TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 672.744 | Formula: C33H45FN6O8
H donors: 1 H acceptors: 5 LogP: 0.05 Rotable bonds: 26
Rule of 5 violations (Lipinski): 2
SMILES: OCCOCCOCCOCCOCCOCCOCCOCCn1nnc(c1)c1nc(c(n1C)c1ccncc1)c1ccc(cc1)F
InChi: 1S/C33H45FN6O8/c1-39-32(28-6-8-35-9-7-28)31(27-2-4-29(34)5-3-27)36-33(39)30-26-40(38-37-30)10-12-42-14-16-44-18-20-46-22-24-48-25-23-47-21-19-45-17-15-43-13-11-41/h2-9,26,41H,10-25H2,1H3
InChiKey: DKOGNSPGLPAQJS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0051	0.0085
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0366	0.4608	0.9985
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.022	0.0624
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0524	0.1116
Echinococcus granulosus	tumor protein p63	0.0328	0.4123	0.8931
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.054	0.1149
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0051	0.0085
Schistosoma mansoni	two-pore calcium channel	0.0366	0.4608	1
Loa Loa (eye worm)	voltage-gated potassium channel	0.0366	0.4608	1
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0366	0.4608	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0366	0.4608	0.4602
Echinococcus granulosus	transient receptor potential cation channel	0.0366	0.4608	0.9985
Brugia malayi	nuclear receptor NHR-88	0.001	0.0051	0.0085
Echinococcus multilocularis	transient receptor potential cation channel	0.0366	0.4608	0.4602
Brugia malayi	RNA, U transporter 1	0.008	0.0944	0.2028
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0051	0.0085
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0366	0.4608	1
Brugia malayi	CHE-14 protein	0.0041	0.045	0.0954
Echinococcus multilocularis	transient receptor potential cation channel	0.0366	0.4608	0.4602
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0296	0.0619
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0366	0.4608	1
Onchocerca volvulus		0.0048	0.054	0.1149
Echinococcus granulosus	shaker cognate	0.0366	0.4608	0.9985
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Echinococcus multilocularis	transfer RNA-Gly	0.0366	0.4608	0.4602
Schistosoma mansoni	hypothetical protein	0.0299	0.375	0.8132
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0051	0.0085
Onchocerca volvulus		0.001	0.0051	0.0085
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0366	0.4608	0.4602
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0283	0.0591
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0051	0.0085
Schistosoma mansoni	transient receptor potential channel	0.0366	0.4608	1
Schistosoma mansoni	hypothetical protein	0.004	0.0431	0.0913
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0085
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0152	0.1869	0.4041
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0085
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0366	0.4608	0.9985
Trichomonas vaginalis	glutaminase, putative	0.0268	0.3347	0.7257
Echinococcus multilocularis	conserved hypothetical protein	0.0366	0.4608	0.4602
Brugia malayi	ion channel NompC	0.0366	0.4608	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0051	0.0039
Brugia malayi	Pre-SET motif family protein	0.0029	0.0296	0.0619
Echinococcus granulosus	hyperpolarization activated cyclic	0.0366	0.4608	0.9985
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0366	0.4608	0.9985
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0366	0.4608	1
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0145	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0051	0.0085
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0216	0.0444
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0366	0.4608	0.9985
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0133	0.5844
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Toxoplasma gondii	hypothetical protein	0.0366	0.4608	1
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0051	0.0085
Echinococcus granulosus	transient receptor potential gamma protein	0.0366	0.4608	0.9985
Loa Loa (eye worm)	hypothetical protein	0.0023	0.022	0.0453
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0366	0.4608	1
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0366	0.4608	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0366	0.4608	0.9985
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0366	0.4608	0.4602
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0366	0.4608	0.4602
Echinococcus granulosus	sodium channel protein	0.0366	0.4608	0.9985
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.1869	0.186
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0366	0.4608	0.9985
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.022	1
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0051	0.0085
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0366	0.4608	0.9985
Echinococcus granulosus	TRP transient receptor potential channel	0.0366	0.4608	0.9985
Schistosoma mansoni	hypothetical protein	0.004	0.0431	0.0913
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.022	0.0453
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0366	0.4608	0.4602
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0366	0.4608	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0085
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Echinococcus multilocularis	protein patched	0.0041	0.045	0.0439
Leishmania major	hypothetical protein, unknown function	0.0366	0.4608	1
Brugia malayi	ecdysteroid receptor	0.001	0.0051	0.0085
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.1869	0.4041
Brugia malayi	Importin beta-1 subunit	0.0028	0.0283	0.0591
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.2511	0.5437
Brugia malayi	hypothetical protein	0.0366	0.4608	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.022	0.0624
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0366	0.4608	0.9985
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0366	0.4608	0.4602
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0366	0.4608	0.4602
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0296	0.0619
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0051	0.0085
Schistosoma mansoni	transient receptor potential channel	0.0366	0.4608	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0145	0.0401
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0051	0.0085
Echinococcus granulosus	Niemann Pick C1 protein	0.0137	0.1673	0.3609
Onchocerca volvulus		0.0029	0.0296	0.0619
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0524	0.0513
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.1869	0.4041
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0366	0.4608	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.1148	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0145	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Echinococcus granulosus	expressed conserved protein	0.009	0.1074	0.2308
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0366	0.4608	0.9985
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.022	0.0453
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0051	0.0085
Echinococcus multilocularis	survival motor neuron protein 1	0.023	0.2863	0.2855
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0051	0.0085
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0085
Leishmania major	hypothetical protein, conserved	0.0366	0.4608	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0296	0.0285
Echinococcus granulosus	hypothetical protein	0.0366	0.4608	0.9985
Plasmodium vivax	SET domain protein, putative	0.0029	0.0296	1
Echinococcus granulosus	sodium leak channel non selective protein	0.0366	0.4608	0.9985
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0051	0.0085
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0366	0.4608	0.4602
Echinococcus multilocularis	transient receptor potential cation channel	0.0366	0.4608	0.4602
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0366	0.4608	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0283	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Brugia malayi	glutaminase DH11.1	0.0268	0.3347	0.7257
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0366	0.4608	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0051	0.0085
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0051	0.0039
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0145	0.4698
Echinococcus granulosus	transient receptor potential cation channel	0.0366	0.4608	0.9985
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0366	0.4608	1
Brugia malayi	hypothetical protein	0.023	0.2863	0.6203
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0051	0.0085
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.1148	0.2469
Brugia malayi	P38 map kinase family protein 2	0.0152	0.1869	0.4041
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0145	0.4916
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0283	0.0591
Schistosoma mansoni	importin beta-1	0.0028	0.0283	0.0591
Onchocerca volvulus		0.0023	0.022	0.0453
Echinococcus multilocularis	Niemann Pick C1 protein	0.0137	0.1673	0.1664
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0524	0.1116
Echinococcus granulosus	transient receptor potential cation channel	0.0366	0.4608	0.9985
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0366	0.4608	1
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0366	0.4608	0.9985
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0051	0.0039
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0051	0.0039
Echinococcus multilocularis	two pore calcium channel protein 2	0.0366	0.4608	0.4602
Echinococcus granulosus	voltage dependent calcium channel	0.0366	0.4608	0.9985
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0051	0.0085
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0366	0.4608	0.4602
Echinococcus multilocularis	sodium leak channel non selective protein	0.0366	0.4608	0.4602
Schistosoma mansoni	hypothetical protein	0.0047	0.0524	0.1116
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0051	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0296	0.0619
Schistosoma mansoni	transient receptor potential channel 4	0.0366	0.4608	1
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0366	0.4608	0.4602
Toxoplasma gondii	hypothetical protein	0.0366	0.4608	1
Echinococcus granulosus	transient receptor potential cation channel	0.0366	0.4608	0.9985
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0145	0.0291
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0051	0.0085
Echinococcus multilocularis	sodium channel protein	0.0366	0.4608	0.4602
Brugia malayi	Pre-SET motif family protein	0.0202	0.2511	0.5437
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0366	0.4608	1
Toxoplasma gondii	transporter, cation channel family protein	0.0366	0.4608	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0216	0.0444
Echinococcus multilocularis	two pore calcium channel protein 1	0.0366	0.4608	0.4602
Loa Loa (eye worm)	calcium channel	0.0366	0.4608	1
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0366	0.4608	0.4602
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.045	0.0952
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.1869	0.186
Echinococcus granulosus	two pore calcium channel protein 1	0.0366	0.4608	0.9985
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0051	0.0085
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0051	0.0085
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0366	0.4608	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0296	0.0619
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0051	0.0085
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0216	0.0444
Echinococcus granulosus	short transient receptor potential channel 6	0.0366	0.4608	0.9985
Schistosoma mansoni	ryanodine receptor related	0.0366	0.4608	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0366	0.4608	0.4602
Mycobacterium ulcerans	hypothetical protein	0.0023	0.022	0.0624
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0366	0.4608	1
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0366	0.4608	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0366	0.4608	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.022	0.0453
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0051	0.0085
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0366	0.4608	0.9985
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0366	0.4608	1
Mycobacterium ulcerans	glutaminase	0.0268	0.3347	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0133	0.5844
Echinococcus granulosus	voltage gated potassium channel	0.0366	0.4608	0.9985
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.022	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0145	0.0291
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0051	0.0085
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.1869	0.186
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0296	0.0619
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0366	0.4608	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.022	0.0624
Loa Loa (eye worm)	voltage-gated calcium channel	0.0366	0.4608	1
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0366	0.4608	1
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0366	0.4608	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0366	0.4608	1
Echinococcus multilocularis	shaker cognate	0.0366	0.4608	0.4602
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0051	0.0085
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0366	0.4608	1
Schistosoma mansoni	glutaminase	0.0268	0.3347	0.7257
Schistosoma mansoni	hypothetical protein	0.004	0.0431	0.0913
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0296	0.0619
Echinococcus granulosus	potassium voltage gated channel protein	0.0366	0.4608	0.9985
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.022	0.0624
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0145	0.6421
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0366	0.4608	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0366	0.4608	0.4602
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.022	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0282	0.0588
Loa Loa (eye worm)	glutaminase	0.0268	0.3347	0.7257
Loa Loa (eye worm)	hypothetical protein	0.0041	0.045	0.0954
Echinococcus multilocularis	calcium activated potassium channel	0.0367	0.4615	0.4609
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Loa Loa (eye worm)	hypothetical protein	0.023	0.2863	0.6203
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0283	0.0272
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.1148	0.2473
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0145	0.0291
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0152	0.1869	0.4041
Schistosoma mansoni	patched 1	0.0041	0.045	0.0954
Loa Loa (eye worm)	hypothetical protein	0.005	0.0568	0.1211
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0051	0.0085
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0051	0.0085
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0051	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.045	0.0954
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0051	0.0039
Schistosoma mansoni	voltage-dependent calcium channel	0.0366	0.4608	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0051	0.0085
Loa Loa (eye worm)	ion channel NompC	0.0366	0.4608	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0296	0.0618
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0051	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0023	0.022	0.0453
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0366	0.4608	1
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0366	0.4608	0.4602
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0051	0.0085
Toxoplasma gondii	transporter, cation channel family protein	0.0366	0.4608	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0366	0.4608	0.4602
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.022	1
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0366	0.4608	1
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Echinococcus granulosus	voltage dependent calcium channel	0.0366	0.4608	0.9985
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.045	0.0439
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0051	0.0085
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.022	0.0453
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0051	0.0085
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.022	0.183
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0366	0.4608	0.9985
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0133	0.5844
Echinococcus multilocularis	voltage dependent calcium channel	0.0366	0.4608	0.4602
Echinococcus granulosus	transient receptor potential cation channel	0.0366	0.4608	0.9985
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0366	0.4608	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0366	0.4608	0.9985
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0007	0.0012	0.0025
Plasmodium falciparum	importin beta, putative	0.0028	0.0283	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0366	0.4608	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0283	0.0615
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0366	0.4608	0.9985
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0085
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0366	0.4608	1
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0366	0.4608	1
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Onchocerca volvulus		0.023	0.2868	0.6214
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0051	0.0085
Echinococcus granulosus	potassium voltage gated channel protein	0.0366	0.4608	0.9985
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0366	0.4608	1
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0366	0.4608	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.1167	0.2514
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.1148	0.1138
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Echinococcus granulosus	short transient receptor potential channel 6	0.0366	0.4608	0.9985
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0366	0.4608	1
Echinococcus granulosus	ryanodine receptor 44f	0.0366	0.4608	0.9985
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0366	0.4608	1
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Echinococcus multilocularis	expressed conserved protein	0.009	0.1074	0.1064
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0051	0.0039
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0051	0.0085
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0366	0.4608	0.4602
Echinococcus multilocularis	transient receptor potential cation channel	0.0366	0.4608	0.4602
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0366	0.4608	0.9985
Echinococcus multilocularis	potassium voltage gated channel protein	0.0366	0.4608	0.4602
Echinococcus multilocularis	short transient receptor potential channel 6	0.0366	0.4608	0.4602
Brugia malayi	Transient-receptor-potential like protein	0.0366	0.4608	1
Echinococcus multilocularis	tumor protein p63	0.0328	0.4123	0.4116
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0366	0.4608	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0051	0.0085
Echinococcus granulosus	mitogen activated protein kinase 14	0.0152	0.1869	0.4034
Schistosoma mansoni	vesicular amine transporter	0.0366	0.4608	1
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0366	0.4608	1
Echinococcus multilocularis	voltage gated potassium channel	0.0366	0.4608	0.4602
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.022	0.0453
Echinococcus multilocularis	short transient receptor potential channel 6	0.0366	0.4608	0.4602
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0085
Echinococcus multilocularis	potassium voltage gated channel protein	0.0366	0.4608	0.4602
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0366	0.4608	0.4602
Echinococcus multilocularis	snurportin 1	0.0299	0.375	0.3742
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.022	1
Echinococcus granulosus	snurportin 1	0.0299	0.375	0.8119
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0051	0.0085
Schistosoma mansoni	60S ribosomal protein L21	0.0366	0.4608	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0296	0.0285
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0051	0.0085
Echinococcus granulosus	mitogen activated protein kinase 11	0.0152	0.1869	0.4034
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0012	0.0025
Echinococcus granulosus	voltage gated potassium channel	0.0366	0.4608	0.9985
Brugia malayi	nuclear hormone receptor	0.001	0.0051	0.0085
Schistosoma mansoni	hypothetical protein	0.0366	0.4608	1
Echinococcus multilocularis	ryanodine receptor 44f	0.0366	0.4608	0.4602
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0133	0.5844
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.1869	0.186
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0051	0.0085
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.022	0.0624
Schistosoma mansoni	voltage-gated ion channel	0.0366	0.4608	1
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0366	0.4608	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0051	0.0085
Onchocerca volvulus		0.0047	0.0524	0.1116
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.045	0.0954
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.022	0.0624
Trichomonas vaginalis	set domain proteins, putative	0.023	0.2868	0.6214
Loa Loa (eye worm)	hypothetical protein	0.0023	0.022	0.0453
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0283	0.9556
Echinococcus granulosus	survival motor neuron protein 1	0.023	0.2863	0.6194
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0366	0.4608	0.4602
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Toxoplasma gondii	transporter, cation channel family protein	0.0366	0.4608	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0366	0.4608	1
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0366	0.4608	0.9985
Brugia malayi	cation channel family protein	0.0366	0.4608	1
Brugia malayi	voltage-dependent calcium channel	0.0366	0.4608	1
Echinococcus granulosus	potassium voltage gated channel protein	0.0366	0.4608	0.9985
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0366	0.4608	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0051	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0145	0.0291
Echinococcus granulosus	potassium large conductance calcium activated	0.0366	0.4608	0.9985
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0216	0.0444
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0366	0.4608	0.9985
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0051	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1148	0.2473
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0299	0.375	0.8132
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0085
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0366	0.4608	1
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0366	0.4608	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0366	0.4608	0.4602
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0051	0.0085
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0051	0.0039
Loa Loa (eye worm)	ryanodine receptor	0.0366	0.4608	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0366	0.4608	0.4602
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0216	0.0444
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0051	0.0085
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0051	0.0085
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0152	0.1869	0.4056
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0051	0.0085
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0366	0.4608	0.9985
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0366	0.4608	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.022	0.0624
Schistosoma mansoni	hypothetical protein	0.004	0.0431	0.0913
Schistosoma mansoni	calcium-activated potassium channel	0.0366	0.4608	1
Echinococcus multilocularis	voltage dependent calcium channel	0.0366	0.4608	0.4602
Brugia malayi	olfactory channel protein osm-9	0.0366	0.4608	1
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0366	0.4608	1
Loa Loa (eye worm)	glutaminase 2	0.0268	0.3347	0.7257
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0366	0.4608	1
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0366	0.4608	0.4602
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.045	0.0952
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0366	0.4608	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0051	0.0039
Echinococcus granulosus	calcium activated potassium channel	0.0367	0.4615	1
Echinococcus multilocularis	voltage gated potassium channel	0.0366	0.4608	0.4602
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0366	0.4608	0.4602
Loa Loa (eye worm)	voltage-gated potassium channel	0.0366	0.4608	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0051	0.0039
Echinococcus granulosus	two pore calcium channel protein 2	0.0366	0.4608	0.9985
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0051	0.0085
Brugia malayi	cation channel family protein	0.0366	0.4608	1
Schistosoma mansoni	transient receptor potential channel	0.0366	0.4608	1
Schistosoma mansoni	voltage-gated cation channel	0.0366	0.4608	1
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0051	0.0085
Schistosoma mansoni	voltage-gated potassium channel	0.0366	0.4608	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0366	0.4608	0.4602
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.022	0.183
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0283	0.059
Brugia malayi	steroid hormone receptor	0.001	0.0051	0.0085
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0366	0.4608	0.9985
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.022	0.183
Echinococcus granulosus	potassium voltage gated channel protein	0.0366	0.4608	0.9985
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0051	0.0085
Echinococcus granulosus	transient receptor potential cation channel	0.0366	0.4608	0.9985
Echinococcus granulosus	potassium voltage gated channel protein	0.0366	0.4608	0.9985
Loa Loa (eye worm)	hypothetical protein	0.0048	0.054	0.1149
Entamoeba histolytica	hypothetical protein	0.0023	0.0216	0.1795
Echinococcus multilocularis	potassium large conductance calcium activated	0.0366	0.4608	0.4602
Onchocerca volvulus		0.0366	0.4608	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0366	0.4608	1
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4608	1
Schistosoma mansoni	coup transcription factor	0.001	0.0051	0.0085
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0366	0.4608	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0085
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0366	0.4608	1
Echinococcus multilocularis	transient receptor potential gamma protein	0.0366	0.4608	0.4602

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 11.6 uM	Inhibition of p38a MAPK (unknown origin) by radiometric assay	ChEMBL.	24508134

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3121009

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1831244