TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 414.093 | Formula: C18H10Br2N2
H donors: 2 H acceptors: 0 LogP: 5.65 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc2c(c1)[nH]c(c2)C#Cc1cc2c([nH]1)cc(cc2)Br
InChi: 1S/C18H10Br2N2/c19-13-3-1-11-7-15(21-17(11)9-13)5-6-16-8-12-2-4-14(20)10-18(12)22-16/h1-4,7-10,21-22H
InChiKey: VPWVPPZZOSWQPJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	ion channel NompC	0.0344	0.3639	0.6203
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0344	0.3639	0.6203
Echinococcus multilocularis	survival motor neuron protein 1	0.0541	0.5867	0.5867
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0344	0.3639	1
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0344	0.3639	0.6203
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0079	0.0646	0.5941
Echinococcus multilocularis	transfer RNA-Gly	0.0344	0.3639	0.3639
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0344	0.3639	0.6203
Schistosoma mansoni	hypothetical protein	0.0196	0.1973	0.5423
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0344	0.3639	0.3639
Echinococcus multilocularis	sodium leak channel non selective protein	0.0344	0.3639	0.3639
Echinococcus granulosus	transient receptor potential cation channel	0.0344	0.3639	0.6203
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0344	0.3639	0.3639
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0344	0.3639	1
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0344	0.3639	0.3639
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0344	0.3639	0.3639
Echinococcus granulosus	shaker cognate	0.0344	0.3639	0.6203
Echinococcus multilocularis	shaker cognate	0.0344	0.3639	0.3639
Echinococcus granulosus	potassium large conductance calcium activated	0.0344	0.3639	0.6203
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0079	0.0646	0.5941
Mycobacterium ulcerans	polyketide synthase MbtD	0.0024	0.0028	0.0256
Echinococcus granulosus	voltage dependent calcium channel	0.0344	0.3639	0.6203
Echinococcus granulosus	hyperpolarization activated cyclic	0.0344	0.3639	0.6203
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Leishmania major	hypothetical protein, conserved	0.0024	0.0022	0.0061
Brugia malayi	voltage-dependent calcium channel	0.0344	0.3639	0.6203
Entamoeba histolytica	hypothetical protein	0.004	0.0208	1
Schistosoma mansoni	transient receptor potential channel	0.0344	0.3639	1
Brugia malayi	Methyltransferase-like protein 4	0.0024	0.0022	0.0038
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0344	0.3639	1
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0344	0.3639	0.6203
Schistosoma mansoni	ryanodine receptor related	0.0344	0.3639	1
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0344	0.3639	0.6203
Echinococcus granulosus	transient receptor potential cation channel	0.0344	0.3639	0.6203
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0344	0.3639	1
Brugia malayi	hypothetical protein	0.0541	0.5867	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0344	0.3639	0.3639
Schistosoma mansoni	hypothetical protein	0.0038	0.0184	0.0506
Echinococcus multilocularis	two pore calcium channel protein 2	0.0344	0.3639	0.3639
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0079	0.0646	0.581
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0344	0.3639	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.011	0.1001	0.1705
Echinococcus granulosus	potassium voltage gated channel protein	0.0344	0.3639	0.6203
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0344	0.3639	1
Echinococcus granulosus	voltage gated potassium channel	0.0344	0.3639	0.6203
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0063	0.0471	0.4337
Toxoplasma gondii	hypothetical protein	0.0344	0.3639	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0104	0.0931	0.1587
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Echinococcus granulosus	two pore calcium channel protein 1	0.0344	0.3639	0.6203
Echinococcus multilocularis	potassium voltage gated channel protein	0.0344	0.3639	0.3639
Echinococcus multilocularis	sodium channel protein	0.0344	0.3639	0.3639
Toxoplasma gondii	transporter, cation channel family protein	0.0344	0.3639	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0087	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1302	0.2219
Mycobacterium ulcerans	fatty acid synthase Fas	0.0025	0.0034	0.0311
Onchocerca volvulus		0.0137	0.1306	0.2356
Entamoeba histolytica	hypothetical protein	0.004	0.0208	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0344	0.3639	0.6203
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0079	0.0646	0.5941
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0344	0.3639	0.3639
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0344	0.3639	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0344	0.3639	1
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0344	0.3639	0.6203
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0087	1
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0344	0.3639	0.6203
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0084	0.0701	0.6337
Schistosoma mansoni	voltage-gated cation channel	0.0344	0.3639	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0344	0.3639	1
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0344	0.3639	0.6203
Echinococcus multilocularis	conserved hypothetical protein	0.0344	0.3639	0.3639
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0184	0.0314
Mycobacterium ulcerans	thioesterase	0.0066	0.0497	0.4572
Echinococcus multilocularis	voltage dependent calcium channel	0.0344	0.3639	0.3639
Schistosoma mansoni	methyltransferase-related	0.0024	0.0022	0.0061
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0118	0.1087	1
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0344	0.3639	0.3639
Echinococcus granulosus	short transient receptor potential channel 6	0.0344	0.3639	0.6203
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0344	0.3639	0.3639
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0344	0.3639	0.6203
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0344	0.3639	1
Loa Loa (eye worm)	calcium channel	0.0344	0.3639	0.6203
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0344	0.3639	0.6203
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0344	0.3639	0.6203
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0084	0.0701	0.6337
Echinococcus granulosus	transient receptor potential cation channel	0.0344	0.3639	0.6203
Toxoplasma gondii	type I fatty acid synthase, putative	0.0084	0.0701	0.1926
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0344	0.3639	0.6203
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0344	0.3639	0.6203
Brugia malayi	cation channel family protein	0.0344	0.3639	0.6203
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Schistosoma mansoni	voltage-dependent calcium channel	0.0344	0.3639	1
Echinococcus granulosus	potassium voltage gated channel protein	0.0344	0.3639	0.6203
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0084	0.0701	0.645
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0344	0.3639	0.6203
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0344	0.3639	0.3639
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0344	0.3639	0.3639
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0344	0.3639	0.6203
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0344	0.3639	0.3639
Mycobacterium tuberculosis	Polyketide synthetase MbtD (polyketide synthase)	0.0024	0.0028	0.0256
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0344	0.3639	1
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0344	0.3639	0.3639
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0104	0.0931	0.0931
Echinococcus granulosus	hypothetical protein	0.0344	0.3639	0.6203
Schistosoma mansoni	voltage-gated ion channel	0.0344	0.3639	1
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0028	0.0047
Schistosoma mansoni	hypothetical protein	0.0344	0.3639	1
Echinococcus multilocularis	geminin	0.0196	0.1973	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0384	0.0654
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0074	0.0587	0.1
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0344	0.3639	0.3639
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0084	0.0701	0.645
Loa Loa (eye worm)	fatty acid synthase	0.0078	0.0634	0.108
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.0931	0.2558
Echinococcus granulosus	hyperpolarization activated cyclic	0.0344	0.3639	0.6203
Loa Loa (eye worm)	ryanodine receptor	0.0344	0.3639	0.6203
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0344	0.3639	1
Brugia malayi	Transient-receptor-potential like protein	0.0344	0.3639	0.6203
Leishmania major	hypothetical protein, conserved	0.0029	0.0087	0.0238
Echinococcus multilocularis	potassium voltage gated channel protein	0.0344	0.3639	0.3639
Echinococcus granulosus	voltage gated potassium channel	0.0344	0.3639	0.6203
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0344	0.3639	0.6203
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0087	1
Toxoplasma gondii	transporter, cation channel family protein	0.0344	0.3639	1
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0344	0.3639	0.6203
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0344	0.3639	1
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0344	0.3639	0.6203
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0344	0.3639	0.3639
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Mycobacterium tuberculosis	Conserved protein	0.0024	0.0022	0.0205
Leishmania major	hypothetical protein, unknown function	0.0344	0.3639	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0344	0.3639	0.6203
Loa Loa (eye worm)	acyl carrier protein	0.0036	0.0164	0.0279
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0344	0.3639	0.6203
Brugia malayi	hypothetical protein	0.0344	0.3639	0.6203
Loa Loa (eye worm)	voltage-gated calcium channel	0.0344	0.3639	0.6203
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0074	0.0587	0.5401
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0344	0.3639	1
Echinococcus granulosus	survival motor neuron protein 1	0.0541	0.5867	1
Leishmania major	hypothetical protein, conserved	0.0344	0.3639	1
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Schistosoma mansoni	calcium-activated potassium channel	0.0344	0.3639	1
Brugia malayi	hypothetical protein	0.0137	0.1302	0.2219
Onchocerca volvulus		0.0344	0.3639	1
Echinococcus multilocularis	calcium activated potassium channel	0.0344	0.3639	0.3639
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0344	0.3639	1
Brugia malayi	hypothetical protein	0.004	0.0208	0.0355
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0344	0.3639	0.6203
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0052	0.0343	0.2941
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.0931	0.2558
Schistosoma mansoni	transient receptor potential channel	0.0344	0.3639	1
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0076	0.0618	0.5689
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0344	0.3639	0.6203
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0344	0.3639	0.6203
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0087	0.0238
Echinococcus granulosus	transient receptor potential cation channel	0.0344	0.3639	0.6203
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0344	0.3639	0.3639
Mycobacterium ulcerans	polyketide synthase Pks13	0.0118	0.1087	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0344	0.3639	1
Echinococcus multilocularis	two pore calcium channel protein 1	0.0344	0.3639	0.3639
Echinococcus multilocularis	potassium large conductance calcium activated	0.0344	0.3639	0.3639
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1302	0.2219
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0087	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0184	0.0314
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0344	0.3639	1
Toxoplasma gondii	hypothetical protein	0.0344	0.3639	1
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0344	0.3639	1
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0344	0.3639	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0384	0.0654
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0344	0.3639	0.6203
Mycobacterium tuberculosis	Hypothetical protein	0.0024	0.0022	0.0205
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0066	0.0497	0.4398
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0063	0.0471	0.4337
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0344	0.3639	1
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0344	0.3639	0.6203
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Onchocerca volvulus	Fatty acid synthase homolog	0.0142	0.1362	0.2537
Echinococcus multilocularis	short transient receptor potential channel 6	0.0344	0.3639	0.3639
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0104	0.0931	0.1587
Mycobacterium ulcerans	polyketide synthase Pks9	0.0052	0.0343	0.316
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0344	0.3639	0.3639
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.0032	0.0114	0.1052
Brugia malayi	olfactory channel protein osm-9	0.0344	0.3639	0.6203
Echinococcus granulosus	two pore calcium channel protein 2	0.0344	0.3639	0.6203
Giardia lamblia	Methyltransferase like 2	0.0024	0.0022	1
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0118	0.1087	1
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0084	0.0701	0.645
Entamoeba histolytica	hypothetical protein	0.004	0.0208	1
Loa Loa (eye worm)	hypothetical protein	0.0541	0.5867	1
Mycobacterium ulcerans	polyketide synthase	0.0079	0.0646	0.5941
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0045	0.0261	0.2399
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0022	0.0061
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0344	0.3639	0.3639
Onchocerca volvulus	Huntingtin homolog	0.0137	0.1302	0.2341
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0208	0.0355
Echinococcus multilocularis	potassium voltage gated channel protein	0.0344	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0253	0.0432
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0344	0.3639	1
Schistosoma mansoni	two-pore calcium channel	0.0344	0.3639	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0052	0.0343	0.316
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0344	0.3639	1
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0344	0.3639	0.6203
Toxoplasma gondii	type I fatty acid synthase, putative	0.0056	0.0389	0.1068
Schistosoma mansoni	transient receptor potential channel	0.0344	0.3639	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0087	0.0238
Onchocerca volvulus	Huntingtin homolog	0.0137	0.1302	0.2341
Schistosoma mansoni	survival motor neuron protein	0.011	0.1001	0.2749
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0208	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1252	0.2134
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0084	0.0701	0.6337
Echinococcus granulosus	short transient receptor potential channel 6	0.0344	0.3639	0.6203
Echinococcus granulosus	transient receptor potential cation channel	0.0344	0.3639	0.6203
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0344	0.3639	0.6203
Echinococcus multilocularis	potassium voltage gated channel protein	0.0344	0.3639	0.3639
Echinococcus granulosus	geminin	0.0196	0.1973	0.3364
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0344	0.3639	0.6203
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0344	0.3639	0.6203
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0344	0.3639	1
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0344	0.3639	0.6203
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0079	0.0646	0.5941
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0087	0.0238
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0104	0.0931	0.1587
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0051	0.0332	0.0913
Echinococcus multilocularis	transient receptor potential cation channel	0.0344	0.3639	0.3639
Echinococcus multilocularis	voltage gated potassium channel	0.0344	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Echinococcus multilocularis	transient receptor potential cation channel	0.0344	0.3639	0.3639
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0384	0.0654
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0344	0.3639	1
Loa Loa (eye worm)	voltage-gated potassium channel	0.0344	0.3639	0.6203
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0079	0.0646	0.5941
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0344	0.3639	0.6203
Brugia malayi	hypothetical protein	0.0029	0.0087	0.0148
Echinococcus granulosus	calcium activated potassium channel	0.0344	0.3639	0.6203
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0344	0.3639	0.3639
Loa Loa (eye worm)	voltage-gated potassium channel	0.0344	0.3639	0.6203
Echinococcus multilocularis	voltage dependent calcium channel	0.0344	0.3639	0.3639
Onchocerca volvulus		0.011	0.1001	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Mycobacterium leprae	Polyketide synthase Pks13	0.0118	0.1087	1
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Echinococcus multilocularis	transient receptor potential cation channel	0.0344	0.3639	0.3639
Mycobacterium tuberculosis	Probable fatty acid synthase Fas (fatty acid synthetase)	0.0025	0.0034	0.0311
Mycobacterium ulcerans	thioesterase TesA	0.0066	0.0497	0.4572
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.0931	0.2558
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0208	0.0208
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0076	0.0618	0.5689
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0344	0.3639	1
Echinococcus granulosus	sodium leak channel non selective protein	0.0344	0.3639	0.6203
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Echinococcus granulosus	TRP transient receptor potential channel	0.0344	0.3639	0.6203
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0344	0.3639	0.6203
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0384	0.0654
Schistosoma mansoni	transient receptor potential channel 4	0.0344	0.3639	1
Echinococcus granulosus	potassium voltage gated channel protein	0.0344	0.3639	0.6203
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0344	0.3639	0.6203
Schistosoma mansoni	hypothetical protein	0.004	0.0208	0.0572
Toxoplasma gondii	transporter, cation channel family protein	0.0344	0.3639	1
Echinococcus granulosus	potassium voltage gated channel protein	0.0344	0.3639	0.6203
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0084	0.0701	0.645
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0344	0.3639	0.3639
Mycobacterium ulcerans	polyketide synthase	0.0084	0.0701	0.645
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0344	0.3639	0.6203
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0079	0.0646	0.581
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0057	0.0394	0.3629
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0104	0.0931	0.1587
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0104	0.0931	0.0931
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0344	0.3639	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0344	0.3639	0.3639
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0079	0.0646	0.5941
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0344	0.3639	0.3639
Brugia malayi	cation channel family protein	0.0344	0.3639	0.6203
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.004	0.0204	0.0562
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0344	0.3639	1
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0079	0.0646	0.11
Echinococcus granulosus	voltage dependent calcium channel	0.0344	0.3639	0.6203
Schistosoma mansoni	hypothetical protein	0.0196	0.1973	0.5423
Echinococcus multilocularis	transient receptor potential cation channel	0.0344	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0063	0.0471	0.4155
Echinococcus multilocularis	ryanodine receptor 44f	0.0344	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0079	0.0646	0.5941
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0344	0.3639	0.6203
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0084	0.0701	0.645
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0344	0.3639	0.6203
Brugia malayi	AMP-binding enzyme family protein	0.0074	0.0587	0.1
Schistosoma mansoni	voltage-gated potassium channel	0.0344	0.3639	1
Echinococcus granulosus	transient receptor potential gamma protein	0.0344	0.3639	0.6203
Schistosoma mansoni	vesicular amine transporter	0.0344	0.3639	1
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Brugia malayi	ion channel NompC	0.0344	0.3639	0.6203
Echinococcus granulosus	sodium channel protein	0.0344	0.3639	0.6203
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0065	0.0483	0.4445
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.015	0.1444	0.2462
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0344	0.3639	1
Entamoeba histolytica	hypothetical protein	0.004	0.0208	1
Schistosoma mansoni	hypothetical protein	0.011	0.1001	0.2749
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0066	0.0497	0.4572
Echinococcus multilocularis	short transient receptor potential channel 6	0.0344	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Mycobacterium tuberculosis	Polyketide synthetase MbtC (polyketide synthase)	0.0027	0.006	0.0554
Echinococcus granulosus	transient receptor potential cation channel	0.0344	0.3639	0.6203
Schistosoma mansoni	60S ribosomal protein L21	0.0344	0.3639	1
Echinococcus multilocularis	transient receptor potential gamma protein	0.0344	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0087	0.0148
Echinococcus multilocularis	voltage gated potassium channel	0.0344	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Echinococcus granulosus	ryanodine receptor 44f	0.0344	0.3639	0.6203
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0344	0.3639	0.6203
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3639	0.6203
Echinococcus granulosus	potassium voltage gated channel protein	0.0344	0.3639	0.6203

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3113868

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1831450