Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MBCTL1 | 0.0066 | 0.0355 | 0.0886 |
Onchocerca volvulus | 0.0058 | 0.0277 | 0.2226 | |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0413 | 0.4004 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0044 | 0.0121 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0271 | 0.0676 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0058 | 0.0271 | 0.0313 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0058 | 0.0271 | 0.0313 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0837 | 0.846 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0277 | 0.0321 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0066 | 0.0355 | 0.0349 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0287 | 0.2677 | 0.3159 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0413 | 0.4004 | 0.4729 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0413 | 0.4004 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0413 | 0.4004 | 0.4001 |
Entamoeba histolytica | hypothetical protein | 0.0044 | 0.0121 | 0.5 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0058 | 0.0271 | 0.0313 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0066 | 0.0355 | 0.0412 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1224 | 0.3057 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0355 | 0.0886 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0287 | 0.2677 | 0.2672 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0837 | 0.846 | 0.8459 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0413 | 0.4004 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0352 | 0.3359 | 0.3966 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0121 | 0.0136 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0058 | 0.0271 | 0.0264 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0006 | 0.0016 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0277 | 0.0678 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0413 | 0.4004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1224 | 0.3057 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0058 | 0.0271 | 0.0676 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0058 | 0.0271 | 0.217 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.2677 | 0.6685 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0058 | 0.0271 | 0.0313 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0066 | 0.0355 | 0.0872 |
Brugia malayi | hypothetical protein | 0.0287 | 0.2677 | 0.668 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0413 | 0.4004 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0044 | 0.0121 | 0.0136 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0413 | 0.4004 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0149 | 0.1224 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0228 | 0.2059 | 0.2054 |
Onchocerca volvulus | 0.0058 | 0.0271 | 0.217 | |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0066 | 0.0355 | 0.0412 |
Brugia malayi | mbt repeat family protein | 0.0058 | 0.0271 | 0.0661 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0413 | 0.4004 | 0.4729 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0413 | 0.4004 | 0.5 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0066 | 0.0355 | 0.0412 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0006 | 0.0016 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0277 | 0.0321 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0413 | 0.4004 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0413 | 0.4004 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0413 | 0.4004 | 0.4729 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0413 | 0.4004 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0413 | 0.4004 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0149 | 0.1224 | 1 |
Brugia malayi | hypothetical protein | 0.0044 | 0.0121 | 0.0287 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0058 | 0.0271 | 0.0313 |
Brugia malayi | mbt repeat family protein | 0.0058 | 0.0271 | 0.0661 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0413 | 0.4004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0006 | 0.0016 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0413 | 0.4004 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0044 | 0.0121 | 0.0115 |
Entamoeba histolytica | hypothetical protein | 0.0044 | 0.0121 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0413 | 0.4004 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0413 | 0.4004 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0044 | 0.0121 | 0.0136 |
Brugia malayi | hypothetical protein | 0.0149 | 0.1224 | 0.3047 |
Brugia malayi | MAP kinase sur-1 | 0.0413 | 0.4004 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0066 | 0.0355 | 0.0349 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0058 | 0.0271 | 0.0264 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0837 | 0.846 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0413 | 0.4004 | 0.4001 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0228 | 0.2059 | 0.2428 |
Entamoeba histolytica | hypothetical protein | 0.0044 | 0.0121 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.