TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 467.58 | Formula: C25H29N3O4S
H donors: 4 H acceptors: 3 LogP: 3.65 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1O)CNc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)C1CCNCC1
InChi: 1S/C25H29N3O4S/c1-32-24-7-3-5-20(25(24)29)17-27-21-8-10-23(11-9-21)33(30,31)28-22-6-2-4-19(16-22)18-12-14-26-15-13-18/h2-11,16,18,26-29H,12-15,17H2,1H3
InChiKey: YHWFRRDUTMCIOC-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	arachidonate 12-lipoxygenase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	arachidonate 5 lipoxygenase	arachidonate 12-lipoxygenase	663 aa	662 aa	22.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Schistosoma mansoni	lamin	0.0026	0.3548	0.3548
Loa Loa (eye worm)	G-protein coupled receptor	0.0033	0.456	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0033	0.456	1
Brugia malayi	G protein-coupled receptor	0.0033	0.456	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0371	0.5
Echinococcus granulosus	RUN	0.0024	0.316	0.2824
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.456	0.456
Schistosoma mansoni	amine GPCR	0.0033	0.456	0.456
Echinococcus granulosus	neuropeptide FF receptor 2	0.0033	0.456	0.4293
Echinococcus granulosus	g protein coupled receptor	0.0033	0.456	0.4293
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0033	0.456	0.456
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0033	0.456	0.4293
Onchocerca volvulus		0.0033	0.456	1
Brugia malayi	Serotonin receptor	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.456	0.456
Brugia malayi	Dopamine receptor	0.0033	0.456	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.3548	0.7351
Onchocerca volvulus		0.0033	0.456	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.456	0.456
Echinococcus multilocularis	musashi	0.0026	0.3548	0.3231
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Schistosoma mansoni	biogenic amine receptor	0.0033	0.456	0.456
Echinococcus granulosus	allatostatin A receptor	0.0033	0.456	0.4293
Brugia malayi	Dopamine receptor protein 1	0.0033	0.456	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.456	0.4293
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.456	0.4293
Echinococcus granulosus	cpg binding protein	0.003	0.4074	0.3783
Schistosoma mansoni	neuropeptide receptor	0.0033	0.456	0.456
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Schistosoma mansoni	growth hormone secretagogue receptor	0.0033	0.456	0.456
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus multilocularis	neuropeptide receptor	0.0033	0.456	0.4293
Brugia malayi	follicle stimulating hormone receptor	0.0033	0.456	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Schistosoma mansoni	cpg binding protein	0.003	0.4074	0.4074
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Onchocerca volvulus		0.0028	0.382	0.4715
Onchocerca volvulus		0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1381	0.1679
Onchocerca volvulus		0.0033	0.456	1
Echinococcus granulosus	g-protein coupled receptor	0.0033	0.456	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Brugia malayi	larval opioid receptor	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus multilocularis	somatostatin receptor	0.0033	0.456	0.4293
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0371	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0371	0.5
Echinococcus granulosus	somatostatin receptor	0.0033	0.456	0.4293
Brugia malayi	hypothetical protein	0.0024	0.316	0.6353
Schistosoma mansoni	cpg binding protein	0.003	0.4074	0.4074
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0033	0.456	0.456
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Schistosoma mansoni	neuropeptide receptor	0.0033	0.456	0.456
Echinococcus granulosus	7TM GPCR rhodopsin	0.0033	0.456	0.4293
Echinococcus multilocularis	lamin dm0	0.0026	0.3548	0.3231
Schistosoma mansoni	biogenic amine receptor	0.0033	0.456	0.456
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0033	0.456	0.456
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0371	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0033	0.456	0.4293
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0033	0.456	0.4293
Echinococcus granulosus	neuropeptide receptor A26	0.0033	0.456	0.4293
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Brugia malayi	Doublecortin family protein	0.0024	0.316	0.6353
Onchocerca volvulus		0.0033	0.456	1
Onchocerca volvulus		0.0033	0.456	1
Echinococcus multilocularis	g-protein coupled receptor	0.0033	0.456	0.4293
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0371	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0033	0.456	0.456
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0033	0.456	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0033	0.456	0.4293
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.456	0.456
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Brugia malayi	ORL1-like opioid receptor	0.0033	0.456	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0033	0.456	0.4293
Schistosoma mansoni	amine GPCR	0.0033	0.456	0.456
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.074	0.0285
Brugia malayi	hypothetical protein	0.0033	0.456	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0033	0.456	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Echinococcus multilocularis	neuropeptides capa receptor	0.0033	0.456	0.4293
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0033	0.456	1
Schistosoma mansoni	histamine h1 receptor	0.0033	0.456	0.456
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0371	0.5
Onchocerca volvulus		0.0033	0.456	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0033	0.456	0.4293
Onchocerca volvulus		0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.316	0.6336
Echinococcus multilocularis	cpg binding protein	0.003	0.4074	0.3783
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0033	0.456	0.456
Schistosoma mansoni	myosin xvIII	0.0033	0.456	0.456
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0033	0.456	0.4293
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0033	0.456	0.4293
Echinococcus granulosus	g protein coupled receptor	0.0033	0.456	0.4293
Echinococcus multilocularis	neuropeptide Y receptor	0.0033	0.456	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Onchocerca volvulus		0.0026	0.3548	0.2771
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0033	0.456	0.4293
Echinococcus multilocularis	sex peptide receptor	0.0033	0.456	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0033	0.456	0.4293
Echinococcus granulosus	lamin dm0	0.0026	0.3548	0.3231
Loa Loa (eye worm)	hypothetical protein	0.0026	0.3548	0.7351
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.456	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0033	0.456	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.0024	0.316	0.2824
Brugia malayi	neuropeptide F receptor	0.0033	0.456	1
Schistosoma mansoni	biogenic amine receptor	0.0033	0.456	0.456
Schistosoma mansoni	neuropeptide F-like receptor	0.0033	0.456	0.456
Schistosoma mansoni	hypothetical protein	0.0033	0.456	0.456
Plasmodium falciparum	LCCL domain-containing protein	0.0024	0.316	0.5
Onchocerca volvulus		0.0033	0.456	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0033	0.456	0.4293
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0033	0.456	1
Schistosoma mansoni	neuropeptide receptor	0.0033	0.456	0.456
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0371	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0033	0.456	0.456
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0033	0.456	1
Schistosoma mansoni	hypothetical protein	0.0033	0.456	0.456
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.382	0.8063
Echinococcus granulosus	serotonin receptor	0.0033	0.456	0.4293
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.1381	0.0958
Loa Loa (eye worm)	TYRA-2 protein	0.0033	0.456	1
Brugia malayi	hypothetical protein	0.0033	0.456	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0033	0.456	0.456
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0033	0.456	0.456
Echinococcus multilocularis	serotonin receptor	0.0033	0.456	0.4293
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0033	0.456	0.456
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0033	0.456	0.4293
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.456	0.4293
Schistosoma mansoni	rab6-interacting	0.0024	0.316	0.316
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0033	0.456	0.456
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0033	0.456	1
Plasmodium vivax	multidomain scavenger receptor, putative	0.0024	0.316	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus multilocularis	neuropeptide s receptor	0.0033	0.456	0.4293
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.456	0.4293
Echinococcus multilocularis	fmrfamide receptor	0.0033	0.456	0.4293
Brugia malayi	G-protein coupled receptor	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.316	0.2824
Brugia malayi	neuropeptide F receptor	0.0033	0.456	1
Echinococcus granulosus	fmrfamide receptor	0.0033	0.456	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0026	0.3472	0.7151
Loa Loa (eye worm)	hypothetical protein	0.0024	0.316	0.6336
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Brugia malayi	RE15519p	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1305	0.1478
Echinococcus multilocularis	serotonin receptor	0.0033	0.456	0.4293
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0033	0.456	0.456
Echinococcus multilocularis	RUN	0.0024	0.316	0.2824
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.456	0.4293
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.882	0.882
Schistosoma mansoni	opsin-like receptor	0.0033	0.456	0.456
Brugia malayi	putative neuropeptide receptor NPR1	0.0033	0.456	1
Echinococcus multilocularis	allatostatin A receptor	0.0033	0.456	0.4293
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.456	0.456
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0371	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0033	0.456	0.4293
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0371	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0033	0.456	1
Schistosoma mansoni	hypothetical protein	0.0033	0.456	0.456
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.781	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Onchocerca volvulus		0.0033	0.456	1
Brugia malayi	hypothetical protein	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Brugia malayi	Melatonin receptor type 1A	0.0033	0.456	1
Brugia malayi	putative neuropeptide receptor	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus granulosus	neuropeptides capa receptor	0.0033	0.456	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.456	0.456
Echinococcus multilocularis	orexin receptor type 2	0.0033	0.456	0.4293
Schistosoma mansoni	lipoxygenase	0.0024	0.316	0.316
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus granulosus	sex peptide receptor	0.0033	0.456	0.4293
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0371	0.5
Schistosoma mansoni	amine GPCR	0.0033	0.456	0.456
Schistosoma mansoni	adenoreceptor	0.0033	0.456	0.456
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.456	0.456
Echinococcus multilocularis	lamin	0.0026	0.3548	0.3231
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.1604	0.2261
Brugia malayi	hypothetical protein	0.0033	0.456	1
Onchocerca volvulus		0.0033	0.456	1
Schistosoma mansoni	polycystin 1-related	0.0024	0.316	0.316
Loa Loa (eye worm)	neuropeptide F receptor	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.456	0.4293
Brugia malayi	sulfakinin receptor protein	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0371	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Schistosoma mansoni	hypothetical protein	0.0024	0.316	0.316
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.316	0.2824
Echinococcus granulosus	g protein coupled receptor	0.0033	0.456	0.4293
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.456	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0033	0.456	0.4293
Onchocerca volvulus		0.0033	0.456	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0033	0.456	0.4293
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Echinococcus granulosus	intermediate filament protein	0.0026	0.3548	0.3231
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.3548	0.7363
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0033	0.456	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0371	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.456	0.456
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.456	0.456
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0033	0.456	1
Onchocerca volvulus		0.0033	0.456	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.074	0.0285
Brugia malayi	hypothetical protein	0.0033	0.456	1
Schistosoma mansoni	rab6-interacting	0.0024	0.316	0.316
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.1381	0.0958
Brugia malayi	G protein-coupled receptor F59B2.13	0.0033	0.456	1
Brugia malayi	hypothetical protein	0.0033	0.456	1
Onchocerca volvulus		0.0026	0.3548	0.2771
Echinococcus granulosus	neuropeptide Y receptor	0.0033	0.456	0.4293
Onchocerca volvulus		0.0033	0.456	1
Brugia malayi	Dopamine receptor protein 2	0.0033	0.456	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0033	0.456	1
Schistosoma mansoni	opsin-like receptor	0.0033	0.456	0.456
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0033	0.456	1
Trichomonas vaginalis	helicase, putative	0.0006	0.0371	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0033	0.456	0.4293
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.456	0.456
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0033	0.456	0.4293
Echinococcus multilocularis	neuropeptides capa receptor	0.0033	0.456	0.4293
Schistosoma mansoni	lamin	0.0026	0.3548	0.3548
Echinococcus multilocularis	neuropeptide Y receptor	0.0033	0.456	0.4293
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.316	0.2824
Echinococcus multilocularis	dro:myosuppressin receptor	0.0033	0.456	0.4293
Schistosoma mansoni	neuropeptide receptor	0.0033	0.456	0.456
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0033	0.456	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Brugia malayi	G-protein coupled receptor	0.0033	0.456	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0371	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0033	0.456	0.4293
Onchocerca volvulus		0.0033	0.456	1
Brugia malayi	hypothetical protein	0.0024	0.316	0.6353
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0033	0.456	0.456
Echinococcus granulosus	G protein coupled receptor 139	0.0033	0.456	0.4293
Brugia malayi	hypothetical protein	0.0033	0.456	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0033	0.456	0.4293
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0033	0.456	0.4293
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0033	0.456	0.456
Brugia malayi	intermediate filament protein	0.0026	0.3548	0.7363
Brugia malayi	CXXC zinc finger family protein	0.0028	0.382	0.8072
Schistosoma mansoni	amine GPCR	0.0033	0.456	0.456
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0033	0.456	1
Brugia malayi	hypothetical protein	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Brugia malayi	AKH receptor	0.0033	0.456	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.456	0.456
Echinococcus granulosus	hypothetical protein	0.0033	0.456	0.4293
Brugia malayi	hypothetical protein	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Brugia malayi	hypothetical protein	0.0033	0.456	1
Schistosoma mansoni	loxhd1	0.0024	0.316	0.316
Schistosoma mansoni	cpg binding protein	0.0028	0.382	0.382
Loa Loa (eye worm)	melatonin receptor type 1A	0.0033	0.456	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0033	0.456	0.4293
Schistosoma mansoni	neuropeptide f receptor 76f	0.0033	0.456	0.456
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0033	0.456	0.4293
Schistosoma mansoni	intermediate filament proteins	0.0026	0.3548	0.3548
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.456	0.456
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus granulosus	lamin	0.0026	0.3548	0.3231
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Onchocerca volvulus		0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus granulosus	neuropeptide receptor	0.0033	0.456	0.4293
Echinococcus granulosus	Polycystic kidney disease protein	0.0024	0.316	0.2824
Schistosoma mansoni	neuropeptide F-like receptor	0.0033	0.456	0.456
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Echinococcus granulosus	biogenic amine 5HT receptor	0.0033	0.456	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1305	0.1478
Loa Loa (eye worm)	doublecortin family protein	0.0024	0.316	0.6336
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.456	0.4293
Onchocerca volvulus		0.0033	0.456	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.316	0.2824
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0033	0.456	0.4293
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0371	0.5
Schistosoma mansoni	hypothetical protein	0.0033	0.456	0.456
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0033	0.456	0.4293
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0033	0.456	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0033	0.456	0.4293
Schistosoma mansoni	amine GPCR	0.0033	0.456	0.456
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Brugia malayi	GnHR receptor homolog	0.0033	0.456	1
Echinococcus granulosus	neuropeptide Y receptor	0.0033	0.456	0.4293
Brugia malayi	Serotonin receptor	0.0033	0.456	1
Schistosoma mansoni	opsin-like receptor	0.0033	0.456	0.456
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0371	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0033	0.456	0.4293
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.3548	0.7351
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0371	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.456	0.4293
Echinococcus granulosus	orexin receptor type 2	0.0033	0.456	0.4293
Echinococcus granulosus	neuropeptide receptor	0.0033	0.456	0.4293
Echinococcus multilocularis	fmrfamide receptor	0.0033	0.456	0.4293
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0371	0.5
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.1604	0.2296
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.456	1
Echinococcus granulosus	neuropeptide s receptor	0.0033	0.456	0.4293

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.1 uM	Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysis	ChEMBL.	24393039
Inhibition (binding)	= 4.7 %	Inhibition of N-terminal His6-tagged human reticulocyte 15-LOX1 using arachidonic acid as substrate at 25 uM by UV-vis spectrophotometric analysis relative to control	ChEMBL.	24393039

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3113196

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1834259