Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.195 | 0.195 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.6742 | 0.7121 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0104 | 0.011 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.195 | 0.206 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0724 | 0.0765 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0724 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0724 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1191 | 0.1191 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0724 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1191 | 0.1258 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.195 | 0.195 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.195 | 0.195 |
Onchocerca volvulus | 0.0176 | 0.9469 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.195 | 0.206 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.2218 | 0.2342 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.9469 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0724 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0724 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1191 | 0.1258 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.2218 | 0.2342 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0724 | 0.0765 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0724 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.195 | 0.195 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.195 | 0.195 |
Brugia malayi | hypothetical protein | 0.0176 | 0.9469 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2218 | 0.2342 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.6742 | 0.7121 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.6742 | 0.7121 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.2218 | 0.2342 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0724 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.195 | 0.195 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.195 | 0.195 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0724 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 27 uM | Cytotoxicity against human SQ20B cells after 72 hrs by MTT assay | ChEMBL. | 24445311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.