Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | phosphoglycerate kinase, putative | 0.019 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable phosphoglycerate kinase Pgk | 0.019 | 0.5 | 0.5 |
Chlamydia trachomatis | phosphoglycerate kinase | 0.019 | 0.5 | 0.5 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.019 | 0.5 | 0.5 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.019 | 0.5 | 0.5 |
Schistosoma mansoni | phosphoglycerate kinase | 0.019 | 0.5 | 0.5 |
Toxoplasma gondii | phosphoglycerate kinase PGKII | 0.019 | 0.5 | 0.5 |
Trypanosoma brucei | phosphoglycerate kinase | 0.019 | 0.5 | 0.5 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.019 | 0.5 | 0.5 |
Mycobacterium ulcerans | phosphoglycerate kinase | 0.019 | 0.5 | 0.5 |
Trypanosoma brucei | phosphoglycerate kinase | 0.019 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.5 | 0.5 |
Plasmodium vivax | phosphoglycerate kinase, putative | 0.019 | 0.5 | 0.5 |
Leishmania major | phosphoglycerate kinase C, glycosomal | 0.019 | 0.5 | 0.5 |
Giardia lamblia | Phosphoglycerate kinase | 0.019 | 0.5 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phosphoglycerate kinase | 0.019 | 0.5 | 0.5 |
Mycobacterium leprae | Probable phosphoglycerate kinase Pgk | 0.019 | 0.5 | 0.5 |
Plasmodium falciparum | phosphoglycerate kinase | 0.019 | 0.5 | 0.5 |
Treponema pallidum | phosphoglycerate kinase | 0.019 | 0.5 | 0.5 |
Toxoplasma gondii | phosphoglycerate kinase PGKI | 0.019 | 0.5 | 0.5 |
Schistosoma mansoni | phosphoglycerate kinase | 0.019 | 0.5 | 0.5 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.019 | 0.5 | 0.5 |
Echinococcus granulosus | phosphoglycerate kinase 1 | 0.019 | 0.5 | 0.5 |
Leishmania major | phosphoglycerate kinase B, cytosolic | 0.019 | 0.5 | 0.5 |
Echinococcus multilocularis | phosphoglycerate kinase 1 | 0.019 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 111.17 uM | Cytotoxicity against human MT4 cells assessed as cell viability | ChEMBL. | 24457088 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.