TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 342.32 | Formula: C14H17F3N6O
H donors: 2 H acceptors: 3 LogP: 1.82 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CNc1nc(ncc1C(F)(F)F)Nc1cnn2c1C(C)O[C@H](C2)C
InChi: 1S/C14H17F3N6O/c1-7-6-23-11(8(2)24-7)10(5-20-23)21-13-19-4-9(14(15,16)17)12(18-3)22-13/h4-5,7-8H,6H2,1-3H3,(H2,18,19,21,22)/t7-,8?/m0/s1
InChiKey: HVPGKPCGQMAXGL-JAMMHHFISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	leucine-rich repeat kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	Get druggable targets OG5_131478	All targets in OG5_131478
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_131478	All targets in OG5_131478
Echinococcus granulosus	leucine rich repeat serine:threonine protein	Get druggable targets OG5_131478	All targets in OG5_131478
Loa Loa (eye worm)	TKL/LRRK protein kinase	Get druggable targets OG5_131478	All targets in OG5_131478

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.022	0.9991	0.9991
Echinococcus granulosus	transient receptor potential cation channel	0.022	0.9991	0.9991
Brugia malayi	olfactory channel protein osm-9	0.022	0.9991	1
Echinococcus granulosus	transient receptor potential cation channel	0.022	0.9991	0.9991
Schistosoma mansoni	voltage-gated cation channel	0.022	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.022	0.9991	0.9991
Schistosoma mansoni	ryanodine receptor related	0.022	0.9991	1
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Schistosoma mansoni	two-pore calcium channel	0.022	0.9991	1
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.022	0.9991	1
Echinococcus granulosus	short transient receptor potential channel 6	0.022	0.9991	0.9991
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.007	0.3099	0.3099
Echinococcus multilocularis	potassium voltage gated channel protein	0.022	0.9991	0.9991
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.022	0.9991	0.9991
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.022	0.9991	0.9991
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.022	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Echinococcus multilocularis	transient receptor potential cation channel	0.022	0.9991	0.9991
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.022	0.9991	1
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.022	0.9991	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.022	0.9991	0.9991
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.022	0.9991	1
Schistosoma mansoni	transient receptor potential channel	0.022	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.022	0.9991	0.9991
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.022	0.9991	1
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.022	0.9991	0.9991
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.022	0.9991	1
Brugia malayi	cation channel family protein	0.022	0.9991	1
Loa Loa (eye worm)	voltage-dependent calcium channel	0.022	0.9991	1
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.022	0.9991	0.9991
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.022	0.9991	1
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.022	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.022	0.9991	1
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.022	0.9991	0.9991
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.022	0.9991	1
Loa Loa (eye worm)	voltage-gated potassium channel	0.022	0.9991	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.022	0.9991	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.022	0.9991	1
Schistosoma mansoni	transient receptor potential channel	0.022	0.9991	1
Schistosoma mansoni	transient receptor potential channel	0.022	0.9991	1
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.022	0.9991	1
Echinococcus multilocularis	transient receptor potential cation channel	0.022	0.9991	0.9991
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.022	0.9991	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.022	0.9991	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.022	0.9991	0.9991
Echinococcus multilocularis	sodium leak channel non selective protein	0.022	0.9991	0.9991
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.022	0.9991	1
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.022	0.9991	0.9991
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.022	0.9991	0.9991
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.022	0.9991	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.022	0.9991	0.9991
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.022	0.9991	1
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.022	0.9991	0.9991
Echinococcus granulosus	voltage gated potassium channel	0.022	0.9991	0.9991
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.022	0.9991	1
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.022	0.9991	1
Toxoplasma gondii	transporter, cation channel family protein	0.022	0.9991	0.5
Toxoplasma gondii	transporter, cation channel family protein	0.022	0.9991	0.5
Echinococcus granulosus	potassium voltage gated channel protein	0.022	0.9991	0.9991
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.022	0.9991	1
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.022	0.9991	0.9991
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.022	0.9991	1
Echinococcus granulosus	potassium voltage gated channel protein	0.022	0.9991	0.9991
Echinococcus multilocularis	voltage dependent calcium channel	0.022	0.9991	0.9991
Echinococcus multilocularis	transient receptor potential cation channel	0.022	0.9991	0.9991
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.022	0.9991	0.9991
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.022	0.9991	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.022	0.9991	0.9991
Echinococcus granulosus	transient receptor potential cation channel	0.022	0.9991	0.9991
Echinococcus granulosus	two pore calcium channel protein 1	0.022	0.9991	0.9991
Brugia malayi	Cyclic-nucleotide gated cation channel	0.022	0.9991	1
Echinococcus multilocularis	two pore calcium channel protein 1	0.022	0.9991	0.9991
Toxoplasma gondii	transporter, cation channel family protein	0.022	0.9991	0.5
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.022	0.9991	1
Echinococcus multilocularis	conserved hypothetical protein	0.022	0.9991	0.9991
Echinococcus granulosus	potassium voltage gated channel protein	0.022	0.9991	0.9991
Schistosoma mansoni	voltage-gated ion channel	0.022	0.9991	1
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.022	0.9991	1
Echinococcus granulosus	sodium leak channel non selective protein	0.022	0.9991	0.9991
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.022	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Echinococcus multilocularis	short transient receptor potential channel 6	0.022	0.9991	0.9991
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.022	0.9991	0.9991
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Echinococcus granulosus	voltage dependent calcium channel	0.022	0.9991	0.9991
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.022	0.9991	1
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.022	0.9991	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.022	0.9991	1
Schistosoma mansoni	vesicular amine transporter	0.022	0.9991	1
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.022	0.9991	0.9991
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.022	0.9991	0.9991
Echinococcus multilocularis	transient receptor potential cation channel	0.022	0.9991	0.9991
Toxoplasma gondii	hypothetical protein	0.022	0.9991	0.5
Echinococcus multilocularis	voltage gated potassium channel	0.022	0.9991	0.9991
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.022	0.9991	0.9991
Leishmania major	hypothetical protein, conserved	0.022	0.9991	1
Echinococcus granulosus	ryanodine receptor 44f	0.022	0.9991	0.9991
Echinococcus granulosus	two pore calcium channel protein 2	0.022	0.9991	0.9991
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.022	0.9991	0.5
Schistosoma mansoni	60S ribosomal protein L21	0.022	0.9991	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.022	0.9991	0.9991
Echinococcus granulosus	transient receptor potential cation channel	0.022	0.9991	0.9991
Echinococcus granulosus	voltage dependent calcium channel	0.022	0.9991	0.9991
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.022	0.9991	0.9991
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.022	0.9991	1
Brugia malayi	cation channel family protein	0.022	0.9991	1
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.022	0.9991	0.9991
Loa Loa (eye worm)	ryanodine receptor	0.022	0.9991	1
Echinococcus multilocularis	short transient receptor potential channel 6	0.022	0.9991	0.9991
Echinococcus multilocularis	transient receptor potential cation channel	0.022	0.9991	0.9991
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Loa Loa (eye worm)	ion channel NompC	0.022	0.9991	1
Loa Loa (eye worm)	calcium channel	0.022	0.9991	1
Echinococcus granulosus	sodium channel protein	0.022	0.9991	0.9991
Schistosoma mansoni	calcium-activated potassium channel	0.022	0.9991	1
Echinococcus granulosus	voltage gated hydrogen channel 1	0.022	0.9991	0.9991
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.022	0.9991	1
Onchocerca volvulus		0.022	0.9991	1
Schistosoma mansoni	transient receptor potential channel 4	0.022	0.9991	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.022	0.9991	0.9991
Schistosoma mansoni	hypothetical protein	0.022	0.9991	1
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.022	0.9991	0.9991
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.022	0.9991	0.9991
Brugia malayi	Transient-receptor-potential like protein	0.022	0.9991	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.022	0.9991	1
Brugia malayi	ion channel NompC	0.022	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0071	0.312	0.312
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.007	0.3099	0.3101
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.022	0.9991	1
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.022	0.9991	0.9991
Echinococcus granulosus	potassium large conductance calcium activated	0.022	0.9991	0.9991
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.022	0.9991	0.9991
Echinococcus granulosus	hyperpolarization activated cyclic	0.022	0.9991	0.9991
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.022	0.9991	1
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Echinococcus granulosus	short transient receptor potential channel 6	0.022	0.9991	0.9991
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.022	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Echinococcus multilocularis	transient receptor potential cation channel	0.022	0.9991	0.9991
Echinococcus multilocularis	shaker cognate	0.022	0.9991	0.9991
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.022	0.9991	0.9991
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.022	0.9991	0.9991
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.022	0.9991	0.9991
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Echinococcus multilocularis	potassium large conductance calcium activated	0.022	0.9991	0.9991
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.022	0.9991	1
Echinococcus multilocularis	transfer RNA-Gly	0.022	0.9991	0.9991
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.022	0.9991	0.9991
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.022	0.9991	1
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Echinococcus multilocularis	voltage gated potassium channel	0.022	0.9991	0.9991
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.022	0.9991	1
Echinococcus granulosus	transient receptor potential gamma protein	0.022	0.9991	0.9991
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Echinococcus granulosus	TRP transient receptor potential channel	0.022	0.9991	0.9991
Echinococcus multilocularis	sodium channel protein	0.022	0.9991	0.9991
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Brugia malayi	Protein kinase domain containing protein	0.007	0.3099	0.3101
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.022	0.9991	1
Brugia malayi	hypothetical protein	0.022	0.9991	1
Leishmania major	hypothetical protein, unknown function	0.022	0.9991	1
Echinococcus granulosus	transient receptor potential cation channel	0.022	0.9991	0.9991
Toxoplasma gondii	hypothetical protein	0.022	0.9991	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.022	0.9991	0.9991
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Echinococcus multilocularis	ryanodine receptor 44f	0.022	0.9991	0.9991
Echinococcus granulosus	shaker cognate	0.022	0.9991	0.9991
Echinococcus multilocularis	two pore calcium channel protein 2	0.022	0.9991	0.9991
Echinococcus granulosus	potassium voltage gated channel protein	0.022	0.9991	0.9991
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.022	0.9991	1
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.022	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.022	0.9991	1
Echinococcus granulosus	transient receptor potential cation channel	0.022	0.9991	0.9991
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.022	0.9991	1
Echinococcus multilocularis	transient receptor potential gamma protein	0.022	0.9991	0.9991
Echinococcus multilocularis	voltage dependent calcium channel	0.022	0.9991	0.9991
Loa Loa (eye worm)	voltage-gated calcium channel	0.022	0.9991	1
Echinococcus granulosus	voltage gated potassium channel	0.022	0.9991	0.9991
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.022	0.9991	0.9991
Echinococcus granulosus	potassium voltage gated channel protein	0.022	0.9991	0.9991
Schistosoma mansoni	voltage-gated potassium channel	0.022	0.9991	1
Echinococcus granulosus	hypothetical protein	0.022	0.9991	0.9991
Echinococcus multilocularis	potassium voltage gated channel protein	0.022	0.9991	0.9991
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.022	0.9991	0.9991
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.022	0.9991	1
Loa Loa (eye worm)	voltage-gated potassium channel	0.022	0.9991	1
Schistosoma mansoni	voltage-dependent calcium channel	0.022	0.9991	1
Brugia malayi	voltage-dependent calcium channel	0.022	0.9991	1
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.022	0.9991	0.9991
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.022	0.9991	0.9991
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.022	0.9991	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.022	0.9991	0.9991

Activities

Activity type	Activity value	Assay description	Source	Reference
CL (ADMET)	= 8 ml/min.kg	Clearance in human hepatocytes at 1 uM by LC-MS/MS analysis	ChEMBL.	24354345
IC50 (binding)	= 49 nM	Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assay	ChEMBL.	24354345
Ki (binding)	= 6 nM	Inhibition of LRRK2 (unknown origin)	ChEMBL.	24354345
Ratio (ADMET)	= 1	Activity at human MDR1 transfected in MDCK cells assessed as efflux ratio of apparent permeability from basolateral to apical side over apical to basolateral side at 5 uM	ChEMBL.	24354345

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3122107

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1831689