Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | bombesin-like receptor 3 | Starlite/ChEMBL | References |
Homo sapiens | bombesin-like receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | bombesin-like receptor 3 | 399 aa | 380 aa | 20.8 % |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | bombesin-like receptor 3 | 399 aa | 375 aa | 21.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0231 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0231 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0231 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0231 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0231 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0231 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0231 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0231 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0231 | 0.5 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0231 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0231 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0231 | 0.5 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0231 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0231 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0231 | 0.5 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0231 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0231 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0231 | 0.5 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0231 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 41 nM | Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay | ChEMBL. | 24412111 |
EC50 (binding) | = 100 nM | Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay | ChEMBL. | 24412111 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.