Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0063 | 0.0063 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0063 | 0.0063 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.3548 | 0.3548 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5145 | 0.5145 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0063 | 0.0063 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0063 | 0.0063 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0063 | 0.0063 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0827 | 0.0827 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0244 | 0.0244 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0827 | 0.0827 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0063 | 0.0063 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0063 | 0.0063 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0244 | 0.0244 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0063 | 0.0063 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0063 | 0.0063 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.133 | 0.133 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0244 | 0.0244 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5145 | 0.5145 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0063 | 0.0063 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0244 | 0.0244 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0244 | 0.0244 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0244 | 0.0244 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0063 | 0.0063 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0827 | 0.0827 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0063 | 0.0063 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0063 | 0.0063 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0063 | 0.0063 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.3548 | 0.3548 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.3548 | 0.3548 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.133 | 0.133 |
Echinococcus granulosus | geminin | 0.0165 | 0.5145 | 0.5145 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.133 | 0.133 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.133 | 0.133 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0244 | 0.0244 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0244 | 0.0244 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0244 | 0.0244 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0063 | 0.0063 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0063 | 0.0063 |
Echinococcus multilocularis | geminin | 0.0165 | 0.5145 | 0.5145 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0063 | 0.0063 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0244 | 0.0244 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0063 | 0.0063 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0063 | 0.0063 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0063 | 0.0063 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0063 | 0.0063 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC80 (functional) | <= 0.125 ug ml-1 | Antifungal activity against Candida albicans SC5314 after 24 hrs by micro-broth dilution method | ChEMBL. | 24487187 |
MIC80 (functional) | = 0.25 ug ml-1 | Antifungal activity against Cryptococcus neoformans after 72 hrs by micro-broth dilution method | ChEMBL. | 24487187 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.