Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.009 | 0.2982 | 0.2925 |
Echinococcus granulosus | carbonic anhydrase | 0.0092 | 0.3107 | 0.2287 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.4658 | 0.4022 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1064 | 0.0992 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.306 | 0.3818 |
Echinococcus multilocularis | carbonic anhydrase | 0.0092 | 0.3107 | 0.2287 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 0.8014 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.306 | 0.3004 |
Echinococcus multilocularis | carbonic anhydrase | 0.0092 | 0.3107 | 0.2287 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0092 | 0.3107 | 0.3052 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1064 | 0.0992 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.306 | 0.0111 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0166 | 0.8014 | 1 |
Onchocerca volvulus | 0.0146 | 0.6693 | 1 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0092 | 0.3107 | 0.2287 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0098 | 0.3514 | 0.4385 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.009 | 0.2982 | 0.2146 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.306 | 0.3818 |
Mycobacterium ulcerans | lysophospholipase | 0.0166 | 0.8014 | 1 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.3514 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.8014 | 1 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0166 | 0.8014 | 0.5 |
Leishmania major | monoglyceride lipase, putative | 0.0166 | 0.8014 | 0.717 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.009 | 0.2982 | 0.2146 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0092 | 0.3107 | 0.2287 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.009 | 0.2982 | 0.2919 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.009 | 0.2982 | 0.2146 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0098 | 0.3514 | 0.4385 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0092 | 0.3107 | 0.2287 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.009 | 0.2982 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0166 | 0.8014 | 0.717 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.306 | 0.3818 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.009 | 0.2982 | 0.2146 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0092 | 0.3107 | 0.3052 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.3107 | 0.2287 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0092 | 0.306 | 0.2233 |
Toxoplasma gondii | hypothetical protein | 0.0092 | 0.3107 | 0.8438 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0092 | 0.306 | 0.2233 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0098 | 0.3514 | 0.4385 |
Trypanosoma brucei | polo-like protein kinase | 0.0092 | 0.306 | 0.0111 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 0.8014 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.306 | 0.3818 |
Echinococcus granulosus | carbonic anhydrase | 0.0092 | 0.3107 | 0.2287 |
Schistosoma mansoni | carbonic anhydrase | 0.0092 | 0.3107 | 0.3052 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0166 | 0.8014 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0092 | 0.3107 | 0.2287 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 0.8014 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.306 | 0.3818 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1064 | 0.0992 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.009 | 0.2982 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.306 | 0.0111 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0092 | 0.3107 | 0.2287 |
Plasmodium falciparum | lysophospholipase, putative | 0.0166 | 0.8014 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0166 | 0.8014 | 0.717 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.6693 | 0.6299 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.4658 | 0.4022 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0098 | 0.3514 | 0.1058 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0166 | 0.8014 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.3107 | 0.2287 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.306 | 0.3818 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.8014 | 1 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0166 | 0.8014 | 0.717 |
Plasmodium falciparum | carbonic anhydrase | 0.0092 | 0.3107 | 0.0249 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1064 | 0.0992 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.3514 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.4658 | 0.4022 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0092 | 0.3107 | 0.3052 |
Mycobacterium ulcerans | hypothetical protein | 0.0166 | 0.8014 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0092 | 0.306 | 0.2233 |
Echinococcus granulosus | carbonic anhydrase | 0.0092 | 0.3107 | 0.2287 |
Brugia malayi | hypothetical protein | 0.0146 | 0.6693 | 0.6299 |
Plasmodium falciparum | lysophospholipase, putative | 0.0166 | 0.8014 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0166 | 0.8014 | 1 |
Plasmodium vivax | PST-A protein | 0.0166 | 0.8014 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.3107 | 0.3052 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 0.8014 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1064 | 0.0992 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0092 | 0.306 | 0.0111 |
Plasmodium falciparum | lysophospholipase, putative | 0.0166 | 0.8014 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 0.8014 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.3107 | 0.2287 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.306 | 0.3818 |
Plasmodium falciparum | esterase, putative | 0.0166 | 0.8014 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0092 | 0.3107 | 0.2287 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0092 | 0.3107 | 0.2287 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0092 | 0.306 | 0.2233 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of FLAG-tagged TNAP (unknown origin) expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay | ChEMBL. | 24412070 |
IC50 (binding) | > 100 uM | Inhibition of mouse duodenal-specific FLAG-tagged IAP expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay | ChEMBL. | 24412070 |
IC50 (binding) | > 100 uM | Inhibition of FLAG-tagged PLAP (unknown origin) expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay | ChEMBL. | 24412070 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.