TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 603.52 | Formula: C27H18F5N5O4S
H donors: 2 H acceptors: 4 LogP: 4.33 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: COc1ncc(cc1S(=O)(=O)Nc1ccc(cc1F)F)c1ccc2c(c1)c(=O)n(c(n2)N)c1cccc(c1)C(F)(F)F
InChi: 1S/C27H18F5N5O4S/c1-41-24-23(42(39,40)36-22-8-6-17(28)12-20(22)29)10-15(13-34-24)14-5-7-21-19(9-14)25(38)37(26(33)35-21)18-4-2-3-16(11-18)27(30,31)32/h2-13,36H,1H3,(H2,33,35)
InChiKey: FCHSEIZGAPJLKJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Starlite/ChEMBL	References
Homo sapiens	phosphatidylinositol 4-kinase, catalytic, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	phosphatidylinositol 4-kinase	Get druggable targets OG5_128362	All targets in OG5_128362
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	Get druggable targets OG5_128362	All targets in OG5_128362
Brugia malayi	hypothetical protein	Get druggable targets OG5_128362	All targets in OG5_128362
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma brucei gambiense	phosphatidylinositol 4-kinase alpha, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania braziliensis	phosphatidylinositol 4-kinase alpha, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Neospora caninum	hypothetical protein	Get druggable targets OG5_128362	All targets in OG5_128362
Schistosoma japonicum	Phosphatidylinositol 4-kinase alpha, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	Get druggable targets OG5_128362	All targets in OG5_128362
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_128362	All targets in OG5_128362
Candida albicans	Phosphatidylinositol-4-kinase.	Get druggable targets OG5_128362	All targets in OG5_128362
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Schistosoma japonicum	Phosphatidylinositol 4-kinase alpha, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	phosphatidylinositol 4-kinase alpha, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania donovani	phosphatidylinositol-kinase domain protein, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128362	All targets in OG5_128362
Schistosoma japonicum	Phosphatidylinositol 4-kinase alpha, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma congolense	phosphatidylinositol 4-kinase alpha, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_128362	All targets in OG5_128362
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	ko:K00888 phosphatidylinositol 4-kinase [EC2.7.1.67], putative	Get druggable targets OG5_128362	All targets in OG5_128362
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Trypanosoma congolense	phosphatidylinositol 4-kinase alpha, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Candida albicans	Phosphatidylinositol-4-kinase.	Get druggable targets OG5_128362	All targets in OG5_128362
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128362	All targets in OG5_128362
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol-kinase domain protein, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	Get druggable targets OG5_128362	All targets in OG5_128362
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128362	All targets in OG5_128362
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	Get druggable targets OG5_128362	All targets in OG5_128362
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	Get druggable targets OG5_128362	All targets in OG5_128362

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	regulator of G protein signaling 7	0.0022	0.0123	0.0246
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.013	0.026
Loa Loa (eye worm)	mbt repeat family protein	0.0054	0.0473	0.105
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0473	0.105
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.013	0.0287
Entamoeba histolytica	hypothetical protein	0.0144	0.1453	0.8084
Echinococcus multilocularis	regulator of G protein signaling 3	0.0022	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0273
Brugia malayi	nuclear hormone receptor	0.0023	0.013	0.0265
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.0118	0.0014
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0026	0.0165	0.0366
Loa Loa (eye worm)	hypothetical protein	0.005	0.0425	0.0945
Brugia malayi	hypothetical protein	0.0058	0.0516	0.1127
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0118	0.0168
Schistosoma mansoni	lipoxygenase	0.0022	0.0123	0.0247
Schistosoma mansoni	axis inhibition protein axin	0.0022	0.0123	0.0248
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0118	0.0168
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0069	0.0631	0.132
Echinococcus multilocularis	regulator of G protein signaling 7	0.0022	0.0123	0.0123
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0094	0.0905	0.478
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.013	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0555	0.1234
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0118	0.0168
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0482	0.1052
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0118	0.0063
Echinococcus granulosus	Polycystic kidney disease protein	0.0022	0.0123	0.0246
Giardia lamblia	DINP protein human, muc B family	0.0022	0.0118	0.0014
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.013	0.0265
Schistosoma mansoni	glutaminase	0.032	0.339	0.6802
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.013	0.0265
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0218	0.2271	0.2271
Onchocerca volvulus		0.0056	0.0495	0.1493
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0069	0.013
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0022	0.0123	0.0026
Toxoplasma gondii	LsmAD domain-containing protein	0.0058	0.0516	0.0921
Echinococcus granulosus	dna polymerase eta	0.0022	0.0118	0.0236
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0118	0.0168
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0118	0.0168
Brugia malayi	hypothetical protein	0.0022	0.0123	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0023	0.013	0.0287
Brugia malayi	glutaminase DH11.1	0.032	0.339	0.7536
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0228	0.0458
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0049	0.0418	0.757
Schistosoma mansoni	loxhd1	0.0022	0.0123	0.0247
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0165	0.0332
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0026	0.0164	0.0163
Echinococcus multilocularis	muscleblind protein	0.034	0.3607	0.3606
Entamoeba histolytica	hypothetical protein	0.0022	0.0123	0.007
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.013	0.026
Onchocerca volvulus		0.0033	0.0236	0.0452
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.013	0.0258
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.013	0.0258
Schistosoma mansoni	hypothetical protein	0.0022	0.0123	0.0247
Echinococcus multilocularis	Zinc finger, PHD finger	0.0049	0.0418	0.0417
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0118	0.0014
Schistosoma mansoni	z-protein (S1r protein)	0.0022	0.0123	0.0248
Schistosoma mansoni	ap endonuclease	0.0021	0.0112	0.0225
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.013	0.0265
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0069	0.0631	0.1184
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0173	0.1771	0.3815
Loa Loa (eye worm)	hypothetical protein	0.0023	0.013	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.0022
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.013	0.0129
Trichomonas vaginalis	CMGC family protein kinase	0.0421	0.4494	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0118	0.0014
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0062	0.0555	0.1113
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.013	0.026
Schistosoma mansoni	rab6-interacting	0.0022	0.0123	0.0247
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.0118	0.0237
Schistosoma mansoni	hypothetical protein	0.0017	0.0069	0.0138
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0173	0.1771	0.3785
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0062	0.0555	0.1215
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.013	0.026
Plasmodium vivax	multidomain scavenger receptor, putative	0.0022	0.0123	0.0281
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0049	0.0418	0.757
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0123	0.1223	0.1222
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0112	0.5
Trichomonas vaginalis	glutaminase, putative	0.032	0.339	0.7479
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0118	0.0261
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0236	0.0502
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0118	0.0019
Giardia lamblia	Kinase, CMGC MAPK	0.0421	0.4494	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0173	0.1771	0.177
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.013	0.0258
Schistosoma mansoni	sex comb on midleg homolog	0.0054	0.0473	0.0948
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0432	0.0868
Brugia malayi	hypothetical protein	0.0038	0.0289	0.0622
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0421	0.4494	1
Onchocerca volvulus	Bile acid receptor homolog	0.0023	0.013	0.0025
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0264	0.2768	0.6159
Schistosoma mansoni	serine/threonine protein kinase	0.0421	0.4494	0.9019
Echinococcus multilocularis	expressed protein	0.0438	0.4673	0.4673
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.013	0.0129
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0123	0.0026
Brugia malayi	PXA domain containing protein	0.0022	0.0123	0.0252
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.013	0.0287
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0022	0.0123	0.0248
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0069	0.0068
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.0123	0.0123
Plasmodium vivax	SET domain protein, putative	0.0032	0.0228	0.2882
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0118	0.0168
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0165	0.0332
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0118	0.0168
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0432	0.0866
Echinococcus granulosus	mitogen activated protein kinase	0.0421	0.4494	0.9019
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0273
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0069	0.0631	0.3129
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0118	0.0063
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0049	0.0418	0.0697
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0049	0.0418	0.0697
Onchocerca volvulus		0.0023	0.013	0.0025
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.0123	0.0123
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.013	0.0258
Echinococcus granulosus	GPCR family 2	0.0017	0.0069	0.0136
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0118	0.024
Trichomonas vaginalis	set domain proteins, putative	0.0249	0.2609	0.5699
Echinococcus multilocularis	mitogen activated protein kinase	0.0421	0.4494	0.4494
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0078	0.0735	0.1422
Schistosoma mansoni	lipoxygenase	0.0063	0.0566	0.1136
Entamoeba histolytica	hypothetical protein	0.0022	0.0123	0.007
Schistosoma mansoni	rab6-interacting	0.0022	0.0123	0.0247
Onchocerca volvulus		0.0249	0.2609	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0123	0.1223	0.2703
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.013	0.0287
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.013	0.0265
Echinococcus granulosus	RUN	0.0022	0.0123	0.0246
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.013	0.0265
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0173	0.1771	1
Onchocerca volvulus		0.0032	0.0228	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.0022
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0173	0.1771	0.3785
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.0022
Echinococcus granulosus	SAM and MBT domain containing protein	0.0054	0.0473	0.0947
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0078	0.0735	0.1476
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0118	0.0168
Trypanosoma brucei	PAB1-binding protein , putative	0.0058	0.0516	0.1061
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.001	0.002
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.013	0.026
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.0022
Echinococcus multilocularis	RUN	0.0022	0.0123	0.0123
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0022	0.0123	0.0248
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0069	0.0631	0.1184
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0482	0.1072
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0062	0.0555	0.0554
Echinococcus granulosus	axis inhibition protein axin	0.0022	0.0123	0.0246
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.013	0.0287
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0432	0.0961
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.013	0.0129
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0062	0.0555	0.0554
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0118	0.0168
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.013	0.0265
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0123	0.0248
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0421	0.4494	1
Brugia malayi	A-kinase anchor protein 10, precursor	0.0022	0.0123	0.0252
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0078	0.0735	0.1422
Echinococcus granulosus	axis inhibition protein axin	0.0022	0.0123	0.0246
Schistosoma mansoni	axis inhibition protein axin	0.0022	0.0123	0.0248
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0123	0.1223	0.2452
Brugia malayi	hypothetical protein	0.0019	0.0091	0.0179
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0219	0.2279	0.5069
Onchocerca volvulus	Protein ultraspiracle homolog	0.0023	0.013	0.0025
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0432	0.0868
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0026	0.0165	0.0165
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0173	0.1771	0.3552
Echinococcus granulosus	dnaJ subfamily B	0.0466	0.4983	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.013	0.0129
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0069	0.0631	0.1227
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.013	0.0287
Loa Loa (eye worm)	PXA domain-containing protein	0.0022	0.0123	0.0273
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0123	0.0026
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0112	0.5
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.001	0.0022
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.001	0.001
Loa Loa (eye worm)	glutaminase 2	0.032	0.339	0.7542
Echinococcus multilocularis	Polycystic kidney disease protein	0.0022	0.0123	0.0123
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0099	0.0966	0.1948
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.0118	0.0117
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0069	0.0151
Echinococcus multilocularis	regulator of G protein signaling 3	0.0022	0.0123	0.0123
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0022	0.0123	0.0252
Schistosoma mansoni	cellular tumor antigen P53	0.0056	0.0495	0.0992
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0421	0.4494	1
Loa Loa (eye worm)	MBCTL1	0.0062	0.0555	0.1234
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0054	0.0473	0.0472
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0069	0.013
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0421	0.4494	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0023	0.013	0.0025
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.013	0.0287
Entamoeba histolytica	hypothetical protein	0.0022	0.0123	0.007
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0049	0.0418	0.0697
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.013	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0091	0.02
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0118	0.0168
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0112	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0023	0.013	0.0287
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.0118	0.0063
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0022	0.0118	0.0037
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0118	0.0168
Brugia malayi	nuclear receptor NHR-88	0.0023	0.013	0.0265
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0123	0.0248
Brugia malayi	MAP kinase sur-1	0.0421	0.4494	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0112	0.0111
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0054	0.0473	0.1405
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0128	0.1283	0.2673
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.0118	0.0236
Brugia malayi	PXA domain containing protein	0.0022	0.0123	0.0252
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0078	0.0735	0.1422
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0118	0.0261
Plasmodium falciparum	ataxin-2 like protein, putative	0.0058	0.0516	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.013	0.0265
Brugia malayi	Doublecortin family protein	0.0022	0.0123	0.0252
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0236	0.0523
Trypanosoma cruzi	PAB1-binding protein , putative	0.0058	0.0516	0.0966
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0228	0.0457
Loa Loa (eye worm)	hypothetical protein	0.034	0.3607	0.8025
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0118	0.0063
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.013	0.0258
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.013	0.0265
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0228	0.0458
Echinococcus multilocularis	tumor protein p63	0.0385	0.4095	0.4095
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.013	0.026
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0208	0.0416
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0123	0.0248
Echinococcus multilocularis	dnaJ subfamily B	0.0466	0.4983	0.4983
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.013	0.0258
Brugia malayi	steroid hormone receptor	0.0023	0.013	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0516	0.1146
Brugia malayi	ecdysteroid receptor	0.0023	0.013	0.0265
Echinococcus multilocularis	regulator of G protein signaling 7	0.0022	0.0123	0.0123
Schistosoma mansoni	hypothetical protein	0.0019	0.0091	0.0182
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.0123	0.0246
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0421	0.4494	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.013	0.0265
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.0118	0.0117
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0026	0.0164	0.0327
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0118	0.0063
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0062	0.0555	0.1114
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0273
Schistosoma mansoni	sex comb on midleg homolog	0.0054	0.0473	0.0948
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0432	0.0866
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.013	0.0265
Brugia malayi	regulator of G-protein signaling egl-10	0.0022	0.0123	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0023	0.013	0.0287
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.013	0.0265
Trypanosoma brucei	unspecified product	0.0022	0.0118	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0273
Leishmania major	hypothetical protein, conserved	0.0058	0.0516	0.0921
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0495	0.1099
Onchocerca volvulus		0.0054	0.0473	0.1405
Echinococcus granulosus	muscleblind protein	0.034	0.3607	0.7237
Brugia malayi	hypothetical protein	0.0022	0.0123	0.0252
Schistosoma mansoni	ap endonuclease	0.0021	0.0112	0.0225
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0069	0.0136
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0165	0.0332
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0421	0.4494	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.013	0.0258
Schistosoma mansoni	hypothetical protein	0.0038	0.0291	0.0584
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0049	0.0418	0.0697
Trypanosoma cruzi	PAB1-binding protein , putative	0.0058	0.0516	0.0966
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0069	0.0631	0.1184
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.0569	0.1043
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0118	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.0022
Plasmodium falciparum	LCCL domain-containing protein	0.0022	0.0123	0.0281
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0022	0.0123	0.0123
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0421	0.4494	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0112	0.0049
Trypanosoma brucei	DNA polymerase eta, putative	0.0022	0.0118	0.0168
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0026	0.0165	0.033
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0026	0.0165	0.0366
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0432	0.0432
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.013	0.0129
Echinococcus granulosus	mitogen activated protein kinase 3	0.0421	0.4494	0.9019
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0078	0.0735	0.1617
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.013	0.0258
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0173	0.1771	0.3553
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.001	0.0021
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.004	0.0318	0.047
Loa Loa (eye worm)	hypothetical protein	0.0023	0.013	0.0287
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0421	0.4494	0.4494
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0112	0.0248
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0078	0.0735	0.3758
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0026	0.0165	0.0345
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0291	0.0625
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0421	0.4494	1
Echinococcus granulosus	tumor protein p63	0.0385	0.4095	0.8218
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0112	0.0223
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0067	0.0612	0.1185
Schistosoma mansoni	cpg binding protein	0.0033	0.0236	0.0473
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.0118	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1223	0.2719
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0228	0.0458
Brugia malayi	mbt repeat family protein	0.0054	0.0473	0.1031
Schistosoma mansoni	hypothetical protein	0.0466	0.4983	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0228	0.0266
Echinococcus multilocularis	axis inhibition protein axin	0.0022	0.0123	0.0123
Schistosoma mansoni	hypothetical protein	0.0026	0.0164	0.0328
Brugia malayi	regulator of G-protein signaling rgs-7	0.0022	0.0123	0.0252
Schistosoma mansoni	cpg binding protein	0.0035	0.0256	0.0514
Brugia malayi	Pre-SET motif family protein	0.0032	0.0228	0.0486
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0228	0.0458
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0112	0.0154
Echinococcus granulosus	polycomb protein SCMH1	0.0054	0.0473	0.0947
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0118	1
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0069	0.0631	0.1384
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0071	0.065	0.1305
Loa Loa (eye worm)	phosphatidylinositol 3	0.0144	0.1453	0.3232
Brugia malayi	hypothetical protein	0.0022	0.0123	0.0252
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0022	0.0123	0.0123
Echinococcus multilocularis	muscleblind protein 1	0.034	0.3607	0.3606
Echinococcus granulosus	Regulator of G protein signaling 20	0.0022	0.0123	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0482	0.1072
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0054	0.0473	0.0948
Echinococcus multilocularis	polycomb protein SCMH1	0.0054	0.0473	0.0472
Loa Loa (eye worm)	hypothetical protein	0.034	0.3607	0.8025
Mycobacterium ulcerans	glutaminase	0.032	0.339	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.013	0.026
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0069	0.0068
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.013	0.0129
Plasmodium vivax	ataxin-2 like protein, putative	0.0058	0.0516	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.0118	0.0014
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0078	0.0735	0.1464
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0123	0.0026
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0118	0.0168
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.013	0.026
Leishmania major	DNA polymerase eta, putative	0.0022	0.0118	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0273
Brugia malayi	Muscleblind-like protein	0.034	0.3607	0.802
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0273
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0482	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0091	0.02
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0273
Echinococcus multilocularis	dna polymerase eta	0.0022	0.0118	0.0117
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0173	0.1771	0.3785
Schistosoma mansoni	hypothetical protein	0.0017	0.0069	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0069	0.0151
Echinococcus granulosus	expressed protein	0.0438	0.4673	0.9378
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.013	0.0287
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0069	0.0631	0.1402
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0022	0.0123	0.0246
Echinococcus multilocularis	regulator of G protein signaling	0.0022	0.0123	0.0123
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.013	0.0265
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0069	0.0631	0.1266
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.013	0.026
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.013	0.0258
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0063	0.0566	0.0566
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0128	0.1283	0.2673
Loa Loa (eye worm)	RGS-3 protein	0.0022	0.0123	0.0273
Brugia malayi	follicle stimulating hormone receptor	0.0264	0.2768	0.6151
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0049	0.0418	0.0837
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0069	0.0068
Echinococcus granulosus	histone acetyltransferase MYST2	0.0062	0.0555	0.1113
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0069	0.0631	0.1227
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0123	0.0248
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.013	0.026
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.013	0.0129
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.001	0.0021
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.013	0.0265
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0432	0.0868
Loa Loa (eye worm)	glutaminase	0.032	0.339	0.7542
Loa Loa (eye worm)	doublecortin family protein	0.0022	0.0123	0.0273
Brugia malayi	hypothetical protein	0.0022	0.0123	0.0252
Loa Loa (eye worm)	phosphatidylinositol 3	0.0067	0.0612	0.1361
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0069	0.0136
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.013	0.0129
Schistosoma mansoni	hypothetical protein	0.0335	0.3544	0.7113
Schistosoma mansoni	cpg binding protein	0.0035	0.0256	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0273
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0123	0.0248
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.013	0.026
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0144	0.1453	0.8084
Echinococcus multilocularis	axis inhibition protein axin	0.0022	0.0123	0.0123
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0228	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0228	0.0507
Schistosoma mansoni	DNA polymerase eta	0.0022	0.0118	0.0237
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0432	0.0941
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0078	0.0735	0.3758
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.013	0.0287
Echinococcus multilocularis	cpg binding protein	0.0035	0.0256	0.0255
Echinococcus granulosus	dna polymerase kappa	0.0022	0.0118	0.0236
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0118	0.0019
Schistosoma mansoni	hypothetical protein	0.0017	0.0069	0.0138
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0069	0.0631	0.1265
Echinococcus granulosus	regulator of G protein signaling 3	0.0022	0.0123	0.0246
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0432	0.0432
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.013	0.026
Echinococcus granulosus	regulator of G protein signaling 3	0.0022	0.0123	0.0246
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0063	0.0566	0.1135
Trichomonas vaginalis	CMGC family protein kinase	0.0421	0.4494	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0228	0.0228
Brugia malayi	mbt repeat family protein	0.0054	0.0473	0.1031
Schistosoma mansoni	polycystin 1-related	0.0022	0.0123	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0023	0.013	0.0287
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0049	0.0418	0.1843
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0218	0.2271	0.4557
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0118	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0291	0.0646
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0118	0.024
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0173	0.1771	0.3815
Trypanosoma brucei	protein kinase, putative	0.0421	0.4494	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0421	0.4494	1
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0022	0.0123	0.0273
Echinococcus granulosus	regulator of G protein signaling 7	0.0022	0.0123	0.0246
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0162	0.1648	0.926
Schistosoma mansoni	hypothetical protein	0.0017	0.0069	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0023	0.013	0.0287
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0031	0.0213	0.0231
Trichomonas vaginalis	CMGC family protein kinase	0.0421	0.4494	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0078	0.0735	0.1555
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0069	0.0631	0.063
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.013	0.0265
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0022	0.0123	0.0248
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0112	0.0049
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0049	0.0418	0.0838
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.013	0.0129
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0173	0.1771	0.3925
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0123	0.0026
Plasmodium falciparum	ataxin-2 like protein, putative	0.0058	0.0516	1
Brugia malayi	Pre-SET motif family protein	0.0219	0.2279	0.5058
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.0123	0.0246
Schistosoma mansoni	coup transcription factor	0.0023	0.013	0.026
Loa Loa (eye worm)	hypothetical protein	0.0023	0.013	0.0287
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0123	0.0026
Echinococcus granulosus	cpg binding protein	0.0035	0.0256	0.0513
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0123	0.0026
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0022	0.0123	0.0252
Trichomonas vaginalis	CMGC family protein kinase	0.0421	0.4494	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.8	Inhibition of PI3Kgamma (2 to 1102) (unknown origin) using diC8-PIP2 as substrate preincubated for 30 mins followed by substrate addition measured after 45 to 60 mins	ChEMBL.	23944386
IC50 (binding)	= 7.3	Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by substrate addition measured after 180 mins by luminescence assay	ChEMBL.	23944386

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3121309

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1833347