Detailed information for compound 1831773

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 610.455 | Formula: C28H28Cl2F3N5O3
  • H donors: 0 H acceptors: 4 LogP: 5.02 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)OC1(CCCN(C1)C(=O)c1cnccc1C(F)(F)F)C(=O)N1CCN(CC1)c1ccccn1.Cl
  • InChi: 1S/C28H27ClF3N5O3.ClH/c29-20-5-7-21(8-6-20)40-27(26(39)36-16-14-35(15-17-36)24-4-1-2-11-34-24)10-3-13-37(19-27)25(38)22-18-33-12-9-23(22)28(30,31)32;/h1-2,4-9,11-12,18H,3,10,13-17,19H2;1H
  • InChiKey: WXKAZORTYAIKOL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens MDM2 proto-oncogene, E3 ubiquitin protein ligase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/RYK protein kinase 0.0009 0.0004 0.001
Onchocerca volvulus Cathepsin L homolog 0.0061 0.0639 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0058 0.0605 0.0561
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0058 0.0605 0.153
Echinococcus granulosus roundabout 2 0.0012 0.0037 0.0085
Loa Loa (eye worm) RGC/RGC protein kinase 0.0009 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0183 0.0465
Brugia malayi hypothetical protein 0.0058 0.0605 0.153
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0178 0.0444
Loa Loa (eye worm) TK/DDR protein kinase 0.0009 0.0004 0.001
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0079 0.0854 0.6352
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0431
Entamoeba histolytica acetyltransferase, GNAT family 0.0072 0.0774 1
Brugia malayi Cathepsin L-like precursor 0.0061 0.0639 0.1619
Onchocerca volvulus 0.0024 0.0183 0.2812
Loa Loa (eye worm) TK protein kinase 0.0009 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0183 0.1336
Brugia malayi brahma associated protein 60 kDa 0.0013 0.0051 0.012
Onchocerca volvulus 0.0061 0.0639 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0009 0.0004 0.001
Plasmodium falciparum cysteine proteinase falcipain 1 0.0024 0.0183 0.2322
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0253
Loa Loa (eye worm) TK/CSK protein kinase 0.0009 0.0004 0.001
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0169 0.0421
Echinococcus multilocularis cathepsin b 0.033 0.393 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0639 0.1627
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.001 0.0019 0.0192
Schistosoma mansoni cathepsin B (C01 family) 0.0024 0.0183 0.0455
Toxoplasma gondii cathepsin B 0.0118 0.1342 1
Onchocerca volvulus 0.0023 0.0169 0.2603
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Plasmodium falciparum serine repeat antigen 2 0.0024 0.0183 0.2322
Plasmodium vivax vivapain-3 0.0024 0.0183 0.2103
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0605 0.707
Loa Loa (eye worm) serine/threonine protein kinase 0.0009 0.0004 0.001
Loa Loa (eye worm) TK/ABL protein kinase 0.0009 0.0004 0.001
Plasmodium falciparum serine repeat antigen 6 0.0024 0.0183 0.2322
Echinococcus granulosus cathepsin L cysteine protease 0.0024 0.0183 0.0455
Brugia malayi Cathepsin L-like precursor 0.0061 0.0639 0.1619
Loa Loa (eye worm) RGC/RGC protein kinase 0.0009 0.0004 0.001
Giardia lamblia TCP-1 chaperonin subunit beta 0.0023 0.0178 0.1303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.0183 0.1336
Echinococcus granulosus cathepsin b 0.033 0.393 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Plasmodium falciparum T-complex protein 1 subunit beta 0.0023 0.0178 0.2265
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Schistosoma mansoni hypothetical protein 0.0149 0.1714 0.4357
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Loa Loa (eye worm) protein kinase domain-containing protein 0.0009 0.0004 0.001
Loa Loa (eye worm) RGC/RGC protein kinase 0.0009 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0061 0.0639 0.1627
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0058 0.0605 0.153
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0024 0.0183 0.1336
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0169 0.0421
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0061 0.0639 0.8257
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Chlamydia trachomatis protoporphyrinogen oxidase 0.0058 0.0605 1
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0023 0.0178 0.0444
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0432 0.11
Echinococcus granulosus geminin 0.0149 0.1714 0.4357
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Schistosoma mansoni hypothetical protein 0.0013 0.0051 0.012
Trichomonas vaginalis chaperonin, putative 0.0023 0.0178 0.1303
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0099 0.1241
Onchocerca volvulus Cathepsin L homolog 0.0061 0.0639 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0009 0.0004 0.001
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0183 0.0455
Giardia lamblia Encystation-specific protease 0.0024 0.0183 0.1336
Echinococcus granulosus neuroglian 0.0012 0.0037 0.0085
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Onchocerca volvulus 0.0061 0.0639 1
Entamoeba histolytica hypothetical protein 0.001 0.0019 0.0192
Onchocerca volvulus 0.0061 0.0639 1
Echinococcus multilocularis geminin 0.0149 0.1714 0.4357
Toxoplasma gondii t-complex protein beta subunit 0.0023 0.0178 0.1303
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0024 0.0183 0.1336
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0058 0.0605 0.051
Schistosoma mansoni nephrin 0.0012 0.0037 0.0085
Loa Loa (eye worm) TK/Met protein kinase 0.0009 0.0004 0.001
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0024 0.0183 0.2103
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0183 0.0455
Loa Loa (eye worm) hypothetical protein 0.0058 0.0605 0.1539
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0013 0.0051 0.0352
Loa Loa (eye worm) hypothetical protein 0.0024 0.0183 0.0465
Onchocerca volvulus 0.0013 0.0051 0.0742
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.0639 0.8257
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0024 0.0183 0.2103
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Trypanosoma cruzi cysteine proteinase, putative 0.0024 0.0183 0.0455
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0639 0.4751
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0183 0.1336
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0639 0.1619
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0079 0.0854 0.6352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0639 0.4751
Echinococcus granulosus histone acetyltransferase KAT2B 0.0079 0.0854 0.2164
Echinococcus multilocularis cysteine protease 0.0061 0.0639 0.1619
Onchocerca volvulus 0.0061 0.0639 1
Brugia malayi cathepsin L precursor 0.0024 0.0183 0.0455
Giardia lamblia Cathepsin B precursor 0.0118 0.1342 1
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Trypanosoma cruzi cysteine proteinase, putative 0.0024 0.0183 0.0455
Mycobacterium ulcerans monoamine oxidase 0.0058 0.0605 0.051
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0058 0.0605 0.7806
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0432 0.1091
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0061 0.0639 0.8257
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0023 0.0178 0.0444
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0058 0.0605 0.7806
Echinococcus granulosus cathepsin l cysteine peptidase 0.0061 0.0639 0.1619
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0013 0.0056 0.0132
Echinococcus multilocularis roundabout 2 0.0012 0.0037 0.0085
Giardia lamblia Cathepsin B precursor 0.0118 0.1342 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0432 0.1091
Mycobacterium ulcerans hypothetical protein 0.0023 0.0169 0.0071
Echinococcus multilocularis SWI:SNF matrix associated 0.0013 0.0051 0.012
Giardia lamblia Cathepsin L precursor 0.0024 0.0183 0.1336
Echinococcus granulosus slit 2 protein 0.0029 0.0243 0.061
Brugia malayi Cathepsin L-like precursor 0.0061 0.0639 0.1619
Giardia lamblia Cathepsin B precursor 0.0024 0.0183 0.1336
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0024 0.0183 0.2103
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0023 0.0178 0.1303
Brugia malayi cathepsin Z-like cysteine proteinase 0.0024 0.0183 0.0455
Echinococcus multilocularis SWI:SNF matrix associated 0.0013 0.0051 0.012
Schistosoma mansoni cathepsin S (C01 family) 0.0024 0.0183 0.0455
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0094
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0183 0.2322
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0639 0.4751
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.0639 0.8257
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0024 0.0183 0.0465
Loa Loa (eye worm) hypothetical protein 0.0058 0.0605 0.1539
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0639 0.1619
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Brugia malayi Cathepsin L-like precursor 0.0061 0.0639 0.1619
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0431
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0013 0.0051 0.0613
Loa Loa (eye worm) hypothetical protein 0.0024 0.0183 0.0465
Schistosoma mansoni brg-1 associated factor 0.0013 0.0051 0.012
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0013 0.0051 0.012
Loa Loa (eye worm) hypothetical protein 0.0061 0.0639 0.1627
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0024 0.0183 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0183 0.1336
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0024 0.0183 0.2322
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0024 0.0183 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Echinococcus granulosus cathepsin l1 0.0061 0.0639 0.1619
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0061 0.0639 0.1619
Schistosoma mansoni cathepsin F (C01 family) 0.0061 0.0639 0.1619
Plasmodium vivax serine-repeat antigen (SERA) 0.0024 0.0183 0.2103
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0024 0.0183 0.0455
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0009 0.0004 0.001
Brugia malayi fibroinase precursor 0.0024 0.0183 0.0455
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Schistosoma mansoni amine oxidase 0.0058 0.0605 0.153
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0058 0.0605 0.707
Loa Loa (eye worm) hypothetical protein 0.033 0.393 1
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Loa Loa (eye worm) fibroinase 0.0061 0.0639 0.1627
Loa Loa (eye worm) ctsf protein 0.0061 0.0639 0.1627
Loa Loa (eye worm) TK/ROR protein kinase 0.0013 0.0056 0.0142
Mycobacterium ulcerans dehydrogenase 0.0058 0.0605 0.051
Trypanosoma cruzi cysteine protease, putative 0.0024 0.0183 0.0455
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0118 0.1342 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0183 0.0465
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0023 0.0178 0.1303
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0183 0.2322
Loa Loa (eye worm) hypothetical protein 0.0024 0.0183 0.0465
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0024 0.0183 0.2103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0183 0.1336
Trypanosoma cruzi UDP-galactopyranose mutase 0.0058 0.0605 0.153
Echinococcus multilocularis SWI:SNF matrix associated 0.0013 0.0051 0.012
Brugia malayi cathepsin L-like precursor 0.0061 0.0639 0.1619
Loa Loa (eye worm) acetyltransferase 0.0267 0.316 0.804
Onchocerca volvulus 0.0061 0.0639 1
Plasmodium vivax vivapain-1 0.0024 0.0183 0.2103
Echinococcus granulosus twitchin 0.0012 0.0037 0.0085
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0024 0.0183 0.2103
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0183 0.2322
Loa Loa (eye worm) TK/FAK protein kinase 0.0009 0.0004 0.001
Plasmodium falciparum histone acetyltransferase GCN5 0.0072 0.0774 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0169 0.0071
Loa Loa (eye worm) TK protein kinase 0.0009 0.0004 0.001
Toxoplasma gondii cathepsin CPL 0.0061 0.0639 0.4751
Giardia lamblia Cathepsin L precursor 0.0024 0.0183 0.1336
Onchocerca volvulus 0.0027 0.0228 0.3533
Loa Loa (eye worm) TK protein kinase 0.0009 0.0004 0.001
Brugia malayi Cathepsin L-like precursor 0.0061 0.0639 0.1619
Loa Loa (eye worm) hypothetical protein 0.0058 0.0605 0.1539
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0096 0.0235
Toxoplasma gondii cathepsin CPC2 0.0024 0.0183 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0183 0.1336
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0605 0.707
Toxoplasma gondii cathepsin CPC1 0.0024 0.0183 0.1336
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0024 0.0183 0.0455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0639 0.4751
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0099 0.1124
Giardia lamblia Cathepsin B precursor 0.0024 0.0183 0.1336
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.0639 0.1619
Giardia lamblia Cathepsin L precursor 0.0024 0.0183 0.1336
Leishmania major cathepsin L-like protease 0.0061 0.0639 0.4751
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0183 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0024 0.0183 0.1336
Onchocerca volvulus 0.0061 0.0639 1
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0183 0.0455
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0169 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0024 0.0183 0.1336
Echinococcus granulosus cysteine protease 0.0024 0.0183 0.0455
Brugia malayi cathepsin F-like cysteine proteinase 0.0024 0.0183 0.0455
Brugia malayi Cathepsin L-like precursor 0.0061 0.0639 0.1619
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0013 0.0051 0.0352
Onchocerca volvulus Cathepsin F homolog 0.0061 0.0639 1
Giardia lamblia Cysteine protease 0.0024 0.0183 0.1336
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0178 0.0444
Brugia malayi cathepsin Z-like cysteine proteinase 0.0024 0.0183 0.0455
Loa Loa (eye worm) TK protein kinase 0.0009 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0058 0.0605 0.1539
Brugia malayi Cathepsin L-like precursor 0.0061 0.0639 0.1619
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0295 0.0742
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.033 0.393 1
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0639 0.1619
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Plasmodium vivax vivapain-2 0.0061 0.0639 0.7479
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0024 0.0183 0.1336
Schistosoma mansoni cathepsin C 0.0024 0.0183 0.0455
Plasmodium vivax unspecified product 0.0024 0.0183 0.2103
Brugia malayi cathepsin L-like cysteine proteinase 0.0024 0.0183 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Plasmodium falciparum serine repeat antigen 5 0.0024 0.0183 0.2322
Echinococcus granulosus cathepsin L 0.0024 0.0183 0.0455
Trypanosoma cruzi cruzipain precursor, putative 0.0061 0.0639 0.1619
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0013 0.0051 0.0555
Trypanosoma brucei cysteine peptidase C (CPC) 0.0118 0.1342 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0033 0.0295 0.0751
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0061 0.0639 0.1627
Giardia lamblia Cysteine protease 0.0024 0.0183 0.1336
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0024 0.0183 0.1336
Echinococcus multilocularis protoporphyrinogen oxidase 0.0058 0.0605 0.153
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0024 0.0183 0.0455
Loa Loa (eye worm) TK/EGFR protein kinase 0.0009 0.0004 0.001
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0058 0.0605 0.4491
Entamoeba histolytica cysteine proteinase 1, putative 0.0024 0.0183 0.2322
Trichomonas vaginalis bromodomain-containing protein, putative 0.0079 0.0854 0.6352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0432 0.1091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0432 0.1091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0169 0.2149
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Entamoeba histolytica hypothetical protein 0.0024 0.0183 0.2322
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0183 0.0455
Giardia lamblia Cathepsin B precursor 0.0024 0.0183 0.1336
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0253
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Trypanosoma cruzi major cysteine proteinase, putative 0.0024 0.0183 0.0455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0639 0.4751
Loa Loa (eye worm) TK protein kinase 0.0009 0.0004 0.001
Echinococcus multilocularis slit 2 protein 0.0029 0.0243 0.061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0639 0.4751
Mycobacterium ulcerans oxidoreductase 0.0058 0.0605 0.051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0169 0.0421
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0183 0.1336
Echinococcus multilocularis cysteine protease 0.0061 0.0639 0.1619
Schistosoma mansoni cathepsin F (C01 family) 0.0061 0.0639 0.1619
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0183 0.1336
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0183 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0183 0.1336
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0024 0.0183 0.1336
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0253
Schistosoma mansoni hypothetical protein 0.0013 0.0051 0.012
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0169 0.1237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0639 0.4751
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0024 0.0183 0.2322
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Onchocerca volvulus Cathepsin L homolog 0.0024 0.0183 0.2812
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0013 0.0051 0.012
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Loa Loa (eye worm) cathepsin B 0.0118 0.1342 0.3414
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Loa Loa (eye worm) TK protein kinase 0.0009 0.0004 0.001
Giardia lamblia Cathepsin L-like protease 0.0024 0.0183 0.1336
Leishmania major cathepsin L-like protease 0.0061 0.0639 0.4751
Brugia malayi Cathepsin L-like cysteine proteinase 0.0061 0.0639 0.1619
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0183 0.1336
Giardia lamblia Cathepsin B precursor 0.0024 0.0183 0.1336
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0058 0.0605 0.153
Plasmodium falciparum serine repeat antigen 7 0.0024 0.0183 0.2322
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0061 0.0639 0.4751
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.0639 0.8257
Trypanosoma cruzi UDP-galactopyranose mutase 0.0058 0.0605 0.153
Plasmodium falciparum serine repeat antigen 8 0.0024 0.0183 0.2322
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0169 0.2149
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0056 0.0132
Echinococcus granulosus cathepsin b 0.033 0.393 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0183 0.0455
Plasmodium falciparum serine repeat antigen 9 0.0024 0.0183 0.2322
Echinococcus granulosus lysine specific histone demethylase 1A 0.0058 0.0605 0.153
Loa Loa (eye worm) hypothetical protein 0.0058 0.0605 0.1539
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0061 0.0639 0.1627
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0183 0.1336
Onchocerca volvulus 0.0061 0.0639 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0267 0.316 0.8038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0639 0.4751
Entamoeba histolytica protein kinase, putative 0.001 0.0019 0.0192
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0169 0.0071
Trypanosoma cruzi major cysteine proteinase, putative 0.0024 0.0183 0.0455
Brugia malayi brahma associated protein 60 kDa 0.0013 0.0051 0.012
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0017 0.0096 0.0245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0639 0.4751
Giardia lamblia Hypothetical protein 0.0024 0.0183 0.1336
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0024 0.0183 0.2103
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0051 0.0352
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Giardia lamblia Cathepsin B precursor 0.0118 0.1342 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0061 0.0639 0.8257
Leishmania major cathepsin L-like protease 0.0061 0.0639 0.4751
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0024 0.0183 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0183 0.1336
Trypanosoma cruzi cysteine peptidase, putative 0.0024 0.0183 0.0455
Onchocerca volvulus 0.0061 0.0639 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0183 0.0455
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0058 0.0605 0.707
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0024 0.0183 0.2103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0183 0.1336
Toxoplasma gondii preprocathepsin c precursor, putative 0.0024 0.0183 0.1336
Leishmania major T-complex protein 1, beta subunit, putative 0.0023 0.0178 0.1303
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0061 0.0639 0.1619
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0768 0.9288 1
Brugia malayi EGF-like domain containing protein 0.0029 0.0243 0.061
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0183 0.1336
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0169 0.0088
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0118 0.1342 0.3407
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0024 0.0183 0.0465
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0009 0.0004 0.001
Echinococcus multilocularis 0.0058 0.0605 0.153
Plasmodium vivax unspecified product 0.0024 0.0183 0.2103
Giardia lamblia Cathepsin B precursor 0.0024 0.0183 0.1336
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.0605 0.0561
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0079 0.0854 0.6352
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Leishmania major cysteine peptidase A (CPA) 0.0061 0.0639 0.4751
Echinococcus granulosus SWI:SNF matrix associated 0.0013 0.0051 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0639 0.4751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0178 0.0444
Loa Loa (eye worm) T-complex protein 1 0.0023 0.0178 0.0454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0639 0.4751
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0253
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0024 0.0183 0.0465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0183 0.0455
Schistosoma mansoni cathepsin F (C01 family) 0.0061 0.0639 0.1619
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0639 0.4751
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0639 0.4751
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0169 0.0071
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0058 0.0605 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0024 0.0183 0.2322
Loa Loa (eye worm) hypothetical protein 0.0058 0.0605 0.1539
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.033 0.393 1
Entamoeba histolytica cysteine proteinase 2 0.0024 0.0183 0.2322
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0009 0.0004 0.001
Echinococcus granulosus lysine specific histone demethylase 1A 0.0058 0.0605 0.153
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Echinococcus multilocularis cathepsin L cysteine protease 0.0061 0.0639 0.1619
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0169 0.0071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0094
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.033 0.393 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Plasmodium falciparum protoporphyrinogen oxidase 0.0058 0.0605 0.7806
Loa Loa (eye worm) TK/EPH protein kinase 0.0009 0.0004 0.001
Leishmania major UDP-galactopyranose mutase 0.0058 0.0605 0.4491
Loa Loa (eye worm) TK protein kinase 0.0009 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0118 0.1342 1
Brugia malayi Cathepsin L-like precursor 0.0061 0.0639 0.1619
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0432 0.1091
Echinococcus multilocularis cathepsin b 0.033 0.393 1
Entamoeba histolytica cysteine protease, putative 0.0061 0.0639 0.8257
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0432 0.1091
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0267 0.316 0.8038
Brugia malayi SWIB/MDM2 domain containing protein 0.0013 0.0051 0.012
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0639 0.1619
Brugia malayi amine oxidase, flavin-containing family protein 0.0058 0.0605 0.153
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0013 0.0051 0.0613
Giardia lamblia Cathepsin L precursor 0.0024 0.0183 0.1336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0639 0.4751
Giardia lamblia Cathepsin L precursor 0.0024 0.0183 0.1336
Leishmania major cathepsin L-like protease 0.0061 0.0639 0.4751
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0639 0.4751
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0183 0.0455
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0013 0.0051 0.013
Leishmania major cathepsin L-like protease 0.0061 0.0639 0.4751
Onchocerca volvulus Tyrosine kinase homolog 0.0013 0.0056 0.0817
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0639 0.4751
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0183 0.0455
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0639 0.4751
Brugia malayi SWIRM domain containing protein 0.0058 0.0605 0.153
Plasmodium vivax vivapain-2 0.0061 0.0639 0.7479
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0169 0.0088
Echinococcus granulosus cathepsin L 0.0024 0.0183 0.0455
Echinococcus granulosus cathepsin l1 0.0061 0.0639 0.1619
Brugia malayi cathepsin B-like cysteine proteinase 0.033 0.393 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0099 0.0012
Echinococcus multilocularis neuroglian 0.0012 0.0037 0.0085
Loa Loa (eye worm) hypothetical protein 0.0029 0.0243 0.0619
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0024 0.0183 0.0455
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0432 0.1091
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0024 0.0183 0.0455
Loa Loa (eye worm) brahma associated protein 0.0013 0.0051 0.013
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0009 0.0004 0.001
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0023 0.0178 0.2052
Plasmodium vivax serine-repeat antigen (SERA) 0.0024 0.0183 0.2103
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0183 0.0455
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0169 0.1237
Loa Loa (eye worm) TK protein kinase 0.0009 0.0004 0.001
Giardia lamblia Cathepsin L precursor 0.0024 0.0183 0.1336
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0169 0.1237
Onchocerca volvulus Slit protein homolog 0.0029 0.0243 0.3766
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Leishmania major cathepsin L-like protease 0.0061 0.0639 0.4751
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0118 0.1342 0.3407
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0099 0.0874
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0024 0.0183 0.2103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0639 0.4751
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0013 0.0056 0.0132
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0051 0.0555
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0023 0.0178 0.2265
Loa Loa (eye worm) TK/ACK protein kinase 0.0009 0.0004 0.001
Entamoeba histolytica hypothetical protein 0.001 0.0019 0.0192
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0169 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0061 0.0639 0.4751
Giardia lamblia Cysteine protease 0.0024 0.0183 0.1336
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.033 0.393 1
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0178 0.0444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0639 0.4751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0639 0.4751
Plasmodium falciparum serine repeat antigen 3 0.0024 0.0183 0.2322
Echinococcus granulosus histone acetyltransferase KAT2B 0.0259 0.3068 0.7805
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0169 0.0071
Schistosoma mansoni amine oxidase 0.0058 0.0605 0.153
Giardia lamblia Histone acetyltransferase GCN5 0.0072 0.0774 0.5753
Giardia lamblia Cysteine protease 0.0024 0.0183 0.1336
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Loa Loa (eye worm) TK/ALK protein kinase 0.0009 0.0004 0.001
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0024 0.0183 0.2103
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0169 0.2149
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0024 0.0183 0.2322
Leishmania major cathepsin L-like protease 0.0061 0.0639 0.4751
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0079 0.0854 1
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0009 0.0004 0.001
Plasmodium falciparum serine repeat antigen 4 0.0024 0.0183 0.2322
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0024 0.0183 0.2103
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Loa Loa (eye worm) SRC-1 0.0009 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Plasmodium falciparum serine repeat antigen 1 0.0024 0.0183 0.2322
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0183 0.0455
Loa Loa (eye worm) hypothetical protein 0.0061 0.0639 0.1627
Leishmania major cathepsin L-like protease 0.0061 0.0639 0.4751
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0432 0.1091
Loa Loa (eye worm) TK/INSR protein kinase 0.0009 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0024 0.0183 0.2322
Entamoeba histolytica hypothetical protein 0.001 0.0019 0.0192
Echinococcus multilocularis cathepsin L 0.0024 0.0183 0.0455
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0431
Schistosoma mansoni tyrosine kinase 0.0013 0.0056 0.0132
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Giardia lamblia Cathepsin L-like protease 0.0024 0.0183 0.1336
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.033 0.393 1
Schistosoma mansoni hypothetical protein 0.0149 0.1714 0.4357
Echinococcus multilocularis cathepsin L cysteine protease 0.0061 0.0639 0.1619
Schistosoma mansoni hypothetical protein 0.0013 0.0051 0.012
Onchocerca volvulus 0.0058 0.0605 0.9453
Brugia malayi acetyltransferase, GNAT family protein 0.0267 0.316 0.8038
Loa Loa (eye worm) cysteine protease 0.0061 0.0639 0.1627
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0023 0.0178 0.0444
Echinococcus granulosus cathepsin L cysteine proteinase 0.0061 0.0639 0.1619
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0024 0.0183 0.1336
Toxoplasma gondii histone lysine-specific demethylase 0.0058 0.0605 0.4491
Loa Loa (eye worm) TK protein kinase 0.0013 0.0056 0.0142
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0639 0.1619
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0009 0.0004 0.001
Entamoeba histolytica cysteine protease, putative 0.0024 0.0183 0.2322
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0024 0.0183 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0639 0.4751
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.0183 0.1336
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0178 0.0444
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0024 0.0183 0.0455
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0183 0.2322
Loa Loa (eye worm) hypothetical protein 0.0024 0.0183 0.0465
Echinococcus multilocularis cathepsin L 0.0024 0.0183 0.0455
Loa Loa (eye worm) TK protein kinase 0.0009 0.0004 0.001
Giardia lamblia Hypothetical protein 0.0024 0.0183 0.1336

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.7 uM Inhibition of human MDM2/p53 interaction by fluorescence polarization assay ChEMBL. 24486134

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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