Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Histamine H3 receptor | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | biogenic amine 5HT receptor | Histamine H3 receptor | 445 aa | 405 aa | 25.2 % |
Loa Loa (eye worm) | hypothetical protein | Histamine H3 receptor | 445 aa | 384 aa | 22.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0064 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0064 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0064 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0064 | 0.5 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Plasmodium falciparum | tubulin beta chain | 0.0064 | 0.5 | 0.5 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0064 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0064 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0064 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0064 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0064 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Echinococcus granulosus | tubulin subunit beta | 0.0064 | 0.5 | 0.5 |
Toxoplasma gondii | beta tubulin | 0.0064 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0064 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Plasmodium vivax | tubulin beta chain, putative | 0.0064 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0064 | 0.5 | 0.5 |
Trypanosoma cruzi | beta tubulin, putative | 0.0064 | 0.5 | 0.5 |
Loa Loa (eye worm) | beta-tubulin | 0.0064 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0064 | 0.5 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0064 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0064 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0064 | 0.5 | 0.5 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0064 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0064 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin, putative | 0.0064 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin subunit beta | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0064 | 0.5 | 0.5 |
Brugia malayi | beta-tubulin, identical | 0.0064 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0064 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0064 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0064 | 0.5 | 0.5 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0064 | 0.5 | 0.5 |
Toxoplasma gondii | beta-tubulin, putative | 0.0064 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0064 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0064 | 0.5 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0064 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0064 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0064 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0064 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0064 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0064 | 0.5 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0064 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0064 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta chain | 0.0064 | 0.5 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0064 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3.5 nM | Displacement of [3H]NAMH from human histamine H3 receptor transfected in CHO cells | ChEMBL. | 24513042 |
Ki (binding) | = 6.7 nM | Displacement of [3H]NAMH from rat histamine H3 receptor transfected in CHO cells | ChEMBL. | 24513042 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.