echinococcus granulosus histone acetyltransferase KAT2B 0.0097 0.1038 0.2066
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0052 0.0128
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0491 0.0703
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0303 0.0132
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0052 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0307 0.0338
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0052 0.0121
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0026 0.0064
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0052 0.0128
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0035 0.0082
Plasmodium vivax hypothetical protein, conserved 0.0065 0.061 0.4844
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0303 0.0333
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0052 0.0128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0401 0.0798
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0303 0.0333
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0323 0.4037 0.8036
Mycobacterium ulcerans hypothetical protein 0.0041 0.0303 0.0279
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0097 0.1038 0.8387
Schistosoma mansoni mannose-6-phosphate isomerase 0.0112 0.1233 0.3054
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Onchocerca volvulus 0.0044 0.0333 0.0924
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0303 0.0602
Schistosoma mansoni lipoxygenase 0.0194 0.2327 0.5764
Loa Loa (eye worm) hypothetical protein 0.0044 0.0333 0.0477
Toxoplasma gondii ABC1 family protein 0.0041 0.0303 0.0385
Schistosoma mansoni glutaminase 0.0314 0.391 0.9684
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0316 0.394 0.5486
Schistosoma mansoni kinase 0.0106 0.1163 0.288
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0112 0.1233 1
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0423 0.0842
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0209 0.2524 0.5024
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.006 0.0556 0.077
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0226 0.0573
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0097 0.1038 0.1444
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0052 0.0103
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0052 0.0128
Onchocerca volvulus Alhambra homolog 0.0065 0.061 0.1832
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.006 0.0556 0.067
Echinococcus multilocularis lysine specific demethylase 6a 0.0056 0.0491 0.0977
Echinococcus granulosus citrate lyase subunit beta protein 0.0054 0.0473 0.0942
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0089 0.0929 0.2301
Plasmodium falciparum JmjC domain-containing protein, putative 0.0056 0.0491 0.3859
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0303 0.045
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0303 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0146 0.0144
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0491 0.0703
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0342 0.4278 0.8515
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0054 0.0473 0.0653
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0085 0.0061
Loa Loa (eye worm) hypothetical protein 0.0027 0.0116 0.0166
Echinococcus multilocularis peregrin 0.0075 0.0747 0.1488
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0401 0.0993
Schistosoma mansoni coup transcription factor 0.0022 0.0052 0.0128
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0084 0.012
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0333 0.0663
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0112 0.1233 0.2882
Loa Loa (eye worm) jmjC domain-containing protein 0.0133 0.152 0.2176
Mycobacterium tuberculosis Conserved protein 0.0041 0.0303 0.0412
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0052 0.0103
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0052 0.0128
Giardia lamblia PHD finger protein 15 0.0065 0.061 0.0474
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0052 0.0121
Onchocerca volvulus 0.0033 0.0188 0.0446
Loa Loa (eye worm) PHD-finger family protein 0.0065 0.061 0.0873
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0401 0.0993
Entamoeba histolytica acetyltransferase, GNAT family 0.0086 0.0901 0.1054
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Toxoplasma gondii PHD-finger domain-containing protein 0.0065 0.061 0.0828
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0085 0.0504
Trypanosoma brucei trypanothione reductase 0.005 0.0423 0.0652
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0052 0.0074
Onchocerca volvulus 0.0027 0.0116 0.021
Onchocerca volvulus 0.0041 0.0303 0.0823
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0052 0.0103
Mycobacterium tuberculosis Probable reductase 0.0115 0.1278 0.1785
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0316 0.394 0.5534
Trichomonas vaginalis glutaminase, putative 0.0314 0.391 0.4681
Onchocerca volvulus 0.0089 0.0929 0.2879
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0417 0.1034
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0226 0.1669
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0226 0.0573
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0052 0.0103
Brugia malayi AF-10 protein 0.0021 0.0035 0.0081
Brugia malayi hypothetical protein 0.0044 0.0333 0.0779
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0052 0.0128
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0218 0.2643 0.3641
Schistosoma mansoni zinc finger protein 0.0029 0.0136 0.0336
Loa Loa (eye worm) acetyltransferase 0.0323 0.4037 0.5779
Schistosoma mansoni axis inhibition protein axin 0.002 0.0026 0.0064
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0303 0.23
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0218 0.2643 0.3753
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0226 0.0276
Brugia malayi Doublecortin family protein 0.0044 0.0333 0.0779
Schistosoma mansoni pyruvate kinase 0.0036 0.0226 0.056
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0035 0.0084
Schistosoma mansoni hypothetical protein 0.0021 0.0035 0.0086
Brugia malayi PHD-finger family protein 0.0065 0.061 0.1426
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0116 0.027
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0116 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0052 0.0121
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0423 0.3296
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0303 0.0602
Trypanosoma cruzi hypothetical protein, conserved 0.0471 0.5991 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0052 0.0103
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0025 0.0021
Plasmodium vivax SET domain protein, putative 0.0032 0.0177 0.1259
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0052 0.0121
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0026 0.0052
Brugia malayi jmjC domain containing protein 0.021 0.2541 0.5939
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0052 0.0121
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0035 0.0087
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0026 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0146 0.0144
Schistosoma mansoni hypothetical protein 0.0065 0.061 0.1511
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0529 0.0757
Brugia malayi Bromodomain containing protein 0.0075 0.0747 0.1747
Plasmodium falciparum thioredoxin reductase 0.005 0.0423 0.3296
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0226 0.0241
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0333 0.0663
Schistosoma mansoni axis inhibition protein axin 0.002 0.0026 0.0064
Mycobacterium tuberculosis Conserved protein 0.0041 0.0303 0.0412
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0739 0.0859
Loa Loa (eye worm) hypothetical protein 0.0051 0.0434 0.0622
Toxoplasma gondii phosphomannose isomerase type I protein 0.0112 0.1233 0.1724
Loa Loa (eye worm) bromodomain containing protein 0.0027 0.0109 0.0156
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0112 0.1233 0.1211
Brugia malayi Pre-SET motif family protein 0.0222 0.2693 0.6295
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0443 0.0634
Mycobacterium leprae Probable lipase LipE 0.0041 0.0303 0.0309
Schistosoma mansoni lipoxygenase 0.0116 0.1287 0.3187
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0417 0.0831
Onchocerca volvulus 0.0044 0.0333 0.0924
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0303 0.0132
Loa Loa (eye worm) hypothetical protein 0.0089 0.0929 0.133
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0074 0.0146
Trichomonas vaginalis bromodomain-containing protein, putative 0.0097 0.1038 0.122
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0303 0.0412
Leishmania major pyruvate kinase 0.0036 0.0226 0.0238
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0423 0.0581
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0226 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0052 0.0121
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0097 0.1038 0.1444
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0209 0.2524 0.3613
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0349 0.0389
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0026 0.0052
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0177 0.0352
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0473 0.0429
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0739 0.0859
Echinococcus granulosus histone acetyltransferase KAT2B 0.0312 0.3885 0.7732
Echinococcus multilocularis phd:f box containing protein 0.0056 0.0491 0.0977
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Loa Loa (eye worm) beta-lactamase 0.0041 0.0303 0.0433
Schistosoma mansoni jumonji/arid domain-containing protein 0.021 0.2541 0.6293
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0226 0.02
Loa Loa (eye worm) RGS-3 protein 0.002 0.0026 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0338 0.0836
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0026 0.0061
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0026 0.0052
Echinococcus granulosus Polycystic kidney disease protein 0.0044 0.0333 0.0663
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0026 0.0037
Plasmodium falciparum pyruvate kinase 0.0036 0.0226 0.1669
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0473 0.0657
Brugia malayi hypothetical protein 0.002 0.0026 0.0061
Loa Loa (eye worm) jmjC domain-containing protein 0.021 0.2541 0.3637
Echinococcus granulosus peregrin 0.0075 0.0747 0.1488
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.1278 0.1785
Echinococcus granulosus pyruvate kinase 0.0036 0.0226 0.045
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0026 0.0052
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0491 0.0703
Echinococcus granulosus expressed protein 0.0398 0.5024 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0085 0.0073
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0323 0.4037 1
Echinococcus granulosus JmjC domain containing protein 4 0.0056 0.0491 0.0977
Echinococcus granulosus lysine specific demethylase 6a 0.0056 0.0491 0.0977
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0065 0.061 0.1511
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0052 0.0103
Schistosoma mansoni loxhd1 0.0044 0.0333 0.0826
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0303 0.0309
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0226 0.0322
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0417 0.1034
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0085 0.0061
Echinococcus multilocularis L aminoadipate semialdehyde 0.0089 0.0929 0.1849
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.1278 0.1697
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0026 0.0052
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0226 0.0529
Schistosoma mansoni jumonji/arid domain-containing protein 0.021 0.2541 0.6293
Entamoeba histolytica hypothetical protein 0.0025 0.0085 0.0072
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0026 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0052 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0052 0.0074
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0085 0.0061
Trichomonas vaginalis set domain proteins, putative 0.0253 0.3099 0.3704
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.0333 0.2555
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0333 0.0663
Loa Loa (eye worm) glutathione reductase 0.005 0.0423 0.0605
Brugia malayi Cytochrome P450 family protein 0.0052 0.0443 0.1035
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1441 0.2062
Trypanosoma cruzi polo-like protein kinase, putative 0.0209 0.2524 0.3986
Echinococcus multilocularis citrate lyase subunit beta protein 0.0054 0.0473 0.0942
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0264 0.3251 0.4564
Leishmania major pyruvate kinase 0.0036 0.0226 0.0238
Plasmodium falciparum histone acetyltransferase GCN5 0.0086 0.0901 0.725
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0529 0.1235
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0116 0.0043
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0052 0.0121
Leishmania major hypothetical protein, conserved 0.0041 0.0303 0.0368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0052 0.0074
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.1448 0.1939
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Brugia malayi beta-lactamase family protein 0.0041 0.0303 0.0707
Brugia malayi hypothetical protein 0.002 0.0026 0.0061
Echinococcus multilocularis chromobox protein 1 0.0074 0.0739 0.1471
Schistosoma mansoni chromobox protein 0.0074 0.0739 0.183
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0303 0.0279
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0056 0.0491 0.0656
Schistosoma mansoni chromobox protein 0.0074 0.0739 0.183
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0401 0.0798
Plasmodium vivax multidomain scavenger receptor, putative 0.0044 0.0333 0.2555
Mycobacterium ulcerans lipase LipD 0.0041 0.0303 0.0279
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0051 0.0432 0.0489
Echinococcus multilocularis expressed protein 0.0398 0.5024 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0303 0.0749
Loa Loa (eye worm) hypothetical protein 0.0033 0.0188 0.0268
Brugia malayi beta-lactamase family protein 0.0041 0.0303 0.0707
Loa Loa (eye worm) glutaminase 2 0.0314 0.391 0.5596
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0052 0.0103
Brugia malayi beta-lactamase 0.0041 0.0303 0.0707
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0556 0.7112 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0116 0.0043
Echinococcus granulosus jumonji domain containing protein 0.009 0.0945 0.188
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0052 0.0103
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Loa Loa (eye worm) hypothetical protein 0.0042 0.0307 0.0439
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.1278 0.1785
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Brugia malayi serine/threonine-protein kinase plk-2 0.0209 0.2524 0.59
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0473 0.0429
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0052 0.0103
Echinococcus granulosus pyruvate kinase 0.0036 0.0226 0.045
Onchocerca volvulus 0.0041 0.0303 0.0823
Plasmodium falciparum glutathione reductase 0.005 0.0423 0.3296
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0116 0.0051
Loa Loa (eye worm) hypothetical protein 0.0056 0.0491 0.0703
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0026 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Brugia malayi jmjC domain containing protein 0.0056 0.0491 0.1147
Brugia malayi Bromodomain containing protein 0.0088 0.0918 0.2146

Activities

Activity type Activity value Assay description Source Reference
Drug metabolism (ADMET) Prodrug conversion assessed as Escherichia coli MurA-mediated 2-bromo-5-(2-nitrovinyl)furan formation at 100 uM by HPLC-UV analysis ChEMBL. 23266177
Drug metabolism (ADMET) Induction of Escherichia coli MurA-mediated 2-bromo-5-(2-nitrovinyl)furan formation assessed as enzyme-(R)-methyl 3-mercapto-2-(6-methoxy-2-oxo-2H-chromene-3-carboxamido)propanoate adduct level at 200 uM after 1 hr by SDS-PAGE analysis in presence of thiol nucleophile DTT in reducing laemmli buffer ChEMBL. 23266177
Drug metabolism (ADMET) Induction of Escherichia coli MurA-mediated 2-bromo-5-(2-nitrovinyl)furan formation assessed as enzyme-(R)-methyl 3-mercapto-2-(6-methoxy-2-oxo-2H-chromene-3-carboxamido)propanoate adduct level at 200 to 300 uM after 1 hr by SDS-PAGE analysis ChEMBL. 23266177
IC50 (binding) = 2.8 uM Inhibition of Escherichia coli MurA expressed in Escherichia coli BL21(lambdaDE3) using UNAG and PEP as substrate incubated for 10 mins prior to PEP addition measured after 60 mins by spectrophotometric analysis ChEMBL. 23266177
IC50 (ADMET) = 10 uM Cytotoxicity against human Calu6 cells after 72 hrs by crystal violet staining method ChEMBL. 23266177
IC50 (ADMET) = 36 uM Cytotoxicity against human Capan1 cells after 72 hrs by crystal violet staining method ChEMBL. 23266177
Inhibition (binding) Inhibition of Escherichia coli MurA expressed in Escherichia coli BL21(lambdaDE3) using UNAG and PEP as substrate at 50 to 500 uM incubated for 30 mins by 2,2'-dithiopyridine based spectrophotometric analysis ChEMBL. 23266177
Inhibition (binding) Irreversible inhibition of Escherichia coli MurA expressed in Escherichia coli BL21(lambdaDE3) using UNAG and PEP as substrate at 1.25 uM incubated up to 80 min prior to PEP addition measured after 60 mins by spectrophotometric analysis ChEMBL. 23266177
Inhibition (binding) Inhibition of human MetAP1 expressed in Escherichia coli BL21(lambdaDE3) using Met-AMC as substrate at 10 uM incubated for 30 mins prior to substrate addition measured for 15 mins fluorometric analysis ChEMBL. 23266177
Inhibition (binding) Inhibition of Escherichia coli MurA expressed in Escherichia coli BL21(lambdaDE3) using UNAG and PEP as substrate at 5 uM incubated for 10 mins prior to UNAG and PEP addition measured after 60 mins by spectrophotometric analysis ChEMBL. 23266177
Inhibition (binding) = 8 % Inhibition of thrombin (unknown origin) expressed in Escherichia coli BL21(lambdaDE3) using Boc-Val-Pro-Arg-AMC as substrate at 25 uM incubated for 15 mins prior to substrate addition measured for 10 mins by fluorometric analysis ChEMBL. 23266177
Inhibition (binding) = 13 % Inhibition of human MetAP2 expressed in Escherichia coli BL21(lambdaDE3) using Met-AMC as substrate at 10 uM incubated for 30 mins prior to substrate addition measured for 15 mins fluorometric analysis ChEMBL. 23266177
MIC (functional) = 4 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 after 20 to 24 hrs by broth microdilution assay ChEMBL. 23266177

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23266177

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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